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Items: 1 to 50 of 257

1.

Tolerogenic Dendritic Cells Attenuate Experimental Autoimmune Antimyeloperoxidase Glomerulonephritis.

Odobasic D, Oudin V, Ito K, Gan PY, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2019 Aug 23. pii: ASN.2019030236. doi: 10.1681/ASN.2019030236. [Epub ahead of print]

PMID:
31444274
2.

Biologicals targeting T helper cell subset differentiating cytokines are effective in the treatment of murine anti-myeloperoxidase glomerulonephritis.

Gan PY, Chan A, Ooi JD, Dick J, Nagai K, O'Sullivan KM, Oudin V, Shim R, Kitching AR, Holdsworth SR.

Kidney Int. 2019 May 27. pii: S0085-2538(19)30531-9. doi: 10.1016/j.kint.2019.05.012. [Epub ahead of print]

PMID:
31443998
3.

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.

Ooi JD, Jiang JH, Eggenhuizen PJ, Chua LL, van Timmeren M, Loh KL, O'Sullivan KM, Gan PY, Zhong Y, Tsyganov K, Shochet LR, Ryan J, Stegeman CA, Fugger L, Reid HH, Rossjohn J, Heeringa P, Holdsworth SR, Peleg AY, Kitching AR.

Nat Commun. 2019 Jul 29;10(1):3392. doi: 10.1038/s41467-019-11255-0.

4.

Apoptotic Cell-Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN.

Gan PY, Godfrey AS, Ooi JD, O'Sullivan KM, Oudin V, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2019 Aug;30(8):1365-1374. doi: 10.1681/ASN.2018090955. Epub 2019 Jul 23.

PMID:
31337690
5.

HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen.

Huynh M, Eggenhuizen PJ, Olson GL, Rao NB, Self CR, Sun Y, Holdsworth SR, Kitching AR, Ooi JD.

J Autoimmun. 2019 Sep;103:102276. doi: 10.1016/j.jaut.2019.05.004. Epub 2019 May 16.

PMID:
31104947
6.

A simple score can identify kidney transplant recipients at high risk of severe infection over the following 2 years.

Dendle C, Polkinghorne KR, Mulley WR, Gan PY, Kanellis J, Stuart RL, Thursky K, Holdsworth SR.

Transpl Infect Dis. 2019 Jun;21(3):e13076. doi: 10.1111/tid.13076. Epub 2019 Apr 22.

PMID:
30875147
7.

The renal draining lymph nodes in acute inflammatory kidney disease.

Kitching AR, Holdsworth SR.

Kidney Int. 2019 Feb;95(2):254-256. doi: 10.1016/j.kint.2018.10.011.

PMID:
30665562
8.

Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients.

Dendle C, Stuart RL, Mulley WR, Polkinghorne KR, Gan PY, Kanellis J, Ngui J, Laurie K, Thursky K, Leung VK, Holdsworth SR.

Transplant Proc. 2018 Dec;50(10):3367-3370. doi: 10.1016/j.transproceed.2018.07.017.

PMID:
30577209
9.

Pneumococcal vaccination in adult solid organ transplant recipients: A review of current evidence.

Dendle C, Stuart RL, Mulley WR, Holdsworth SR.

Vaccine. 2018 Oct 8;36(42):6253-6261. doi: 10.1016/j.vaccine.2018.08.069. Epub 2018 Sep 11. Review.

PMID:
30217523
10.

HLA and kidney disease: from associations to mechanisms.

Robson KJ, Ooi JD, Holdsworth SR, Rossjohn J, Kitching AR.

Nat Rev Nephrol. 2018 Oct;14(10):636-655. doi: 10.1038/s41581-018-0057-8. Review.

PMID:
30206339
11.

OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis.

Odobasic D, Ruth AJ, Oudin V, Kitching AR, Holdsworth SR.

Nephrol Dial Transplant. 2019 Mar 1;34(3):429-441. doi: 10.1093/ndt/gfy177.

PMID:
29939347
12.

Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis.

O'Sullivan KM, Ford SL, Longano A, Kitching AR, Holdsworth SR.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1283-F1294. doi: 10.1152/ajprenal.00040.2018. Epub 2018 Jun 20.

PMID:
29923769
13.

Formyl peptide receptor activation inhibits the expansion of effector T cells and synovial fibroblasts and attenuates joint injury in models of rheumatoid arthritis.

Odobasic D, Jia Y, Kao W, Fan H, Wei X, Gu R, Ngo D, Kitching AR, Holdsworth SR, Morand EF, Yang YH.

Int Immunopharmacol. 2018 Aug;61:140-149. doi: 10.1016/j.intimp.2018.05.028. Epub 2018 Jun 4.

PMID:
29879657
14.

The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis.

Dick J, Gan PY, Kitching AR, Holdsworth SR.

PLoS One. 2018 Jan 9;13(1):e0190655. doi: 10.1371/journal.pone.0190655. eCollection 2018.

15.

Immune-mediated kidney disease in 2017: Progress in mechanisms and therapy for immunological kidney disease.

