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The health effects of fine particulate air pollution.

Loxham M, Davies DE, Holgate ST.

BMJ. 2019 Nov 27;367:l6609. doi: 10.1136/bmj.l6609. No abstract available.


Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma.

Busse WW, Humbert M, Haselkorn T, Ortiz B, Trzaskoma BL, Stephenson P, Garcia Conde L, Kianifard F, Holgate ST.

Ann Allergy Asthma Immunol. 2019 Nov 22. pii: S1081-1206(19)31396-1. doi: 10.1016/j.anai.2019.11.016. [Epub ahead of print]


A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood.

Bedke N, Swindle EJ, Molnar C, Holt PG, Strickland DH, Roberts GC, Morris R, Holgate ST, Davies DE, Blume C.

J Immunol Methods. 2019 Nov 9:112703. doi: 10.1016/j.jim.2019.112703. [Epub ahead of print]


Air pollution: The time has arrived for the medical profession to take ownership of the problem and act.

Holgate ST.

Respirology. 2019 Dec;24(12):1138-1139. doi: 10.1111/resp.13690. Epub 2019 Sep 10. Review. No abstract available.


The Future of Asthma Care: Personalized Asthma Treatment.

Holgate ST, Walker S, West B, Boycott K.

Clin Chest Med. 2019 Mar;40(1):227-241. doi: 10.1016/j.ccm.2018.10.013. Review.


Letter from the UK (if we still exist after recent events!): Air pollution: The public health challenge of our time.

Holgate ST.

Respirology. 2019 Mar;24(3):286-287. doi: 10.1111/resp.13475. Epub 2019 Jan 25. No abstract available.


Neonatal listeriosis during a countrywide epidemic in South Africa: A tertiary hospital's experience.

Dramowski A, Lloyd LG, Bekker A, Holgate S, Aucamp M, Reddy K, Finlayson H.

S Afr Med J. 2018 Oct 2;108(10):818-827. doi: 10.7196/SAMJ.2018.v108i10.13207.


Evaluating the long-term consequences of air pollution in early life: geographical correlations between coal consumption in 1951/1952 and current mortality in England and Wales.

Phillips DIW, Osmond C, Southall H, Aucott P, Jones A, Holgate ST.

BMJ Open. 2018 Apr 27;8(4):e018231. doi: 10.1136/bmjopen-2017-018231.


Local action on outdoor air pollution to improve public health.

Vardoulakis S, Kettle R, Cosford P, Lincoln P, Holgate S, Grigg J, Kelly F, Pencheon D.

Int J Public Health. 2018 Jun;63(5):557-565. doi: 10.1007/s00038-018-1104-8. Epub 2018 Apr 20. Review.


Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Bruton A, Lee A, Yardley L, Raftery J, Arden-Close E, Kirby S, Zhu S, Thiruvothiyur M, Webley F, Taylor L, Gibson D, Yao G, Stafford-Watson M, Versnel J, Moore M, George S, Little P, Djukanovic R, Price D, Pavord ID, Holgate ST, Thomas M.

Lancet Respir Med. 2018 Jan;6(1):19-28. doi: 10.1016/S2213-2600(17)30474-5. Epub 2017 Dec 14.


A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults.

Thomas M, Bruton A, Little P, Holgate S, Lee A, Yardley L, George S, Raftery J, Versnel J, Price D, Pavord I, Djukanovic R, Moore M, Kirby S, Yao G, Zhu S, Arden-Close E, Thiruvothiyur M, Webley F, Stafford-Watson M, Dixon E, Taylor L.

Health Technol Assess. 2017 Sep;21(53):1-162. doi: 10.3310/hta21530.


Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus.

Loxham M, Smart DE, Bedke NJ, Smithers NP, Filippi I, Blume C, Swindle EJ, Tariq K, Howarth PH, Holgate ST, Davies DE.

Mucosal Immunol. 2018 Mar;11(2):404-414. doi: 10.1038/mi.2017.63. Epub 2017 Jul 5.


Air pollution--a wicked problem.

Holgate S, Stokes-Lampard H.

BMJ. 2017 Jun 14;357:j2814. doi: 10.1136/bmj.j2814. No abstract available.


Severe eosinophilic asthma: a roadmap to consensus.

Buhl R, Humbert M, Bjermer L, Chanez P, Heaney LG, Pavord I, Quirce S, Virchow JC, Holgate S; expert group of the European Consensus Meeting for Severe Eosinophilic Asthma.

Eur Respir J. 2017 May 1;49(5). pii: 1700634. doi: 10.1183/13993003.00634-2017. Print 2017 May. No abstract available.


The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP).

Masefield S, Edwards J, Hansen K, Hamerlijnck D, Lisspers K, van der Schee M, Silva L, Matthews J, Gaga M, Adcock I, Holgate S, Walker S, Powell P.

Eur Respir J. 2017 May 1;49(5). pii: 1602295. doi: 10.1183/13993003.02295-2016. Print 2017 May. No abstract available.


Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit.

Bucchieri F, Pitruzzella A, Fucarino A, Gammazza AM, Bavisotto CC, Marcianò V, Cajozzo M, Lo Iacono G, Marchese R, Zummo G, Holgate ST, Davies DE.

