Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 384


2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.

Kraus WE, Bhapkar M, Huffman KM, Pieper CF, Krupa Das S, Redman LM, Villareal DT, Rochon J, Roberts SB, Ravussin E, Holloszy JO, Fontana L; CALERIE Investigators.

Lancet Diabetes Endocrinol. 2019 Sep;7(9):673-683. doi: 10.1016/S2213-8587(19)30151-2. Epub 2019 Jul 11.


AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle.

Koh JH, Hancock CR, Han DH, Holloszy JO, Nair KS, Dasari S.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E931-E939. doi: 10.1152/ajpendo.00460.2018. Epub 2019 Mar 19.


PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise.

Koh JH, Hancock CR, Terada S, Higashida K, Holloszy JO, Han DH.

Cell Metab. 2017 May 2;25(5):1176-1185.e5. doi: 10.1016/j.cmet.2017.04.029.


Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.

Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L.

Aging (Albany NY). 2016 Jul;8(7):1416-31. doi: 10.18632/aging.100994.


Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L.

Cell Rep. 2016 Jan 26;14(3):422-428. doi: 10.1016/j.celrep.2015.12.042. Epub 2016 Jan 7.


Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial.

Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO; CALERIE Study Group.

Aging Cell. 2016 Feb;15(1):22-7. doi: 10.1111/acel.12400. Epub 2015 Oct 6.


A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.

Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB; CALERIE Study Group.

J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1097-104. doi: 10.1093/gerona/glv057. Epub 2015 Jul 17. Erratum in: J Gerontol A Biol Sci Med Sci. 2016 Jun;71(6):839-40.


PGC-1α mediates a rapid, exercise-induced downregulation of glycogenolysis in rat skeletal muscle.

Kim SH, Koh JH, Higashida K, Jung SR, Holloszy JO, Han DH.

J Physiol. 2015 Feb 1;593(3):635-43. doi: 10.1113/jphysiol.2014.283820. Epub 2014 Dec 23.


Multiple dietary supplements do not affect metabolic and cardio-vascular health.

Soare A, Weiss EP, Holloszy JO, Fontana L.

Aging (Albany NY). 2014 Feb;6(2):149-57.


Postprandial plasma incretin hormones in exercise-trained versus untrained subjects.

Weiss EP, Royer NK, Fisher JS, Holloszy JO, Fontana L.

Med Sci Sports Exerc. 2014 Jun;46(6):1098-103. doi: 10.1249/MSS.0000000000000204.


Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation.

Higashida K, Kim SH, Jung SR, Asaka M, Holloszy JO, Han DH.

PLoS Biol. 2013 Jul;11(7):e1001603. doi: 10.1371/journal.pbio.1001603. Epub 2013 Jul 9. Erratum in: PLoS Biol. 2014 Jan;12(1). doi:10.1371/annotation/900c9397-eeb9-4d4e-9a05-ff18d657be79.


"Deficiency" of mitochondria in muscle does not cause insulin resistance.

Holloszy JO.

Diabetes. 2013 Apr;62(4):1036-40. doi: 10.2337/db12-1107.


β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle.

Kim SH, Asaka M, Higashida K, Takahashi Y, Holloszy JO, Han DH.

Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E844-52. doi: 10.1152/ajpendo.00581.2012. Epub 2013 Feb 26.


Urgent call for the third wish.

Roth J, Holloszy JO.

Diabetes Metab Res Rev. 2013 Jan;29(1):98-100. doi: 10.1002/dmrr.2374.


Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness.

Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO.

Aging Cell. 2012 Oct;11(5):876-84. doi: 10.1111/j.1474-9726.2012.00852.x. Epub 2012 Aug 1.


Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.

Han DH, Kim SH, Higashida K, Jung SR, Polonsky KS, Klein S, Holloszy JO.

Metabolism. 2012 Nov;61(11):1615-21. doi: 10.1016/j.metabol.2012.04.008. Epub 2012 May 8.


Caloric restriction may reverse age-related autonomic decline in humans.

Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L.

Aging Cell. 2012 Aug;11(4):644-50. doi: 10.1111/j.1474-9726.2012.00825.x. Epub 2012 May 21.


Bayesian functional integral method for inferring continuous data from discrete measurements.

Heuett WJ, Miller BV 3rd, Racette SB, Holloszy JO, Chow CC, Periwal V.

Biophys J. 2012 Feb 8;102(3):399-406. doi: 10.1016/j.bpj.2011.12.046. Epub 2012 Feb 7.


Normal adaptations to exercise despite protection against oxidative stress.

Higashida K, Kim SH, Higuchi M, Holloszy JO, Han DH.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E779-84. doi: 10.1152/ajpendo.00655.2010. Epub 2011 Jul 12.


Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance.

Han DH, Hancock CR, Jung SR, Higashida K, Kim SH, Holloszy JO.

PLoS One. 2011 May 12;6(5):e19739. doi: 10.1371/journal.pone.0019739.


Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.

Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO.

Aging (Albany NY). 2011 May;3(5):533-42.


Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans.

Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L.

Aging (Albany NY). 2011 Apr;3(4):374-9.


Regulation of mitochondrial biogenesis and GLUT4 expression by exercise.

