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Items: 1 to 50 of 97

1.

Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches.

Bortolomai I, Sandri M, Draghici E, Fontana E, Campodoni E, Marcovecchio GE, Ferrua F, Perani L, Spinelli A, Canu T, Catucci M, Di Tomaso T, Sergi Sergi L, Esposito A, Lombardo A, Naldini L, Tampieri A, Hollander GA, Villa A, Bosticardo M.

Stem Cells Transl Med. 2019 May 29. doi: 10.1002/sctm.18-0218. [Epub ahead of print]

2.

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.

Fergusson JR, Morgan MD, Bruchard M, Huitema L, Heesters BA, van Unen V, van Hamburg JP, van der Wel NN, Picavet D, Koning F, Tas SW, Anderson MS, Marioni JC, Holländer GA, Spits H.

Front Immunol. 2019 Jan 14;9:2902. doi: 10.3389/fimmu.2018.02902. eCollection 2018.

3.

The role of thymic tolerance in CNS autoimmune disease.

Handel AE, Irani SR, Holländer GA.

Nat Rev Neurol. 2018 Dec;14(12):723-734. doi: 10.1038/s41582-018-0095-7. Review.

PMID:
30451970
4.

Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho.

Xing Y, Smith MJ, Goetz CA, McElmurry RT, Parker SL, Min D, Hollander GA, Weinberg KI, Tolar J, Stefanski HE, Blazar BR.

J Immunol. 2018 Dec 1;201(11):3320-3328. doi: 10.4049/jimmunol.1800670. Epub 2018 Oct 29.

PMID:
30373854
5.

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development.

Handel AE, Shikama-Dorn N, Zhanybekova S, Maio S, Graedel AN, Zuklys S, Ponting CP, Holländer GA.

Front Immunol. 2018 Sep 19;9:2120. doi: 10.3389/fimmu.2018.02120. eCollection 2018.

6.

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development.

Stefanski HE, Xing Y, Taylor PA, Maio S, Henao-Meija J, Williams A, Flavell RA, Hollander GA, Blazar BR.

PLoS One. 2018 Jun 27;13(6):e0198871. doi: 10.1371/journal.pone.0198871. eCollection 2018.

7.

Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis.

Wendland K, Niss K, Kotarsky K, Wu NYH, White AJ, Jendholm J, Rivollier A, Izarzugaza JMG, Brunak S, Holländer GA, Anderson G, Sitnik KM, Agace WW.

J Immunol. 2018 Jul 15;201(2):524-532. doi: 10.4049/jimmunol.1800418. Epub 2018 May 30.

8.

Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT.

Smith AR, Rota IA, Maio S, Massaad MJ, Lund TC, Notarangelo LD, Holländer GA, Blazar BR.

Blood Adv. 2017 Oct 23;1(23):2083-2087. doi: 10.1182/bloodadvances.2017010926. eCollection 2017 Oct 24.

9.

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Wu Q, Ferry QRV, Baeumler TA, Michaels YS, Vitsios DM, Habib O, Arnold R, Jiang X, Maio S, Steinkraus BR, Tapia M, Piazza P, Xu N, Holländer GA, Milne TA, Kim JS, Enright AJ, Bassett AR, Fulga TA.

Nat Commun. 2017 Dec 13;8(1):2109. doi: 10.1038/s41467-017-00686-2.

10.

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice.

Jain R, Sheridan JM, Policheni A, Heinlein M, Gandolfo LC, Dewson G, Smyth GK, Sansom SN, Fu NY, Visvader JE, Holländer GA, Strasser A, Gray DHD.

Blood. 2017 Dec 7;130(23):2504-2515. doi: 10.1182/blood-2017-03-771576. Epub 2017 Sep 29.

11.

T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.

Smith MJ, Reichenbach DK, Parker SL, Riddle MJ, Mitchell J, Osum KC, Mohtashami M, Stefanski HE, Fife BT, Bhandoola A, Hogquist KA, Holländer GA, Zúñiga-Pflücker JC, Tolar J, Blazar BR.

JCI Insight. 2017 May 18;2(10). pii: 92056. doi: 10.1172/jci.insight.92056. eCollection 2017 May 18.

12.

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

Žuklys S, Handel A, Zhanybekova S, Govani F, Keller M, Maio S, Mayer CE, Teh HY, Hafen K, Gallone G, Barthlott T, Ponting CP, Holländer GA.

Nat Immunol. 2016 Oct;17(10):1206-1215. doi: 10.1038/ni.3537. Epub 2016 Aug 22.

13.

Open Access Could Transform Drug Discovery: A Case Study of JQ1.

Arshad Z, Smith J, Roberts M, Lee WH, Davies B, Bure K, Hollander GA, Dopson S, Bountra C, Brindley D.

Expert Opin Drug Discov. 2016;11(3):321-32. doi: 10.1517/17460441.2016.1144587. Review.

PMID:
26791045
14.

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.

