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Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells.

Wolfisberg R, Holmbeck K, Nielsen L, Kapoor A, Rice CM, Bukh J, Scheel TKH.

J Virol. 2019 Jul 10. pii: JVI.00733-19. doi: 10.1128/JVI.00733-19. [Epub ahead of print]


MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.

Sanz RL, Ferraro GB, Kacervosky J, Salesse C, Gowing E, Hua L, Rambaldi I, Beaubien F, Holmbeck K, Cloutier JF, Lévesque M, Murai K, Fournier AE.

J Neurosci. 2018 Jan 17;38(3):518-529. doi: 10.1523/JNEUROSCI.0962-17.2017. Epub 2017 Dec 1.


Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia.

Mayer B, Németh K, Krepuska M, Myneni VD, Maric D, Tisdale JF, Hsieh MM, Uchida N, Lee HJ, Nemeth MJ, Holmbeck K, Noguchi CT, Rogers H, Dey S, Hansen A, Hong J, Chow I, Key S, Szalayova I, Pagani J, Markó K, McClain-Caldwell I, Vitale-Cross L, Young WS, Brownstein MJ, Mezey É.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaao1632. doi: 10.1126/scitranslmed.aao1632.


Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis in vivo.

Daley WP, Matsumoto K, Doyle AD, Wang S, DuChez BJ, Holmbeck K, Yamada KM.

Development. 2017 Jun 15;144(12):2200-2211. doi: 10.1242/dev.146894. Epub 2017 May 15.


Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream.

Langenfurth A, Gu S, Bautze V, Zhang C, Neumann JE, Schüller U, Stock K, Wolf SA, Maier AM, Mastrella G, Pak A, Cheng H, Kälin RE, Holmbeck K, Strotmann J, Kettenmann H, Glass R.

Sci Rep. 2016 Aug 30;6:32203. doi: 10.1038/srep32203.


Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.

Xu H, Snider TN, Wimer HF, Yamada SS, Yang T, Holmbeck K, Foster BL.

Matrix Biol. 2016 May-Jul;52-54:266-283. doi: 10.1016/j.matbio.2016.01.002. Epub 2016 Jan 15.


A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH.

Blood. 2016 Mar 3;127(9):1085-96. doi: 10.1182/blood-2015-05-644260. Epub 2015 Dec 8.


Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis.

Koide H, Holmbeck K, Lui JC, Guo XC, Driggers P, Chu T, Tatsuno I, Quaglieri C, Kino T, Baron J, Young MF, Robey PG, Segars JH.

J Bone Miner Res. 2015 Oct;30(10):1887-95. doi: 10.1002/jbmr.2534. Epub 2015 May 10.


WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.

Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny EM, Tantillo MA, Kohn DH, Lyons KM, Robey PG, Young MF.

J Biol Chem. 2015 May 29;290(22):14004-18. doi: 10.1074/jbc.M114.628818. Epub 2015 Apr 11.


Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse.

Remoli C, Michienzi S, Sacchetti B, Consiglio AD, Cersosimo S, Spica E, Robey PG, Holmbeck K, Cumano A, Boyde A, Davis G, Saggio I, Riminucci M, Bianco P.

J Bone Miner Res. 2015 Jun;30(6):1030-43. doi: 10.1002/jbmr.2425.


Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history.

Saggio I, Remoli C, Spica E, Cersosimo S, Sacchetti B, Robey PG, Holmbeck K, Cumano A, Boyde A, Bianco P, Riminucci M.

J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267.


The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity.

Peters DE, Szabo R, Friis S, Shylo NA, Uzzun Sales K, Holmbeck K, Bugge TH.

J Biol Chem. 2014 May 23;289(21):14740-9. doi: 10.1074/jbc.M113.541318. Epub 2014 Apr 4.


Biglycan modulates angiogenesis and bone formation during fracture healing.

Berendsen AD, Pinnow EL, Maeda A, Brown AC, McCartney-Francis N, Kram V, Owens RT, Robey PG, Holmbeck K, de Castro LF, Kilts TM, Young MF.

Matrix Biol. 2014 Apr;35:223-31. doi: 10.1016/j.matbio.2013.12.004. Epub 2013 Dec 25.


M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.

Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH.

J Cell Biol. 2013 Sep 16;202(6):951-66. doi: 10.1083/jcb.201301081. Epub 2013 Sep 9.


Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis.

Madsen DH, Jürgensen HJ, Ingvarsen S, Melander MC, Albrechtsen R, Hald A, Holmbeck K, Bugge TH, Behrendt N, Engelholm LH.