Exp Lung Res. 2017 Mar;43(2):82-92. doi: 10.1080/01902148.2017.1303098. Epub 2017 Apr 3.


'Every breath we take: the lifelong impact of air pollution' - a call for action.

Holgate ST.

Clin Med (Lond). 2017 Feb;17(1):8-12. doi: 10.7861/clinmedicine.17-1-8.


The era of research collaborations: new models for working together.

Djukanović R, Bruselle G, Walker S, Holgate ST, Škrgat S, Kuna P, Heaney LG, Canonica GW, Vestbo J.

Eur Respir J. 2017 Jan 3;49(1). pii: 1601848. doi: 10.1183/13993003.01848-2016. Print 2017 Jan. No abstract available.


Antiretroviral Treatment Initiated in the First Month of Life.

Frigati L, Wynberg E, Maritz J, Holgate S, Cotton MF, Rabie H.

Pediatr Infect Dis J. 2017 Jun;36(6):584-587. doi: 10.1097/INF.0000000000001504.


CD48 on blood leukocytes and in serum of asthma patients varies with severity.

Gangwar RS, Minai-Fleminger Y, Seaf M, Gutgold A, Shikotra A, Barber C, Chauhan A, Holgate S, Bradding P, Howarth P, Eliashar R, Berkman N, Levi-Schaffer F.

Allergy. 2017 Jun;72(6):888-895. doi: 10.1111/all.13082. Epub 2016 Dec 1. Erratum in: Allergy. 2017 Oct;72 (10 ):1591.


The ever-expanding ERS fellowship programmes: achievements over the past 3 years.

Belvisi MG, Morty RE, Rohde G, Miravitlles M, Forrest KA, Genton C, Ritter N, Luludi N, Jimenez A, Rigau D, Tonia T, Vaccaro V, Pannetier C, Brusselle GG, Holgate ST.

Eur Respir J. 2016 Sep;48(3):595-9. doi: 10.1183/13993003.01146-2016. No abstract available.


Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM.

JCI Insight. 2016 Jul 21;1(11). pii: e87632.


Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

Manuyakorn W, Smart DE, Noto A, Bucchieri F, Haitchi HM, Holgate ST, Howarth PH, Davies DE.

PLoS One. 2016 Apr 21;11(4):e0153926. doi: 10.1371/journal.pone.0153926. eCollection 2016.


An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA Jr, Solway J, Liggett SB.

J Allergy Clin Immunol. 2016 Jul;138(1):294-297.e4. doi: 10.1016/j.jaci.2015.12.1315. Epub 2016 Feb 28. No abstract available.


The European Respiratory Society evaluates its 2013-2018 strategic plan implementation.

Migliori GB, Bel E, Joos G, Elliott M, Rohde G, Holgate ST, Gratziou C, Smyth D, Gaga M, Cordeiro CR, Burghuber OC, Brusselle G, Martin-Burrieza F, Bill W, Sax B, Vestbo J.

Eur Respir J. 2016 Mar;47(3):693-8. doi: 10.1183/13993003.02110-2015. No abstract available.


Treatable traits: toward precision medicine of chronic airway diseases.

Agusti A, Bel E, Thomas M, Vogelmeier C, Brusselle G, Holgate S, Humbert M, Jones P, Gibson PG, Vestbo J, Beasley R, Pavord ID.

Eur Respir J. 2016 Feb;47(2):410-9. doi: 10.1183/13993003.01359-2015.


The last and first frontier--emerging challenges for HIV treatment and prevention in the first week of life with emphasis on premature and low birth weight infants.

Cotton MF, Holgate S, Nelson A, Rabie H, Wedderburn C, Mirochnick M.

J Int AIDS Soc. 2015 Dec 2;18(Suppl 6):20271. doi: 10.7448/IAS.18.7.20271. eCollection 2015.


Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control.

Busse WW, Holgate ST, Wenzel SW, Klekotka P, Chon Y, Feng J, Ingenito EP, Nirula A.

Chest. 2015 Dec;148(6):1489-1496. doi: 10.1378/chest.14-2457.


Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.

D'Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet LP, Buters JT, D'Amato M, Dorsano S, Douwes J, Finlay SE, Garrasi D, Gómez M, Haahtela T, Halwani R, Hassani Y, Mahboub B, Marks G, Michelozzi P, Montagni M, Nunes C, Oh JJ, Popov TA, Portnoy J, Ridolo E, Rosário N, Rottem M, Sánchez-Borges M, Sibanda E, Sienra-Monge JJ, Vitale C, Annesi-Maesano I.

World Allergy Organ J. 2015 Jul 14;8(1):25. doi: 10.1186/s40413-015-0073-0. eCollection 2015.


The current state of respiratory research in the UK.

Snell N, Jarrold I, Holgate S.

Thorax. 2015 Nov;70(11):1011-3. doi: 10.1136/thoraxjnl-2015-207509. Epub 2015 Jul 20. No abstract available.


The expanding role of immunopharmacology: IUPHAR Review 16.

