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Items: 28


Targeting a glioblastoma cancer stem-cell population defined by EGF receptor variant III.

Emlet DR, Gupta P, Holgado-Madruga M, Del Vecchio CA, Mitra SS, Han SY, Li G, Jensen KC, Vogel H, Xu LW, Skirboll SS, Wong AJ.

Cancer Res. 2014 Feb 15;74(4):1238-49. doi: 10.1158/0008-5472.CAN-13-1407. Epub 2013 Dec 23.


Development of an EGFRvIII specific recombinant antibody.

Gupta P, Han SY, Holgado-Madruga M, Mitra SS, Li G, Nitta RT, Wong AJ.

BMC Biotechnol. 2010 Oct 7;10:72. doi: 10.1186/1472-6750-10-72.


The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

Laramée M, Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, Royal I.

J Biol Chem. 2007 Mar 16;282(11):7758-69. Epub 2006 Dec 17.


c-Jun NH(2)-terminal kinase 2alpha2 promotes the tumorigenicity of human glioblastoma cells.

Cui J, Han SY, Wang C, Su W, Harshyne L, Holgado-Madruga M, Wong AJ.

Cancer Res. 2006 Oct 15;66(20):10024-31.


Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment.

Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR.

Cancer Res. 2006 Jan 1;66(1):331-42.


Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.

Sun H, Shen Y, Dokainish H, Holgado-Madruga M, Wong A, Ireton K.

Cell Microbiol. 2005 Mar;7(3):443-57.


Identification of a specific domain responsible for JNK2alpha2 autophosphorylation.

Cui J, Holgado-Madruga M, Su W, Tsuiki H, Wedegaertner P, Wong AJ.

J Biol Chem. 2005 Mar 18;280(11):9913-20. Epub 2005 Jan 6.


Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.

Holgado-Madruga M, Wong AJ.

Cancer Res. 2004 Mar 15;64(6):2007-15.


Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.

Holgado-Madruga M, Wong AJ.

Mol Cell Biol. 2003 Jul;23(13):4471-84.


Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors.

Tsuiki H, Tnani M, Okamoto I, Kenyon LC, Emlet DR, Holgado-Madruga M, Lanham IS, Joynes CJ, Vo KT, Wong AJ.

Cancer Res. 2003 Jan 1;63(1):250-5.


Elevated JNK activation contributes to the pathogenesis of human brain tumors.

Antonyak MA, Kenyon LC, Godwin AK, James DC, Emlet DR, Okamoto I, Tnani M, Holgado-Madruga M, Moscatello DK, Wong AJ.

Oncogene. 2002 Aug 1;21(33):5038-46.


Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors.

Okamoto I, Tsuiki H, Kenyon LC, Godwin AK, Emlet DR, Holgado-Madruga M, Lanham IS, Joynes CJ, Vo KT, Guha A, Matsumoto M, Ushio Y, Saya H, Wong AJ.

Am J Pathol. 2002 Feb;160(2):441-7.


The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.

Ingham RJ, Santos L, Dang-Lawson M, Holgado-Madruga M, Dudek P, Maroun CR, Wong AJ, Matsuuchi L, Gold MR.

J Biol Chem. 2001 Apr 13;276(15):12257-65. Epub 2001 Jan 22.


A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis.

Maroun CR, Moscatello DK, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M.

J Biol Chem. 1999 Oct 29;274(44):31719-26.


Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.

Bruening W, Prowse AH, Schultz DC, Holgado-Madruga M, Wong A, Godwin AK.

Cancer Res. 1999 Oct 1;59(19):4973-83.


The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.

Maroun CR, Holgado-Madruga M, Royal I, Naujokas MA, Fournier TM, Wong AJ, Park M.

Mol Cell Biol. 1999 Mar;19(3):1784-99.


The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

Ingham RJ, Holgado-Madruga M, Siu C, Wong AJ, Gold MR.

J Biol Chem. 1998 Nov 13;273(46):30630-7.


Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules.

Rocchi S, Tartare-Deckert S, Murdaca J, Holgado-Madruga M, Wong AJ, Van Obberghen E.

Mol Endocrinol. 1998 Jul;12(7):914-23.


Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor.

Moscatello DK, Holgado-Madruga M, Emlet DR, Montgomery RB, Wong AJ.

J Biol Chem. 1998 Jan 2;273(1):200-6.


Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.

Holgado-Madruga M, Moscatello DK, Emlet DR, Dieterich R, Wong AJ.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12419-24.


Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

Nguyen L, Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M.

J Biol Chem. 1997 Aug 15;272(33):20811-9.


Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M.

J Biol Chem. 1997 Aug 8;272(32):20167-72.


A Grb2-associated docking protein in EGF- and insulin-receptor signalling.

Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ.

Nature. 1996 Feb 8;379(6565):560-4.


Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

Moscatello DK, Holgado-Madruga M, Godwin AK, Ramirez G, Gunn G, Zoltick PW, Biegel JA, Hayes RL, Wong AJ.

Cancer Res. 1995 Dec 1;55(23):5536-9.


Improved survival in intestinal ischemia by allopurinol not related to xanthine-oxidase inhibition.

Garcia Garcia J, Martin Rollan C, Refoyo Enrinquez MA, Holgado Madruga M, Mariño Hernandez E, Macias Nuñez JF, Gomez Alonso A.

J Surg Res. 1990 Feb;48(2):144-6.


[Effect of xanthine oxidase inhibitors on the prognosis of acute intestinal ischemia].

Holgado Madruga M, Refoyo Enríquez A, Mariño Hernández E, Martín Rollán C, García García J, Macías Núñez JF.

An Med Interna. 1989 Apr;6(4):177-82. Spanish.


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