PLoS One. 2013 Aug 5;8(8):e71261. doi: 10.1371/journal.pone.0071261. Print 2013.


Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.

Ingvarsen S, Porse A, Erpicum C, Maertens L, Jürgensen HJ, Madsen DH, Melander MC, Gårdsvoll H, Høyer-Hansen G, Noel A, Holmbeck K, Engelholm LH, Behrendt N.

J Biol Chem. 2013 Apr 12;288(15):10195-204. doi: 10.1074/jbc.M112.447169. Epub 2013 Feb 14.


Membrane-type MMPs are indispensable for placental labyrinth formation and development.

Szabova L, Son MY, Shi J, Sramko M, Yamada SS, Swaim WD, Zerfas P, Kahan S, Holmbeck K.

Blood. 2010 Dec 16;116(25):5752-61. doi: 10.1182/blood-2009-10-249847. Epub 2010 Sep 21.


Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.

Makareeva E, Han S, Vera JC, Sackett DL, Holmbeck K, Phillips CL, Visse R, Nagase H, Leikin S.

Cancer Res. 2010 Jun 1;70(11):4366-74. doi: 10.1158/0008-5472.CAN-09-4057. Epub 2010 May 11.


MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis.

Rebustini IT, Myers C, Lassiter KS, Surmak A, Szabova L, Holmbeck K, Pedchenko V, Hudson BG, Hoffman MP.

Dev Cell. 2009 Oct;17(4):482-93. doi: 10.1016/j.devcel.2009.07.016.


Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.

Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12530-5. doi: 10.1073/pnas.0804273106. Epub 2009 Jul 15.


MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.

Szabova L, Yamada SS, Wimer H, Chrysovergis K, Ingvarsen S, Behrendt N, Engelholm LH, Holmbeck K.

J Bone Miner Res. 2009 Nov;24(11):1905-16. doi: 10.1359/jbmr.090510.


Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells.

Ingvarsen S, Madsen DH, Hillig T, Lund LR, Holmbeck K, Behrendt N, Engelholm LH.

Biol Chem. 2008 Jul;389(7):943-53. doi: 10.1515/BC.2008.097.


MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease.

Szabova L, Chrysovergis K, Yamada SS, Holmbeck K.

Oncogene. 2008 May 22;27(23):3274-81. Epub 2007 Dec 10.


Development of craniofacial structures in transgenic mice with constitutively active PTH/PTHrP receptor.

Tsutsui TW, Riminucci M, Holmbeck K, Bianco P, Robey PG.

Bone. 2008 Feb;42(2):321-31. Epub 2007 Oct 16.


Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.

Shi J, Son MY, Yamada S, Szabova L, Kahan S, Chrysovergis K, Wolf L, Surmak A, Holmbeck K.

Dev Biol. 2008 Jan 1;313(1):196-209. Epub 2007 Oct 23.


Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.

Madsen DH, Engelholm LH, Ingvarsen S, Hillig T, Wagenaar-Miller RA, Kjøller L, Gårdsvoll H, Høyer-Hansen G, Holmbeck K, Bugge TH, Behrendt N.

J Biol Chem. 2007 Sep 14;282(37):27037-45. Epub 2007 Jul 9.


Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.

Wagenaar-Miller RA, Engelholm LH, Gavard J, Yamada SS, Gutkind JS, Behrendt N, Bugge TH, Holmbeck K.

Mol Cell Biol. 2007 Sep;27(18):6309-22. Epub 2007 Jul 9.


GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha.

Michienzi S, Cherman N, Holmbeck K, Funari A, Collins MT, Bianco P, Robey PG, Riminucci M.

Hum Mol Genet. 2007 Aug 15;16(16):1921-30. Epub 2007 Jun 12.


Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury.

Atkinson JJ, Toennies HM, Holmbeck K, Senior RM.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L600-10. Epub 2007 Jun 8.


MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.

Basile JR, Holmbeck K, Bugge TH, Gutkind JS.

J Biol Chem. 2007 Mar 2;282(9):6899-905. Epub 2007 Jan 4.


Aspects of extracellular matrix remodeling in development and disease.

Holmbeck K, Szabova L.

Birth Defects Res C Embryo Today. 2006 Mar;78(1):11-23. Review.


Collagenase in cranial morphogenesis.

Holmbeck K.

Cells Tissues Organs. 2005;181(3-4):154-65. Review.


Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo.

