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Items: 1 to 50 of 559

1.

NOX2 mediates quiescent handling of dead cell remnants in phagocytes.

Hahn J, Euler M, Kilgus E, Kienhöfer D, Stoof J, Knopf J, Hahn M, Harrer T, Hultqvist M, Olofsson P, Mokhir A, Holmdahl R, Herrmann M, Schett G, Muñoz LE, Hoffmann MH.

Redox Biol. 2019 Sep;26:101279. doi: 10.1016/j.redox.2019.101279. Epub 2019 Jul 20.

2.

Low Production of Reactive Oxygen Species Drives Systemic Lupus Erythematosus.

Urbonaviciute V, Luo H, Sjöwall C, Bengtsson A, Holmdahl R.

Trends Mol Med. 2019 Jul 11. pii: S1471-4914(19)30132-7. doi: 10.1016/j.molmed.2019.06.001. [Epub ahead of print] Review.

PMID:
31303528
3.

The structure, specificity and function of anti-citrullinated protein antibodies.

Ge C, Holmdahl R.

Nat Rev Rheumatol. 2019 Aug;15(8):503-508. doi: 10.1038/s41584-019-0244-4. Epub 2019 Jun 28. Review.

PMID:
31253945
4.

Comment on editorial 'Pathogenic effector functions of ACPA: where do we stand?'

Holmdahl R.

Ann Rheum Dis. 2019 Jun 21. pii: annrheumdis-2019-215857. doi: 10.1136/annrheumdis-2019-215857. [Epub ahead of print] No abstract available.

PMID:
31227487
5.

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.

Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, Sandor K, Xu B, Abdelmoaty S, Hunt MA, Ängeby Möller K, Baharpoor A, Sinclair J, Jardemark K, Lanner JT, Khmaladze I, Borm LE, Zhang L, Wermeling F, Cragg MS, Lengqvist J, Chabot-Doré AJ, Diatchenko L, Belfer I, Collin M, Kultima K, Heyman B, Jimenez-Andrade JM, Codeluppi S, Holmdahl R, Svensson CI.

J Exp Med. 2019 Aug 5;216(8):1904-1924. doi: 10.1084/jem.20181657. Epub 2019 Jun 13.

PMID:
31196979
6.

Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949.

Lind S, Sundqvist M, Holmdahl R, Dahlgren C, Forsman H, Olofsson P.

Biochem Pharmacol. 2019 Aug;166:163-173. doi: 10.1016/j.bcp.2019.04.030. Epub 2019 May 11.

PMID:
31085160
7.

Editorial: Autoantibodies.

Holmdahl R, Nimmerjahn F, Ludwig RJ.

Front Immunol. 2019 Apr 2;10:484. doi: 10.3389/fimmu.2019.00484. eCollection 2019. No abstract available.

8.

Editorial: Oxidants and Redox Signaling in Inflammation.

Singla B, Holmdahl R, Csanyi G.

Front Immunol. 2019 Mar 26;10:545. doi: 10.3389/fimmu.2019.00545. eCollection 2019. No abstract available.

9.

Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2.

Henríquez-Olguín C, Renani LB, Arab-Ceschia L, Raun SH, Bhatia A, Li Z, Knudsen JR, Holmdahl R, Jensen TE.

Redox Biol. 2019 Jun;24:101188. doi: 10.1016/j.redox.2019.101188. Epub 2019 Apr 3.

10.

The autoantibody response to cyclic citrullinated collagen type II peptides in rheumatoid arthritis.

Liang B, Ge C, Lönnblom E, Lin X, Feng H, Xiao L, Bai J, Ayoglu B, Nilsson P, Nandakumar KS, Zhao M, Holmdahl R.

Rheumatology (Oxford). 2019 Sep 1;58(9):1623-1633. doi: 10.1093/rheumatology/kez073.

PMID:
30892636
11.

Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants.

Löhr S, Ekici AB, Uebe S, Büttner C, Köhm M, Behrens F, Böhm B, Sticherling M, Schett G, Simon D, Mössner R, Nimeh A, Oji V, Assmann G, Rech J, Holmdahl R, Burkhardt H, Reis A, Hüffmeier U.

Rheumatology (Oxford). 2019 May 1;58(5):915-917. doi: 10.1093/rheumatology/key448. No abstract available.

PMID:
30753645
12.

Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure.

