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Items: 1 to 50 of 104

1.

Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest.

Dirks ML, Smeets JSJ, Holwerda AM, Kouw IWK, Marzuca-Nassr GN, Gijsen AP, Holloway GP, Verdijk LB, van Loon LJC.

Am J Physiol Endocrinol Metab. 2019 Jan 15. doi: 10.1152/ajpendo.00378.2018. [Epub ahead of print]

PMID:
30645176
2.

High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to l-carnitine.

Petrick HL, Holloway GP.

Biochem J. 2019 Feb 8;476(3):547-558. doi: 10.1042/BCJ20180849.

PMID:
30635360
3.

Mitochondrial-derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity.

Barbeau PA, Miotto PM, Holloway GP.

Biochem J. 2018 Sep 28;475(18):2997-3008. doi: 10.1042/BCJ20180419.

PMID:
30111574
4.

High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity.

Miotto PM, LeBlanc PJ, Holloway GP.

Diabetes. 2018 Nov;67(11):2199-2205. doi: 10.2337/db18-0417. Epub 2018 Jul 6.

PMID:
29980534
5.

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ.

Haematologica. 2018 Sep;103(9):1557-1567. doi: 10.3324/haematol.2017.185165. Epub 2018 Jun 7.

6.

Alpha-linolenic acid and linoleic acid differentially regulate the skeletal muscle secretome of obese Zucker rats.

Rajna A, Gibling H, Sarr O, Matravadia S, Holloway GP, Mutch DM.

Physiol Genomics. 2018 Aug 1;50(8):580-589. doi: 10.1152/physiolgenomics.00038.2018. Epub 2018 May 4.

PMID:
29727591
7.

Cytosolic reverse CrAT activity in cardiac tissue: potential importance for fuel selection.

Petrick HL, Holloway GP.

Biochem J. 2018 Apr 9;475(7):1267-1269. doi: 10.1042/BCJ20180121.

PMID:
29632149
8.

Exercise-induced reductions in mitochondrial ADP sensitivity contribute to the induction of gene expression and mitochondrial biogenesis through enhanced mitochondrial H2O2 emission.

Miotto PM, Holloway GP.

Mitochondrion. 2018 Mar 26. pii: S1567-7249(17)30277-5. doi: 10.1016/j.mito.2018.03.003. [Epub ahead of print]

PMID:
29588219
9.

Response.

Whitfield J, Heigenhauser GJF, van Loon LJC, Spriet LL, Tupling AR, Holloway GP.

Med Sci Sports Exerc. 2018 Apr;50(4):875. doi: 10.1249/MSS.0000000000001490. No abstract available.

PMID:
29547496
10.

Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle.

Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC.

Cell Rep. 2018 Mar 13;22(11):2837-2848. doi: 10.1016/j.celrep.2018.02.069.

11.

Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats.

Monaco CMF, Miotto PM, Huber JS, van Loon LJC, Simpson JA, Holloway GP.

Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R191-R204. doi: 10.1152/ajpregu.00275.2017. Epub 2018 Mar 7.

PMID:
29513565
12.

Sex differences in mitochondrial respiratory function in human skeletal muscle.

Miotto PM, McGlory C, Holloway TM, Phillips SM, Holloway GP.

Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R909-R915. doi: 10.1152/ajpregu.00025.2018. Epub 2018 Mar 7.

PMID:
29513564
13.

Lactate is oxidized outside of the mitochondrial matrix in rodent brain.

Herbst EAF, George MAJ, Brebner K, Holloway GP, Kane DA.

Appl Physiol Nutr Metab. 2018 May;43(5):467-474. doi: 10.1139/apnm-2017-0450. Epub 2017 Dec 5.

14.

α-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats.

Monaco CMF, Proudfoot R, Miotto PM, Herbst EAF, MacPherson REK, Holloway GP.

Diabetologia. 2018 Feb;61(2):433-444. doi: 10.1007/s00125-017-4456-3. Epub 2017 Oct 1.

PMID:
28965129
15.

Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.

Whitfield J, Paglialunga S, Smith BK, Miotto PM, Simnett G, Robson HL, Jain SS, Herbst EAF, Desjardins EM, Dyck DJ, Spriet LL, Steinberg GR, Holloway GP.

J Biol Chem. 2017 Oct 6;292(40):16653-16664. doi: 10.1074/jbc.M117.806786. Epub 2017 Aug 14.

16.

Beetroot Juice Increases Human Muscle Force without Changing Ca2+-Handling Proteins.

Whitfield J, Gamu D, Heigenhauser GJF, VAN Loon LJC, Spriet LL, Tupling AR, Holloway GP.

Med Sci Sports Exerc. 2017 Oct;49(10):2016-2024. doi: 10.1249/MSS.0000000000001321.

PMID:
28509762
17.

α-Linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats.

Barbeau PA, Holloway TM, Whitfield J, Baechler BL, Quadrilatero J, van Loon LJC, Chabowski A, Holloway GP.

J Physiol. 2017 Jul 1;595(13):4351-4364. doi: 10.1113/JP274036. Epub 2017 May 24.