Holloszy JO.

Compr Physiol. 2011 Apr;1(2):921-40. doi: 10.1002/cphy.c100052. Review.


Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.

Reeds DN, Patterson BW, Okunade A, Holloszy JO, Polonsky KS, Klein S.

Diabetes Care. 2011 May;34(5):1071-6. doi: 10.2337/dc10-2299. Epub 2011 Mar 16.


Does calorie restriction induce mitochondrial biogenesis? A reevaluation.

Hancock CR, Han DH, Higashida K, Kim SH, Holloszy JO.

FASEB J. 2011 Feb;25(2):785-91. doi: 10.1096/fj.10-170415. Epub 2010 Nov 3.


Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.

Rochon J, Bales CW, Ravussin E, Redman LM, Holloszy JO, Racette SB, Roberts SB, Das SK, Romashkan S, Galan KM, Hadley EC, Kraus WE; CALERIE Study Group.

J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):97-108. doi: 10.1093/gerona/glq168. Epub 2010 Oct 5.


Long-term effects of calorie restriction on serum sex-hormone concentrations in men.

Cangemi R, Friedmann AJ, Holloszy JO, Fontana L.

Aging Cell. 2010 Apr;9(2):236-42. doi: 10.1111/j.1474-9726.2010.00553.x. Epub 2010 Jan 20.


Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production.

Fontana L, Klein S, Holloszy JO.

Age (Dordr). 2010 Mar;32(1):97-108. doi: 10.1007/s11357-009-9118-z. Epub 2009 Nov 11.


Is "fat-induced" muscle insulin resistance rapidly reversible?

Han DH, Hancock C, Jung SR, Holloszy JO.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E236-41. doi: 10.1152/ajpendo.00244.2009. Epub 2009 May 12.


Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus.

Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E151-6. doi: 10.1152/ajpendo.00210.2009. Epub 2009 Apr 21.


Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.

Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DT.

Am J Clin Nutr. 2009 May;89(5):1459-67. doi: 10.3945/ajcn.2008.27265. Epub 2009 Mar 25.


Regulation by exercise of skeletal muscle content of mitochondria and GLUT4.

Holloszy JO.

J Physiol Pharmacol. 2008 Dec;59 Suppl 7:5-18. Review.


Exercise: it's the real thing!

Hawley JA, Holloszy JO.

Nutr Rev. 2009 Mar;67(3):172-8. doi: 10.1111/j.1753-4887.2009.00185.x. Review.


Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance.

Holloszy JO.

Am J Clin Nutr. 2009 Jan;89(1):463S-6S. doi: 10.3945/ajcn.2008.26717C. Epub 2008 Dec 3. Review.


Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO.

Aging Cell. 2008 Oct;7(5):681-7.


Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day.

Weiss EP, Arif H, Villareal DT, Marzetti E, Holloszy JO.

Am J Clin Nutr. 2008 Jul;88(1):51-7.


Influence of weekend lifestyle patterns on body weight.

Racette SB, Weiss EP, Schechtman KB, Steger-May K, Villareal DT, Obert KA, Holloszy JO.

Obesity (Silver Spring). 2008 Aug;16(8):1826-30. doi: 10.1038/oby.2008.320. Epub 2008 Jun 12.


High-fat diets cause insulin resistance despite an increase in muscle mitochondria.

Hancock CR, Han DH, Chen M, Terada S, Yasuda T, Wright DC, Holloszy JO.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7815-20. doi: 10.1073/pnas.0802057105. Epub 2008 May 28.


The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function.

Riordan MM, Weiss EP, Meyer TE, Ehsani AA, Racette SB, Villareal DT, Fontana L, Holloszy JO, Kovács SJ.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1174-82. Epub 2007 Dec 27.


A role for the transcriptional coactivator PGC-1alpha in muscle refueling.

Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO, Kelly DP.

J Biol Chem. 2007 Dec 14;282(50):36642-51. Epub 2007 Oct 11.


Comparison of methods for assessing abdominal adipose tissue from magnetic resonance images.

Arif H, Racette SB, Villareal DT, Holloszy JO, Weiss EP.

Obesity (Silver Spring). 2007 Sep;15(9):2240-4.


Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

Garcia-Roves P, Huss JM, Han DH, Hancock CR, Iglesias-Gutierrez E, Chen M, Holloszy JO.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10709-13. Epub 2007 Jun 4.


Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk.

Fontana L, Meyer TE, Klein S, Holloszy JO.

Rejuvenation Res. 2007 Jun;10(2):225-34.


Caloric restriction in humans.

Holloszy JO, Fontana L.

Exp Gerontol. 2007 Aug;42(8):709-12. Epub 2007 Mar 31. Review.


Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial.

Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO; Washington University School of Medicine CALERIE Group.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E197-202. Epub 2007 Mar 27.


IL-6 increases muscle insulin sensitivity only at superphysiological levels.

Geiger PC, Hancock C, Wright DC, Han DH, Holloszy JO.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1842-6. Epub 2007 Feb 27.


Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.

Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO.

Arch Intern Med. 2006 Dec 11-25;166(22):2502-10. Erratum in: Arch Intern Med. 2007 Mar 12;167(5):452.


Supplemental Content

Loading ...
Support Center