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The health effects of fine particulate air pollution.

Loxham M, Davies DE, Holgate ST.

BMJ. 2019 Nov 27;367:l6609. doi: 10.1136/bmj.l6609. No abstract available.


Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma.

Busse WW, Humbert M, Haselkorn T, Ortiz B, Trzaskoma BL, Stephenson P, Garcia Conde L, Kianifard F, Holgate ST.

Ann Allergy Asthma Immunol. 2019 Nov 22. pii: S1081-1206(19)31396-1. doi: 10.1016/j.anai.2019.11.016. [Epub ahead of print]


A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood.

Bedke N, Swindle EJ, Molnar C, Holt PG, Strickland DH, Roberts GC, Morris R, Holgate ST, Davies DE, Blume C.

J Immunol Methods. 2019 Nov 9:112703. doi: 10.1016/j.jim.2019.112703. [Epub ahead of print]


Air pollution: The time has arrived for the medical profession to take ownership of the problem and act.

Holgate ST.

Respirology. 2019 Dec;24(12):1138-1139. doi: 10.1111/resp.13690. Epub 2019 Sep 10. Review. No abstract available.


The Future of Asthma Care: Personalized Asthma Treatment.

Holgate ST, Walker S, West B, Boycott K.

Clin Chest Med. 2019 Mar;40(1):227-241. doi: 10.1016/j.ccm.2018.10.013. Review.


Letter from the UK (if we still exist after recent events!): Air pollution: The public health challenge of our time.

Holgate ST.

Respirology. 2019 Mar;24(3):286-287. doi: 10.1111/resp.13475. Epub 2019 Jan 25. No abstract available.


Evaluating the long-term consequences of air pollution in early life: geographical correlations between coal consumption in 1951/1952 and current mortality in England and Wales.

Phillips DIW, Osmond C, Southall H, Aucott P, Jones A, Holgate ST.

BMJ Open. 2018 Apr 27;8(4):e018231. doi: 10.1136/bmjopen-2017-018231.


Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Bruton A, Lee A, Yardley L, Raftery J, Arden-Close E, Kirby S, Zhu S, Thiruvothiyur M, Webley F, Taylor L, Gibson D, Yao G, Stafford-Watson M, Versnel J, Moore M, George S, Little P, Djukanovic R, Price D, Pavord ID, Holgate ST, Thomas M.

Lancet Respir Med. 2018 Jan;6(1):19-28. doi: 10.1016/S2213-2600(17)30474-5. Epub 2017 Dec 14.


Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus.

Loxham M, Smart DE, Bedke NJ, Smithers NP, Filippi I, Blume C, Swindle EJ, Tariq K, Howarth PH, Holgate ST, Davies DE.

Mucosal Immunol. 2018 Mar;11(2):404-414. doi: 10.1038/mi.2017.63. Epub 2017 Jul 5.


Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit.

Bucchieri F, Pitruzzella A, Fucarino A, Gammazza AM, Bavisotto CC, Marcianò V, Cajozzo M, Lo Iacono G, Marchese R, Zummo G, Holgate ST, Davies DE.

Exp Lung Res. 2017 Mar;43(2):82-92. doi: 10.1080/01902148.2017.1303098. Epub 2017 Apr 3.


'Every breath we take: the lifelong impact of air pollution' - a call for action.

Holgate ST.

Clin Med (Lond). 2017 Feb;17(1):8-12. doi: 10.7861/clinmedicine.17-1-8.


The era of research collaborations: new models for working together.

Djukanović R, Bruselle G, Walker S, Holgate ST, Škrgat S, Kuna P, Heaney LG, Canonica GW, Vestbo J.

Eur Respir J. 2017 Jan 3;49(1). pii: 1601848. doi: 10.1183/13993003.01848-2016. Print 2017 Jan. No abstract available.


The ever-expanding ERS fellowship programmes: achievements over the past 3 years.

Belvisi MG, Morty RE, Rohde G, Miravitlles M, Forrest KA, Genton C, Ritter N, Luludi N, Jimenez A, Rigau D, Tonia T, Vaccaro V, Pannetier C, Brusselle GG, Holgate ST.

Eur Respir J. 2016 Sep;48(3):595-9. doi: 10.1183/13993003.01146-2016. No abstract available.


Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM.

JCI Insight. 2016 Jul 21;1(11). pii: e87632.


Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

Manuyakorn W, Smart DE, Noto A, Bucchieri F, Haitchi HM, Holgate ST, Howarth PH, Davies DE.

PLoS One. 2016 Apr 21;11(4):e0153926. doi: 10.1371/journal.pone.0153926. eCollection 2016.


An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA Jr, Solway J, Liggett SB.

J Allergy Clin Immunol. 2016 Jul;138(1):294-297.e4. doi: 10.1016/j.jaci.2015.12.1315. Epub 2016 Feb 28. No abstract available.


The European Respiratory Society evaluates its 2013-2018 strategic plan implementation.

