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Items: 1 to 50 of 106

1.

Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.

Shimizu H, Lu Y, Vella KR, Damilano F, Astapova I, Amano I, Ritter M, Gallop MR, Rosenzweig AN, Cohen RN, Hollenberg AN.

PLoS One. 2019 Aug 12;14(8):e0220717. doi: 10.1371/journal.pone.0220717. eCollection 2019.

2.

Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.

Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW.

Thyroid. 2019 Jun;29(6):760-777. doi: 10.1089/thy.2018.0416. Epub 2019 May 13.

PMID:
31081722
3.

Thyroid and Cardiovascular Disease Research Agenda for Enhancing Knowledge, Prevention, and Treatment.

Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW.

Circulation. 2019 May 13. doi: 10.1161/CIRCULATIONAHA.118.036859. [Epub ahead of print]

PMID:
31081673
4.

Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha.

Freudenthal B, Shetty S, Butterfield NC, Logan JG, Han CR, Zhu X, Astapova I, Hollenberg AN, Cheng SY, Bassett JHD, Williams GR.

Thyroid. 2019 May;29(5):726-734. doi: 10.1089/thy.2018.0399. Epub 2019 Mar 14.

5.

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.

Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM.

Sci Signal. 2018 Jun 26;11(536). pii: eaam5855. doi: 10.1126/scisignal.aam5855.

PMID:
29945885
6.

Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity.

Hine C, Zhu Y, Hollenberg AN, Mitchell JR.

Antioxid Redox Signal. 2018 Jun 1;28(16):1483-1502. doi: 10.1089/ars.2017.7434.

7.

Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.

Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB.

J Biol Chem. 2018 Feb 9;293(6):2006-2014. doi: 10.1074/jbc.M117.782557. Epub 2017 Dec 8.

8.

Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification.

Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN.

Development. 2017 Nov 1;144(21):3879-3893. doi: 10.1242/dev.150193. Epub 2017 Sep 25.

9.

NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.

Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8458-E8467. doi: 10.1073/pnas.1706917114. Epub 2017 Sep 18.

10.

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.

11.

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S.

Endocrinology. 2017 Jul 1;158(7):2052-2057. doi: 10.1210/en.2017-00250.

12.

Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells.

Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN.

J Clin Invest. 2017 Jun 1;127(6):2277-2294. doi: 10.1172/JCI89950. Epub 2017 May 2.

13.

The actions of thyroid hormone signaling in the nucleus.

Vella KR, Hollenberg AN.

Mol Cell Endocrinol. 2017 Dec 15;458:127-135. doi: 10.1016/j.mce.2017.03.001. Epub 2017 Mar 10. Review.

14.

New insights into thyroid hormone action.

Mendoza A, Hollenberg AN.

Pharmacol Ther. 2017 May;173:135-145. doi: 10.1016/j.pharmthera.2017.02.012. Epub 2017 Feb 4. Review.

15.

Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1.

Dame K, Cincotta S, Lang AH, Sanghrajka RM, Zhang L, Choi J, Kwok L, Wilson T, Kańduła MM, Monti S, Hollenberg AN, Mehta P, Kotton DN, Ikonomou L.

Stem Cell Reports. 2017 Feb 14;8(2):216-225. doi: 10.1016/j.stemcr.2016.12.024. Epub 2017 Feb 2.

16.

Regenerative therapy for hypothyroidism: Mechanisms and possibilities.

Hollenberg AN, Choi J, Serra M, Kotton DN.

Mol Cell Endocrinol. 2017 Apr 15;445:35-41. doi: 10.1016/j.mce.2016.11.012. Epub 2016 Nov 19. Review.

17.

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.

Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM.

Autophagy. 2017 Jan 2;13(1):169-186. doi: 10.1080/15548627.2016.1235123. Epub 2016 Nov 15.

18.

Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells.

Kyono Y, Subramani A, Ramadoss P, Hollenberg AN, Bonett RM, Denver RJ.

Endocrinology. 2016 Sep;157(9):3647-57. doi: 10.1210/en.2015-1529. Epub 2016 Jul 7.

19.

HDAC3 Is a Master Regulator of mTEC Development.

Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen RN, Hollenberg AN, Abramson J.

Cell Rep. 2016 Apr 19;15(3):651-665. doi: 10.1016/j.celrep.2016.03.048. Epub 2016 Apr 7.

20.

The Endocrine Society Centennial: The Thyroid Leads the Way.

Hollenberg AN.

Endocrinology. 2016 Jan;157(1):1-3. doi: 10.1210/en.2015-1982. No abstract available.

21.

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.

Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN.

Cell Stem Cell. 2015 Nov 5;17(5):527-42. doi: 10.1016/j.stem.2015.09.004. Epub 2015 Oct 22.

22.

Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.

Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM.

J Biol Chem. 2016 Jan 1;291(1):198-214. doi: 10.1074/jbc.M115.668673. Epub 2015 Oct 9.

23.

ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism.

Castinetti F, Brinkmeier ML, Mortensen AH, Vella KR, Gergics P, Brue T, Hollenberg AN, Gan L, Camper SA.

Mol Endocrinol. 2015 Oct;29(10):1510-21. doi: 10.1210/me.2015-1192. Epub 2015 Aug 21.

24.

Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1.

Ng L, Cordas E, Wu X, Vella KR, Hollenberg AN, Forrest D.

Endocrinology. 2015 Oct;156(10):3853-65. doi: 10.1210/en.2015-1468. Epub 2015 Aug 4.

25.

Endocrine disorders in Fanconi anemia: recommendations for screening and treatment.

Petryk A, Kanakatti Shankar R, Giri N, Hollenberg AN, Rutter MM, Nathan B, Lodish M, Alter BP, Stratakis CA, Rose SR.