Satoh R, Kakugawa K, Yasuda T, Yoshida H, Sibilia M, Katsura Y, Levi B, Abramson J, Koseki Y, Koseki H, van Ewijk W, Hollander GA, Kawamoto H.

PLoS Genet. 2016 Jan 20;12(1):e1005776. doi: 10.1371/journal.pgen.1005776. eCollection 2016 Jan.

15.

Evolution of the immune system in humans from infancy to old age.

Simon AK, Hollander GA, McMichael A.

Proc Biol Sci. 2015 Dec 22;282(1821):20143085. doi: 10.1098/rspb.2014.3085. Review.

16.

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.

Mayer CE, Žuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Holländer GA.

Eur J Immunol. 2016 Apr;46(4):846-56. doi: 10.1002/eji.201545995. Epub 2016 Jan 18.

17.

Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors.

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.

Cell Rep. 2015 Nov 17;13(7):1432-1443. doi: 10.1016/j.celrep.2015.10.012. Epub 2015 Nov 5.

18.

A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage.

Barthlott T, Bosch AJ, Berkemeier C, Nogales-Cadenas R, Jeker LT, Keller MP, Pascual-Montano A, Holländer GA.

Eur J Immunol. 2015 Jun;45(6):1760-71. doi: 10.1002/eji.201445235. Epub 2015 Apr 17.

19.

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD.

Dertschnig S, Hauri-Hohl MM, Vollmer M, Holländer GA, Krenger W.

Blood. 2015 Apr 23;125(17):2720-3. doi: 10.1182/blood-2014-08-597245. Epub 2015 Feb 17.

20.

Essential role for autophagy during invariant NKT cell development.

Salio M, Puleston DJ, Mathan TS, Shepherd D, Stranks AJ, Adamopoulou E, Veerapen N, Besra GS, Hollander GA, Simon AK, Cerundolo V.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112. Epub 2014 Dec 15.

21.

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

Sansom SN, Shikama-Dorn N, Zhanybekova S, Nusspaumer G, Macaulay IC, Deadman ME, Heger A, Ponting CP, Holländer GA.

Genome Res. 2014 Dec;24(12):1918-31. doi: 10.1101/gr.171645.113. Epub 2014 Sep 15.

22.

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.

Hauri-Hohl M, Zuklys S, Holländer GA, Ziegler SF.

Nat Immunol. 2014 Jun;15(6):554-61. doi: 10.1038/ni.2869. Epub 2014 Apr 13.

PMID:
24728352
23.

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9.

24.

TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.

Odaka C, Hauri-Hohl M, Takizawa K, Nishikawa Y, Yano M, Matsumoto M, Boyd R, Holländer GA.

Int Immunol. 2013 Nov;25(11):633-42. doi: 10.1093/intimm/dxt026. Epub 2013 Aug 8.

25.

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Holländer GA, Takahama Y.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9885-90. doi: 10.1073/pnas.1301799110. Epub 2013 May 29.

26.

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.

Dertschnig S, Nusspaumer G, Ivanek R, Hauri-Hohl MM, Holländer GA, Krenger W.

Blood. 2013 Aug 1;122(5):837-41. doi: 10.1182/blood-2012-12-474759. Epub 2013 May 29.

27.

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.

Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Holländer GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K.

J Immunol. 2013 Jun 15;190(12):6173-9. doi: 10.4049/jimmunol.1202573. Epub 2013 May 17.

28.

MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.

Zuklys S, Mayer CE, Zhanybekova S, Stefanski HE, Nusspaumer G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Cadenas R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano A, Holländer GA.

J Immunol. 2012 Oct 15;189(8):3894-904. doi: 10.4049/jimmunol.1200783. Epub 2012 Sep 12.

29.

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

Lopez-Rios J, Speziale D, Robay D, Scotti M, Osterwalder M, Nusspaumer G, Galli A, Holländer GA, Kmita M, Zeller R.

Dev Cell. 2012 Apr 17;22(4):837-48. doi: 10.1016/j.devcel.2012.01.006. Epub 2012 Mar 29.

30.

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, Zuklys S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A.

Nat Immunol. 2011 Dec 18;13(2):181-7. doi: 10.1038/ni.2193.

31.

CD43 regulates the threshold for T cell activation by targeting Cbl functions.

Pedraza-Alva G, Mérida LB, del Rio R, Fierro NA, Cruz-Muñoz ME, Olivares N, Melchy E, Igras V, Holländer GA, Burakoff SJ, Rosenstein Y.

IUBMB Life. 2011 Oct;63(10):940-8. doi: 10.1002/iub.554. Epub 2011 Sep 9.

32.

Thymic T-cell development in allogeneic stem cell transplantation.

Krenger W, Blazar BR, Holländer GA.

Blood. 2011 Jun 23;117(25):6768-76. doi: 10.1182/blood-2011-02-334623. Epub 2011 Mar 22. Review.

33.

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, Malefyt Rde W, Nitta T, Takahama Y.

