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Items: 32

1.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]

PMID:
31501192
2.

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.

Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM.

Sci Rep. 2019 Jul 16;9(1):10292. doi: 10.1038/s41598-019-46500-5.

3.

AMP and adenosine are both ligands for adenosine 2B receptor signaling.

Holien JK, Seibt B, Roberts V, Salvaris E, Parker MW, Cowan PJ, Dwyer KM.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. doi: 10.1016/j.bmcl.2017.11.019. Epub 2017 Nov 20.

PMID:
29191553
4.

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.

Hodson C, Yang J, Hocking DM, Azzopardi K, Chen Q, Holien JK, Parker MW, Tauschek M, Robins-Browne RM.

Front Microbiol. 2017 Aug 11;8:1525. doi: 10.3389/fmicb.2017.01525. eCollection 2017.

5.

A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17.

Holien JK, Parker MW, Conley AJ, Corbin CJ, Rodgers RJ, Martin LL.

Curr Protein Pept Sci. 2017;18(5):515-521. doi: 10.2174/1389203717666161220142957. Review.

PMID:
28000554
6.

The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.

Tomlinson CG, Holien JK, Mathias JA, Parker MW, Bryan TM.

Biochimie. 2016 Sep-Oct;128-129:114-21. doi: 10.1016/j.biochi.2016.07.010. Epub 2016 Jul 22.

7.

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

Simonov AN, Holien JK, Yeung JC, Nguyen AD, Corbin CJ, Zheng J, Kuznetsov VL, Auchus RJ, Conley AJ, Bond AM, Parker MW, Rodgers RJ, Martin LL.

PLoS One. 2015 Nov 20;10(11):e0141252. doi: 10.1371/journal.pone.0141252. eCollection 2015.

8.

Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency.

Martin LL, Holien JK, Mizrachi D, Corbin CJ, Conley AJ, Parker MW, Rodgers RJ.

J Steroid Biochem Mol Biol. 2015 Nov;154:294-301. doi: 10.1016/j.jsbmb.2015.09.006. Epub 2015 Sep 7.

PMID:
26361012
9.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J.

Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442.

PMID:
25778803
10.

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

Hermans SJ, Ascher DB, Hancock NC, Holien JK, Michell BJ, Chai SY, Morton CJ, Parker MW.

Protein Sci. 2015 Feb;24(2):190-9. doi: 10.1002/pro.2604. Epub 2014 Dec 26.

11.

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.

Tomlinson CG, Moye AL, Holien JK, Parker MW, Cohen SB, Bryan TM.

Biochem J. 2015 Jan 15;465(2):347-57. doi: 10.1042/BJ20140922.

PMID:
25365545
12.

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.

Sanderson-Smith M, De Oliveira DM, Guglielmini J, McMillan DJ, Vu T, Holien JK, Henningham A, Steer AC, Bessen DE, Dale JB, Curtis N, Beall BW, Walker MJ, Parker MW, Carapetis JR, Van Melderen L, Sriprakash KS, Smeesters PR; M Protein Study Group.

J Infect Dis. 2014 Oct 15;210(8):1325-38. doi: 10.1093/infdis/jiu260. Epub 2014 May 5.

13.

Oncogenic protein interfaces: small molecules, big challenges.

Nero TL, Morton CJ, Holien JK, Wielens J, Parker MW.

Nat Rev Cancer. 2014 Apr;14(4):248-62. doi: 10.1038/nrc3690. Epub 2014 Mar 13. Review.

PMID:
24622521
14.

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

Mountford SJ, Albiston AL, Charman WN, Ng L, Holien JK, Parker MW, Nicolazzo JA, Thompson PE, Chai SY.

J Med Chem. 2014 Feb 27;57(4):1368-77. doi: 10.1021/jm401540f. Epub 2014 Feb 7.

PMID:
24471437
15.

Computational Analysis of Amiloride Analogue Inhibitors of Coxsackievirus B3 RNA Polymerase.

Holien JK, Gazina EV, Elliott RW, Jarrott B, Cameron CE, Williams SJ, Parker MW, Petrou S.

J Proteomics Bioinform. 2014;Suppl 9:004. doi: 10.4172/jpb.S9-004. Epub 2014 Aug 12.

16.

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

Yang J, Hocking DM, Cheng C, Dogovski C, Perugini MA, Holien JK, Parker MW, Hartland EL, Tauschek M, Robins-Browne RM.

J Biol Chem. 2013 Oct 25;288(43):31115-26. doi: 10.1074/jbc.M113.503912. Epub 2013 Sep 9.

17.