Holdsworth SR, Kitching AR.

Nat Rev Nephrol. 2018 Feb;14(2):76-78. doi: 10.1038/nrneph.2017.171. Epub 2017 Dec 18. Review. No abstract available.

PMID:
29292371
16.

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.

Dick J, Gan PY, Ford SL, Odobasic D, Alikhan MA, Loosen SH, Hall P, Westhorpe CL, Li A, Ooi JD, Woodruff TM, Mackay CR, Kitching AR, Hickey MJ, Holdsworth SR.

Kidney Int. 2018 Mar;93(3):615-625. doi: 10.1016/j.kint.2017.09.018. Epub 2017 Dec 12.

PMID:
29241626
17.

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy.

Sharma R, O'Sullivan KM, Holdsworth SR, Bardin PG, King PT.

J Vis Exp. 2017 Oct 19;(128). doi: 10.3791/56459.

PMID:
29155721
18.

Pathogenic Role for γδ T Cells in Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, Fujita T, Ooi JD, Alikhan MA, Dick J, Shim R, Odobasic D, O'Sullivan KM, Kitching AR, Holdsworth SR.

J Immunol. 2017 Nov 1;199(9):3042-3050. doi: 10.4049/jimmunol.1602025. Epub 2017 Sep 27.

19.

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung.

King PT, Sharma R, O'Sullivan KM, Callaghan J, Dousha L, Thomas B, Ruwanpura S, Lim S, Farmer MW, Jennings BR, Finsterbusch M, Brooks G, Selemidis S, Anderson GP, Holdsworth SR, Bardin PG.

Sci Rep. 2017 Sep 21;7(1):12128. doi: 10.1038/s41598-017-12474-5.

20.

ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing.

Hutton HL, Holdsworth SR, Kitching AR.

Semin Nephrol. 2017 Sep;37(5):418-435. doi: 10.1016/j.semnephrol.2017.05.016. Review.

PMID:
28863790
21.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR.

Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.

22.

Erratum to: Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli.

Holdsworth SR, Law CJ.

BMC Microbiol. 2017 Apr 12;17(1):91. doi: 10.1186/s12866-017-0995-5. No abstract available.

23.

T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ.

Oftedal BE, Ardesjö Lundgren B, Hamm D, Gan PY, Holdsworth SR, Hahn CN, Schreiber AW, Scott HS.

J Autoimmun. 2017 Jul;81:24-33. doi: 10.1016/j.jaut.2017.03.002. Epub 2017 Mar 18.

24.

Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis.

Ghali JR, O'Sullivan KM, Eggenhuizen PJ, Holdsworth SR, Kitching AR.

Nephron. 2017;135(3):207-223. doi: 10.1159/000453059. Epub 2016 Dec 10.

PMID:
27941331
25.

Induced regulatory T cells are phenotypically unstable and do not protect mice from rapidly progressive glomerulonephritis.

Ghali JR, Alikhan MA, Holdsworth SR, Kitching AR.

Immunology. 2017 Jan;150(1):100-114. doi: 10.1111/imm.12671. Epub 2016 Oct 10.

26.

Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury.

Snelgrove SL, Lo C, Hall P, Lo CY, Alikhan MA, Coates PT, Holdsworth SR, Hickey MJ, Kitching AR.

Transplantation. 2017 May;101(5):1013-1024. doi: 10.1097/TP.0000000000001427.

PMID:
27495751
27.

CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.

Chang J, Eggenhuizen P, O'Sullivan KM, Alikhan MA, Holdsworth SR, Ooi JD, Kitching AR.

J Am Soc Nephrol. 2017 Jan;28(1):47-55. doi: 10.1681/ASN.2015121356. Epub 2016 Jun 10.

28.

The NLRP3 inflammasome in kidney disease and autoimmunity.

Hutton HL, Ooi JD, Holdsworth SR, Kitching AR.

Nephrology (Carlton). 2016 Sep;21(9):736-44. doi: 10.1111/nep.12785. Review.

PMID:
27011059
29.

Biologics for the treatment of autoimmune renal diseases.

Holdsworth SR, Gan PY, Kitching AR.

Nat Rev Nephrol. 2016 Apr;12(4):217-31. doi: 10.1038/nrneph.2016.18. Epub 2016 Mar 7. Review.

PMID:
26949177
30.

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase.

Odobasic D, Kitching AR, Holdsworth SR.

J Immunol Res. 2016;2016:2349817. doi: 10.1155/2016/2349817. Epub 2016 Jan 20. Review.

31.

Targeting IL-17 and IL-23 in Immune Mediated Renal Disease.

Ghali JR, Holdsworth SR, Kitching AR.

Curr Med Chem. 2015;22(38):4341-65. Review.

PMID:
26521930
32.

The lung immune response to bacteria in chronic obstructive pulmonary disease.

King PT, Bardin PG, Holdsworth SR.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):902-3. doi: 10.1164/rccm.201506-1117LE. No abstract available.

PMID:
26426789
33.

Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 May;27(5):1321-33. doi: 10.1681/ASN.2014090906. Epub 2015 Sep 15.

