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Items: 11


Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition.

Weeden CE, Ah-Cann C, Holik AZ, Pasquet J, Garnier JM, Merino D, Lessene G, Asselin-Labat ML.

Oncogene. 2018 Aug;37(32):4475-4488. doi: 10.1038/s41388-018-0268-2. Epub 2018 May 10.


Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma.

Weeden CE, Holik AZ, Young RJ, Ma SB, Garnier JM, Fox SB, Antippa P, Irving LB, Steinfort DP, Wright GM, Russell PA, Ritchie ME, Burns CJ, Solomon B, Asselin-Labat ML.

Mol Cancer Ther. 2017 Aug;16(8):1610-1622. doi: 10.1158/1535-7163.MCT-17-0174. Epub 2017 Jun 13.


Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death.

Sandow JJ, Infusini G, Holik AZ, Brumatti G, Averink TV, Ekert PG, Webb AI.

Proteomics Clin Appl. 2017 Sep;11(9-10). doi: 10.1002/prca.201700013. Epub 2017 May 15.


RNA-seq mixology: designing realistic control experiments to compare protocols and analysis methods.

Holik AZ, Law CW, Liu R, Wang Z, Wang W, Ahn J, Asselin-Labat ML, Smyth GK, Ritchie ME.

Nucleic Acids Res. 2017 Mar 17;45(5):e30. doi: 10.1093/nar/gkw1063.


Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing.

Keniry A, Gearing LJ, Jansz N, Liu J, Holik AZ, Hickey PF, Kinkel SA, Moore DL, Breslin K, Chen K, Liu R, Phillips C, Pakusch M, Biben C, Sheridan JM, Kile BT, Carmichael C, Ritchie ME, Hilton DJ, Blewitt ME.

Epigenetics Chromatin. 2016 May 18;9:16. doi: 10.1186/s13072-016-0064-6. eCollection 2016.


Transcriptome and H3K27 tri-methylation profiling of Ezh2-deficient lung epithelium.

Holik AZ, Galvis LA, Lun AT, Ritchie ME, Asselin-Labat ML.

Genom Data. 2015 Jul 16;5:346-51. doi: 10.1016/j.gdata.2015.07.006. eCollection 2015 Sep.


The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.

Holik AZ, Filby CE, Pasquet J, Viitaniemi K, Ciciulla J, Sutherland KD, Asselin-Labat ML.

Respir Res. 2015 Jun 7;16:67. doi: 10.1186/s12931-015-0228-0.


Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses.

Liu R, Holik AZ, Su S, Jansz N, Chen K, Leong HS, Blewitt ME, Asselin-Labat ML, Smyth GK, Ritchie ME.

Nucleic Acids Res. 2015 Sep 3;43(15):e97. doi: 10.1093/nar/gkv412. Epub 2015 Apr 29.


Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung.

Galvis LA, Holik AZ, Short KM, Pasquet J, Lun AT, Blewitt ME, Smyth IM, Ritchie ME, Asselin-Labat ML.

Development. 2015 Apr 15;142(8):1458-69. doi: 10.1242/dev.122077. Epub 2015 Mar 19.


Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.

Holik AZ, Young M, Krzystyniak J, Williams GT, Metzger D, Shorning BY, Clarke AR.

PLoS Genet. 2014 Jul 10;10(7):e1004453. doi: 10.1371/journal.pgen.1004453. eCollection 2014 Jul.


Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner.

Holik AZ, Krzystyniak J, Young M, Richardson K, Jardé T, Chambon P, Shorning BY, Clarke AR.

Stem Cells. 2013 Nov;31(11):2457-66. doi: 10.1002/stem.1498.

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