Tiligada E, Ishii M, Riccardi C, Spedding M, Simon HU, Teixeira MM, Cuervo ML, Holgate ST, Levi-Schaffer F.

Br J Pharmacol. 2015 Sep;172(17):4217-27. doi: 10.1111/bph.13219. Epub 2015 Jul 21. Review.


Drug development for airway diseases: looking forward.

Holgate S, Agusti A, Strieter RM, Anderson GP, Fogel R, Bel E, Martin TR, Reiss TF.

Nat Rev Drug Discov. 2015 Jun;14(6):367-8. doi: 10.1038/nrd4645. Epub 2015 May 22.


Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial).

Malerba M, D Amato M, Radaeli A, Giacovelli G, Rovati L, Arshad SH, Holgate ST.

Curr Pharm Des. 2015;21(26):3835-43.


Strength in disability.

O'Neill K, Holgate SA.

Science. 2015 Mar 27;347(6229):1510. doi: 10.1126/science.347.6229.1510. No abstract available.


Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.

Bucchieri F, Marino Gammazza A, Pitruzzella A, Fucarino A, Farina F, Howarth P, Holgate ST, Zummo G, Davies DE.

PLoS One. 2015 Mar 20;10(3):e0120510. doi: 10.1371/journal.pone.0120510. eCollection 2015.


Asthma diagnosis: addressing the challenges.

Pavord ID, Bush A, Holgate S.

Lancet Respir Med. 2015 May;3(5):339-41. doi: 10.1016/S2213-2600(15)00056-9. Epub 2015 Mar 6. Review. No abstract available.


Human tissue models for a human disease: what are the barriers?

Edwards J, Belvisi M, Dahlen SE, Holgate S, Holmes A.

Thorax. 2015 Jul;70(7):695-7. doi: 10.1136/thoraxjnl-2014-206648. Epub 2015 Jan 28.


A comment on "Scientometrics in a changing research landscape".

Holgate ST.

EMBO Rep. 2015 Mar;16(3):261. doi: 10.15252/embr.201439972. Epub 2015 Jan 20. No abstract available.



Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD.

Nat Rev Dis Primers. 2015 Sep 10;1:15025. doi: 10.1038/nrdp.2015.25. Review.


A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells.

Martinez-Nunez RT, Bondanese VP, Louafi F, Francisco-Garcia AS, Rupani H, Bedke N, Holgate S, Howarth PH, Davies DE, Sanchez-Elsner T.

PLoS One. 2014 Oct 31;9(10):e111659. doi: 10.1371/journal.pone.0111659. eCollection 2014.


Life inspires applications.

Holgate SA.

Science. 2014 Oct 17;346(6207):390. doi: 10.1126/science.346.6207.390. No abstract available.


Omalizumab in asthma: an update on recent developments.

Humbert M, Busse W, Hanania NA, Lowe PJ, Canvin J, Erpenbeck VJ, Holgate S.

J Allergy Clin Immunol Pract. 2014 Sep-Oct;2(5):525-36.e1. doi: 10.1016/j.jaip.2014.03.010. Epub 2014 Jun 11. Review.


Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients.

Mauri P, Riccio AM, Rossi R, Di Silvestre D, Benazzi L, De Ferrari L, Dal Negro RW, Holgate ST, Canonica GW.

Immunol Lett. 2014 Nov;162(1 Pt A):2-10. doi: 10.1016/j.imlet.2014.08.010. Epub 2014 Sep 3.


Asthma in the elderly: what we know and what we have yet to know.

Yáñez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedón JC, Canonica GW, Busse P, Boulet LP, Baena-Cagnani CE, Hamid Q, Bachert C, Pawankar R, Holgate ST.

World Allergy Organ J. 2014 May 30;7(1):8. doi: 10.1186/1939-4551-7-8. eCollection 2014. Review.


New strategies with anti-IgE in allergic diseases.

Holgate ST.

World Allergy Organ J. 2014 Jul 29;7(1):17. doi: 10.1186/1939-4551-7-17. eCollection 2014. Review.


Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma.

Kupczyk M, Dahlén B, Sterk PJ, Nizankowska-Mogilnicka E, Papi A, Bel EH, Chanez P, Howarth PH, Holgate ST, Brusselle G, Siafakas NM, Gjomarkaj M, Dahlén SE; BIOAIR investigators.

Allergy. 2014 Sep;69(9):1198-204. doi: 10.1111/all.12445. Epub 2014 Jul 8.


Nevirapine concentrations in preterm and low birth weight HIV-exposed infants: implications for dosing recommendations.

de Waal R, Kroon SM, Holgate SL, Horn AR, Tooke LJ, Norman J, Smith P, Blockman M, Cotton MF, McIlleron HM, Cohen K.

Pediatr Infect Dis J. 2014 Dec;33(12):1231-3. doi: 10.1097/INF.0000000000000453.


The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Djukanović R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk P; INTERCIA Study Group.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.


A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

Aryan Z, Holgate ST, Radzioch D, Rezaei N.

Int Arch Allergy Immunol. 2014;164(1):46-63. doi: 10.1159/000362553. Epub 2014 May 21. Review.

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