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Items: 1 to 50 of 714

1.
2.

Distinct effects of Q925 mutation on intracellular and extracellular Na+ and K+ binding to the Na+, K+-ATPase.

Nielsen HN, Spontarelli K, Holm R, Andersen JP, Einholm AP, Artigas P, Vilsen B.

Sci Rep. 2019 Sep 16;9(1):13344. doi: 10.1038/s41598-019-50009-2.

3.

Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport.

Nielsen RB, Kahnt A, Dillen L, Wuyts K, Snoeys J, Nielsen UG, Holm R, Nielsen CU.

Int J Pharm. 2019 Sep 13:118696. doi: 10.1016/j.ijpharm.2019.118696. [Epub ahead of print]

PMID:
31525443
4.

Toward the establishment of a standardized pre-clinical porcine model to predict food effects - Case studies on fenofibrate and paracetamol.

Henze LJ, Koehl NJ, O'Shea JP, Holm R, Vertzoni M, Griffin BT.

Int J Pharm X. 2019 May 28;1:100017. doi: 10.1016/j.ijpx.2019.100017. eCollection 2019 Dec.

5.

In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats.

Hemelryck SV, Dewulf J, Niekus H, van Heerden M, Ingelse B, Holm R, Mannaert E, Langguth P.

Int J Pharm X. 2019 May 24;1:100016. doi: 10.1016/j.ijpx.2019.100016. eCollection 2019 Dec.

6.

Controlled Incorporation of Nitrides into W-Fe-S Clusters.

Xu G, Zhou J, Wang Z, Holm RH, Chen XD.

Angew Chem Int Ed Engl. 2019 Sep 6. doi: 10.1002/anie.201908968. [Epub ahead of print]

PMID:
31489739
7.

Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential.

Holm R, Schwiertz D, Weber B, Schultze J, Kuhn J, Koynov K, Lächelt U, Barz M.

Macromol Biosci. 2019 Aug 20:e1900152. doi: 10.1002/mabi.201900152. [Epub ahead of print]

PMID:
31430057
8.

Correlation between the stability constant and pH for β-cyclodextrin complexes.

Samuelsen L, Holm R, Lathuile A, Schönbeck C.

Int J Pharm. 2019 Sep 10;568:118523. doi: 10.1016/j.ijpharm.2019.118523. Epub 2019 Jul 15.

PMID:
31319150
9.

Exploring the Origins of Enthalpy-Entropy Compensation by Calorimetric Studies of Cyclodextrin Complexes.

Schönbeck C, Holm R.

J Phys Chem B. 2019 Aug 8;123(31):6686-6693. doi: 10.1021/acs.jpcb.9b03393. Epub 2019 Jul 25.

PMID:
31298858
10.

Lasting results: A qualitative assessment of efforts to make community-led total sanitation more inclusive of the needs of people with disabilities in Rumphi District, Malawi.

Kayoka C, Itimu-Phiri A, Biran A, Holm RH.

Disabil Health J. 2019 Oct;12(4):718-721. doi: 10.1016/j.dhjo.2019.05.007. Epub 2019 May 28.

PMID:
31167740
11.

Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): Relevance to oral drug absorption.

Al-Ali AAA, Nielsen RB, Steffansen B, Holm R, Nielsen CU.

Int J Pharm. 2019 Jul 20;566:410-433. doi: 10.1016/j.ijpharm.2019.05.033. Epub 2019 May 21. Review.

PMID:
31125713
12.

Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells.

Rasmussen RN, Christensen KV, Holm R, Nielsen CU.

FEBS Open Bio. 2019 Jun;9(6):1071-1081. doi: 10.1002/2211-5463.12630. Epub 2019 May 7.

13.

Agent-Based Modelling for Simulation-Based Design of Sustainable Faecal Sludge Management Systems.

Mallory A, Crapper M, Holm RH.

Int J Environ Res Public Health. 2019 Mar 28;16(7). pii: E1125. doi: 10.3390/ijerph16071125.

14.

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects.

Bergström CAS, Box K, Holm R, Matthews W, McAllister M, Müllertz A, Rades T, Schäfer KJ, Teleki A.