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

Etemadi N, Holien JK, Chau D, Dewson G, Murphy JM, Alexander WS, Parker MW, Silke J, Nachbur U.

FEBS J. 2013 Nov;280(21):5283-97. doi: 10.1111/febs.12419. Epub 2013 Aug 2.

18.

Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34.

Suryadinata R, Holien JK, Yang G, Parker MW, Papaleo E, Šarčević B.

Cell Cycle. 2013 Jun 1;12(11):1732-44. doi: 10.4161/cc.24818. Epub 2013 May 8.

19.

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

Lonic A, Powell JA, Kong Y, Thomas D, Holien JK, Truong N, Parker MW, Guthridge MA.

J Biol Chem. 2013 May 24;288(21):14874-85. doi: 10.1074/jbc.M112.421669. Epub 2013 Apr 5.

20.

Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin.

Lawrence SL, Feil SC, Holien JK, Kuiper MJ, Doughty L, Dolezal O, Mulhern TD, Tweten RK, Parker MW.

Front Immunol. 2012 Nov 5;3:330. doi: 10.3389/fimmu.2012.00330. eCollection 2012.

21.

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.

Bell JL, Malyukova A, Holien JK, Koach J, Parker MW, Kavallaris M, Marshall GM, Cheung BB.

PLoS One. 2012;7(5):e37470. doi: 10.1371/journal.pone.0037470. Epub 2012 May 21.

22.

Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.

Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW.

Structure. 2012 Feb 8;20(2):248-58. doi: 10.1016/j.str.2011.11.017.

23.

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Nankervis JL, Feil SC, Hancock NC, Zheng Z, Ng HL, Morton CJ, Holien JK, Ho PW, Frazzetto MM, Jennings IG, Manallack DT, Martin TJ, Thompson PE, Parker MW.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7089-93. doi: 10.1016/j.bmcl.2011.09.109. Epub 2011 Oct 5.

PMID:
22030030
24.

Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase.

Gazina EV, Smidansky ED, Holien JK, Harrison DN, Cromer BA, Arnold JJ, Parker MW, Cameron CE, Petrou S.

J Virol. 2011 Oct;85(19):10364-74. doi: 10.1128/JVI.05022-11. Epub 2011 Jul 27.

25.

An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia.

Topcic D, Kim W, Holien JK, Jia F, Armstrong PC, Hohmann JD, Straub A, Krippner G, Haller CA, Domeij H, Hagemeyer CE, Parker MW, Chaikof EL, Peter K.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2015-23. doi: 10.1161/ATVBAHA.111.226241. Epub 2011 Jun 9.

PMID:
21659646
26.

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.

Albiston AL, Diwakarla S, Fernando RN, Mountford SJ, Yeatman HR, Morgan B, Pham V, Holien JK, Parker MW, Thompson PE, Chai SY.

Br J Pharmacol. 2011 Sep;164(1):37-47. doi: 10.1111/j.1476-5381.2011.01402.x. Review.

27.

Direct involvement of the TEN domain at the active site of human telomerase.

Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM.

Nucleic Acids Res. 2011 Mar;39(5):1774-88. doi: 10.1093/nar/gkq1083. Epub 2010 Nov 3.

28.

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase.

Albiston AL, Pham V, Ye S, Ng L, Lew RA, Thompson PE, Holien JK, Morton CJ, Parker MW, Chai SY.

Mol Pharmacol. 2010 Oct;78(4):600-7. doi: 10.1124/mol.110.065458. Epub 2010 Jul 13.

PMID:
20628006
29.

Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.

Quesada-Soriano I, Parker LJ, Primavera A, Wielens J, Holien JK, Casas-Solvas JM, Vargas-Berenguel A, Aguilera AM, Nuccetelli M, Mazzetti AP, Lo Bello M, Parker MW, García-Fuentes L.

J Mol Recognit. 2011 Mar-Apr;24(2):220-34. doi: 10.1002/jmr.1040.

PMID:
20540076
30.

Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses.

Hurt AC, Holien JK, Parker MW, Barr IG.

Drugs. 2009;69(18):2523-31. doi: 10.2165/11531450-000000000-00000.

PMID:
19943705
31.

In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.

Hurt AC, Holien JK, Barr IG.

Antimicrob Agents Chemother. 2009 Oct;53(10):4433-40. doi: 10.1128/AAC.00334-09. Epub 2009 Aug 3.

32.

Zanamivir-resistant influenza viruses with a novel neuraminidase mutation.

Hurt AC, Holien JK, Parker M, Kelso A, Barr IG.

J Virol. 2009 Oct;83(20):10366-73. doi: 10.1128/JVI.01200-09. Epub 2009 Jul 29.

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