Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26

1.

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors.

Pemberton N, Mogemark M, Arlbrandt S, Bold P, Cox RJ, Gardelli C, Holden NS, Karabelas K, Karlsson J, Lever S, Li X, Lindmark H, Norberg M, Perry MWD, Petersen J, Rodrigo Blomqvist S, Thomas M, Tyrchan C, Westin Eriksson A, Zlatoidsky P, Öster L.

J Med Chem. 2018 Jun 28;61(12):5435-5441. doi: 10.1021/acs.jmedchem.8b00447. Epub 2018 Jun 18.

PMID:
29852070
2.

Pulmonary Rehabilitation, Exercise, and Exacerbations of COPD: Known Clinical Efficacy and the Unknown Mechanisms.

Jenkins AR, Holden NS, Jones AW.

Chest. 2018 May;153(5):1281-1282. doi: 10.1016/j.chest.2018.01.054. No abstract available.

PMID:
29731043
3.

Efficacy of supervised maintenance exercise following pulmonary rehabilitation on health care use: a systematic review and meta-analysis.

Jenkins AR, Gowler H, Curtis F, Holden NS, Bridle C, Jones AW.

Int J Chron Obstruct Pulmon Dis. 2018 Jan 10;13:257-273. doi: 10.2147/COPD.S150650. eCollection 2018. Review.

4.

Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.

Perry MWD, Björhall K, Bonn B, Carlsson J, Chen Y, Eriksson A, Fredlund L, Hao H, Holden NS, Karabelas K, Lindmark H, Liu F, Pemberton N, Petersen J, Rodrigo Blomqvist S, Smith RW, Svensson T, Terstiege I, Tyrchan C, Yang W, Zhao S, Öster L.

J Med Chem. 2017 Jun 22;60(12):5057-5071. doi: 10.1021/acs.jmedchem.7b00401. Epub 2017 Jun 7.

PMID:
28520415
5.

Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration.

Shariff S, Shelfoon C, Holden NS, Traves SL, Wiehler S, Kooi C, Proud D, Leigh R.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):796-803. doi: 10.1165/rcmb.2016-0252OC.

PMID:
28257236
6.

Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2014 Jan;348(1):12-24. doi: 10.1124/jpet.113.204586. Epub 2013 Oct 25.

PMID:
24163441
7.

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11.

8.

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide.

Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R.

Br J Pharmacol. 2012 Mar;165(6):1737-1747. doi: 10.1111/j.1476-5381.2011.01620.x.

9.

Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists.

Rider CF, King EM, Holden NS, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. doi: 10.1124/jpet.111.181016. Epub 2011 May 27.

PMID:
21622733
10.

Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action.

Holden NS, Rider CF, Bell MJ, Velayudhan J, King EM, Kaur M, Salmon M, Giembycz MA, Newton R.

Br J Pharmacol. 2010 May;160(2):410-20. doi: 10.1111/j.1476-5381.2010.00708.x.

11.

Principles and problems of the electrophoretic mobility shift assay.

Holden NS, Tacon CE.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):7-14. doi: 10.1016/j.vascn.2010.03.002. Epub 2010 Mar 27.

PMID:
20348003
12.

Glucocorticoids inhibit IL-1beta-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1.

Newton R, King EM, Gong W, Rider CF, Staples KJ, Holden NS, Bergmann MW.

Biochem J. 2010 Mar 15;427(1):113-24. doi: 10.1042/BJ20091038.

PMID:
20100175
13.

Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B.

Tacon CE, Wiehler S, Holden NS, Newton R, Proud D, Leigh R.

Am J Respir Cell Mol Biol. 2010 Aug;43(2):201-9. doi: 10.1165/rcmb.2009-0216OC. Epub 2009 Sep 25.

PMID:
19783786
14.

Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK.

King EM, Holden NS, Gong W, Rider CF, Newton R.

J Biol Chem. 2009 Sep 25;284(39):26803-15. doi: 10.1074/jbc.M109.028381. Epub 2009 Jul 31.

15.

Regulation of tristetraprolin expression by interleukin-1 beta and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-kappa B and p38 mitogen-activated protein kinase.

King EM, Kaur M, Gong W, Rider CF, Holden NS, Newton R.

J Pharmacol Exp Ther. 2009 Aug;330(2):575-85. doi: 10.1124/jpet.109.151423. Epub 2009 May 12.

PMID:
19435930
16.

Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway.

Zaheer RS, Koetzler R, Holden NS, Wiehler S, Proud D.

J Immunol. 2009 Apr 15;182(8):4854-64. doi: 10.4049/jimmunol.0802401.

17.

Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells.

Koetzler R, Zaheer RS, Wiehler S, Holden NS, Giembycz MA, Proud D.

J Allergy Clin Immunol. 2009 Jan;123(1):201-208.e9. doi: 10.1016/j.jaci.2008.09.041. Epub 2008 Nov 4.

PMID:
18986693
18.

Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.

Kaur M, Holden NS, Wilson SM, Sukkar MB, Chung KF, Barnes PJ, Newton R, Giembycz MA.

Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L505-14. doi: 10.1152/ajplung.00046.2008. Epub 2008 Jun 27.

19.

Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C.

Holden NS, Squires PE, Kaur M, Bland R, Jones CE, Newton R.

Cell Signal. 2008 Jul;20(7):1338-48. doi: 10.1016/j.cellsig.2008.03.001. Epub 2008 Mar 18.

PMID:
18436431
20.

Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.

Holden NS, Gong W, King EM, Kaur M, Giembycz MA, Newton R.

Br J Pharmacol. 2007 Nov;152(6):891-902. Epub 2007 Sep 24.

21.

Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?

Newton R, Holden NS.

Mol Pharmacol. 2007 Oct;72(4):799-809. Epub 2007 Jul 10. Review.

PMID:
17622575
22.

Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.

Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, Barnes PJ.

J Pharmacol Exp Ther. 2007 May;321(2):734-42. Epub 2007 Feb 22.

PMID:
17322026
23.

Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids.

Chivers JE, Gong W, King EM, Seybold J, Mak JC, Donnelly LE, Holden NS, Newton R.

Mol Pharmacol. 2006 Dec;70(6):2084-95. Epub 2006 Sep 20.

PMID:
16988013
25.

Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding.

Catley MC, Cambridge LM, Nasuhara Y, Ito K, Chivers JE, Beaton A, Holden NS, Bergmann MW, Barnes PJ, Newton R.

J Biol Chem. 2004 Apr 30;279(18):18457-66. Epub 2004 Feb 19.

26.

ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK.

Holden NS, Catley MC, Cambridge LM, Barnes PJ, Newton R.

Eur J Biochem. 2004 Feb;271(4):785-91.

Supplemental Content

Loading ...
Support Center