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Items: 35

1.

Brain-targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms.

Gleitz HF, Liao AY, Cook JR, Rowlston SF, Forte GM, D'Souza Z, O'Leary C, Holley RJ, Bigger BW.

EMBO Mol Med. 2018 Jun 8. pii: e8730. doi: 10.15252/emmm.201708730. [Epub ahead of print]

2.

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E.

Brain. 2018 May 16. doi: 10.1093/brain/awy126. [Epub ahead of print]

PMID:
29788236
3.

Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.

Holley RJ, Ellison SM, Fil D, O'Leary C, McDermott J, Senthivel N, Langford-Smith AWW, Wilkinson FL, D'Souza Z, Parker H, Liao A, Rowlston S, Gleitz HFE, Kan SH, Dickson PI, Bigger BW.

Brain. 2018 Jan 1;141(1):99-116. doi: 10.1093/brain/awx311.

PMID:
29186350
4.

Identification of age-dependent motor and neuropsychological behavioural abnormalities in a mouse model of Mucopolysaccharidosis Type II.

Gleitz HF, O'Leary C, Holley RJ, Bigger BW.

PLoS One. 2017 Feb 16;12(2):e0172435. doi: 10.1371/journal.pone.0172435. eCollection 2017.

5.

Using Wearable Sensors and Machine Learning Models to Separate Functional Upper Extremity Use From Walking-Associated Arm Movements.

McLeod A, Bochniewicz EM, Lum PS, Holley RJ, Emmer G, Dromerick AW.

Arch Phys Med Rehabil. 2016 Feb;97(2):224-31. doi: 10.1016/j.apmr.2015.08.435. Epub 2015 Oct 3.

PMID:
26435302
6.

Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells.

Holley RJ, Tai G, Williamson AJ, Taylor S, Cain SA, Richardson SM, Merry CL, Whetton AD, Kielty CM, Canfield AE.

Stem Cell Reports. 2015 Mar 10;4(3):473-88. doi: 10.1016/j.stemcr.2015.01.007. Epub 2015 Feb 13.

7.

Evaluation of HEXORR Tone Assistance Mode Against Spring Assistance.

Godfrey SB, Holley RJ, Lum PS.

IEEE Trans Neural Syst Rehabil Eng. 2015 Jul;23(4):610-7. doi: 10.1109/TNSRE.2015.2398933. Epub 2015 Feb 4.

PMID:
25667355
8.

Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I.

Watson HA, Holley RJ, Langford-Smith KJ, Wilkinson FL, van Kuppevelt TH, Wynn RF, Wraith JE, Merry CL, Bigger BW.

J Biol Chem. 2014 Dec 26;289(52):36194-203. doi: 10.1074/jbc.M114.599944. Epub 2014 Oct 30.

9.

Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes.

Holley RJ, Smith RA, van de Westerlo EM, Pickford CE, Merry CL, van Kuppevelt TH.

Methods Mol Biol. 2015;1229:239-51. doi: 10.1007/978-1-4939-1714-3_21.

PMID:
25325958
10.

Internal models of upper limb prosthesis users when grasping and lifting a fragile object with their prosthetic limb.

Lum PS, Black I, Holley RJ, Barth J, Dromerick AW.

Exp Brain Res. 2014 Dec;232(12):3785-95. doi: 10.1007/s00221-014-4071-1. Epub 2014 Aug 21.

PMID:
25142151
11.

Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration.

Keenan TD, Pickford CE, Holley RJ, Clark SJ, Lin W, Dowsey AW, Merry CL, Day AJ, Bishop PN.

Invest Ophthalmol Vis Sci. 2014 Jul 29;55(8):5370-9. doi: 10.1167/iovs.14-14126.

PMID:
25074778
12.

Using embryonic stem cells to understand how glycosaminoglycans regulate differentiation.

Holley RJ, Meade KA, Merry CL.