Hagert C, Siitonen R, Li XG, Liljenbäck H, Roivainen A, Holmdahl R.

Clin Exp Immunol. 2019 Jun;196(3):383-391. doi: 10.1111/cei.13268. Epub 2019 Feb 27.

PMID:
30712330
13.

The Specificity of Monoclonal Anti-Citrullinated Protein Antibodies: Comment on the Article by Steen et al.

Holmdahl R.

Arthritis Rheumatol. 2019 Feb;71(2):324-325. doi: 10.1002/art.40758. Epub 2019 Jan 9. No abstract available.

PMID:
30303300
14.

Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.

Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R.

Arthritis Rheumatol. 2019 Feb;71(2):210-221. doi: 10.1002/art.40698. Epub 2019 Jan 4.

PMID:
30152126
15.

Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo.

Nandakumar KS, Collin M, Happonen KE, Lundström SL, Croxford AM, Xu B, Zubarev RA, Rowley MJ, Blom AM, Kjellman C, Holmdahl R.

Front Immunol. 2018 Jul 16;9:1623. doi: 10.3389/fimmu.2018.01623. eCollection 2018.

16.

The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis.

Fischer A, Abdollahi-Roodsaz S, Böhm C, Niederreiter B, Meyer B, Yau ACY, Lönnblom E, Joosten LAB, Koenders M, Lehmann CHK, Dudziak D, Krönke G, Holmdahl R, Steiner G.

J Cell Mol Med. 2018 Sep;22(9):4399-4409. doi: 10.1111/jcmm.13735. Epub 2018 Jul 11.

17.

Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T-lymphocyte antigen-4.

Yang M, Klocke K, Hernandez CM, Xu B, Gjertsson I, Wing K, Holmdahl R.

Immunology. 2018 Dec;155(4):446-457. doi: 10.1111/imm.12983. Epub 2018 Jul 31.

PMID:
29992549
18.

Reactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis.

Carvalho L, Gomes JRM, Tavares LC, Xavier AR, Klika KD, Holmdahl R, Carvalho RA, Souto-Carneiro MM.

Front Immunol. 2018 May 14;9:701. doi: 10.3389/fimmu.2018.00701. eCollection 2018.

19.

Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes.

Zhong J, Scholz T, Yau ACY, Guerard S, Hüffmeier U, Burkhardt H, Holmdahl R.

Sci Adv. 2018 May 16;4(5):eaas9864. doi: 10.1126/sciadv.aas9864. eCollection 2018 May.

20.

Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis.

Lindgren C, Tyagi M, Viljanen J, Toms J, Ge C, Zhang N, Holmdahl R, Kihlberg J, Linusson A.

J Med Chem. 2018 Jun 14;61(11):4774-4790. doi: 10.1021/acs.jmedchem.7b01880. Epub 2018 May 24.

PMID:
29727183
21.

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis.

Tong D, Lönnblom E, Yau ACY, Nandakumar KS, Liang B, Ge C, Viljanen J, Li L, Bãlan M, Klareskog L, Chagin AS, Gjertsson I, Kihlberg J, Zhao M, Holmdahl R.

Front Immunol. 2018 Apr 12;9:451. doi: 10.3389/fimmu.2018.00451. eCollection 2018.

22.

Association of NOX2 subunits genetic variants with autoimmune diseases.

Zhong J, Olsson LM, Urbonaviciute V, Yang M, Bäckdahl L, Holmdahl R.

Free Radic Biol Med. 2018 Sep;125:72-80. doi: 10.1016/j.freeradbiomed.2018.03.005. Epub 2018 Mar 9. Review.

PMID:
29526808
23.

A Restricted Role for FcγR in the Regulation of Adaptive Immunity.

Fransen MF, Benonisson H, van Maren WW, Sow HS, Breukel C, Linssen MM, Claassens JWC, Brouwers C, van der Kaa J, Camps M, Kleinovink JW, Vonk KK, van Heiningen S, Klar N, van Beek L, van Harmelen V, Daxinger L, Nandakumar KS, Holmdahl R, Coward C, Lin Q, Hirose S, Salvatori D, van Hall T, van Kooten C, Mastroeni P, Ossendorp F, Verbeek JS.

J Immunol. 2018 Apr 15;200(8):2615-2626. doi: 10.4049/jimmunol.1700429. Epub 2018 Mar 9.

24.

Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells: A Novel Experimental Model of Rheumatoid Arthritis.

