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Items: 1 to 50 of 404

1.

Active thrombin produced by the intestinal epithelium controls mucosal biofilms.

Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N.

Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w.

2.

Proceedings from the 9th Annual University of Calgary Leaders in Medicine Research Symposium.

Ward R, Delaloye N, Logan L, Jenkins S, Hollenberg MD, Rabi DM.

Clin Invest Med. 2019 Jun 23;42(2):E1-E18. doi: 10.25011/cim.v42i2.32811.

PMID:
31228961
3.

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.

Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18.

PMID:
31211619
4.

Protease-Activated Receptor 2 Agonist as Adjuvant: Augmenting Development of Protective Memory CD8 T Cell Responses Induced by Influenza Virosomes.

Zhou G, Hollenberg MD, Vliagoftis H, Kane KP.

J Immunol. 2019 Jul 15;203(2):441-452. doi: 10.4049/jimmunol.1800915. Epub 2019 Jun 10.

PMID:
31182479
5.

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5.

Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg MD, Gieseler F, Lehnert H, Witte D.

Cancers (Basel). 2019 May 17;11(5). pii: E691. doi: 10.3390/cancers11050691.

6.

PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation.

Rayees S, Joshi JC, Tauseef M, Anwar M, Baweja S, Rochford I, Joshi B, Hollenberg MD, Reddy SP, Mehta D.

Cell Rep. 2019 Apr 16;27(3):793-805.e4. doi: 10.1016/j.celrep.2019.03.053.

7.

TRPV1 promotes opioid analgesia during inflammation.

Basso L, Aboushousha R, Fan CY, Iftinca M, Melo H, Flynn R, Agosti F, Hollenberg MD, Thompson R, Bourinet E, Trang T, Altier C.

Sci Signal. 2019 Apr 2;12(575). pii: eaav0711. doi: 10.1126/scisignal.aav0711.

PMID:
30940767
8.

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.

Pulakazhi Venu VK, El-Daly M, Saifeddine M, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Can J Diabetes. 2019 Jan 23. pii: S1499-2671(18)30879-7. doi: 10.1016/j.jcjd.2019.01.005. [Epub ahead of print]

PMID:
30930073
9.

Proceedings from the 8th Annual University of Calgary Leaders in Medicine Research Symposium.

Logan LM, Jensen SK, Singh N, Peplowski MA, Rabi D, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2019 Jan 30;41(4):E165-E185. doi: 10.25011/cim.v41i4.32220.

PMID:
30737977
10.

HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG.

Cell Death Differ. 2019 Jan 25. doi: 10.1038/s41418-018-0264-7. [Epub ahead of print]

PMID:
30683917
11.

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation.

Melo H, Basso L, Iftinca M, MacNaughton WK, Hollenberg MD, McKay DM, Altier C.

Sci Rep. 2018 Oct 19;8(1):15551. doi: 10.1038/s41598-018-33620-7.

12.

Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.

Yee MC, Nichols HL, Polley D, Saifeddine M, Pal K, Lee K, Wilson EH, Daines MO, Hollenberg MD, Boitano S, DeFea KA.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L1042-L1057. doi: 10.1152/ajplung.00196.2018. Epub 2018 Oct 18.

PMID:
30335499
13.

The Need for an Executive Leadership Curriculum in Scientist-Clinician Training Programs.

Barton KI, Capozzi LC, Aker G, Yipp BG, Hollenberg MD, Rabi DM, Beck PL.

Clin Invest Med. 2018 Sep 30;41(3):E144-E147. doi: 10.25011/cim.v41i3.30855.

PMID:
30315750
14.

Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription.

Peplowski MA, Dicay M, Baggio CH, Wysokinski F, Renaux B, Hollenberg MD, Proud D, MacNaughton WK.

J Mol Med (Berl). 2018 Oct;96(10):1081-1093. doi: 10.1007/s00109-018-1681-2. Epub 2018 Aug 8.

PMID:
30090948
15.

Bioactive Extracellular Matrix Scaffold Promotes Adaptive Cardiac Remodeling and Repair.

Mewhort HEM, Svystonyuk DA, Turnbull JD, Teng G, Belke DD, Guzzardi DG, Park DS, Kang S, Hollenberg MD, Fedak PWM.

