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Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

Zeeshan M, Shilliday F, Liu T, Abel S, Mourier T, Ferguson DJP, Rea E, Stanway RR, Roques M, Williams D, Daniel E, Brady D, Roberts AJ, Holder AA, Pain A, Le Roch KG, Moores CA, Tewari R.

PLoS Pathog. 2019 Oct 10;15(10):e1008048. doi: 10.1371/journal.ppat.1008048. eCollection 2019 Oct.


Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission.

Zeeshan M, Ferguson DJ, Abel S, Burrrell A, Rea E, Brady D, Daniel E, Delves M, Vaughan S, Holder AA, Le Roch KG, Moores CA, Tewari R.

Life Sci Alliance. 2019 Aug 13;2(4). pii: e201900488. doi: 10.26508/lsa.201900488. Print 2019 Aug.


Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages.

Wall RJ, Zeeshan M, Katris NJ, Limenitakis R, Rea E, Stock J, Brady D, Waller RF, Holder AA, Tewari R.

Cell Microbiol. 2019 Oct;21(10):e13082. doi: 10.1111/cmi.13082. Epub 2019 Jul 23.


Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Knuepfer E, Wright KE, Kumar Prajapati S, Rawlinson TA, Mohring F, Koch M, Lyth OR, Howell SA, Villasis E, Snijders AP, Moon RW, Draper SJ, Rosanas-Urgell A, Higgins MK, Baum J, Holder AA.

PLoS Pathog. 2019 Jun 11;15(6):e1007809. doi: 10.1371/journal.ppat.1007809. eCollection 2019 Jun.


Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA.

Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.


Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation.

Roques M, Stanway RR, Rea EI, Markus R, Brady D, Holder AA, Guttery DS, Tewari R.

Biol Open. 2019 Jan 29;8(1). pii: bio036822. doi: 10.1242/bio.036822.


Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors.

Hurtado M, Sankpal UT, Kaba A, Mahammad S, Chhabra J, Brown DT, Gurung RK, Holder AA, Vishwanatha JK, Basha R.

Cell Physiol Biochem. 2018;51(4):1894-1907. doi: 10.1159/000495715. Epub 2018 Nov 30.


Low plasma haptoglobin is a risk factor for life-threatening childhood severe malarial anemia and not an exclusive consequence of hemolysis.

Abah SE, Burté F, Marquet S, Brown BJ, Akinkunmi F, Oyinloye G, Afolabi NK, Omokhodion S, Lagunju I, Shokunbi WA, Wahlgren M, Dessein H, Argiro L, Dessein AJ, Noyvert B, Hunt L, Elgar G, Sodeinde O, Holder AA, Fernandez-Reyes D.

Sci Rep. 2018 Dec 3;8(1):17527. doi: 10.1038/s41598-018-35944-w.


Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives.

Abzianidze VV, Zakharenkova SA, Moiseeva NI, Beltyukov PP, Polukeev VA, Dubrovskii YA, Kuznetsov VA, Trishin YG, Mejia JE, Holder AA.

Bioorg Med Chem Lett. 2019 Jan 1;29(1):59-61. doi: 10.1016/j.bmcl.2018.11.003. Epub 2018 Nov 9.


Author Correction: Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.

Wall RJ, Ferguson DJP, Freville A, Franke-Fayard B, Brady D, Zeeshan M, Bottrill AR, Wheatley S, Fry AM, Janse CJ, Yamano H, Holder AA, Guttery DS, Tewari R.

Sci Rep. 2018 Aug 21;8(1):12814. doi: 10.1038/s41598-018-30924-6.


Ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase.

Altaf AA, Hamayun M, Lal B, Tahir MN, Holder AA, Badshah A, Crans DC.

Dalton Trans. 2018 Aug 29;47(34):11769-11781. doi: 10.1039/c8dt01726c.


Polynuclear ruthenium organometallic complexes containing a 1,3,5-triazine ligand: synthesis, DNA interaction, and biological activity.

Beckford FA, Niece MB, Lassiter BP, Beebe SJ, Holder AA.