Hagert C, Sareila O, Kelkka T, Nandakumar KS, Collin M, Xu B, Guérard S, Bäcklund J, Jalkanen S, Holmdahl R.

Arthritis Rheumatol. 2018 Aug;70(8):1343-1353. doi: 10.1002/art.40482. Epub 2018 Jun 20.

25.

Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T-cell-associated autoimmunity.

Vaartjes D, Nandakumar KS, Holmdahl R, Raposo B.

Immunology. 2018 Mar 7. doi: 10.1111/imm.12923. [Epub ahead of print]

26.

The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.

Hagert C, Sareila O, Kelkka T, Jalkanen S, Holmdahl R.

Front Immunol. 2018 Feb 6;9:114. doi: 10.3389/fimmu.2018.00114. eCollection 2018.

27.

T cells specific for post-translational modifications escape intrathymic tolerance induction.

Raposo B, Merky P, Lundqvist C, Yamada H, Urbonaviciute V, Niaudet C, Viljanen J, Kihlberg J, Kyewski B, Ekwall O, Holmdahl R, Bäcklund J.

Nat Commun. 2018 Jan 24;9(1):353. doi: 10.1038/s41467-017-02763-y.

28.

Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis.

Yang M, Haase C, Viljanen J, Xu B, Ge C, Kihlberg J, Holmdahl R.

J Immunol. 2017 Dec 15;199(12):3937-3942. doi: 10.4049/jimmunol.1700774. Epub 2017 Nov 10.

29.

Influence of hydrocarbon oil structure on adjuvanticity and autoimmunity.

Yau ACY, Lönnblom E, Zhong J, Holmdahl R.

Sci Rep. 2017 Nov 8;7(1):14998. doi: 10.1038/s41598-017-15096-z.

30.

Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants.

Rönnelid J, Hansson M, Mathsson-Alm L, Cornillet M, Reed E, Jakobsson PJ, Alfredsson L, Holmdahl R, Skriner K, Serre G, Lundberg K, Klareskog L.

Ann Rheum Dis. 2018 Feb;77(2):203-211. doi: 10.1136/annrheumdis-2017-211782. Epub 2017 Oct 25.

PMID:
29070529
31.

Germinal Center B Cells Are Essential for Collagen-Induced Arthritis.

Dahdah A, Habir K, Nandakumar KS, Saxena A, Xu B, Holmdahl R, Malin S.

Arthritis Rheumatol. 2018 Feb;70(2):193-203. doi: 10.1002/art.40354. Epub 2018 Jan 22.

32.

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

Sorce S, Stocker R, Seredenina T, Holmdahl R, Aguzzi A, Chio A, Depaulis A, Heitz F, Olofsson P, Olsson T, Duveau V, Sanoudou D, Skosgater S, Vlahou A, Wasquel D, Krause KH, Jaquet V.

Free Radic Biol Med. 2017 Nov;112:387-396. doi: 10.1016/j.freeradbiomed.2017.08.006. Epub 2017 Aug 12. Review.

33.

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R.

JCI Insight. 2017 Jul 6;2(13). pii: 93688. doi: 10.1172/jci.insight.93688. eCollection 2017 Jul 6.

34.

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus.

Olsson LM, Johansson ÅC, Gullstrand B, Jönsen A, Saevarsdottir S, Rönnblom L, Leonard D, Wetterö J, Sjöwall C, Svenungsson E, Gunnarsson I, Bengtsson AA, Holmdahl R.

Ann Rheum Dis. 2017 Sep;76(9):1607-1613. doi: 10.1136/annrheumdis-2017-211287. Epub 2017 Jun 12.

PMID:
28606963
35.

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH.

JCI Insight. 2017 May 18;2(10). pii: 92920. doi: 10.1172/jci.insight.92920. eCollection 2017 May 18.

36.

CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.

Klocke K, Holmdahl R, Wing K.

Immunology. 2017 Sep;152(1):125-137. doi: 10.1111/imm.12754. Epub 2017 Jun 20.

37.

Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.

Sareila O, Hagert C, Kelkka T, Linja M, Xu B, Kihlberg J, Holmdahl R.

Antioxid Redox Signal. 2017 Dec 20;27(18):1473-1490. doi: 10.1089/ars.2016.6981. Epub 2017 Jun 1.

PMID:
28467721
38.

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.

