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Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta.

Natale BV, Gustin KN, Lee K, Holloway AC, Laviolette SR, Natale DRC, Hardy DB.

Sci Rep. 2020 Jan 17;10(1):544. doi: 10.1038/s41598-019-57318-6.


Association of urinary polycyclic aromatic hydrocarbons and obesity in children aged 3-18: Canadian Health Measures Survey 2009-2015.

Bushnik T, Wong SL, Holloway AC, Thomson EM.

J Dev Orig Health Dis. 2019 Dec 6:1-9. doi: 10.1017/S2040174419000825. [Epub ahead of print]


Adverse effects of naphthenic acids on reproductive health: A focus on placental trophoblast cells.

Raez-Villanueva S, Jamshed L, Ratnayake G, Cheng L, Thomas PJ, Holloway AC.

Reprod Toxicol. 2019 Dec;90:126-133. doi: 10.1016/j.reprotox.2019.09.002. Epub 2019 Sep 11.


Quantifying cellular protrusion in alginate capsules with covalently crosslinked shells.

Johnson MA, Kleinberger R, Abu Helal A, Latchminarine N, Ayyash A, Shi S, Burke NAD, Holloway AC, Stöver HDH.

J Microencapsul. 2019 Aug;36(5):421-431. doi: 10.1080/02652048.2019.1618404. Epub 2019 Aug 19.


Toxicity of Flame Retardant Isopropylated Triphenyl Phosphate: Liver, Adrenal, and Metabolic Effects.

Wade MG, Kawata A, Rigden M, Caldwell D, Holloway AC.

Int J Toxicol. 2019 Jul/Aug;38(4):279-290. doi: 10.1177/1091581819851502. Epub 2019 May 27.


Δ9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts.

Lojpur T, Easton Z, Raez-Villanueva S, Laviolette S, Holloway AC, Hardy DB.

Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.


Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors.

Nielsen AJ, Raez-Villanueva S, Crankshaw DJ, Holloway AC, McNulty J.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1395-1398. doi: 10.1016/j.bmcl.2019.03.033. Epub 2019 Mar 26.


The role of the endocannabinoid system in female reproductive tissues.

Walker OS, Holloway AC, Raha S.

J Ovarian Res. 2019 Jan 15;12(1):3. doi: 10.1186/s13048-018-0478-9. Review.


A risk of bias instrument for non-randomized studies of exposures: A users' guide to its application in the context of GRADE.

Morgan RL, Thayer KA, Santesso N, Holloway AC, Blain R, Eftim SE, Goldstone AE, Ross P, Ansari M, Akl EA, Filippini T, Hansell A, Meerpohl JJ, Mustafa RA, Verbeek J, Vinceti M, Whaley P, Schünemann HJ; GRADE Working Group.

Environ Int. 2019 Jan;122:168-184. doi: 10.1016/j.envint.2018.11.004. Epub 2018 Nov 22.


Evaluation of the risk of bias in non-randomized studies of interventions (ROBINS-I) and the 'target experiment' concept in studies of exposures: Rationale and preliminary instrument development.

Morgan RL, Thayer KA, Santesso N, Holloway AC, Blain R, Eftim SE, Goldstone AE, Ross P, Guyatt G, Schünemann HJ.

Environ Int. 2018 Nov;120:382-387. doi: 10.1016/j.envint.2018.08.018. Epub 2018 Aug 17.


The effects of electronic cigarette vapor on placental trophoblast cell function.

Raez-Villanueva S, Ma C, Kleiboer S, Holloway AC.

Reprod Toxicol. 2018 Oct;81:115-121. doi: 10.1016/j.reprotox.2018.07.084. Epub 2018 Jul 23.


Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD.

Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK.

Reprod Toxicol. 2018 Aug;79:16-20. doi: 10.1016/j.reprotox.2018.04.016. Epub 2018 Apr 27.