J Biol Inorg Chem. 2018 Dec;23(8):1205-1217. doi: 10.1007/s00775-018-1599-8. Epub 2018 Jul 23.


Copper-tolfenamic acid: evaluation of stability and anti-cancer activity.

Hurtado M, Sankpal UT, Chhabra J, Brown DT, Maram R, Patel R, Gurung RK, Simecka J, Holder AA, Basha R.

Invest New Drugs. 2019 Feb;37(1):27-34. doi: 10.1007/s10637-018-0594-9. Epub 2018 May 15.


Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.

Wall RJ, Ferguson DJP, Freville A, Franke-Fayard B, Brady D, Zeeshan M, Bottrill AR, Wheatley S, Fry AM, Janse CJ, Yamano H, Holder AA, Guttery DS, Tewari R.

Sci Rep. 2018 Apr 4;8(1):5610. doi: 10.1038/s41598-018-23871-9. Erratum in: Sci Rep. 2018 Aug 21;8(1):12814.


N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action.

Schlott AC, Holder AA, Tate EW.

ACS Infect Dis. 2018 Apr 13;4(4):449-457. doi: 10.1021/acsinfecdis.7b00203. Epub 2018 Feb 2. Review.


A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line.

Benavente ED, de Sessions PF, Moon RW, Grainger M, Holder AA, Blackman MJ, Roper C, Drakeley CJ, Pain A, Sutherland CJ, Hibberd ML, Campino S, Clark TG.

Int J Parasitol. 2018 Mar;48(3-4):191-196. doi: 10.1016/j.ijpara.2017.09.008. Epub 2017 Dec 16.


Plasmodium Peekaboo: PK4 Mediates Parasite Latency.

Rea E, Holder AA, Tewari R.

Cell Host Microbe. 2017 Dec 13;22(6):724-725. doi: 10.1016/j.chom.2017.11.011.


Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development.

Saini E, Zeeshan M, Brady D, Pandey R, Kaiser G, Koreny L, Kumar P, Thakur V, Tatiya S, Katris NJ, Limenitakis RS, Kaur I, Green JL, Bottrill AR, Guttery DS, Waller RF, Heussler V, Holder AA, Mohmmed A, Malhotra P, Tewari R.

Sci Rep. 2017 Nov 14;7(1):15577. doi: 10.1038/s41598-017-15781-z.


Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.

Dutta S, Celestine MJ, Khanal S, Huddleston A, Simms C, Arca JF, Mitra A, Heller L, Kraj PJ, Ledizet M, Anderson JF, Neelakanta G, Holder AA, Sultana H.

Biochim Biophys Acta Gen Subj. 2018 Jan;1862(1):40-50. doi: 10.1016/j.bbagen.2017.10.004. Epub 2017 Oct 13.


Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations.

Diez Benavente E, Florez de Sessions P, Moon RW, Holder AA, Blackman MJ, Roper C, Drakeley CJ, Pain A, Sutherland CJ, Hibberd ML, Campino S, Clark TG.

PLoS Genet. 2017 Sep 18;13(9):e1007008. doi: 10.1371/journal.pgen.1007008. eCollection 2017 Sep.


Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA.

J Biol Chem. 2017 Oct 27;292(43):17857-17875. doi: 10.1074/jbc.M117.802769. Epub 2017 Sep 11.


Generating conditional gene knockouts in Plasmodium - a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9.

Knuepfer E, Napiorkowska M, van Ooij C, Holder AA.

Sci Rep. 2017 Jun 20;7(1):3881. doi: 10.1038/s41598-017-03984-3.


Kinetics and mechanism of the oxidation of a cobaloxime by sodium hypochlorite in aqueous solution: Is it an outer-sphere mechanism?

Celestine MJ, Joseph LS, Holder AA.

Inorganica Chim Acta. 2017 Jan 1;454:254-265. doi: 10.1016/j.ica.2016.07.013.


Synthesis and characterization of azo-guanidine based alcoholic media naked eye DNA sensor.

Altaf AA, Hashmat U, Yousaf M, Lal B, Ullah S, Holder AA, Badshah A.