JACC Basic Transl Sci. 2017 Aug 18;2(4):450-464. doi: 10.1016/j.jacbts.2017.05.005. eCollection 2017 Aug.

16.

Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation.

Eftekhari R, de Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD.

Biol Chem. 2018 Sep 25;399(9):1023-1039. doi: 10.1515/hsz-2018-0001.

PMID:
29924723
17.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13.

PMID:
29908295
18.

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562.

PMID:
29860464
19.

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation.

Darby WG, Potocnik S, Ramachandran R, Hollenberg MD, Woodman OL, McIntyre P.

Pharmacol Res. 2018 Jul;133:152-159. doi: 10.1016/j.phrs.2018.05.009. Epub 2018 May 19.

PMID:
29787869
20.

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease.

Denadai-Souza A, Bonnart C, Tapias NS, Marcellin M, Gilmore B, Alric L, Bonnet D, Burlet-Schiltz O, Hollenberg MD, Vergnolle N, Deraison C.

Sci Rep. 2018 May 18;8(1):7834. doi: 10.1038/s41598-018-26282-y.

21.
22.

Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD.

Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25.

23.

Proteinases and their receptors in inflammatory arthritis: an overview.

Oikonomopoulou K, Diamandis EP, Hollenberg MD, Chandran V.

Nat Rev Rheumatol. 2018 Mar;14(3):170-180. doi: 10.1038/nrrheum.2018.17. Epub 2018 Feb 8. Review.

PMID:
29416136
24.

Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia.

van den Boogaard FE, Brands X, Duitman J, de Stoppelaar SF, Borensztajn KS, Roelofs JJTH, Hollenberg MD, Spek CA, Schultz MJ, van 't Veer C, van der Poll T.

J Infect Dis. 2018 Apr 11;217(9):1462-1471. doi: 10.1093/infdis/jiy010.

PMID:
29415278
25.

Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription.

Peplowski MA, Vegso AJ, Iablokov V, Dicay M, Zaheer RS, Renaux B, Proud D, Hollenberg MD, Beck PL, MacNaughton WK.

Physiol Rep. 2017 Oct;5(19). pii: e13451. doi: 10.14814/phy2.13451. Epub 2017 Oct 16.

26.

Granulocyte-colony-stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis.

Basso L, Lapointe TK, Iftinca M, Marsters C, Hollenberg MD, Kurrasch DM, Altier C.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11235-11240. doi: 10.1073/pnas.1706053114. Epub 2017 Oct 2.

27.

Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

Ungefroren H, Witte D, Mihara K, Rauch BH, Henklein P, Jöhren O, Bonni S, Settmacher U, Lehnert H, Hollenberg MD, Kaufmann R, Gieseler F.

Mol Pharmacol. 2017 Nov;92(5):519-532. doi: 10.1124/mol.117.109017. Epub 2017 Aug 25.

PMID:
28842394
28.

Career and research outcomes of the physician-scientist training program at the University of Calgary: a retrospective cohort study.

Bau JT, Frolkis AD, Nathoo N, Yipp BG, Hollenberg MD, Beck PL.

CMAJ Open. 2017 May 15;5(2):E395-E401. doi: 10.9778/cmajo.20160103. Epub 2017 May 15.

29.

Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD.

Clin Exp Allergy. 2017 Jul;47(7):946-960. doi: 10.1111/cea.12921. Epub 2017 Apr 27.

30.

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors.

Chaplin R, Thach L, Hollenberg MD, Cao Y, Little PJ, Kamato D.

J Cell Commun Signal. 2017 Jun;11(2):117-125. doi: 10.1007/s12079-017-0375-9. Epub 2017 Feb 6. Review.

31.

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.

Mol Pharmacol. 2017 Apr;91(4):287-295. doi: 10.1124/mol.116.106526. Epub 2017 Jan 26.

PMID:
28126849
32.

Proteinases, Their Extracellular Targets, and Inflammatory Signaling.

Ramachandran R, Altier C, Oikonomopoulou K, Hollenberg MD.

Pharmacol Rev. 2016 Oct;68(4):1110-1142. Review.

PMID:
27677721
33.

Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence.

Gillrie MR, Renaux B, Russell-Goldman E, Avril M, Brazier AJ, Mihara K, Di Cera E, Milner DA Jr, Hollenberg MD, Smith JD, Ho M.

