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Items: 1 to 50 of 69

1.

LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels.

Dudem S, Large RJ, Kulkarni S, McClafferty H, Tikhonova IG, Sergeant GP, Thornbury KD, Shipston MJ, Perrino BA, Hollywood MA.

Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2194-2200. doi: 10.1073/pnas.1916715117. Epub 2020 Jan 13.

2.

Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and Kv 7 channels.

Zavaritskaya O, Dudem S, Ma D, Rabab KE, Albrecht S, Tsvetkov D, Kassmann M, Thornbury K, Mladenov M, Kammermeier C, Sergeant G, Mullins N, Wouappi O, Wurm H, Kannt A, Gollasch M, Hollywood MA, Schubert R.

Br J Pharmacol. 2019 Oct 28. doi: 10.1111/bph.14910. [Epub ahead of print]

PMID:
31658366
3.

Ion Channels and Intracellular Calcium Signalling in Corpus Cavernosum.

Thornbury KD, Hollywood MA, Sergeant GP.

Adv Exp Med Biol. 2019;1124:171-194. doi: 10.1007/978-981-13-5895-1_7. Review.

PMID:
31183827
4.

Spontaneous Activity in Urethral Smooth Muscle.

Sergeant GP, Hollywood MA, Thornbury KD.

Adv Exp Med Biol. 2019;1124:149-167. doi: 10.1007/978-981-13-5895-1_6. Review.

PMID:
31183826
5.

β3-Adrenoceptor agonists inhibit purinergic receptor-mediated contractions of the murine detrusor.

Fong Z, Griffin CS, Hollywood MA, Thornbury KD, Sergeant GP.

Am J Physiol Cell Physiol. 2019 Jul 1;317(1):C131-C142. doi: 10.1152/ajpcell.00488.2018. Epub 2019 May 1.

PMID:
31042424
6.

Inhibitory effects of openers of large-conductance Ca2+-activated K+ channels on agonist-induced phasic contractions in rabbit and mouse bronchial smooth muscle.

Bradley E, Large RJ, Bihun VV, Mullins ND, Hollywood MA, Sergeant GP, Thornbury KD.

Am J Physiol Cell Physiol. 2018 Dec 1;315(6):C818-C829. doi: 10.1152/ajpcell.00068.2018. Epub 2018 Sep 26.

7.

Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice.

Griffin CS, Thornbury KD, Hollywood MA, Sergeant GP.

Sci Rep. 2018 Jun 18;8(1):9264. doi: 10.1038/s41598-018-27617-5.

8.

Ca2+ signalling in mouse urethral smooth muscle in situ: role of Ca2+ stores and Ca2+ influx mechanisms.

Drumm BT, Rembetski BE, Cobine CA, Baker SA, Sergeant GP, Hollywood MA, Thornbury KD, Sanders KM.

J Physiol. 2018 Apr 15;596(8):1433-1466. doi: 10.1113/JP275719.

9.

β3-adrenoceptor agonists inhibit carbachol-evoked Ca2+ oscillations in murine detrusor myocytes.

Griffin CS, Bradley E, Hollywood MA, McHale NG, Thornbury KD, Sergeant GP.

BJU Int. 2018 Jun;121(6):959-970. doi: 10.1111/bju.14090. Epub 2018 Jan 17.

10.

Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum.

Pratt CP, Kuljis DA, Homanics GE, He J, Kolodieznyi D, Dudem S, Hollywood MA, Barth AL, Bruchez MP.

Front Cell Neurosci. 2017 Oct 31;11:337. doi: 10.3389/fncel.2017.00337. eCollection 2017.

11.

The role of Ca2+-activated Cl- current in tone generation in the rabbit corpus cavernosum.

Hannigan KI, Griffin CS, Large RJ, Sergeant GP, Hollywood MA, McHale NG, Thornbury KD.

Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C475-C486. doi: 10.1152/ajpcell.00025.2017. Epub 2017 Aug 23.

12.

Involvement of cyclic nucleotide-gated channels in spontaneous activity generated in isolated interstitial cells of Cajal from the rabbit urethra.

Sancho M, Bradley E, Garcia-Pascual A, Triguero D, Thornbury KD, Hollywood MA, Sergeant GP.

Eur J Pharmacol. 2017 Nov 5;814:216-225. doi: 10.1016/j.ejphar.2017.08.020. Epub 2017 Aug 16.

PMID:
28822854
13.

Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal.

Fedigan S, Bradley E, Webb T, Large RJ, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP.

Pflugers Arch. 2017 Nov;469(11):1443-1455. doi: 10.1007/s00424-017-2028-5. Epub 2017 Jul 21.

PMID:
28733893
14.

A seminal study on the mechanisms underlying spontaneous activity of the seminal vesicles?

Hollywood MA, Thornbury KD, Sergeant GP.

J Physiol. 2017 Jul 15;595(14):4567. doi: 10.1113/JP274499. Epub 2017 Jun 1. No abstract available.

15.

Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels.

Griffin CS, Bradley E, Dudem S, Hollywood MA, McHale NG, Thornbury KD, Sergeant GP.

