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Items: 44


Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes.

Subramanian VV, Zhu X, Markowitz TE, Vale-Silva LA, San-Segundo PA, Hollingsworth NM, Keeney S, Hochwagen A.

Nat Commun. 2019 Feb 27;10(1):970. doi: 10.1038/s41467-019-08875-x.


The meiotic-specific Mek1 kinase in budding yeast regulates interhomolog recombination and coordinates meiotic progression with double-strand break repair.

Hollingsworth NM, Gaglione R.

Curr Genet. 2019 Jun;65(3):631-641. doi: 10.1007/s00294-019-00937-3. Epub 2019 Jan 22. Review.


Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

Chen X, Gaglione R, Leong T, Bednor L, de Los Santos T, Luk E, Airola M, Hollingsworth NM.

PLoS Genet. 2018 Nov 29;14(11):e1007832. doi: 10.1371/journal.pgen.1007832. eCollection 2018 Nov.


Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.

Kniewel R, Murakami H, Liu Y, Ito M, Ohta K, Hollingsworth NM, Keeney S.

Genetics. 2017 Dec;207(4):1313-1333. doi: 10.1534/genetics.117.300359. Epub 2017 Oct 6.


Coordination of Double Strand Break Repair and Meiotic Progression in Yeast by a Mek1-Ndt80 Negative Feedback Loop.

Prugar E, Burnett C, Chen X, Hollingsworth NM.

Genetics. 2017 May;206(1):497-512. doi: 10.1534/genetics.117.199703. Epub 2017 Mar 1.


Correction: Mek1 Down Regulates Rad51 Activity during Yeast Meiosis by Phosphorylation of Hed1.

Callender TL, Laureau R, Wan L, Chen X, Sandhu R, Laljee S, Zhou S, Suhandynata RT, Prugar E, Gaines WA, Kwon Y, Börner GV, Nicolas A, Neiman AM, Hollingsworth NM.

PLoS Genet. 2016 Aug 24;12(8):e1006283. doi: 10.1371/journal.pgen.1006283. eCollection 2016 Aug.


Mek1 Down Regulates Rad51 Activity during Yeast Meiosis by Phosphorylation of Hed1.

Callender TL, Laureau R, Wan L, Chen X, Sandhu R, Laljee S, Zhou S, Suhandynata RT, Prugar E, Gaines WA, Kwon Y, Börner GV, Nicolas A, Neiman AM, Hollingsworth NM.

PLoS Genet. 2016 Aug 2;12(8):e1006226. doi: 10.1371/journal.pgen.1006226. eCollection 2016 Aug. Erratum in: PLoS Genet. 2016 Aug 24;12 (8):e1006283.


Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites.

Park JS, Thorsness MK, Policastro R, McGoldrick LL, Hollingsworth NM, Thorsness PE, Neiman AM.

Mol Biol Cell. 2016 Aug 1;27(15):2435-49. doi: 10.1091/mbc.E16-02-0112. Epub 2016 Jun 8.


Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics.

Suhandynata RT, Wan L, Zhou H, Hollingsworth NM.

PLoS One. 2016 May 23;11(5):e0155931. doi: 10.1371/journal.pone.0155931. eCollection 2016.


Mek1/Mre4 is a master regulator of meiotic recombination in budding yeast.

Hollingsworth NM.

Microb Cell. 2016 Feb 22;3(3):129-131. doi: 10.15698/mic2016.03.487.


Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis.

Chen X, Suhandynata RT, Sandhu R, Rockmill B, Mohibullah N, Niu H, Liang J, Lo HC, Miller DE, Zhou H, Börner GV, Hollingsworth NM.

PLoS Biol. 2015 Dec 18;13(12):e1002329. doi: 10.1371/journal.pbio.1002329. eCollection 2015 Dec.


A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture.

Suhandynata R, Liang J, Albuquerque CP, Zhou H, Hollingsworth NM.

G3 (Bethesda). 2014 Aug 27;4(11):2125-35. doi: 10.1534/g3.114.013888.


Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks.

Liu Y, Gaines WA, Callender T, Busygina V, Oke A, Sung P, Fung JC, Hollingsworth NM.

PLoS Genet. 2014 Jan;10(1):e1004005. doi: 10.1371/journal.pgen.1004005. Epub 2014 Jan 23.


Cdc7-Dbf4 is a gene-specific regulator of meiotic transcription in yeast.

Lo HC, Kunz RC, Chen X, Marullo A, Gygi SP, Hollingsworth NM.

Mol Cell Biol. 2012 Jan;32(2):541-57. doi: 10.1128/MCB.06032-11. Epub 2011 Nov 21.


Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1.

Lo HC, Hollingsworth NM.