MBio. 2016 Sep 13;7(5). pii: e01120-16. doi: 10.1128/mBio.01120-16.

34.

Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.

Zeeh F, Witte D, Gädeken T, Rauch BH, Grage-Griebenow E, Leinung N, Fromm SJ, Stölting S, Mihara K, Kaufmann R, Settmacher U, Lehnert H, Hollenberg MD, Ungefroren H.

Oncotarget. 2016 Jul 5;7(27):41095-41109. doi: 10.18632/oncotarget.9600.

35.

Lost: Young Canadian physician-scientists need a map.

Lewinson RT, Keough MB, Beck PL, Hollenberg MD, Yipp BG.

Sci Transl Med. 2016 Mar 9;8(329):329fs6. doi: 10.1126/scitranslmed.aad4355. Review.

PMID:
26962153
36.

Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling.

Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD.

Mol Pharmacol. 2016 May;89(5):606-14. doi: 10.1124/mol.115.102723. Epub 2016 Mar 8.

PMID:
26957205
37.

Proceedings from the 6th Annual University of Calgary Leaders in Medicine Research Symposium.

Roberts JI, Beatty JK, Peplowski MA, Keough MB, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2015 Dec 4;38(6):E318-50.

PMID:
26654516
38.

Highlights from the 6th Annual University of Calgary Leaders in Medicine Research Symposium and the Keynote Address by Dr. Danuta Skowronski.

Roberts JI, Beatty JK, Peplowski MA, Keough MB, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2015 Dec 4;38(6):E314-7.

PMID:
26654515
39.

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.

Little PJ, Hollenberg MD, Kamato D, Thomas W, Chen J, Wang T, Zheng W, Osman N.

Br J Pharmacol. 2016 Oct;173(20):2992-3000. doi: 10.1111/bph.13398. Epub 2016 Feb 16. Review.

40.

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

Kamato D, Thach L, Getachew R, Burch M, Hollenberg MD, Zheng W, Little PJ, Osman N.

Cell Signal. 2016 Jan;28(1):110-9. doi: 10.1016/j.cellsig.2015.11.003. Epub 2015 Nov 5.

PMID:
26548632
41.

Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation.

Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H.

Clin Exp Allergy. 2015 Dec;45(12):1844-55. doi: 10.1111/cea.12628.

PMID:
26312432
42.

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.

Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG.

Mol Cell Biol. 2015 Nov;35(21):3684-700. doi: 10.1128/MCB.00764-15. Epub 2015 Aug 17.

43.

Vitamin D, the autonomic nervous system, and cardiovascular risk.

Mann MC, Hollenberg MD, Hanley DA, Ahmed SB.

Physiol Rep. 2015 Apr;3(4). pii: e12349. doi: 10.14814/phy2.12349. No abstract available.

44.

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature.

Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R.

Br J Pharmacol. 2015 May;172(10):2493-506. doi: 10.1111/bph.13072. Epub 2015 Mar 18.

45.

Proteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connection.

Hollenberg MD.

Br J Pharmacol. 2015 Jul;172(13):3196-211. doi: 10.1111/bph.13041. Epub 2015 Mar 17. Review.

46.

Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.

Iablokov V, Hirota CL, Peplowski MA, Ramachandran R, Mihara K, Hollenberg MD, MacNaughton WK.

J Biol Chem. 2014 Dec 5;289(49):34366-77. doi: 10.1074/jbc.M114.610485. Epub 2014 Oct 20.

47.

KLKs and their hormone-like signaling actions: a new life for the PSA-KLK family.

Hollenberg MD.

Biol Chem. 2014 Sep;395(9):915-29. doi: 10.1515/hsz-2014-0123. Review.

PMID:
25153380
48.

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C.

J Biol Chem. 2014 Jul 4;289(27):19067-78. doi: 10.1074/jbc.M113.538470. Epub 2014 May 19.

49.

Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.

Fischer CD, Duquette SC, Renaux BS, Feener TD, Morck DW, Hollenberg MD, Lucas MJ, Buret AG.

Antimicrob Agents Chemother. 2014 Aug;58(8):4298-307. doi: 10.1128/AAC.02813-14. Epub 2014 May 12.

50.

Hypothetical structure of prostate-specific antigen.

Hollenberg MD.

Clin Chem. 2014 Apr;60(4):702. doi: 10.1373/clinchem.2014.221457. No abstract available.

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