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Items: 43


Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys.

Holland SJ, Berghuis LM, King JJ, Iyer LM, Sikora K, Fifield H, Peter S, Quinlan EM, Sugahara F, Shingate P, Trancoso I, Iwanami N, Temereva E, Strohmeier C, Kuratani S, Venkatesh B, Evanno G, Aravind L, Schorpp M, Larijani M, Boehm T.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3211-E3220. doi: 10.1073/pnas.1720871115. Epub 2018 Mar 19.


Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.

Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3201-E3210. doi: 10.1073/pnas.1720897115. Epub 2018 Mar 19.


Evolution of Alternative Adaptive Immune Systems in Vertebrates.

Boehm T, Hirano M, Holland SJ, Das S, Schorpp M, Cooper MD.

Annu Rev Immunol. 2018 Apr 26;36:19-42. doi: 10.1146/annurev-immunol-042617-053028. Epub 2017 Nov 16. Review.


Situational Strength Cues from Social Sources at Work: Relative Importance and Mediated Effects.

Alaybek B, Dalal RS, Sheng Z, Morris AG, Tomassetti AJ, Holland SJ.

Front Psychol. 2017 Sep 5;8:1512. doi: 10.3389/fpsyg.2017.01512. eCollection 2017.


αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity.

Attaf M, Holland SJ, Bartok I, Dyson J.

Sci Rep. 2016 Oct 24;6:35006. doi: 10.1038/srep35006.


Characterization of Lamprey IL-17 Family Members and Their Receptors.

Han Q, Das S, Hirano M, Holland SJ, McCurley N, Guo P, Rosenberg CS, Boehm T, Cooper MD.

J Immunol. 2015 Dec 1;195(11):5440-51. doi: 10.4049/jimmunol.1500892. Epub 2015 Oct 21.


Selection of the lamprey VLRC antigen receptor repertoire.

Holland SJ, Gao M, Hirano M, Iyer LM, Luo M, Schorpp M, Cooper MD, Aravind L, Mariuzza RA, Boehm T.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14834-9. doi: 10.1073/pnas.1415655111. Epub 2014 Sep 16.


Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates.

Das S, Li J, Holland SJ, Iyer LM, Hirano M, Schorpp M, Aravind L, Cooper MD, Boehm T.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14828-33. doi: 10.1073/pnas.1415580111. Epub 2014 Sep 16.


Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration.

Tuinstra HM, Margul DJ, Goodman AG, Boehler RM, Holland SJ, Zelivyanskaya ML, Cummings BJ, Anderson AJ, Shea LD.

Tissue Eng Part A. 2014 Mar;20(5-6):1027-37. doi: 10.1089/ten.TEA.2013.0111. Epub 2013 Dec 11.


Characterization of polymer adsorption onto drug nanoparticles using depletion measurements and small-angle neutron scattering.

Goodwin DJ, Sepassi S, King SM, Holland SJ, Martini LG, Lawrence MJ.

Mol Pharm. 2013 Nov 4;10(11):4146-58. doi: 10.1021/mp400138e. Epub 2013 Oct 22.


Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury.

Thomas AM, Kubilius MB, Holland SJ, Seidlits SK, Boehler RM, Anderson AJ, Cummings BJ, Shea LD.

Biomaterials. 2013 Mar;34(9):2213-20. doi: 10.1016/j.biomaterials.2012.12.002. Epub 2013 Jan 2.


The T-cell receptor is not hardwired to engage MHC ligands.

Holland SJ, Bartok I, Attaf M, Genolet R, Luescher IF, Kotsiou E, Richard A, Wang E, White M, Coe DJ, Chai JG, Ferreira C, Dyson J.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3111-8. doi: 10.1073/pnas.1210882109. Epub 2012 Oct 17.


Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury.

Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY, Margul DJ, Bartels AK, Boehler RM, Cummings BJ, Anderson AJ, Shea LD.

Biomaterials. 2012 Feb;33(5):1618-26. doi: 10.1016/j.biomaterials.2011.11.002. Epub 2011 Nov 29.


Gene therapy vectors with enhanced transfection based on hydrogels modified with affinity peptides.

Shepard JA, Wesson PJ, Wang CE, Stevans AC, Holland SJ, Shikanov A, Grzybowski BA, Shea LD.

Biomaterials. 2011 Aug;32(22):5092-9. doi: 10.1016/j.biomaterials.2011.03.083. Epub 2011 Apr 22.