Ozone modifies the metabolic and endocrine response to glucose: Reproduction of effects with the stress hormone corticosterone.

Thomson EM, Pilon S, Guénette J, Williams A, Holloway AC.

Toxicol Appl Pharmacol. 2018 Mar 1;342:31-38. doi: 10.1016/j.taap.2018.01.020. Epub 2018 Jan 31.


Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants.

Stearns JC, Simioni J, Gunn E, McDonald H, Holloway AC, Thabane L, Mousseau A, Schertzer JD, Ratcliffe EM, Rossi L, Surette MG, Morrison KM, Hutton EK.

Sci Rep. 2017 Nov 28;7(1):16527. doi: 10.1038/s41598-017-16606-9.


Metabolic, stress, and inflammatory biomarker responses to glucose administration in Fischer-344 rats: intraperitoneal vs. oral delivery.

Pilon S, Holloway AC, Thomson EM.

J Pharmacol Toxicol Methods. 2018 Mar - Apr;90:1-6. doi: 10.1016/j.vascn.2017.10.010. Epub 2017 Nov 2.


Maternal nicotine exposure leads to decreased cardiac protein disulfide isomerase and impaired mitochondrial function in male rat offspring.

Barra NG, Lisyansky M, Vanduzer TA, Raha S, Holloway AC, Hardy DB.

J Appl Toxicol. 2017 Dec;37(12):1517-1526. doi: 10.1002/jat.3503. Epub 2017 Jul 6.


Gestational and Lactational Exposure to an Environmentally-Relevant Mixture of Brominated Flame Retardants: Effects on Neurodevelopment and Metabolism.

Tung EWY, Kawata A, Rigden M, Bowers WJ, Caldwell D, Holloway AC, Robaire B, Hales BF, Wade MG.

Birth Defects Res. 2017 Apr 17;109(7):497-512. doi: 10.1002/bdr2.1021. Epub 2017 Mar 24.


Early-life chemical exposures and risk of metabolic syndrome.

De Long NE, Holloway AC.

Diabetes Metab Syndr Obes. 2017 Mar 21;10:101-109. doi: 10.2147/DMSO.S95296. eCollection 2017. Review.


A comparison of intestinal microbiota in a population of low-risk infants exposed and not exposed to intrapartum antibiotics: The Baby & Microbiota of the Intestine cohort study protocol.

Simioni J, Hutton EK, Gunn E, Holloway AC, Stearns JC, McDonald H, Mousseau A, Schertzer JD, Ratcliffe EM, Thabane L, Surette MG, Morrison KM.

BMC Pediatr. 2016 Nov 10;16(1):183.


Effects of depression pharmacotherapy in fertility treatment on conception, birth, and neonatal health: A systematic review.

Akioyamen LE, Minhas H, Holloway AC, Taylor VH, Akioyamen NO, Sherifali D.

J Psychosom Res. 2016 May;84:69-80. doi: 10.1016/j.jpsychores.2016.03.015. Epub 2016 Mar 23. Review.


Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways.

Thomson EM, Pal S, Guénette J, Wade MG, Atlas E, Holloway AC, Williams A, Vincent R.

Toxicol Sci. 2016 Jul;152(1):17-28. doi: 10.1093/toxsci/kfw061. Epub 2016 Apr 1.


Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats.

Sanches JR, França LM, Chagas VT, Gaspar RS, Dos Santos KA, Gonçalves LM, Sloboda DM, Holloway AC, Dutra RP, Carneiro EM, Cappelli AP, Paes AM.

Front Pharmacol. 2016 Mar 10;7:48. doi: 10.3389/fphar.2016.00048. eCollection 2016.


Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data.

Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA.

Environ Health Perspect. 2016 Aug;124(8):1141-54. doi: 10.1289/ehp.1510456. Epub 2016 Mar 15.


GRADE: Assessing the quality of evidence in environmental and occupational health.