18.

Nutrition and Training Influences on the Regulation of Mitochondrial Adenosine Diphosphate Sensitivity and Bioenergetics.

Holloway GP.

Sports Med. 2017 Mar;47(Suppl 1):13-21. doi: 10.1007/s40279-017-0693-3. Review.

19.

CL 316, 243 mediated reductions in blood glucose are enhanced in RIP140-/- mice independent of alterations in lipolysis.

Peppler WT, Miotto PM, Holloway GP, Wright DC.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):486-491. doi: 10.1016/j.bbrc.2017.03.067. Epub 2017 Mar 18.

PMID:
28322782
20.

α-Linolenic acid supplementation and exercise training reveal independent and additive responses on hepatic lipid accumulation in obese rats.

Miotto PM, Horbatuk M, Proudfoot R, Matravadia S, Bakovic M, Chabowski A, Holloway GP.

Am J Physiol Endocrinol Metab. 2017 Jun 1;312(6):E461-E470. doi: 10.1152/ajpendo.00438.2016. Epub 2017 Mar 7.

21.

The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.

Paglialunga S, Simnett G, Robson H, Hoang M, Pillai R, Arkell AM, Simpson JA, Bonen A, Huising M, Joseph JW, Holloway GP.

Appl Physiol Nutr Metab. 2017 Jun;42(6):647-655. doi: 10.1139/apnm-2016-0585. Epub 2017 Jan 31.

PMID:
28177704
22.

Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.

Miotto PM, Steinberg GR, Holloway GP.

Biochem J. 2017 Feb 15;474(4):557-569. doi: 10.1042/BCJ20160913. Epub 2016 Dec 8.

PMID:
27941154
23.

Dietary α-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates.

Chorner Z, Barbeau PA, Castellani L, Wright DC, Chabowski A, Holloway GP.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1234-R1242. doi: 10.1152/ajpregu.00346.2016. Epub 2016 Nov 2.

24.

In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport.

Miotto PM, Holloway GP.

Biochem J. 2016 Sep 15;473(18):2831-43. doi: 10.1042/BCJ20160373. Epub 2016 Jul 8.

PMID:
27402793
25.

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation.

Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJ.

Diabetes. 2016 Oct;65(10):2862-75. doi: 10.2337/db15-1661. Epub 2016 Jun 29.

26.

Postprandial control of fatty acid transport proteins' subcellular location is not dependent on insulin.

Snook LA, Wright DC, Holloway GP.

FEBS Lett. 2016 Aug;590(16):2661-70. doi: 10.1002/1873-3468.12260. Epub 2016 Jul 4.

27.

Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex.

Herbst EA, Holloway GP.

Appl Physiol Nutr Metab. 2016 Jul;41(7):799-801. doi: 10.1139/apnm-2016-0033. Epub 2016 May 17.

28.

Prior exercise training blunts short-term high-fat diet-induced weight gain.

Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC.

Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R315-24. doi: 10.1152/ajpregu.00072.2016. Epub 2016 Apr 13.

29.

Combined high-fat-resveratrol diet and RIP140 knockout mice reveal a novel relationship between elevated bone mitochondrial content and compromised bone microarchitecture, bone mineral mass, and bone strength in the tibia.

Miotto PM, Frendo-Cumbo S, Sacco SM, Wright DC, Ward WE, Holloway GP.

Mol Nutr Food Res. 2016 Sep;60(9):1994-2007. doi: 10.1002/mnfr.201500870. Epub 2016 Apr 21.

PMID:
27006200
30.

LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition.

Matravadia S, Zabielski P, Chabowski A, Mutch DM, Holloway GP.

Am J Physiol Regul Integr Comp Physiol. 2016 Apr 1;310(7):R619-30. doi: 10.1152/ajpregu.00297.2015. Epub 2016 Jan 13.

31.

Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle.

Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, Spriet LL, Holloway GP.

J Physiol. 2016 Jan 15;594(2):421-35. doi: 10.1113/JP270844. Epub 2015 Dec 16.

32.

Changes in nuclear receptor corepressor RIP140 do not influence mitochondrial content in the cortex.

Herbst EA, Bonen A, Holloway GP.

Appl Physiol Nutr Metab. 2015 Oct;40(10):1086-8. doi: 10.1139/apnm-2015-0192. Epub 2015 Jul 10.

PMID:
26360644
33.

Chronic treadmill running does not enhance mitochondrial oxidative capacity in the cortex or striatum.

Herbst EA, Roussakis C, Matravadia S, Holloway GP.

Metabolism. 2015 Nov;64(11):1419-25. doi: 10.1016/j.metabol.2015.07.002. Epub 2015 Jul 6.

PMID:
26307661
34.

Fatty acid transport and transporters in muscle are critically regulated by Akt2.

Jain SS, Luiken JJ, Snook LA, Han XX, Holloway GP, Glatz JF, Bonen A.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2769-75. doi: 10.1016/j.febslet.2015.08.010. Epub 2015 Aug 18.

35.

