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Items: 16


Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

Brown MC, Holl EK, Boczkowski D, Dobrikova E, Mosaheb M, Chandramohan V, Bigner DD, Gromeier M, Nair SK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan4220. doi: 10.1126/scitranslmed.aan4220.


Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.

Holl EK, Brown MC, Boczkowski D, McNamara MA, George DJ, Bigner DD, Gromeier M, Nair SK.

Oncotarget. 2016 Nov 29;7(48):79828-79841. doi: 10.18632/oncotarget.12975.


Holding the Inflammatory System in Check: TLRs and NLRs.

Holl EK, Allen IC, Martinez J.

Mediators Inflamm. 2016;2016:8156816. doi: 10.1155/2016/8156816. Epub 2016 Aug 25. No abstract available.


Scavenging nucleic acid debris to combat autoimmunity and infectious disease.

Holl EK, Shumansky KL, Borst LB, Burnette AD, Sample CJ, Ramsburg EA, Sullenger BA.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9728-33. doi: 10.1073/pnas.1607011113. Epub 2016 Aug 15. Erratum in: Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6545.


RNA-Based Vaccines in Cancer Immunotherapy.

McNamara MA, Nair SK, Holl EK.

J Immunol Res. 2015;2015:794528. doi: 10.1155/2015/794528. Epub 2015 Nov 19. Review.


The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction.

Holl EK, Bond JE, Selim MA, Ehanire T, Sullenger B, Levinson H.

Plast Reconstr Surg. 2014 Sep;134(3):420e-33e. doi: 10.1097/PRS.0000000000000471.


Generation of bone marrow and fetal liver chimeric mice.

Holl EK.

Methods Mol Biol. 2013;1032:315-21. doi: 10.1007/978-1-62703-496-8_24.


Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses.

Holl EK, Shumansky KL, Pitoc G, Ramsburg E, Sullenger BA.

PLoS One. 2013 Jul 23;8(7):e69413. doi: 10.1371/journal.pone.0069413. Print 2013.


Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production.

Holl EK, Roney KE, Allen IC, Steinbach E, Arthur JC, Buntzman A, Plevy S, Frelinger J, Ting JP.

PLoS One. 2012;7(8):e43333. doi: 10.1371/journal.pone.0043333. Epub 2012 Aug 15.


The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.

Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson KV, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, Rahman AH, Conti BJ, Eitas TK, Koller BH, Ting JP.

Nat Immunol. 2012 Sep;13(9):823-31. doi: 10.1038/ni.2378. Epub 2012 Aug 5.


Nucleic acid scavengers inhibit thrombosis without increasing bleeding.

Jain S, Pitoc GA, Holl EK, Zhang Y, Borst L, Leong KW, Lee J, Sullenger BA.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12938-43. doi: 10.1073/pnas.1204928109. Epub 2012 Jul 25.


Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.

Roney KE, O'Connor BP, Wen H, Holl EK, Guthrie EH, Davis BK, Jones SW, Jha S, Sharek L, Garcia-Mata R, Bear JE, Ting JP.

PLoS One. 2011;6(9):e24795. doi: 10.1371/journal.pone.0024795. Epub 2011 Sep 23.


Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.

Holl EK, O'Connor BP, Holl TM, Roney KE, Zimmermann AG, Jha S, Kelsoe G, Ting JP.

J Immunol. 2011 May 15;186(10):5603-11. doi: 10.4049/jimmunol.1003464. Epub 2011 Apr 4.


The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.

Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C, Ting JP.

J Exp Med. 2010 May 10;207(5):1045-56. doi: 10.1084/jem.20100050. Epub 2010 Apr 12.


The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP.

Immunity. 2009 Apr 17;30(4):556-65. doi: 10.1016/j.immuni.2009.02.005. Epub 2009 Apr 9.


Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.

O'Connor BP, Eun SY, Ye Z, Zozulya AL, Lich JD, Moore CB, Iocca HA, Roney KE, Holl EK, Wu QP, van Deventer HW, Fabry Z, Ting JP.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13015-20. doi: 10.1073/pnas.0803386105. Epub 2008 Aug 26.

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