Morgan RL, Thayer KA, Bero L, Bruce N, Falck-Ytter Y, Ghersi D, Guyatt G, Hooijmans C, Langendam M, Mandrioli D, Mustafa RA, Rehfuess EA, Rooney AA, Shea B, Silbergeld EK, Sutton P, Wolfe MS, Woodruff TJ, Verbeek JH, Holloway AC, Santesso N, Schünemann HJ.

Environ Int. 2016 Jul-Aug;92-93:611-6. doi: 10.1016/j.envint.2016.01.004. Epub 2016 Jan 27.


Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells.

Wong MK, Holloway AC, Hardy DB.

Toxicol Sci. 2016 May;151(1):23-34. doi: 10.1093/toxsci/kfw019. Epub 2016 Jan 23.


An Overview of Links Between Obesity and Mental Health.

Avila C, Holloway AC, Hahn MK, Morrison KM, Restivo M, Anglin R, Taylor VH.

Curr Obes Rep. 2015 Sep;4(3):303-10. doi: 10.1007/s13679-015-0164-9. Review.


Adverse effects of perinatal nicotine exposure on reproductive outcomes.

Wong MK, Barra NG, Alfaidy N, Hardy DB, Holloway AC.

Reproduction. 2015 Dec;150(6):R185-93. doi: 10.1530/REP-15-0295. Epub 2015 Oct 2. Review.


Heat treatment enhances the antimicrobial activity of (+)-Catechin when combined with copper sulphate.

Holloway AC, Mueller-Harvey I, Gould SW, Fielder MD, Naughton DP, Kelly AF.

Lett Appl Microbiol. 2015 Oct;61(4):381-9. doi: 10.1111/lam.12472. Epub 2015 Aug 30.


Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring.

Moore CJ, DeLong NE, Chan KA, Holloway AC, Petrik JJ, Sloboda DM.

Reprod Sci. 2015 Oct;22(10):1297-311. doi: 10.1177/1933719115578925. Epub 2015 Mar 29.


Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta.

Wong MK, Nicholson CJ, Holloway AC, Hardy DB.

PLoS One. 2015 Mar 26;10(3):e0122295. doi: 10.1371/journal.pone.0122295. eCollection 2015.


Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats.

De Long NE, Barry EJ, Pinelli C, Wood GA, Hardy DB, Morrison KM, Taylor VH, Gerstein HC, Holloway AC.

Toxicol Appl Pharmacol. 2015 May 15;285(1):32-40. doi: 10.1016/j.taap.2015.03.006. Epub 2015 Mar 12.


Fetal Exposure to Sertraline Hydrochloride Impairs Pancreatic β-Cell Development.

De Long NE, Gutgesell MK, Petrik JJ, Holloway AC.

Endocrinology. 2015 Jun;156(6):1952-7. doi: 10.1210/en.2014-1779. Epub 2015 Mar 12.


Characterization of immune cells and cytokine localization in the rat utero-placental unit mid- to late gestation.

Tessier DR, Raha S, Holloway AC, Yockell-Lelièvre J, Tayade C, Gruslin A.

J Reprod Immunol. 2015 Aug;110:89-101. doi: 10.1016/j.jri.2015.01.006. Epub 2015 Feb 12.


Major depressive disorder and diabetes: does serotonin bridge the gap?

De Long NE, Stepita RA, Taylor VH, Holloway AC.

Curr Diabetes Rev. 2015;11(2):71-8. Review.


Angiogenesis in the placenta: the role of reactive oxygen species signaling.

Pereira RD, De Long NE, Wang RC, Yazdi FT, Holloway AC, Raha S.

Biomed Res Int. 2015;2015:814543. doi: 10.1155/2015/814543. Epub 2015 Jan 29. Review.


Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.

Barra NG, Palanivel R, Denou E, Chew MV, Gillgrass A, Walker TD, Kong J, Richards CD, Jordana M, Collins SM, Trigatti BL, Holloway AC, Raha S, Steinberg GR, Ashkar AA.

