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Items: 9


Implementing a Respiratory Therapist-Driven Continuous Albuterol Weaning Protocol in the Pediatric ICU.

Maue DK, Tori AJ, Beardsley AL, Krupp NL, Hole AJ, Moser EA, Rowan CM.

Respir Care. 2019 Nov;64(11):1358-1365. doi: 10.4187/respcare.06447. Epub 2019 Mar 19.


Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.

Blaquiere N, Castanedo GM, Burch JD, Berezhkovskiy LM, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, Grabbe A, Hole AJ, Hu B, Hymowitz SG, Alaoui Ismaili MH, Le H, Lee P, Lee W, Lin X, Liu N, McEwan PA, McKenzie B, Silvestre HL, Suto E, Sujatha-Bhaskar S, Wu G, Wu LC, Zhang Y, Zhong Z, Staben ST.

J Med Chem. 2018 Aug 9;61(15):6801-6813. doi: 10.1021/acs.jmedchem.8b00678. Epub 2018 Jul 24.


An Interprofessional Quality Improvement Initiative to Standardize Pediatric Extubation Readiness Assessment.

Abu-Sultaneh S, Hole AJ, Tori AJ, Benneyworth BD, Lutfi R, Mastropietro CW.

Pediatr Crit Care Med. 2017 Oct;18(10):e463-e471. doi: 10.1097/PCC.0000000000001285.


An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

Echalier A, Hole AJ, Lolli G, Endicott JA, Noble ME.

ACS Chem Biol. 2014 Jun 20;9(6):1251-6. doi: 10.1021/cb500135f. Epub 2014 Apr 10.


Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities.

Shao H, Shi S, Huang S, Hole AJ, Abbas AY, Baumli S, Liu X, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang S.

J Med Chem. 2013 Feb 14;56(3):640-59. doi: 10.1021/jm301475f. Epub 2013 Jan 25.


Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.

Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME.

J Med Chem. 2013 Feb 14;56(3):660-70. doi: 10.1021/jm301495v. Epub 2013 Jan 29.


The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.

Baumli S, Hole AJ, Wang LZ, Noble ME, Endicott JA.

Structure. 2012 Oct 10;20(10):1788-95. doi: 10.1016/j.str.2012.08.011. Epub 2012 Sep 6.


The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508.

Baumli S, Hole AJ, Noble ME, Endicott JA.

ACS Chem Biol. 2012 May 18;7(5):811-6. doi: 10.1021/cb2004516. Epub 2012 Feb 10.


CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells.

Bettayeb K, Baunbæk D, Delehouze C, Loaëc N, Hole AJ, Baumli S, Endicott JA, Douc-Rasy S, Bénard J, Oumata N, Galons H, Meijer L.

Genes Cancer. 2010 Apr;1(4):369-80. doi: 10.1177/1947601910369817.

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