J Exp Med. 2011 Feb 14;208(2):383-94. doi: 10.1084/jem.20102327. Epub 2011 Feb 7.

34.

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.

Gossens K, Naus S, Holländer GA, Ziltener HJ.

PLoS One. 2010 Sep 15;5(9):e12766. doi: 10.1371/journal.pone.0012766.

35.

Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.

Fayard E, Moncayo G, Hemmings BA, Holländer GA.

Sci Signal. 2010 Aug 17;3(135):re5. doi: 10.1126/scisignal.3135re5. Review.

PMID:
20716765
36.

The role of the thymus in allogeneic hematopoietic stem cell transplantation.

Krenger W, Holländer GA.

Swiss Med Wkly. 2010 Jul 19;140:w13051. doi: 10.4414/smw.2010.13051. eCollection 2010. Review.

PMID:
20648397
37.

Emerging strategies to boost thymic function.

Holländer GA, Krenger W, Blazar BR.

Curr Opin Pharmacol. 2010 Aug;10(4):443-53. doi: 10.1016/j.coph.2010.04.008. Epub 2010 May 4. Review.

38.

Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

Kelly RM, Goren EM, Taylor PA, Mueller SN, Stefanski HE, Osborn MJ, Scott HS, Komarova EA, Gudkov AV, Holländer GA, Blazar BR.

Blood. 2010 Feb 4;115(5):1088-97. doi: 10.1182/blood-2009-05-223198. Epub 2009 Dec 4.

39.

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

Vroegindeweij E, Crobach S, Itoi M, Satoh R, Zuklys S, Happe C, Germeraad WT, Cornelissen JJ, Cupedo T, Holländer GA, Kawamoto H, van Ewijk W.

Mol Immunol. 2010 Feb;47(5):1106-13. doi: 10.1016/j.molimm.2009.10.034. Epub 2009 Nov 27.

PMID:
19945167
40.

Spatial (Tbata) expression in mature medullary thymic epithelial cells.

Saade M, Irla M, Yammine M, Boulanger N, Victorero G, Vincentelli R, Penninger JM, Holländer GA, Chauvet S, Nguyen C.

Eur J Immunol. 2010 Feb;40(2):530-8. doi: 10.1002/eji.200939605.

41.

Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.

Kenins L, Gill JW, Holländer GA, Wodnar-Filipowicz A.

Eur J Immunol. 2010 Jan;40(1):81-90. doi: 10.1002/eji.200839213.

42.

Learning to be tolerant: how T cells keep out of trouble.

Holländer GA, Peterson P.

J Intern Med. 2009 May;265(5):541-61. doi: 10.1111/j.1365-2796.2009.02093.x. Review.

43.

The Global Thymus Network: past, present and future.

Takahama Y, Saito T, Kawamoto H, Itoi M, Boyd RL, Chidgey A, Zamoyska R, Holländer GA, Anderson G, Taylor N, Petrie HT, Nikolich-Zugich J.

Trends Immunol. 2009 May;30(5):191-2. doi: 10.1016/j.it.2009.03.005. Epub 2009 Apr 8. No abstract available.

PMID:
19362055
44.

Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.

Shikama N, Nusspaumer G, Holländer GA.

Endocrinol Metab Clin North Am. 2009 Jun;38(2):273-88, vii. doi: 10.1016/j.ecl.2009.01.011. Review.

PMID:
19328411
45.

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

Zuklys S, Gill J, Keller MP, Hauri-Hohl M, Zhanybekova S, Balciunaite G, Na KJ, Jeker LT, Hafen K, Tsukamoto N, Amagai T, Taketo MM, Krenger W, Holländer GA.

J Immunol. 2009 Mar 1;182(5):2997-3007. doi: 10.4049/jimmunol.0713723.

46.

The immunopathology of thymic GVHD.

Krenger W, Holländer GA.

Semin Immunopathol. 2008 Dec;30(4):439-56. doi: 10.1007/s00281-008-0131-6. Epub 2008 Oct 31. Review.

PMID:
18974988
47.

Lymphoid reconstitution following hematopoietic stem cell transplantation. Of mice and men: progress made in HSCT immunobiology.

Holländer GA.

Semin Immunopathol. 2008 Dec;30(4):369-70. doi: 10.1007/s00281-008-0139-y. No abstract available.

PMID:
18972113
48.

Delta-like 4 is indispensable in thymic environment specific for T cell development.

Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Holländer GA, Shima DT, Habu S.

J Exp Med. 2008 Oct 27;205(11):2507-13. doi: 10.1084/jem.20080134. Epub 2008 Sep 29.

49.

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Holländer GA, Reith W.

Immunity. 2008 Sep 19;29(3):451-63. doi: 10.1016/j.immuni.2008.08.007.

50.

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.

Jeker LT, Barthlott T, Keller MP, Zuklys S, Hauri-Hohl M, Deng CX, Holländer GA.

Blood. 2008 Nov 1;112(9):3688-95. doi: 10.1182/blood-2008-04-150532. Epub 2008 Aug 11.

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