PLoS One. 2014 Dec 17;9(12):e114799. doi: 10.1371/journal.pone.0114799. eCollection 2014.


Is it safe to use smoking cessation therapeutics during pregnancy?

De Long NE, Barra NG, Hardy DB, Holloway AC.

Expert Opin Drug Saf. 2014 Dec;13(12):1721-31. doi: 10.1517/14740338.2014.973846. Epub 2014 Oct 21. Review.


Chronic prenatal ethanol exposure alters expression of central and peripheral insulin signaling molecules in adult guinea pig offspring.

Dobson CC, Thevasundaram K, Mongillo DL, Winterborn A, Holloway AC, Brien JF, Reynolds JN.

Alcohol. 2014 Nov;48(7):687-93. doi: 10.1016/j.alcohol.2014.09.001. Epub 2014 Sep 6.


Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1).

McNulty J, Keskar K, Crankshaw DJ, Holloway AC.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4586-4589. doi: 10.1016/j.bmcl.2014.07.083. Epub 2014 Aug 7.


Fluoxetine-induced pancreatic beta cell dysfunction: New insight into the benefits of folic acid in the treatment of depression.

De Long NE, Hyslop JR, Raha S, Hardy DB, Holloway AC.

J Affect Disord. 2014 Sep;166:6-13. doi: 10.1016/j.jad.2014.04.063. Epub 2014 May 4.


Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.

Salman S, Holloway AC, Nurse CA.

Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C266-77. doi: 10.1152/ajpcell.00135.2014. Epub 2014 Jun 4.


Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies.

Holloway AC, Salomon A, Soares MJ, Garnier V, Raha S, Sergent F, Nicholson CJ, Feige JJ, Benharouga M, Alfaidy N.

Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E443-56. doi: 10.1152/ajpendo.00478.2013. Epub 2013 Dec 24.


Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase.

Ma N, Nicholson CJ, Wong M, Holloway AC, Hardy DB.

Toxicol Appl Pharmacol. 2014 Feb 15;275(1):1-11. doi: 10.1016/j.taap.2013.12.010. Epub 2013 Dec 22.


Trophoblast invasion and blood vessel remodeling are altered in a rat model of lifelong maternal obesity.

Hayes EK, Tessier DR, Percival ME, Holloway AC, Petrik JJ, Gruslin A, Raha S.

Reprod Sci. 2014 May;21(5):648-57. doi: 10.1177/1933719113508815. Epub 2013 Oct 23.


Investigation of aryl halides as ketone bioisosteres: refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).

McNulty J, Nielsen AJ, Brown CE, DiFrancesco BR, Vurgun N, Nair JJ, Crankshaw DJ, Holloway AC.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6060-3. doi: 10.1016/j.bmcl.2013.09.030. Epub 2013 Sep 18.


Postnatal metabolic and reproductive consequences of fetal and neonatal exposure to the smoking cessation drug bupropion.

De Long N, Hyslop JR, Nicholson CJ, Morrison KM, Gerstein HC, Holloway AC.

Reprod Sci. 2013 Oct;20(10):1156-61. doi: 10.1177/1933719113477493. Epub 2013 Feb 25.


The effects of extracellular calcium-sensing receptor ligands on the contractility of pregnant human myometrium in vitro.

Crankshaw DJ, Pistilli MJ, O'Brien YM, Sweeney EM, Dockery P, Holloway AC, Morrison JJ.

Reprod Sci. 2013 Aug;20(8):882-90. doi: 10.1177/1933719112468949. Epub 2013 Jan 3.


Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring.

Dobson CC, Mongillo DL, Brien DC, Stepita R, Poklewska-Koziell M, Winterborn A, Holloway AC, Brien JF, Reynolds JN.

Nutr Diabetes. 2012 Dec 17;2:e57. doi: 10.1038/nutd.2012.31.

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