Methods Mol Biol. 2011;745:135-49. doi: 10.1007/978-1-61779-129-1_9.


Mek1 suppression of meiotic double-strand break repair is specific to sister chromatids, chromosome autonomous and independent of Rec8 cohesin complexes.

Callender TL, Hollingsworth NM.

Genetics. 2010 Jul;185(3):771-82. doi: 10.1534/genetics.110.117523. Epub 2010 Apr 26.


Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.

Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE.

Sci Signal. 2010 Feb 16;3(109):ra12. doi: 10.1126/scisignal.2000482.


Phosphorylation and the creation of interhomolog bias during meiosis in yeast.

Hollingsworth NM.

Cell Cycle. 2010 Feb 1;9(3):436-7. Epub 2010 Mar 2. No abstract available.


Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.

Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat KM, Gygi SP, Hollingsworth NM.

Mol Cell. 2009 Nov 13;36(3):393-404. doi: 10.1016/j.molcel.2009.09.029.


Deconstructing meiosis one kinase at a time: polo pushes past pachytene.

Hollingsworth NM.

Genes Dev. 2008 Oct 1;22(19):2596-600. doi: 10.1101/gad.1727508. Review.


Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis.

Lo HC, Wan L, Rosebrock A, Futcher B, Hollingsworth NM.

Mol Biol Cell. 2008 Nov;19(11):4956-67. doi: 10.1091/mbc.E08-07-0755. Epub 2008 Sep 3.


Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast.

Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM.

Genes Dev. 2008 Feb 1;22(3):386-97. doi: 10.1101/gad.1626408.


Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis.

Niu H, Li X, Job E, Park C, Moazed D, Gygi SP, Hollingsworth NM.

Mol Cell Biol. 2007 Aug;27(15):5456-67. Epub 2007 May 25.


Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.

Niu H, Wan L, Baumgartner B, Schaefer D, Loidl J, Hollingsworth NM.

Mol Biol Cell. 2005 Dec;16(12):5804-18. Epub 2005 Oct 12.


Does chromosome size affect map distance and genetic interference in budding yeast?

Turney D, de Los Santos T, Hollingsworth NM.

Genetics. 2004 Dec;168(4):2421-4.


DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.

Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, Carotenuto W, Liberi G, Bressan D, Wan L, Hollingsworth NM, Haber JE, Foiani M.

Nature. 2004 Oct 21;431(7011):1011-7.


The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions.

Hollingsworth NM, Brill SJ.

Genes Dev. 2004 Jan 15;18(2):117-25. Review. No abstract available.


Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.

Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM.

Mol Biol Cell. 2004 Jan;15(1):11-23. Epub 2003 Oct 31.


A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae.

de los Santos T, Loidl J, Larkin B, Hollingsworth NM.

Genetics. 2001 Dec;159(4):1511-25.


Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.

Woltering D, Baumgartner B, Bagchi S, Larkin B, Loidl J, de los Santos T, Hollingsworth NM.

Mol Cell Biol. 2000 Sep;20(18):6646-58.


PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase.

Suzuki T, Park H, Hollingsworth NM, Sternglanz R, Lennarz WJ.

J Cell Biol. 2000 May 29;149(5):1039-52.


Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.

de los Santos T, Hollingsworth NM.

J Biol Chem. 1999 Jan 15;274(3):1783-90.


DNA-binding activities of Hop1 protein, a synaptonemal complex component from Saccharomyces cerevisiae.

Kironmai KM, Muniyappa K, Friedman DB, Hollingsworth NM, Byers B.

Mol Cell Biol. 1998 Mar;18(3):1424-35.


Conserved properties between functionally distinct MutS homologs in yeast.

Pochart P, Woltering D, Hollingsworth NM.

J Biol Chem. 1997 Nov 28;272(48):30345-9.


Meiosis. DNA branching during meiotic recombination.

Byers B, Hollingsworth NM.

Curr Biol. 1994 May 1;4(5):448-51. Review.


Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis.

Friedman DB, Hollingsworth NM, Byers B.

Genetics. 1994 Feb;136(2):449-64.


Meiotic induction of the yeast HOP1 gene is controlled by positive and negative regulatory sites.

Vershon AK, Hollingsworth NM, Johnson AD.

Mol Cell Biol. 1992 Sep;12(9):3706-14.


The HOP1 gene encodes a meiosis-specific component of yeast chromosomes.

Hollingsworth NM, Goetsch L, Byers B.

Cell. 1990 Apr 6;61(1):73-84.


HOP1: a yeast meiotic pairing gene.

Hollingsworth NM, Byers B.

Genetics. 1989 Mar;121(3):445-62. Erratum in: Genetics 1989 Jul;122(3):719.

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