Biochem Soc Trans. 2014 Jun;42(3):689-95. doi: 10.1042/BST20140064.

PMID:
24849238
13.

Robotic therapy provides a stimulus for upper limb motor recovery after stroke that is complementary to and distinct from conventional therapy.

Brokaw EB, Nichols D, Holley RJ, Lum PS.

Neurorehabil Neural Repair. 2014 May;28(4):367-76. doi: 10.1177/1545968313510974. Epub 2013 Dec 2.

PMID:
24297763
14.

Clinical effects of using HEXORR (Hand Exoskeleton Rehabilitation Robot) for movement therapy in stroke rehabilitation.

Godfrey SB, Holley RJ, Lum PS.

Am J Phys Med Rehabil. 2013 Nov;92(11):947-58. doi: 10.1097/PHM.0b013e31829e7a07.

PMID:
23900016
15.

Comparison of joint space and end point space robotic training modalities for rehabilitation of interjoint coordination in individuals with moderate to severe impairment from chronic stroke.

Brokaw EB, Holley RJ, Lum PS.

IEEE Trans Neural Syst Rehabil Eng. 2013 Sep;21(5):787-95. doi: 10.1109/TNSRE.2013.2238251. Epub 2013 Jan 9.

PMID:
23314781
16.

Immobilization of heparan sulfate on electrospun meshes to support embryonic stem cell culture and differentiation.

Meade KA, White KJ, Pickford CE, Holley RJ, Marson A, Tillotson D, van Kuppevelt TH, Whittle JD, Day AJ, Merry CL.

J Biol Chem. 2013 Feb 22;288(8):5530-8. doi: 10.1074/jbc.M112.423012. Epub 2012 Dec 12.

17.

Robotic approaches for rehabilitation of hand function after stroke.

Lum PS, Godfrey SB, Brokaw EB, Holley RJ, Nichols D.

Am J Phys Med Rehabil. 2012 Nov;91(11 Suppl 3):S242-54. doi: 10.1097/PHM.0b013e31826bcedb. Review.

PMID:
23080040
18.

Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB.

Wilkinson FL, Holley RJ, Langford-Smith KJ, Badrinath S, Liao A, Langford-Smith A, Cooper JD, Jones SA, Wraith JE, Wynn RF, Merry CL, Bigger BW.

PLoS One. 2012;7(4):e35787. doi: 10.1371/journal.pone.0035787. Epub 2012 Apr 27.

19.

Hematopoietic stem cell and gene therapy corrects primary neuropathology and behavior in mucopolysaccharidosis IIIA mice.

Langford-Smith A, Wilkinson FL, Langford-Smith KJ, Holley RJ, Sergijenko A, Howe SJ, Bennett WR, Jones SA, Wraith J, Merry CL, Wynn RF, Bigger BW.

Mol Ther. 2012 Aug;20(8):1610-21. doi: 10.1038/mt.2012.82. Epub 2012 May 1.

20.

Characterization of compensatory trunk movements during prosthetic upper limb reaching tasks.

Metzger AJ, Dromerick AW, Holley RJ, Lum PS.

Arch Phys Med Rehabil. 2012 Nov;93(11):2029-34. doi: 10.1016/j.apmr.2012.03.011. Epub 2012 Mar 23.

PMID:
22449551
21.

Time Independent Functional task Training: a case study on the effect of inter-joint coordination driven haptic guidance in stroke therapy.

Brokaw EB, Murray TM, Nef T, Lum PS, Brokaw EB, Nichols D, Holley RJ.

IEEE Int Conf Rehabil Robot. 2011;2011:5975501. doi: 10.1109/ICORR.2011.5975501.

PMID:
22275697
22.

Comparison of Tone compensation and Spring assistance for hand rehabilitation in HEXORR.

Godfrey SB, Holley RJ, Lum PS.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:8535-8. doi: 10.1109/IEMBS.2011.6092106.

PMID:
22256330
23.

Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking α-l-iduronidase.

Holley RJ, Deligny A, Wei W, Watson HA, Niñonuevo MR, Dagälv A, Leary JA, Bigger BW, Kjellén L, Merry CL.

J Biol Chem. 2011 Oct 28;286(43):37515-24. doi: 10.1074/jbc.M111.287474. Epub 2011 Aug 26.

24.

Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera.

Clark SJ, Keenan TD, Fielder HL, Collinson LJ, Holley RJ, Merry CL, van Kuppevelt TH, Day AJ, Bishop PN.

Invest Ophthalmol Vis Sci. 2011 Aug 17;52(9):6511-21. doi: 10.1167/iovs.11-7909.

25.

Hand Spring Operated Movement Enhancer (HandSOME): a portable, passive hand exoskeleton for stroke rehabilitation.

Brokaw EB, Black I, Holley RJ, Lum PS.

IEEE Trans Neural Syst Rehabil Eng. 2011 Aug;19(4):391-9. doi: 10.1109/TNSRE.2011.2157705. Epub 2011 May 27.

PMID:
21622079
26.

Specific glycosaminoglycans modulate neural specification of mouse embryonic stem cells.

Pickford CE, Holley RJ, Rushton G, Stavridis MP, Ward CM, Merry CL.

Stem Cells. 2011 Apr;29(4):629-40. doi: 10.1002/stem.610.

27.

Glycosaminoglycans as regulators of stem cell differentiation.

Smith RA, Meade K, Pickford CE, Holley RJ, Merry CL.

Biochem Soc Trans. 2011 Jan;39(1):383-7. doi: 10.1042/BST0390383.

PMID:
21265809
28.

Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.

Holley RJ, Pickford CE, Rushton G, Lacaud G, Gallagher JT, Kouskoff V, Merry CL.

J Biol Chem. 2011 Feb 25;286(8):6241-52. doi: 10.1074/jbc.M110.178483. Epub 2010 Dec 10.

29.

Hand spring operated movement enhancer (HandSOME) device for hand rehabilitation after stroke.

Brokaw EB, Holley RJ, Lum PS.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:5867-70. doi: 10.1109/IEMBS.2010.5627516.

PMID:
21096926
30.

Hand function recovery in chronic stroke with HEXORR robotic training: A case series.

Godfrey SB, Schabowsky CN, Holley RJ, Lum PS.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:4485-8. doi: 10.1109/IEMBS.2010.5626037.

PMID:
21095777
31.

Development and pilot testing of HEXORR: hand EXOskeleton rehabilitation robot.

Schabowsky CN, Godfrey SB, Holley RJ, Lum PS.

J Neuroeng Rehabil. 2010 Jul 28;7:36. doi: 10.1186/1743-0003-7-36.

32.

Feedforward control strategies of subjects with transradial amputation in planar reaching.

Metzger AJ, Dromerick AW, Schabowsky CN, Holley RJ, Monroe B, Lum PS.

J Rehabil Res Dev. 2010;47(3):201-11.

33.

Effect of training on upper-extremity prosthetic performance and motor learning: a single-case study.

Dromerick AW, Schabowsky CN, Holley RJ, Monroe B, Markotic A, Lum PS.

Arch Phys Med Rehabil. 2008 Jun;89(6):1199-204. doi: 10.1016/j.apmr.2007.09.058.

PMID:
18503820
34.

Trans-radial upper extremity amputees are capable of adapting to a novel dynamic environment.

Schabowsky CN, Dromerick AW, Holley RJ, Monroe B, Lum PS.

Exp Brain Res. 2008 Jul;188(4):589-601. doi: 10.1007/s00221-008-1394-9. Epub 2008 Apr 29.

PMID:
18443766
35.

Hospital closings, conversions: where do employees go?

Reilly JF, Holley RJ.

Hosp Prog. 1980 Nov;61(11):57-61.

PMID:
10248582

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