34.

Regulatory T cells in immune-mediated renal disease.

Ghali JR, Wang YM, Holdsworth SR, Kitching AR.

Nephrology (Carlton). 2016 Feb;21(2):86-96. doi: 10.1111/nep.12574. Review.

PMID:
26206106
35.

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.

O'Sullivan KM, Lo CY, Summers SA, Elgass KD, McMillan PJ, Longano A, Ford SL, Gan PY, Kerr PG, Kitching AR, Holdsworth SR.

Kidney Int. 2015 Nov;88(5):1030-46. doi: 10.1038/ki.2015.202. Epub 2015 Jul 15.

PMID:
26176828
36.

Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment.

Alikhan MA, Summers SA, Gan PY, Chan AJ, Khouri MB, Ooi JD, Ghali JR, Odobasic D, Hickey MJ, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 Mar;27(3):706-14. doi: 10.1681/ASN.2014090927. Epub 2015 Jun 26.

37.

Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN.

Gan PY, Tan DS, Ooi JD, Alikhan MA, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 Feb;27(2):385-91. doi: 10.1681/ASN.2015010089. Epub 2015 Jun 5.

38.

Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis.

Ooi JD, Li M, Kourkoutzelos K, Yagita H, Azuma M, Holdsworth SR, Kitching AR.

Nephrology (Carlton). 2015 Dec;20(12):892-8. doi: 10.1111/nep.12532.

PMID:
26043977
39.

Cytokines: Names and Numbers You Should Care About.

Holdsworth SR, Gan PY.

Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2243-54. doi: 10.2215/CJN.07590714. Epub 2015 May 4. Review.

40.

FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis.

Ghali JR, O'Sullivan KM, Eggenhuizen PJ, Holdsworth SR, Kitching AR.

PLoS One. 2015 Apr 7;10(4):e0123118. doi: 10.1371/journal.pone.0123118. eCollection 2015.

41.

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression.

King PT, Sharma R, O'Sullivan K, Selemidis S, Lim S, Radhakrishna N, Lo C, Prasad J, Callaghan J, McLaughlin P, Farmer M, Steinfort D, Jennings B, Ngui J, Broughton BR, Thomas B, Essilfie AT, Hickey M, Holmes PW, Hansbro P, Bardin PG, Holdsworth SR.

PLoS One. 2015 Mar 20;10(3):e0120371. doi: 10.1371/journal.pone.0120371. eCollection 2015.

42.

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.

Odobasic D, Muljadi RC, O'Sullivan KM, Kettle AJ, Dickerhof N, Summers SA, Kitching AR, Holdsworth SR.

Arthritis Rheumatol. 2015 Jul;67(7):1868-80. doi: 10.1002/art.39109.

43.

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Gan PY, Ooi JD, Kitching AR, Holdsworth SR.

Curr Pharm Des. 2015;21(18):2380-90. Review.

PMID:
25777754
44.

T cell mediated autoimmune glomerular disease in mice.

Ooi JD, Gan PY, Odobasic D, Holdsworth SR, Kitching AR.

Curr Protoc Immunol. 2014 Nov 3;107:15.27.1-19. doi: 10.1002/0471142735.im1527s107. Review.

PMID:
25367126
45.

Glomerulonephritis Induced by Heterologous Anti-GBM Globulin as a Planted Foreign Antigen.

Odobasic D, Ghali JR, O'Sullivan KM, Holdsworth SR, Kitching AR.

Curr Protoc Immunol. 2014 Aug 1;106:15.26.1-20. doi: 10.1002/0471142735.im1526s106. Review.

PMID:
25081909
46.

FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis.

Ooi JD, Gan PY, Chen T, Eggenhuizen PJ, Chang J, Alikhan MA, Odobasic D, Holdsworth SR, Kitching AR.

Kidney Int. 2014 Dec;86(6):1140-9. doi: 10.1038/ki.2014.189. Epub 2014 May 28.

47.

Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis.

Odobasic D, Yang Y, Muljadi RC, O'Sullivan KM, Kao W, Smith M, Morand EF, Holdsworth SR.

Arthritis Rheumatol. 2014 Apr;66(4):907-17. doi: 10.1002/art.38299.

48.

A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress.

Paul S, Alegre KO, Holdsworth SR, Rice M, Brown JA, McVeigh P, Kelly SM, Law CJ.

Mol Microbiol. 2014 May;92(4):872-84. doi: 10.1111/mmi.12597. Epub 2014 Apr 13.

49.

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.

Chan AJ, Alikhan MA, Odobasic D, Gan PY, Khouri MB, Steinmetz OM, Mansell AS, Kitching AR, Holdsworth SR, Summers SA.

Am J Pathol. 2014 May;184(5):1411-8. doi: 10.1016/j.ajpath.2014.01.023. Epub 2014 Mar 14.

50.

Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane.

Summers SA, Odobasic D, Khouri MB, Steinmetz OM, Yang Y, Holdsworth SR, Kitching AR.

Clin Exp Immunol. 2014 Jun;176(3):341-50. doi: 10.1111/cei.12287.

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