Eur J Pharm Biopharm. 2019 Jun;139:101-114. doi: 10.1016/j.ejpb.2019.03.011. Epub 2019 Mar 9. Review.

PMID:
30862481
15.

Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer.

Jonsson M, Fjeldbo CS, Holm R, Stokke T, Kristensen GB, Lyng H.

Neoplasia. 2019 Apr;21(4):353-362. doi: 10.1016/j.neo.2019.01.002. Epub 2019 Mar 8.

16.

Buffer solutions in drug formulation and processing: How pKa values depend on temperature, pressure and ionic strength.

Samuelsen L, Holm R, Lathuile A, Schönbeck C.

Int J Pharm. 2019 Apr 5;560:357-364. doi: 10.1016/j.ijpharm.2019.02.019. Epub 2019 Feb 22.

PMID:
30797864
17.

New Insights into Using Lipid Based Suspensions for 'Brick Dust' Molecules: Case Study of Nilotinib.

Koehl NJ, Holm R, Kuentz M, Griffin BT.

Pharm Res. 2019 Feb 22;36(4):56. doi: 10.1007/s11095-019-2590-y.

PMID:
30796596
18.

Unpacking healthcare waste management at rural village health clinics in the Ntcheu District (Malawi).

Mmanga M, Singini W, Di Bella V, Flaherty MG, Holm RH.

Environ Monit Assess. 2019 Feb 20;191(3):175. doi: 10.1007/s10661-019-7306-6.

PMID:
30788632
19.

Bridging the gaps between academic research and industrial product developments of lipid-based formulations.

Holm R.

Adv Drug Deliv Rev. 2019 Mar 1;142:118-127. doi: 10.1016/j.addr.2019.01.009. Epub 2019 Jan 22. Review.

PMID:
30682399
20.

Size Analysis of Small Particles in Wet Dispersions by Laser Diffractometry: A Guidance to Quality Data.

De Cleyn E, Holm R, Van den Mooter G.

J Pharm Sci. 2019 May;108(5):1905-1914. doi: 10.1016/j.xphs.2018.12.010. Epub 2018 Dec 19.

PMID:
30578802
21.

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Keemink J, Sjögren E, Holm R, Bergström CAS.

J Pharm Sci. 2019 May;108(5):1765-1771. doi: 10.1016/j.xphs.2018.12.006. Epub 2018 Dec 16.

22.

Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges.

Joyce P, Dening TJ, Meola TR, Schultz HB, Holm R, Thomas N, Prestidge CA.

Adv Drug Deliv Rev. 2019 Mar 1;142:102-117. doi: 10.1016/j.addr.2018.11.006. Epub 2018 Dec 4. Review.

PMID:
30529138
23.

Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer.

Ditzinger F, Scherer U, Schönenberger M, Holm R, Kuentz M.

Mol Pharm. 2019 Jan 7;16(1):141-150. doi: 10.1021/acs.molpharmaceut.8b00920. Epub 2018 Dec 6.

PMID:
30484651
24.

Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers.

Holm R, Douverne M, Weber B, Bauer T, Best A, Ahlers P, Koynov K, Besenius P, Barz M.

Biomacromolecules. 2019 Jan 14;20(1):375-388. doi: 10.1021/acs.biomac.8b01545. Epub 2018 Dec 11.

PMID:
30475598
25.

Functional consequences of the CAPOS mutation E818K of Na+,K+-ATPase.

Roenn CP, Li M, Schack VR, Forster IC, Holm R, Toustrup-Jensen MS, Andersen JP, Petrou S, Vilsen B.

J Biol Chem. 2019 Jan 4;294(1):269-280. doi: 10.1074/jbc.RA118.004591. Epub 2018 Nov 8.

PMID:
30409907
26.

Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells.

Rasmussen RN, Christensen KV, Holm R, Nielsen CU.

Genomics. 2018 Oct 31. pii: S0888-7543(18)30394-X. doi: 10.1016/j.ygeno.2018.10.014. [Epub ahead of print]

PMID:
30389539
27.

Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.