R Soc Open Sci. 2016 Nov 2;3(11):160351. doi: 10.1098/rsos.160351. eCollection 2016 Nov.


Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and Research.

Ścibior A, Llopis J, Holder AA, Altamirano-Lozano M.

Oxid Med Cell Longev. 2016;2016:7612347. doi: 10.1155/2016/7612347. Epub 2016 Aug 29. No abstract available.


The Binding of Plasmodium falciparum Adhesins and Erythrocyte Invasion Proteins to Aldolase Is Enhanced by Phosphorylation.

Diaz SA, Martin SR, Howell SA, Grainger M, Moon RW, Green JL, Holder AA.

PLoS One. 2016 Sep 8;11(9):e0161850. doi: 10.1371/journal.pone.0161850. eCollection 2016.


Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi.

Moon RW, Sharaf H, Hastings CH, Ho YS, Nair MB, Rchiad Z, Knuepfer E, Ramaprasad A, Mohring F, Amir A, Yusuf NA, Hall J, Almond N, Lau YL, Pain A, Blackman MJ, Holder AA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7231-6. doi: 10.1073/pnas.1522469113. Epub 2016 Jun 14.


Computational, electrochemical, and spectroscopic studies of two mononuclear cobaloximes: the influence of an axial pyridine and solvent on the redox behaviour and evidence for pyridine coordination to cobalt(i) and cobalt(ii) metal centres.

Lawrence MA, Celestine MJ, Artis ET, Joseph LS, Esquivel DL, Ledbetter AJ, Cropek DM, Jarrett WL, Bayse CA, Brewer MI, Holder AA.

Dalton Trans. 2016 Jun 21;45(25):10326-42. doi: 10.1039/c6dt01583b.


Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.

Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ, Kamuyu G, Goulding D, Bustamante LY, Miles A, Moore SC, Dougan G, Holder AA, Kwiatkowski DP, Rayner JC, Pleass RJ, Wright GJ.

J Biol Chem. 2016 Jul 1;291(27):14285-99. doi: 10.1074/jbc.M116.722074. Epub 2016 May 12.


The Use of Inorganic Compounds in Photodynamic Therapy: Improvements in Methods and Photosensitizer Design

Boodram S, Bullock JL, Rambaran VH, Holder AA.

Recent Pat Nanotechnol. 2016 Feb 3;11(1):3 - 14.


Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.

Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW.

Medchemcomm. 2015 Oct 8;6(10):1767-1772. Epub 2015 Aug 19.


A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.

Sandhaus S, Taylor R, Edwards T, Huddleston A, Wooten Y, Venkatraman R, Weber RT, González-Sarrías A, Martin PM, Cagle P, Tse-Dinh YC, Beebe SJ, Seeram N, Holder AA.

Inorg Chem Commun. 2016 Feb;64:45-49.


Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.

Green JL, Moon RW, Whalley D, Bowyer PW, Wallace C, Rochani A, Nageshan RK, Howell SA, Grainger M, Jones HM, Ansell KH, Chapman TM, Taylor DL, Osborne SA, Baker DA, Tatu U, Holder AA.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1464-75. doi: 10.1128/AAC.01748-15.


Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.

Roques M, Wall RJ, Douglass AP, Ramaprasad A, Ferguson DJ, Kaindama ML, Brusini L, Joshi N, Rchiad Z, Brady D, Guttery DS, Wheatley SP, Yamano H, Holder AA, Pain A, Wickstead B, Tewari R.

PLoS Pathog. 2015 Nov 13;11(11):e1005273. doi: 10.1371/journal.ppat.1005273. eCollection 2015 Nov.


Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.

Abzianidze VV, Prokofieva DS, Chisty LA, Bolshakova KP, Berestetskiy AO, Panikorovskii TL, Bogachenkov AS, Holder AA.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5566-9. doi: 10.1016/j.bmcl.2015.10.048. Epub 2015 Oct 19.


Commit and Transmit: Molecular Players in Plasmodium Sexual Development and Zygote Differentiation.

Guttery DS, Roques M, Holder AA, Tewari R.