J Urol. 2016 Dec;196(6):1796-1808. doi: 10.1016/j.juro.2016.05.108. Epub 2016 Jun 7.

PMID:
27287524
16.

Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels.

Kshatri AS, Li Q, Yan J, Large RJ, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA.

Channels (Austin). 2017 Jan 2;11(1):66-78. doi: 10.1080/19336950.2016.1213930. Epub 2016 Jul 20.

17.

Effect of a novel BKCa opener on BKCa currents and contractility of the rabbit corpus cavernosum.

Hannigan KI, Large RJ, Bradley E, Hollywood MA, Sergeant GP, McHale NG, Thornbury KD.

Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C284-92. doi: 10.1152/ajpcell.00273.2015. Epub 2015 Dec 9.

18.

Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.

Wallace A, Gabriel D, McHale NG, Hollywood MA, Thornbury KD, Sergeant GP.

Physiol Rep. 2015 Sep;3(9). pii: e12520. doi: 10.14814/phy2.12520.

19.

The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra.

Drumm BT, Large RJ, Hollywood MA, Thornbury KD, Baker SA, Harvey BJ, McHale NG, Sergeant GP.

J Physiol. 2015 Aug 1;593(15):3333-50. doi: 10.1113/JP270883. Epub 2015 Jun 26.

20.

Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.

Webb TI, Kshatri AS, Large RJ, Akande AM, Roy S, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2064-9. doi: 10.1073/pnas.1400555112. Epub 2015 Feb 4.

21.

Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits.

Large RJ, Kshatri A, Webb TI, Roy S, Akande A, Bradley E, Sergeant GP, Thornbury KD, McHale NG, Hollywood MA.

Br J Pharmacol. 2015 May;172(10):2544-56. doi: 10.1111/bph.13085. Epub 2015 Mar 26.

22.

The role of cAMP dependent protein kinase in modulating spontaneous intracellular Ca²⁺ waves in interstitial cells of Cajal from the rabbit urethra.

Drumm BT, Sergeant GP, Hollywood MA, Thornbury KD, McHale NG, Harvey BJ.

Cell Calcium. 2014 Sep;56(3):181-7. doi: 10.1016/j.ceca.2014.07.002. Epub 2014 Jul 10.

PMID:
25063367
23.

The effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra.

Drumm BT, Sergeant GP, Hollywood MA, Thornbury KT, Matsuda TT, Baba A, Harvey BJ, McHale NG.

Physiol Rep. 2014 Jan 21;2(1):e00203. doi: 10.1002/phy2.203. eCollection 2014 Jan 1.

24.

Pharmacological characterization of TMEM16A currents.

Bradley E, Fedigan S, Webb T, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP.

Channels (Austin). 2014;8(4):308-20. Erratum in: Channels (Austin). 2015;9(6):397.

25.

Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels.

Roy S, Large RJ, Akande AM, Kshatri A, Webb TI, Domene C, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA.

Eur J Med Chem. 2014 Mar 21;75:426-37. doi: 10.1016/j.ejmech.2014.01.035. Epub 2014 Feb 3.

PMID:
24561672
26.

ATP evokes inward currents in corpus cavernosum myocytes.

Doyle C, Sergeant GP, Hollywood MA, McHale NG, Thornbury KD.

J Sex Med. 2014 Jan;11(1):64-74. doi: 10.1111/jsm.12364. Epub 2013 Oct 24.

27.

Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.

Kyle BD, Bradley E, Large R, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA.

Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C609-22. doi: 10.1152/ajpcell.00025.2013. Epub 2013 Jun 26.

28.

The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells.

Bradley E, Webb TI, Hollywood MA, Sergeant GP, McHale NG, Thornbury KD.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C427-35. doi: 10.1152/ajpcell.00034.2013. Epub 2013 Jun 19.

29.

Investigation of L-type Ca(2+) current in the aganglionic bowel segment in Hirschsprung's disease.

Large RJ, Bradley E, Webb T, O'Donnell AM, Puri P, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP.

Neurogastroenterol Motil. 2012 Dec;24(12):1126-e571. doi: 10.1111/nmo.12006. Epub 2012 Sep 4.

PMID:
22947173
30.

Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family.

Roy S, Morayo Akande A, Large RJ, Webb TI, Camarasu C, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA.

ChemMedChem. 2012 Oct;7(10):1763-9. doi: 10.1002/cmdc.201200321. Epub 2012 Aug 28.

PMID:
22930560
31.

Effects of phenylephrine on spontaneous activity and L-type Ca2+ current in isolated corpus cavernosum myocytes.

Doyle C, Sergeant GP, Hollywood MA, McHale NG, Thornbury KD.

J Sex Med. 2012 Nov;9(11):2795-805. doi: 10.1111/j.1743-6109.2012.02847.x. Epub 2012 Jul 12.

PMID:
22788218
32.

Cajal beyond the gut: interstitial cells in the urinary system--towards general regulatory mechanisms of smooth muscle contractility?

Thornbury KD, Hollywood MA, McHale NG, Sergeant GP.