The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma.

Hector A, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM, Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A.

Cancer Biol Ther. 2010 Nov 15;10(10):1009-18. doi: 10.4161/cbt.10.10.13248. Epub 2010 Nov 15.


T cell receptor CDR3 loops influence alphabeta pairing.

Bartok I, Holland SJ, Kessels HW, Silk JD, Alkhinji M, Dyson J.

Mol Immunol. 2010 Apr;47(7-8):1613-8. doi: 10.1016/j.molimm.2010.01.012. Epub 2010 Mar 1.


R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.

Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ, Zhang J, Ding P, Apatira A, Chua J, Brandt R, Pine P, Goff D, Singh R, Payan DG, Hitoshi Y.

Cancer Res. 2010 Feb 15;70(4):1544-54. doi: 10.1158/0008-5472.CAN-09-2997. Epub 2010 Feb 9.


Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic mice.

Furmanski AL, Bartok I, Chai JG, Singh Y, Ferreira C, Scott D, Holland SJ, Bourdeaux C, Crompton T, Dyson J.

J Immunol. 2010 Jan 15;184(2):650-7. doi: 10.4049/jimmunol.0902291. Epub 2009 Dec 7.


Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.

McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y.

J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1.


Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ.

Cancer Cell. 2008 May;13(5):454-63. doi: 10.1016/j.ccr.2008.03.004.


Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.

Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K, Evans K, Gray AJ, Holland SJ, Feeder N, Moore RS, Brown DG.

J Med Chem. 2007 Nov 29;50(24):6095-103. Epub 2007 Nov 9.


F-like type IV secretion systems encode proteins with thioredoxin folds that are putative DsbC homologues.

Elton TC, Holland SJ, Frost LS, Hazes B.

J Bacteriol. 2005 Dec;187(24):8267-77.


Multiple roles for the receptor tyrosine kinase axl in tumor formation.

Holland SJ, Powell MJ, Franci C, Chan EW, Friera AM, Atchison RE, McLaughlin J, Swift SE, Pali ES, Yam G, Wong S, Lasaga J, Shen MR, Yu S, Xu W, Hitoshi Y, Bogenberger J, Nör JE, Payan DG, Lorens JB.

Cancer Res. 2005 Oct 15;65(20):9294-303.


Crystallization and preliminary diffraction studies of TraF, a component of the Escherichia coli type IV secretory system.

Audette GF, Holland SJ, Elton TC, Manchak J, Hayakawa K, Frost LS, Hazes B.

Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):2025-7. Epub 2004 Oct 20.


Factors affecting gestation length in the Thoroughbred mare.

Davies Morel MC, Newcombe JR, Holland SJ.

Anim Reprod Sci. 2002 Dec 16;74(3-4):175-85.


Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.

Danilewicz JC, Abel SM, Brown AD, Fish PV, Hawkeswood E, Holland SJ, James K, McElroy AB, Overington J, Powling MJ, Rance DJ.

J Med Chem. 2002 Jun 6;45(12):2432-53.


Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.

Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J.

J Exp Med. 2001 Nov 5;194(9):1263-76.


Fine specificity of the myelin-reactive T cell repertoire: implications for TCR antagonism in autoimmunity.

Anderton SM, Manickasingham SP, Burkhart C, Luckcuck TA, Holland SJ, Lamont AG, Wraith DC.

J Immunol. 1998 Oct 1;161(7):3357-64.


Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.

Holland SJ, Peles E, Pawson T, Schlessinger J.

Curr Opin Neurobiol. 1998 Feb;8(1):117-27. Review.


Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T.

EMBO J. 1997 Jul 1;16(13):3877-88.


Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands.

Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T.

Nature. 1996 Oct 24;383(6602):722-5.


Soluble CD46 (membrane cofactor protein, MCP) in human reproductive tract fluids.

McLaughlin PJ, Holland SJ, Taylor CT, Olah KS, Lewis-Jones DI, Hara T, Seya T, Johnson PM.

J Reprod Immunol. 1996 Oct;31(3):209-19.


Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.

Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD.

Neuron. 1996 Jul;17(1):9-19.


Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE, et al.

EMBO J. 1995 Oct 16;14(20):5100-8.


Dermatophyte fungi: improved isolation in a hospital laboratory.

Cheetham P, Holland SJ.

Med Lab Sci. 1988 Apr;45(2):139-42. No abstract available.


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