Zhang W, Matrisian LM, Holmbeck K, Vick CC, Rosenthal EL.

BMC Cancer. 2006 Mar 6;6:52.


MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.

Filippov S, Koenig GC, Chun TH, Hotary KB, Ota I, Bugge TH, Roberts JD, Fay WP, Birkedal-Hansen H, Holmbeck K, Sabeh F, Allen ED, Weiss SJ.

J Exp Med. 2005 Sep 5;202(5):663-71.


Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.

Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo AA, Behrendt N, Nielsen BS, Bugge TH.

J Cell Biol. 2005 Jun 20;169(6):977-85.


Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.

Szabova L, Yamada SS, Birkedal-Hansen H, Holmbeck K.

J Cell Physiol. 2005 Oct;205(1):123-32.


An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature.

Lehti K, Allen E, Birkedal-Hansen H, Holmbeck K, Miyake Y, Chun TH, Weiss SJ.

Genes Dev. 2005 Apr 15;19(8):979-91. Epub 2005 Apr 1.


Membrane-type 1 matrix metalloproteinase is required for normal alveolar development.

Atkinson JJ, Holmbeck K, Yamada S, Birkedal-Hansen H, Parks WC, Senior RM.

Dev Dyn. 2005 Apr;232(4):1079-90.


The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone.

Holmbeck K, Bianco P, Pidoux I, Inoue S, Billinghurst RC, Wu W, Chrysovergis K, Yamada S, Birkedal-Hansen H, Poole AR.

J Cell Sci. 2005 Jan 1;118(Pt 1):147-56. Epub 2004 Dec 15.


Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP.

Sabeh F, Ota I, Holmbeck K, Birkedal-Hansen H, Soloway P, Balbin M, Lopez-Otin C, Shapiro S, Inada M, Krane S, Allen E, Chung D, Weiss SJ.

J Cell Biol. 2004 Nov 22;167(4):769-81.


MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix.

Chun TH, Sabeh F, Ota I, Murphy H, McDonagh KT, Holmbeck K, Birkedal-Hansen H, Allen ED, Weiss SJ.

J Cell Biol. 2004 Nov 22;167(4):757-67. Epub 2004 Nov 15.


MT1-MMP: a tethered collagenase.

Holmbeck K, Bianco P, Yamada S, Birkedal-Hansen H.

J Cell Physiol. 2004 Jul;200(1):11-9. Review.


MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth.

Holmbeck K, Bianco P, Chrysovergis K, Yamada S, Birkedal-Hansen H.

J Cell Biol. 2003 Nov 10;163(3):661-71.


MT1-mmp: a collagenase essential for tumor cell invasive growth.

Holmbeck K, Bianco P, Birkedal-Hansen H.

Cancer Cell. 2003 Aug;4(2):83-4.


Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice.

Beertsen W, Holmbeck K, Niehof A, Bianco P, Chrysovergis K, Birkedal-Hansen H, Everts V.

Connect Tissue Res. 2003;44 Suppl 1:298-9.


uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.

Engelholm LH, List K, Netzel-Arnett S, Cukierman E, Mitola DJ, Aaronson H, Kjøller L, Larsen JK, Yamada KM, Strickland DK, Holmbeck K, Danø K, Birkedal-Hansen H, Behrendt N, Bugge TH.

J Cell Biol. 2003 Mar 31;160(7):1009-15.


On the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth.

Beertsen W, Holmbeck K, Niehof A, Bianco P, Chrysovergis K, Birkedal-Hansen H, Everts V.

Eur J Oral Sci. 2002 Dec;110(6):445-51.


Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity.

Netzel-Arnett S, Mitola DJ, Yamada SS, Chrysovergis K, Holmbeck K, Birkedal-Hansen H, Bugge TH.

J Biol Chem. 2002 Nov 22;277(47):45154-61. Epub 2002 Aug 20.


Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes.

Hotary KB, Yana I, Sabeh F, Li XY, Holmbeck K, Birkedal-Hansen H, Allen ED, Hiraoka N, Weiss SJ.

J Exp Med. 2002 Feb 4;195(3):295-308.


MT1-MMP-dependent and -independent regulation of gelatinase A activation in long-term, ascorbate-treated fibroblast cultures: regulation by fibrillar collagen.

Ruangpanit N, Price JT, Holmbeck K, Birkedal-Hansen H, Guenzler V, Huang X, Chan D, Bateman JF, Thompson EW.

Exp Cell Res. 2002 Jan 15;272(2):109-18.


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