Schlingmann KP, Bandulik S, Mammen C, Tarailo-Graovac M, Holm R, Baumann M, König J, Lee JJY, Drögemöller B, Imminger K, Beck BB, Altmüller J, Thiele H, Waldegger S, Van't Hoff W, Kleta R, Warth R, van Karnebeek CDM, Vilsen B, Bockenhauer D, Konrad M.

Am J Hum Genet. 2018 Nov 1;103(5):808-816. doi: 10.1016/j.ajhg.2018.10.004.

28.

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.

Macintyre F, Ramachandruni H, Burrows JN, Holm R, Thomas A, Möhrle JJ, Duparc S, Hooft van Huijsduijnen R, Greenwood B, Gutteridge WE, Wells TNC, Kaszubska W.

Malar J. 2018 Nov 1;17(1):402. doi: 10.1186/s12936-018-2549-1. Review.

29.

Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells: Impact on P-glycoprotein inhibition, barrier function, and repeated cellular exposure.

Al-Ali AAA, Steffansen B, Holm R, Nielsen CU.

Int J Pharm. 2018 Nov 15;551(1-2):270-280. doi: 10.1016/j.ijpharm.2018.09.039. Epub 2018 Sep 18.

PMID:
30240828
30.

Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches - a PEARRL review.

Ditzinger F, Price DJ, Ilie AR, Köhl NJ, Jankovic S, Tsakiridou G, Aleandri S, Kalantzi L, Holm R, Nair A, Saal C, Griffin B, Kuentz M.

J Pharm Pharmacol. 2019 Apr;71(4):464-482. doi: 10.1111/jphp.12984. Epub 2018 Aug 2. Review.

PMID:
30070363
31.

Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations.

Dening TJ, Thomas N, Rao S, van Looveren C, Cuyckens F, Holm R, Prestidge CA.

Mol Pharm. 2018 Sep 4;15(9):4148-4160. doi: 10.1021/acs.molpharmaceut.8b00555. Epub 2018 Aug 14.

PMID:
30067372
32.

Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion.

Knopp MM, Wendelboe J, Holm R, Rades T.

Eur J Pharm Biopharm. 2018 Sep;130:290-295. doi: 10.1016/j.ejpb.2018.07.005. Epub 2018 Jul 3.

PMID:
30064702
33.

Solid lipid nanocarriers in drug delivery: characterization and design.

Mu H, Holm R.

Expert Opin Drug Deliv. 2018 Aug;15(8):771-785. doi: 10.1080/17425247.2018.1504018. Review.

PMID:
30064267
34.

It Had a Hold on Me.

Holm RP.

S D Med. 2018 Jul;71(7):293. No abstract available.

PMID:
30005537
35.

Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review.

Jankovic S, Tsakiridou G, Ditzinger F, Koehl NJ, Price DJ, Ilie AR, Kalantzi L, Kimpe K, Holm R, Nair A, Griffin B, Saal C, Kuentz M.

J Pharm Pharmacol. 2019 Apr;71(4):441-463. doi: 10.1111/jphp.12948. Epub 2018 Jul 5. Review.

PMID:
29978475
36.

Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products - a PEARRL review.

Guimarães M, Statelova M, Holm R, Reppas C, Symilllides M, Vertzoni M, Fotaki N.

J Pharm Pharmacol. 2019 Apr;71(4):603-642. doi: 10.1111/jphp.12955. Epub 2018 Jul 3. Review.

PMID:
29971768
37.

Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro.

Wang Z, Førsund MS, Trope CG, Nesland JM, Holm R, Slipicevic A.

Cancer Med. 2018 Aug;7(8):3955-3964. doi: 10.1002/cam4.1638. Epub 2018 Jul 2.

38.

Food for thought: formulating away the food effect - a PEARRL review.

O'Shea JP, Holm R, O'Driscoll CM, Griffin BT.

J Pharm Pharmacol. 2019 Apr;71(4):510-535. doi: 10.1111/jphp.12957. Epub 2018 Jun 28. Review.

PMID:
29956330
39.

The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration.

Kourentas A, Vertzoni M, Barmpatsalou V, Augustijns P, Beato S, Butler J, Holm R, Ouwerkerk N, Rosenberg J, Tajiri T, Tannergren C, Symillides M, Reppas C.