Respiratory muscle weakness in the Zucker diabetic fatty rat.

Allwood MA, Foster AJ, Arkell AM, Beaudoin MS, Snook LA, Romanova N, Murrant CL, Holloway GP, Wright DC, Simpson JA.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R780-7. doi: 10.1152/ajpregu.00447.2014. Epub 2015 Aug 5.

36.

Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.

Bonen A, Jain SS, Snook LA, Han XX, Yoshida Y, Buddo KH, Lally JS, Pask ED, Paglialunga S, Beaudoin MS, Glatz JF, Luiken JJ, Harasim E, Wright DC, Chabowski A, Holloway GP.

Diabetologia. 2015 Oct;58(10):2381-91. doi: 10.1007/s00125-015-3691-8. Epub 2015 Jul 22.

PMID:
26197708
37.

Sarcoplasmic Reticulum Phospholipid Fatty Acid Composition and Sarcolipin Content in Rat Skeletal Muscle.

Fajardo VA, Bombardier E, Tran K, Metherel AH, Irvine T, Holloway GP, Green HJ, Stark KD, Tupling AR.

J Membr Biol. 2015 Dec;248(6):1089-96. doi: 10.1007/s00232-015-9822-9. Epub 2015 Jul 21.

PMID:
26193810
38.

Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6/1 model of Huntington's disease.

Herbst EA, Holloway GP.

Neuroscience. 2015 Sep 10;303:515-23. doi: 10.1016/j.neuroscience.2015.07.025. Epub 2015 Jul 14.

PMID:
26186895
39.

Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle.

Snook LA, Nelson EM, Dyck DJ, Wright DC, Holloway GP.

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R295-303. doi: 10.1152/ajpregu.00003.2015. Epub 2015 Jun 3.

40.

Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice.

Basu P, Alibhai FJ, Tsimakouridze EV, Singh RK, Paglialunga S, Holloway GP, Martino TA, Bakovic M.

Mol Cell Biol. 2015 Aug;35(15):2641-57. doi: 10.1128/MCB.00380-15. Epub 2015 May 18.

41.

Activation of AMPKα2 Is Not Required for Mitochondrial FAT/CD36 Accumulation during Exercise.

Monaco C, Whitfield J, Jain SS, Spriet LL, Bonen A, Holloway GP.

PLoS One. 2015 May 12;10(5):e0126122. doi: 10.1371/journal.pone.0126122. eCollection 2015.

42.

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling.

Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP.

Diabetes. 2015 Aug;64(8):2769-79. doi: 10.2337/db14-1838. Epub 2015 Apr 6.

43.

Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.

Ralston JC, Matravadia S, Gaudio N, Holloway GP, Mutch DM.

Obesity (Silver Spring). 2015 Apr;23(4):725-8. doi: 10.1002/oby.21035. Epub 2015 Mar 6.

44.

In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice.

Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP.

Diabetologia. 2015 May;58(5):1071-80. doi: 10.1007/s00125-015-3531-x. Epub 2015 Mar 11.

PMID:
25754553
45.

Permeabilization of brain tissue in situ enables multiregion analysis of mitochondrial function in a single mouse brain.

Herbst EA, Holloway GP.

J Physiol. 2015 Feb 15;593(4):787-801. doi: 10.1113/jphysiol.2014.285379. Epub 2015 Jan 23.

46.

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.

O'Neill HM, Lally JS, Galic S, Thomas M, Azizi PD, Fullerton MD, Smith BK, Pulinilkunnil T, Chen Z, Samaan MC, Jorgensen SB, Dyck JR, Holloway GP, Hawke TJ, van Denderen BJ, Kemp BE, Steinberg GR.

Diabetologia. 2014 Aug;57(8):1693-702. doi: 10.1007/s00125-014-3273-1. Epub 2014 Jun 10.

PMID:
24913514
47.

Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats.

Matravadia S, Herbst EA, Jain SS, Mutch DM, Holloway GP.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E102-14. doi: 10.1152/ajpendo.00032.2014. Epub 2014 May 20.

48.

Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats.

Beaudoin MS, Perry CG, Arkell AM, Chabowski A, Simpson JA, Wright DC, Holloway GP.

J Physiol. 2014 Jun 15;592(12):2519-33. doi: 10.1113/jphysiol.2013.270538. Epub 2014 Mar 17.

49.

High-fat diet-induced mitochondrial biogenesis is regulated by mitochondrial-derived reactive oxygen species activation of CaMKII.

Jain SS, Paglialunga S, Vigna C, Ludzki A, Herbst EA, Lally JS, Schrauwen P, Hoeks J, Tupling AR, Bonen A, Holloway GP.

Diabetes. 2014 Jun;63(6):1907-13. doi: 10.2337/db13-0816. Epub 2014 Feb 11.

50.

Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats.

Beaudoin MS, Snook LA, Arkell AM, Stefanson A, Wan Z, Simpson JA, Holloway GP, Wright DC.

Obesity (Silver Spring). 2014 Jul;22(7):1632-42. doi: 10.1002/oby.20717. Epub 2014 Feb 19.

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