Guerreiro-Cacais AO, Norin U, Gyllenberg A, Berglund R, Beyeen AD; Rheumatoid Arthritis Consortium International (RACI), Petit-Teixeira E, Cornélis F, Saoudi A, Fournié GJ, Holmdahl R, Alfredsson L, Klareskog L, Jagodic M, Olsson T, Kockum I, Padyukov L.

Genes Immun. 2017 Mar;18(2):109. doi: 10.1038/gene.2017.7. No abstract available.

PMID:
28446790
39.

The Major Histocompatibility Complex Class III Haplotype Ltab-Ncr3 Regulates Adjuvant-Induced but Not Antigen-Induced Autoimmunity.

Yau ACY, Tuncel J, Holmdahl R.

Am J Pathol. 2017 May;187(5):987-998. doi: 10.1016/j.ajpath.2016.12.022. Epub 2017 Mar 18.

PMID:
28315676
40.

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.

Guerreiro-Cacais AO, Norin U, Gyllenberg A, Berglund R, Beyeen AD; Rheumatoid Arthritis Consortium International (RACI), Petit-Teixeira E, Cornélis F, Saoudi A, Fournié GJ, Holmdahl R, Alfredsson L, Klareskog L, Jagodic M, Olsson T, Kockum I, Padyukov L.

Genes Immun. 2017 Jan;18(1):48-56. doi: 10.1038/gene.2016.49. Epub 2017 Jan 5. Erratum in: Genes Immun. 2017 Mar;18(2):109.

PMID:
28053322
41.

MHC class II alleles associated with Th1 rather than Th17 type immunity drive the onset of early arthritis in a rat model of rheumatoid arthritis.

Tuncel J, Haag S, Holmdahl R.

Eur J Immunol. 2017 Mar;47(3):563-574. doi: 10.1002/eji.201646760. Epub 2017 Feb 14.

42.

Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.

Zhu W, Xu J, Jiang C, Wang B, Geng M, Wu X, Hussain N, Gao N, Han Y, Li D, Lan X, Ning Q, Zhang F, Holmdahl R, Meng L, Lu S.

Clin Immunol. 2017 Feb;175:56-68. doi: 10.1016/j.clim.2016.11.017. Epub 2016 Dec 7.

PMID:
27940139
43.

Effects of C2ta genetic polymorphisms on MHC class II expression and autoimmune diseases.

Yau AC, Piehl F, Olsson T, Holmdahl R.

Immunology. 2017 Apr;150(4):408-417. doi: 10.1111/imm.12692. Epub 2016 Dec 22.

44.

Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.

Stubelius A, Andersson A, Holmdahl R, Ohlsson C, Islander U, Carlsten H.

BMC Musculoskelet Disord. 2016 Nov 9;17(1):464.

45.

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.

Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7.

46.

Effects by periodontitis on pristane-induced arthritis in rats.

Eriksson K, Lönnblom E, Tour G, Kats A, Mydel P, Georgsson P, Hultgren C, Kharlamova N, Norin U, Jönsson J, Lundmark A, Hellvard A, Lundberg K, Jansson L, Holmdahl R, Yucel-Lindberg T.

J Transl Med. 2016 Nov 3;14(1):311.

47.

Reply to Liu et al.: Translation of rat congenic data to humans on a conserved MHC-III haplotype associated with rheumatoid arthritis.

Yau AC, Houtman M, Padyukov L, Holmdahl R.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6323-E6324. Epub 2016 Oct 11. No abstract available.

48.

Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.

Peleli M, Zollbrecht C, Montenegro MF, Hezel M, Zhong J, Persson EG, Holmdahl R, Weitzberg E, Lundberg JO, Carlström M.

Free Radic Biol Med. 2016 Oct;99:472-484. doi: 10.1016/j.freeradbiomed.2016.09.004. Epub 2016 Sep 5.

PMID:
27609225
49.

Rheumatoid arthritis: identifying and characterising polymorphisms using rat models.

Yau AC, Holmdahl R.

Dis Model Mech. 2016 Oct 1;9(10):1111-1123. Review.

50.

(18)F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography.

Li XG, Hagert C, Siitonen R, Virtanen H, Sareila O, Liljenbäck H, Tuisku J, Knuuti J, Bergman J, Holmdahl R, Roivainen A.

ACS Med Chem Lett. 2016 May 16;7(9):826-30. doi: 10.1021/acsmedchemlett.6b00160. eCollection 2016 Sep 8.

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