AAPS J. 2018 May 24;20(4):71. doi: 10.1208/s12248-018-0231-8.

PMID:
29797293
40.

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations - a PEARRL review.

Price DJ, Ditzinger F, Koehl NJ, Jankovic S, Tsakiridou G, Nair A, Holm R, Kuentz M, Dressman JB, Saal C.

J Pharm Pharmacol. 2019 Apr;71(4):483-509. doi: 10.1111/jphp.12927. Epub 2018 May 16. Review.

PMID:
29770440
41.

Ligand metathesis as rational strategy for the synthesis of cubane-type heteroleptic iron-sulfur clusters relevant to the FeMo cofactor.

Xu G, Wang Z, Ling R, Zhou J, Chen XD, Holm RH.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5089-5092. doi: 10.1073/pnas.1801025115. Epub 2018 Apr 13.

42.

The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review.

Henze LJ, Koehl NJ, O'Shea JP, Kostewicz ES, Holm R, Griffin BT.

J Pharm Pharmacol. 2019 Apr;71(4):581-602. doi: 10.1111/jphp.12912. Epub 2018 Apr 10. Review.

PMID:
29635685
43.

Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats.

Al-Ali AAA, Quach JRC, Bundgaard C, Steffansen B, Holm R, Nielsen CU.

Int J Pharm. 2018 May 30;543(1-2):352-360. doi: 10.1016/j.ijpharm.2018.04.006. Epub 2018 Apr 7.

PMID:
29635055
44.

Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide.

Henze LJ, Griffin BT, Christiansen M, Bundgaard C, Langguth P, Holm R.

Eur J Pharm Sci. 2018 Jun 15;118:183-190. doi: 10.1016/j.ejps.2018.03.017. Epub 2018 Mar 17.

PMID:
29559403
45.

Expression of 14-3-3 sigma and eta proteins is unrelated to survival in metastatic high-grade serous carcinoma.

Davidson B, Holth A, Wang Z, Hellsylt E, Tropé CG, Hetland Falkenthal TE, Holm R.

APMIS. 2018 Apr;126(4):309-313. doi: 10.1111/apm.12816. Epub 2018 Feb 21.

PMID:
29464778
46.

Comparison of two DSC-based methods to predict drug-polymer solubility.

Rask MB, Knopp MM, Olesen NE, Holm R, Rades T.

Int J Pharm. 2018 Apr 5;540(1-2):98-105. doi: 10.1016/j.ijpharm.2018.02.002. Epub 2018 Feb 6.

PMID:
29425764
47.

A Cluster-Randomized Trial to Evaluate the Impact of an Inclusive, Community-Led Total Sanitation Intervention on Sanitation Access for People with Disabilities in Malawi.

Biran A, Danquah L, Chunga J, Schmidt WP, Holm R, Itimu-Phiri A, Singini W, Jones H, Kuper H, White S.

Am J Trop Med Hyg. 2018 Apr;98(4):984-994. doi: 10.4269/ajtmh.17-0435. Epub 2018 Feb 1.

48.

Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation.

Beck S, Schultze J, Räder HJ, Holm R, Schinnerer M, Barz M, Koynov K, Zentel R.

Polymers (Basel). 2018 Feb 2;10(2). pii: E141. doi: 10.3390/polym10020141.

49.

Atopic dermatitis and alcohol use - a meta-analysis and systematic review.

Halling-Overgaard AS, Hamann CR, Holm RP, Linneberg A, Silverberg JI, Egeberg A, Thyssen JP.

J Eur Acad Dermatol Venereol. 2018 Aug;32(8):1238-1245. doi: 10.1111/jdv.14814. Epub 2018 Feb 14.

PMID:
29377395
50.

Quality of care for people with multimorbidity - a case series.

Schiøtz ML, Høst D, Christensen MB, Domínguez H, Hamid Y, Almind M, Sørensen KL, Saxild T, Holm RH, Frølich A.

BMC Health Serv Res. 2017 Nov 18;17(1):745. doi: 10.1186/s12913-017-2724-z.

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