Acta Gastroenterol Belg. 2011 Dec;74(4):536-42.

PMID:
22319963
33.

Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells.

Koh BH, Roy R, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP, Hatton WJ, Ward SM, Sanders KM, Koh SD.

J Cell Mol Med. 2012 Apr;16(4):691-700. doi: 10.1111/j.1582-4934.2011.01506.x.

34.

Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.

Kyle B, Bradley E, Ohya S, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1186-200. doi: 10.1152/ajpcell.00455.2010. Epub 2011 Aug 3.

35.

P2X receptor currents in smooth muscle cells contribute to nerve mediated contractions of rabbit urethral smooth muscle.

Bradley E, Kadima S, Kyle B, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP.

J Urol. 2011 Aug;186(2):745-52. doi: 10.1016/j.juro.2011.03.140. Epub 2011 Jun 17.

36.

Ionic currents in intimal cultured synoviocytes from the rabbit.

Large RJ, Hollywood MA, Sergeant GP, Thornbury KD, Bourke S, Levick JR, McHale NG.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1180-94. doi: 10.1152/ajpcell.00028.2010. Epub 2010 Aug 18.

37.

The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle.

Hollywood MA, Sergeant GP, Thornbury KD, McHale NG.

Br J Pharmacol. 2010 Jul;160(6):1293-4. doi: 10.1111/j.1476-5381.2010.00795.x.

38.

Novel excitatory effects of adenosine triphosphate on contractile and pacemaker activity in rabbit urethral smooth muscle.

Bradley E, Kadima S, Drumm B, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP.

J Urol. 2010 Feb;183(2):801-11. doi: 10.1016/j.juro.2009.09.075.

39.

Spontaneous Ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cGMP.

Sergeant GP, Craven M, Hollywood MA, McHale NG, Thornbury KD.

J Sex Med. 2009 Apr;6(4):958-966. doi: 10.1111/j.1743-6109.2008.01090.x. Epub 2008 Dec 9.

PMID:
19138373
40.

Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra.

Sergeant GP, Bradley E, Thornbury KD, McHale NG, Hollywood MA.

J Physiol. 2008 Oct 1;586(19):4631-42. doi: 10.1113/jphysiol.2008.159194. Epub 2008 Aug 14.

41.

Spontaneous electrical activity in sheep mesenteric lymphatics.

Beckett EA, Hollywood MA, Thornbury KD, McHale NG.

Lymphat Res Biol. 2007;5(1):29-43.

PMID:
17508900
42.

Ca2+ signalling in urethral interstitial cells of Cajal.

Sergeant GP, Hollywood MA, McHale NG, Thornbury KD.

J Physiol. 2006 Nov 1;576(Pt 3):715-20. Epub 2006 Aug 17. Review.

43.

Organization and function of ICC in the urinary tract.

McHale NG, Hollywood MA, Sergeant GP, Shafei M, Thornbury KT, Ward SM.

J Physiol. 2006 Nov 1;576(Pt 3):689-94. Epub 2006 Aug 17. Review.

44.

Interstitial cells of Cajal in the urethra.

Sergeant GP, Thornbury KD, McHale NG, Hollywood MA.

J Cell Mol Med. 2006 Apr-Jun;10(2):280-91. Review.

45.

Contribution of reverse Na+-Ca2+ exchange to spontaneous activity in interstitial cells of Cajal in the rabbit urethra.

Bradley E, Hollywood MA, Johnston L, Large RJ, Matsuda T, Baba A, McHale NG, Thornbury KD, Sergeant GP.

J Physiol. 2006 Aug 1;574(Pt 3):651-61. Epub 2006 May 25.

46.

Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves.

Sergeant GP, Johnston L, McHale NG, Thornbury KD, Hollywood MA.

J Physiol. 2006 Jul 1;574(Pt 1):167-81. Epub 2006 Apr 27.

47.

Pacemaker activity in urethral interstitial cells is not dependent on capacitative calcium entry.

Bradley E, Hollywood MA, McHale NG, Thornbury KD, Sergeant GP.

Am J Physiol Cell Physiol. 2005 Sep;289(3):C625-32.

48.

Calcium oscillations in interstitial cells of the rabbit urethra.

Johnston L, Sergeant GP, Hollywood MA, Thornbury KD, McHale NG.

J Physiol. 2005 Jun 1;565(Pt 2):449-61. Epub 2005 Mar 10.

49.

Optimizing low-light microscopy with back-illuminated electron multiplying charge-coupled device: enhanced sensitivity, speed, and resolution.

Coates CG, Denvir DJ, McHale NG, Thornbury KD, Hollywood MA.

J Biomed Opt. 2004 Nov-Dec;9(6):1244-52.

50.

Characterization of T-type calcium current and its contribution to electrical activity in rabbit urethra.

Bradley JE, Anderson UA, Woolsey SM, Thornbury KD, McHale NG, Hollywood MA.

Am J Physiol Cell Physiol. 2004 May;286(5):C1078-88. Epub 2003 Dec 3.

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