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Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis.

Banda NK, Desai D, Scheinman RI, Pihl R, Sekine H, Fujita T, Sharma V, Hansen AG, Garred P, Thiel S, Borodovsky A, Holers VM.

Immunohorizons. 2018 Sep;2(8):274-295. doi: 10.4049/immunohorizons.1800053.


Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction.

Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD.

Nat Rev Rheumatol. 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. Review.


Preface to the Special issue for the 27th International complement workshop.

Tenner AJ, Atkinson JP, Holers VM.

Mol Immunol. 2018 Oct;102:1-2. doi: 10.1016/j.molimm.2018.07.010. Epub 2018 Jul 27. No abstract available.


Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.

Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM.

J Am Heart Assoc. 2018 Jul 13;7(14). pii: e007818. doi: 10.1161/JAHA.117.007818.


Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.


Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients.

Hughes-Austin JM, Deane KD, Giles JT, Derber LA, Zerbe GO, Dabelea DM, Sokolove J, Robinson WH, Holers VM, Norris JM.

PLoS One. 2018 Jun 25;13(6):e0199578. doi: 10.1371/journal.pone.0199578. eCollection 2018.


Complement in the Initiation and Evolution of Rheumatoid Arthritis.

Holers VM, Banda NK.

Front Immunol. 2018 May 28;9:1057. doi: 10.3389/fimmu.2018.01057. eCollection 2018. Review.


Combination of anti-citrullinated protein antibodies and rheumatoid factor is associated with increased systemic inflammatory mediators and more rapid progression from preclinical to clinical rheumatoid arthritis.

Lingampalli N, Sokolove J, Lahey LJ, Edison JD, Gilliland WR, Holers VM, Deane KD, Robinson WH.

Clin Immunol. 2018 Oct;195:119-126. doi: 10.1016/j.clim.2018.05.004. Epub 2018 May 26.


Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis: Implications for Very Early Identification of At-Risk Individuals.

Verheul MK, Böhringer S, van Delft MAM, Jones JD, Rigby WFC, Gan RW, Holers VM, Edison JD, Deane KD, Janssen KMJ, Westra J, Brink M, Rantapää-Dahlqvist S, Huizinga TWJ, van der Helm-van Mil AHM, van der Woude D, Toes REM, Trouw LA.

Arthritis Rheumatol. 2018 Nov;70(11):1721-1731. doi: 10.1002/art.40562. Epub 2018 Sep 16.


Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.

Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F.

Front Immunol. 2018 Mar 16;9:535. doi: 10.3389/fimmu.2018.00535. eCollection 2018.


The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.

Okamoto T, Mathai SK, Hennessy CE, Hancock LA, Walts AD, Stefanski AL, Brown KK, Lynch DA, Cosgrove GP, Groshong SD, Cool CD, Schwarz MI, Banda NK, Thurman JM, Yang IV, Holers VM, Schwartz DA.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L1-L10. doi: 10.1152/ajplung.00395.2017. Epub 2018 Mar 22.


Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.

Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM.

Eur J Immunol. 2018 May;48(5):791-802. doi: 10.1002/eji.201747240. Epub 2018 Feb 22.


Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis.

Demoruelle MK, Bowers E, Lahey LJ, Sokolove J, Purmalek M, Seto NL, Weisman MH, Norris JM, Kaplan MJ, Holers VM, Robinson WH, Deane KD.

Arthritis Rheumatol. 2018 Apr;70(4):516-527. doi: 10.1002/art.40401. Epub 2018 Mar 2.


Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis.

Hughes-Austin JM, Gan RW, Deane KD, Weisman MH, Demoruelle MK, Sokolove J, Robinson WH, Holers VM, Norris JM, Ix JH.

Am J Nephrol. 2017;46(6):481-487. doi: 10.1159/000485259. Epub 2017 Dec 13.


Genetic and environmental risk factors for rheumatoid arthritis.

Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM.

Best Pract Res Clin Rheumatol. 2017 Feb;31(1):3-18. doi: 10.1016/j.berh.2017.08.003. Epub 2017 Sep 18. Review.


Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.

Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM.

J Immunol. 2018 Jan 1;200(1):316-326. doi: 10.4049/jimmunol.1602017. Epub 2017 Nov 29.