J Clin Endocrinol Metab. 2015 Mar;100(3):803-11. doi: 10.1210/jc.2014-4357. Epub 2015 Jan 9. Review.

26.

NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.

Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN.

Mol Cell Biol. 2015 Feb;35(3):555-65. doi: 10.1128/MCB.01208-14. Epub 2014 Nov 24.

27.

Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.

Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN.

J Clin Invest. 2014 May;124(5):1976-86. doi: 10.1172/JCI73419. Epub 2014 Apr 8.

28.

Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.

Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E.

Endocrinology. 2014 May;155(5):2031-40. doi: 10.1210/en.2013-1902. Epub 2014 Feb 24.

29.

Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.

Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN.

Mol Cell Biol. 2014 May;34(9):1564-75. doi: 10.1128/MCB.00129-14. Epub 2014 Feb 18.

30.

Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.

Horm Behav. 2014 Feb;65(2):190-3. doi: 10.1016/j.yhbeh.2013.09.001. Epub 2013 Nov 28. No abstract available.

PMID:
24289987
31.

Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver.

Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN.

J Biol Chem. 2014 Jan 17;289(3):1313-28. doi: 10.1074/jbc.M113.521450. Epub 2013 Nov 27.

32.

Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.

Front Neuroendocrinol. 2014 Jan;35(1):2-5. doi: 10.1016/j.yfrne.2013.09.003. Epub 2013 Nov 21. No abstract available.

PMID:
24268499
33.

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.

Andrology. 2013 Nov;1(6):802-5. doi: 10.1111/j.2047-2927.2013.00151.x. No abstract available.

34.

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.

Horm Res Paediatr. 2013;80(5):305-8. doi: 10.1159/000355668. Epub 2013 Oct 9. No abstract available.

35.

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.

Eur J Endocrinol. 2013 Oct 21;169(6):E1-4. doi: 10.1530/EJE-13-0763. Print 2013 Dec. No abstract available.

PMID:
24057478
36.

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS.

Endocrinology. 2013 Nov;154(11):3957-60. doi: 10.1210/en.2013-1854. Epub 2013 Sep 18. No abstract available.

37.

Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α.

Fozzatti L, Kim DW, Park JW, Willingham MC, Hollenberg AN, Cheng SY.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7850-5. doi: 10.1073/pnas.1222334110. Epub 2013 Apr 22.

38.

Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus.

Chiappini F, Ramadoss P, Vella KR, Cunha LL, Ye FD, Stuart RC, Nillni EA, Hollenberg AN.

Mol Cell Endocrinol. 2013 Jan 5;365(1):84-94. doi: 10.1016/j.mce.2012.09.006. Epub 2012 Sep 20.

39.

The thyroid axis is regulated by NCoR1 via its actions in the pituitary.

Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN.

Endocrinology. 2012 Oct;153(10):5049-57. Epub 2012 Aug 9.

40.

The in vivo role of nuclear receptor corepressors in thyroid hormone action.

Astapova I, Hollenberg AN.

Biochim Biophys Acta. 2013 Jul;1830(7):3876-81. doi: 10.1016/j.bbagen.2012.07.001. Epub 2012 Jul 16. Review.

41.

Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis.

Costa-e-Sousa RH, Hollenberg AN.

Endocrinology. 2012 Sep;153(9):4128-35. doi: 10.1210/en.2012-1467. Epub 2012 Jul 3. Review.

42.

Metabolic health and nuclear-receptor sensitivity.

Hollenberg AN.

N Engl J Med. 2012 Apr 5;366(14):1345-7. doi: 10.1056/NEJMcibr1114529. No abstract available.

PMID:
22475600
43.

Reducing systemic hypermetabolism by inducing hypothyroidism does not prolong survival in the SOD1-G93A mouse.

Li J, Paulson JM, Ye FD, Sung M, Hollenberg AN, Rutkove SB.

Amyotroph Lateral Scler. 2012 Jun;13(4):372-7. doi: 10.3109/17482968.2012.662988. Epub 2012 Mar 16.

PMID:
22424124
44.

NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways.

Vella KR, Ramadoss P, Lam FS, Harris JC, Ye FD, Same PD, O'Neill NF, Maratos-Flier E, Hollenberg AN.

Cell Metab. 2011 Dec 7;14(6):780-90. doi: 10.1016/j.cmet.2011.10.009. Epub 2011 Nov 17.

45.

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).

Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17462-7. doi: 10.1073/pnas.1107474108. Epub 2011 Oct 10.

46.

The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis.

Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN.

Mol Endocrinol. 2011 Feb;25(2):212-24. doi: 10.1210/me.2010-0462. Epub 2011 Jan 14.

47.

Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity.

Chiappini F, Cunha LL, Harris JC, Hollenberg AN.

J Biol Chem. 2011 Mar 11;286(10):8094-105. doi: 10.1074/jbc.M110.178186. Epub 2011 Jan 5.

48.

Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.

Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD.

Mol Endocrinol. 2010 Dec;24(12):2366-81. doi: 10.1210/me.2010-0203. Epub 2010 Oct 13.

49.

Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level.

Perello M, Cakir I, Cyr NE, Romero A, Stuart RC, Chiappini F, Hollenberg AN, Nillni EA.

Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E976-89. doi: 10.1152/ajpendo.00448.2010. Epub 2010 Sep 21. Erratum in: Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E422.

50.

Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha.

Ramadoss P, Chiappini F, Bilban M, Hollenberg AN.

J Biol Chem. 2010 May 28;285(22):16453-66. doi: 10.1074/jbc.M109.066936. Epub 2010 Mar 19.

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