Trends Parasitol. 2015 Dec;31(12):676-685. doi: 10.1016/ Epub 2015 Oct 1. Review.


Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.

Alam MM, Solyakov L, Bottrill AR, Flueck C, Siddiqui FA, Singh S, Mistry S, Viskaduraki M, Lee K, Hopp CS, Chitnis CE, Doerig C, Moon RW, Green JL, Holder AA, Baker DA, Tobin AB.

Nat Commun. 2015 Jul 7;6:7285. doi: 10.1038/ncomms8285.


Alternative Protein Secretion in the Malaria Parasite Plasmodium falciparum.

Thavayogarajah T, Gangopadhyay P, Rahlfs S, Becker K, Lingelbach K, Przyborski JM, Holder AA.

PLoS One. 2015 Apr 24;10(4):e0125191. doi: 10.1371/journal.pone.0125191. eCollection 2015.


Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites.

Lasonder E, Green JL, Grainger M, Langsley G, Holder AA.

Proteomics. 2015 Aug;15(15):2716-29. doi: 10.1002/pmic.201400508. Epub 2015 May 19. Review.


The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA.

J Biol Chem. 2015 May 8;290(19):12147-64. doi: 10.1074/jbc.M115.637694. Epub 2015 Mar 23.


Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ.

Mol Microbiol. 2015 Apr;96(2):368-87. doi: 10.1111/mmi.12941. Epub 2015 Feb 11.


A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Otto TD, Böhme U, Jackson AP, Hunt M, Franke-Fayard B, Hoeijmakers WA, Religa AA, Robertson L, Sanders M, Ogun SA, Cunningham D, Erhart A, Billker O, Khan SM, Stunnenberg HG, Langhorne J, Holder AA, Waters AP, Newbold CI, Pain A, Berriman M, Janse CJ.

BMC Biol. 2014 Oct 30;12:86. doi: 10.1186/s12915-014-0086-0.


Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.

Diaz SA, Martin SR, Grainger M, Howell SA, Green JL, Holder AA.

Mol Biochem Parasitol. 2014 Oct;197(1-2):9-14. doi: 10.1016/j.molbiopara.2014.09.006. Epub 2014 Sep 27. Review.


Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation.

Kumar K, Schniper S, González-Sarrías A, Holder AA, Sanders N, Sullivan D, Jarrett WL, Davis K, Bai F, Seeram NP, Kumar V.

Eur J Med Chem. 2014 Oct 30;86:81-6. doi: 10.1016/j.ejmech.2014.08.054. Epub 2014 Aug 16.


Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.

Ansell KH, Jones HM, Whalley D, Hearn A, Taylor DL, Patin EC, Chapman TM, Osborne SA, Wallace C, Birchall K, Large J, Bouloc N, Smiljanic-Hurley E, Clough B, Moon RW, Green JL, Holder AA.

Antimicrob Agents Chemother. 2014 Oct;58(10):6032-43. doi: 10.1128/AAC.02959-14. Epub 2014 Jul 28.


Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R.

Cell Host Microbe. 2014 Jul 9;16(1):128-40. doi: 10.1016/j.chom.2014.05.020.


Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

Chapman TM, Osborne SA, Wallace C, Birchall K, Bouloc N, Jones HM, Ansell KH, Taylor DL, Clough B, Green JL, Holder AA.

J Med Chem. 2014 Apr 24;57(8):3570-87. doi: 10.1021/jm500342d. Epub 2014 Apr 11.


Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).

Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW.

J Med Chem. 2014 Mar 27;57(6):2773-88. doi: 10.1021/jm500066b. Epub 2014 Mar 18.


Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.

Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT.

Cell Microbiol. 2014 May;16(5):612-20. doi: 10.1111/cmi.12275. Epub 2014 Mar 12. Review.


Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes.

Ezougou CN, Ben-Rached F, Moss DK, Lin JW, Black S, Knuepfer E, Green JL, Khan SM, Mukhopadhyay A, Janse CJ, Coppens I, Yera H, Holder AA, Langsley G.

PLoS One. 2014 Feb 3;9(2):e87695. doi: 10.1371/journal.pone.0087695. eCollection 2014.

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