The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population.

Gan RW, Bemis EA, Demoruelle MK, Striebich CC, Brake S, Feser ML, Moss L, Clare-Salzler M, Holers VM, Deane KD, Norris JM.

Rheumatology (Oxford). 2017 Dec 1;56(12):2229-2236. doi: 10.1093/rheumatology/kex360.


A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.

He YG, Pappworth IY, Rossbach A, Paulin J, Mavimba T, Hayes C, Kulik L, Holers VM, Knight AM, Marchbank KJ.

Immunobiology. 2018 Jan;223(1):125-134. doi: 10.1016/j.imbio.2017.10.002. Epub 2017 Oct 4.


Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.

Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM.

J Immunol. 2017 Sep 1;199(5):1835-1845. doi: 10.4049/jimmunol.1700119. Epub 2017 Jul 24.


The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases.

Thurman JM, Frazer-Abel A, Holers VM.

Arthritis Rheumatol. 2017 Nov;69(11):2102-2113. doi: 10.1002/art.40219. Epub 2017 Oct 17. Review.


Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.

Narang A, Qiao F, Atkinson C, Zhu H, Yang X, Kulik L, Holers VM, Tomlinson S.

J Neuroinflammation. 2017 Jun 19;14(1):120. doi: 10.1186/s12974-017-0894-6.


Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study.

Birru Talabi M, Mackey RH, Kuller LH, Dorman JS, Deane KD, Robinson WH, Walitt BT, Chang Y, Holers VM, Liu S, Moreland LW.

Am J Epidemiol. 2017 Jul 15;186(2):245-254. doi: 10.1093/aje/kwx087.


In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms.

Wang G, Griffin JI, Inturi S, Brenneman B, Banda NK, Holers VM, Moghimi SM, Simberg D.

Front Immunol. 2017 Feb 15;8:151. doi: 10.3389/fimmu.2017.00151. eCollection 2017.


Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?

Deane KD, Striebich CC, Holers VM.

Arthritis Rheumatol. 2017 May;69(5):873-877. doi: 10.1002/art.40061. Epub 2017 Apr 11. No abstract available.


Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients.

Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, Mahler M, Norris JM, Kaplan MJ, Cherrington BD, Holers VM, Deane KD.

Arthritis Rheumatol. 2017 Jun;69(6):1165-1175. doi: 10.1002/art.40066. Epub 2017 May 2.


Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.

Willis VC, Banda NK, Cordova KN, Chandra PE, Robinson WH, Cooper DC, Lugo D, Mehta G, Taylor S, Tak PP, Prinjha RK, Lewis HD, Holers VM.

Clin Exp Immunol. 2017 May;188(2):263-274. doi: 10.1111/cei.12932. Epub 2017 Mar 9.


Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo.

Chen F, Wang G, Griffin JI, Brenneman B, Banda NK, Holers VM, Backos DS, Wu L, Moghimi SM, Simberg D.

Nat Nanotechnol. 2017 May;12(4):387-393. doi: 10.1038/nnano.2016.269. Epub 2016 Dec 19.


Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions.

Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM.

PLoS One. 2016 Nov 4;11(11):e0166200. doi: 10.1371/journal.pone.0166200. eCollection 2016.


A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.

Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC.

JCI Insight. 2016 Oct 20;1(17):e90045.


Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking.

Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D.

Front Immunol. 2016 Oct 10;7:418. eCollection 2016.


Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing.

Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM.

J Immunol. 2016 Nov 1;197(9):3680-3694. Epub 2016 Oct 5.


New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities.

Holers VM, Tomlinson S, Kulik L, Atkinson C, Rohrer B, Banda N, Thurman JM.

Semin Immunol. 2016 Jun;28(3):260-7. doi: 10.1016/j.smim.2016.05.007. Epub 2016 Jun 6. Review.


Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis.

Kinslow JD, Blum LK, Deane KD, Demoruelle MK, Okamoto Y, Parish MC, Kongpachith S, Lahey LJ, Norris JM, Robinson WH, Holers VM.

Arthritis Rheumatol. 2016 Oct;68(10):2372-83. doi: 10.1002/art.39771.


Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis.

Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM.

Ann Rheum Dis. 2017 Jan;76(1):147-152. doi: 10.1136/annrheumdis-2016-209154. Epub 2016 May 17.


Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM.

Kidney Int. 2016 Jul;90(1):109-22. doi: 10.1016/j.kint.2016.02.036. Epub 2016 May 7.


Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains.

Rich MC, Keene CN, Neher MD, Johnson K, Yu ZX, Ganivet A, Holers VM, Stahel PF.

Neurosci Lett. 2016 Mar 23;617:188-94. doi: 10.1016/j.neulet.2016.02.025. Epub 2016 Feb 15.


Annexin A2 Enhances Complement Activation by Inhibiting Factor H.

Renner B, Tong HH, Laskowski J, Jonscher K, Goetz L, Woolaver R, Hannan J, Li YX, Hourcade D, Pickering MC, Holers VM, Thurman JM.

J Immunol. 2016 Feb 1;196(3):1355-65. doi: 10.4049/jimmunol.1500793. Epub 2016 Jan 4.


The relationship of circulating proteins in early pregnancy with preterm birth.

Lynch AM, Wagner BD, Deterding RR, Giclas PC, Gibbs RS, Janoff EN, Holers VM, Santoro NF.

Am J Obstet Gynecol. 2016 Apr;214(4):517.e1-517.e8. doi: 10.1016/j.ajog.2015.11.001. Epub 2015 Nov 11.


The Relationship of Longitudinal Levels of Complement Bb During Pregnancy with Preeclampsia.

Lynch AM, Wagner BD, Giclas PC, West NA, Gibbs RS, Holers VM.

Am J Reprod Immunol. 2016 Feb;75(2):104-11. doi: 10.1111/aji.12439. Epub 2015 Oct 29.


Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake.

Inturi S, Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D.

ACS Nano. 2015 Nov 24;9(11):10758-68. doi: 10.1021/acsnano.5b05061. Epub 2015 Oct 21.


Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study.

Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM.

Rheumatology (Oxford). 2016 Feb;55(2):367-76. doi: 10.1093/rheumatology/kev266. Epub 2015 Sep 13.


Predicting and preventing the development of rheumatoid arthritis.

Raza K, Klareskog L, Holers VM.

Rheumatology (Oxford). 2016 Jan;55(1):1-3. doi: 10.1093/rheumatology/kev261. Epub 2015 Jul 29. No abstract available.


Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative.

Mackey RH, Kuller LH, Deane KD, Walitt BT, Chang YF, Holers VM, Robinson WH, Tracy RP, Hlatky MA, Eaton CB, Liu S, Freiberg MS, Talabi MB, Schelbert EB, Moreland LW.

Arthritis Rheumatol. 2015 Sep;67(9):2311-22. doi: 10.1002/art.39198.


Targeting mechanisms at sites of complement activation for imaging and therapy.

Holers VM.

Immunobiology. 2016 Jun;221(6):726-32. doi: 10.1016/j.imbio.2015.04.005. Epub 2015 Apr 30. Review.


IgM exacerbates glomerular disease progression in complement-induced glomerulopathy.

Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM.

Kidney Int. 2015 Sep;88(3):528-37. doi: 10.1038/ki.2015.120. Epub 2015 May 6.


A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA.

Mehta G, Scheinman RI, Holers VM, Banda NK.

J Immunol. 2015 Jun 1;194(11):5446-54. doi: 10.4049/jimmunol.1403012. Epub 2015 Apr 27.


Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury.

Atkinson C, Qiao F, Yang X, Zhu P, Reaves N, Kulik L, Goddard M, Holers VM, Tomlinson S.

Circulation. 2015 Mar 31;131(13):1171-80. doi: 10.1161/CIRCULATIONAHA.114.010482. Epub 2015 Feb 17.


Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility.

Cruickshank MN, Dods J, Taylor RL, Karimi M, Fenwick EJ, Quail EA, Rea AJ, Holers VM, Abraham LJ, Ulgiati D.

Int J Biochem Cell Biol. 2015 Jul;64:107-19. doi: 10.1016/j.biocel.2015.03.016. Epub 2015 Mar 27.


Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis.

Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM.

J Rheumatol. 2015 Apr;42(4):572-9. doi: 10.3899/jrheum.140767. Epub 2015 Jan 15.


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