Migliori GB, Bel E, Joos G, Elliott M, Rohde G, Holgate ST, Gratziou C, Smyth D, Gaga M, Cordeiro CR, Burghuber OC, Brusselle G, Martin-Burrieza F, Bill W, Sax B, Vestbo J.

Eur Respir J. 2016 Mar;47(3):693-8. doi: 10.1183/13993003.02110-2015. No abstract available.


Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.

James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén SE; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC.


Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control.

Busse WW, Holgate ST, Wenzel SW, Klekotka P, Chon Y, Feng J, Ingenito EP, Nirula A.

Chest. 2015 Dec;148(6):1489-1496. doi: 10.1378/chest.14-2457.


Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.

D'Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet LP, Buters JT, D'Amato M, Dorsano S, Douwes J, Finlay SE, Garrasi D, Gómez M, Haahtela T, Halwani R, Hassani Y, Mahboub B, Marks G, Michelozzi P, Montagni M, Nunes C, Oh JJ, Popov TA, Portnoy J, Ridolo E, Rosário N, Rottem M, Sánchez-Borges M, Sibanda E, Sienra-Monge JJ, Vitale C, Annesi-Maesano I.

World Allergy Organ J. 2015 Jul 14;8(1):25. doi: 10.1186/s40413-015-0073-0. eCollection 2015.


The expanding role of immunopharmacology: IUPHAR Review 16.

Tiligada E, Ishii M, Riccardi C, Spedding M, Simon HU, Teixeira MM, Cuervo ML, Holgate ST, Levi-Schaffer F.

Br J Pharmacol. 2015 Sep;172(17):4217-27. doi: 10.1111/bph.13219. Epub 2015 Jul 21. Review.


Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial).

Malerba M, D Amato M, Radaeli A, Giacovelli G, Rovati L, Arshad SH, Holgate ST.

Curr Pharm Des. 2015;21(26):3835-43.


Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.

Bucchieri F, Marino Gammazza A, Pitruzzella A, Fucarino A, Farina F, Howarth P, Holgate ST, Zummo G, Davies DE.

PLoS One. 2015 Mar 20;10(3):e0120510. doi: 10.1371/journal.pone.0120510. eCollection 2015.


A comment on "Scientometrics in a changing research landscape".

Holgate ST.

EMBO Rep. 2015 Mar;16(3):261. doi: 10.15252/embr.201439972. Epub 2015 Jan 20. No abstract available.



Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD.

Nat Rev Dis Primers. 2015 Sep 10;1:15025. doi: 10.1038/nrdp.2015.25. Review.


Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients.

Mauri P, Riccio AM, Rossi R, Di Silvestre D, Benazzi L, De Ferrari L, Dal Negro RW, Holgate ST, Canonica GW.

Immunol Lett. 2014 Nov;162(1 Pt A):2-10. doi: 10.1016/j.imlet.2014.08.010. Epub 2014 Sep 3.


Asthma in the elderly: what we know and what we have yet to know.

Yáñez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedón JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST.

World Allergy Organ J. 2014 May 30;7(1):8. doi: 10.1186/1939-4551-7-8. eCollection 2014. Review.


New strategies with anti-IgE in allergic diseases.

Holgate ST.

World Allergy Organ J. 2014 Jul 29;7(1):17. doi: 10.1186/1939-4551-7-17. eCollection 2014. Review.


Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma.

Kupczyk M, Dahlén B, Sterk PJ, Nizankowska-Mogilnicka E, Papi A, Bel EH, Chanez P, Howarth PH, Holgate ST, Brusselle G, Siafakas NM, Gjomarkaj M, Dahlén SE; BIOAIR investigators.

Allergy. 2014 Sep;69(9):1198-204. doi: 10.1111/all.12445. Epub 2014 Jul 8.


The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Djukanović R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk P; INTERCIA Study Group.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.


A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

Aryan Z, Holgate ST, Radzioch D, Rezaei N.

Int Arch Allergy Immunol. 2014;164(1):46-63. doi: 10.1159/000362553. Epub 2014 May 21. Review.


Asthma genetics and personalised medicine.

Meyers DA, Bleecker ER, Holloway JW, Holgate ST.

Lancet Respir Med. 2014 May;2(5):405-15. doi: 10.1016/S2213-2600(14)70012-8. Epub 2014 May 2. Review.


Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model.

Cakebread JA, Haitchi HM, Xu Y, Holgate ST, Roberts G, Davies DE.

PLoS One. 2014 Apr 4;9(4):e94010. doi: 10.1371/journal.pone.0094010. eCollection 2014.


The European Respiratory Society plans its future: the 2013-2018 strategic plan.

Migliori GB, Rabe KF, Bel E, Elliott M, Gaga M, Holgate ST, Joos G, Burrieza FM, Sax B, Sculier JP, Simonds AK, Blasi F, Barnes PJ.

Eur Respir J. 2014 Apr;43(4):927-32. doi: 10.1183/09031936.00221613. No abstract available.


Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

Parnia S, Hamilton LM, Puddicombe SM, Holgate ST, Frew AJ, Davies DE.

Respir Res. 2014 Feb 20;15:22. doi: 10.1186/1465-9921-15-22.


Frequent exacerbators--a distinct phenotype of severe asthma.

Kupczyk M, ten Brinke A, Sterk PJ, Bel EH, Papi A, Chanez P, Nizankowska-Mogilnicka E, Gjomarkaj M, Gaga M, Brusselle G, Dahlén B, Dahlén SE; BIOAIR investigators.

Clin Exp Allergy. 2014 Feb;44(2):212-21. doi: 10.1111/cea.12179.


Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.

Abdelmotelb AM, Rose-Zerilli MJ, Barton SJ, Holgate ST, Walls AF, Holloway JW.

Clin Exp Allergy. 2014 Jun;44(6):822-30. doi: 10.1111/cea.12259.


Mechanisms of asthma and implications for its prevention and treatment: a personal journey.

Holgate ST.

Allergy Asthma Immunol Res. 2013 Nov;5(6):343-7. doi: 10.4168/aair.2013.5.6.343. Epub 2013 Jun 25. Review.


The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.

Andrews AL, Nordgren IK, Campbell-Harding G, Holloway JW, Holgate ST, Davies DE, Tavassoli A.

Mol Biosyst. 2013 Dec;9(12):3009-14. doi: 10.1039/c3mb70298g. Epub 2013 Sep 20.


Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors.

Leino MS, Loxham M, Blume C, Swindle EJ, Jayasekera NP, Dennison PW, Shamji BW, Edwards MJ, Holgate ST, Howarth PH, Davies DE.

PLoS One. 2013 Aug 23;8(8):e71278. doi: 10.1371/journal.pone.0071278. eCollection 2013.


Immune circuits in asthma.

Holgate ST.

Curr Opin Pharmacol. 2013 Jun;13(3):345-50. doi: 10.1016/j.coph.2013.03.008. Epub 2013 Apr 29. Review.


TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

Hardyman MA, Wilkinson E, Martin E, Jayasekera NP, Blume C, Swindle EJ, Gozzard N, Holgate ST, Howarth PH, Davies DE, Collins JE.

J Allergy Clin Immunol. 2013 Sep;132(3):665-675.e8. doi: 10.1016/j.jaci.2013.03.005. Epub 2013 Apr 28.


Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study.

Kupczyk M, Haque S, Sterk PJ, Niżankowska-Mogilnicka E, Papi A, Bel EH, Chanez P, Dahlén B, Gaga M, Gjomarkaj M, Howarth PH, Johnston SL, Joos GF, Kanniess F, Tzortzaki E, James A, Middelveld RJ, Dahlén SE; BIOAIR investigators.

Thorax. 2013 Jul;68(7):611-8. doi: 10.1136/thoraxjnl-2012-201815. Epub 2013 Apr 6.


Airway remodelling in asthma and novel therapy.

Manuyakorn W, Howarth PH, Holgate ST.

Asian Pac J Allergy Immunol. 2013 Mar;31(1):3-10. Review.


A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies.

Calder PC, Ahluwalia N, Albers R, Bosco N, Bourdet-Sicard R, Haller D, Holgate ST, Jönsson LS, Latulippe ME, Marcos A, Moreines J, M'Rini C, Müller M, Pawelec G, van Neerven RJ, Watzl B, Zhao J.

Br J Nutr. 2013 Jan;109 Suppl 1:S1-34. doi: 10.1017/S0007114512005119. Review.


Stratified approaches to the treatment of asthma.

Holgate ST.

Br J Clin Pharmacol. 2013 Aug;76(2):277-91. doi: 10.1111/bcp.12036. Review.


Barrier responses of human bronchial epithelial cells to grass pollen exposure.

Blume C, Swindle EJ, Dennison P, Jayasekera NP, Dudley S, Monk P, Behrendt H, Schmidt-Weber CB, Holgate ST, Howarth PH, Traidl-Hoffmann C, Davies DE.

Eur Respir J. 2013 Jul;42(1):87-97. doi: 10.1183/09031936.00075612. Epub 2012 Nov 8.


Are marine environmental pollutants influencing global patterns of human disease?

Depledge MH, Tyrrell J, Fleming LE, Holgate ST.

Mar Environ Res. 2013 Feb;83:93-5. doi: 10.1016/j.marenvres.2012.10.003. Epub 2012 Oct 29.


The future of technologies for personalised medicine.

Harvey A, Brand A, Holgate ST, Kristiansen LV, Lehrach H, Palotie A, Prainsack B.

N Biotechnol. 2012 Sep 15;29(6):625-33.


The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts.

Campbell-Harding G, Sawkins H, Bedke N, Holgate ST, Davies DE, Andrews AL.

J Allergy Clin Immunol. 2013 Mar;131(3):849-55. doi: 10.1016/j.jaci.2012.08.030. Epub 2012 Oct 12.


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