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Items: 1 to 50 of 151

1.

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchêne S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ.

Nat Genet. 2019 Jun;51(6):1035-1043. doi: 10.1038/s41588-019-0417-8. Epub 2019 May 27.

PMID:
31133745
2.

Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States.

Mohamed N, Timofeyeva Y, Jamrozy D, Rojas E, Hao L, Silmon de Monerri NC, Hawkins J, Singh G, Cai B, Liberator P, Sebastian S, Donald RGK, Scully IL, Jones CH, Creech CB, Thomsen I, Parkhill J, Peacock SJ, Jansen KU, Holden MTG, Anderson AS.

PLoS One. 2019 Jan 14;14(1):e0208356. doi: 10.1371/journal.pone.0208356. eCollection 2019.

3.

Chlorhexidine and octenidine use, carriage of qac genes, and reduced antiseptic susceptibility in methicillin-resistant Staphylococcus aureus isolates from a healthcare network.

Htun HL, Hon PY, Holden MTG, Ang B, Chow A.

Clin Microbiol Infect. 2019 Jan 6. pii: S1198-743X(18)30855-3. doi: 10.1016/j.cmi.2018.12.036. [Epub ahead of print]

PMID:
30625411
4.

Antimicrobial resistance in atopic dermatitis: Need for an urgent rethink.

Harkins CP, Holden MTG, Irvine AD.

Ann Allergy Asthma Immunol. 2019 Mar;122(3):236-240. doi: 10.1016/j.anai.2018.11.027. Epub 2018 Nov 29. No abstract available.

PMID:
30503409
5.

Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes.

Zapotoczna M, Riboldi GP, Moustafa AM, Dickson E, Narechania A, Morrissey JA, Planet PJ, Holden MTG, Waldron KJ, Geoghegan JA.

MBio. 2018 Oct 16;9(5). pii: e00550-18. doi: 10.1128/mBio.00550-18.

6.

Global Scale Dissemination of ST93: A Divergent Staphylococcus aureus Epidemic Lineage That Has Recently Emerged From Remote Northern Australia.

van Hal SJ, Steinig EJ, Andersson P, Holden MTG, Harris SR, Nimmo GR, Williamson DA, Heffernan H, Ritchie SR, Kearns AM, Ellington MJ, Dickson E, de Lencastre H, Coombs GW, Bentley SD, Parkhill J, Holt DC, Giffard PM, Tong SYC.

Front Microbiol. 2018 Jul 9;9:1453. doi: 10.3389/fmicb.2018.01453. eCollection 2018.

7.

Gene exchange drives the ecological success of a multi-host bacterial pathogen.

Richardson EJ, Bacigalupe R, Harrison EM, Weinert LA, Lycett S, Vrieling M, Robb K, Hoskisson PA, Holden MTG, Feil EJ, Paterson GK, Tong SYC, Shittu A, van Wamel W, Aanensen DM, Parkhill J, Peacock SJ, Corander J, Holmes M, Fitzgerald JR.

Nat Ecol Evol. 2018 Sep;2(9):1468-1478. doi: 10.1038/s41559-018-0617-0. Epub 2018 Jul 23.

8.

Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility.

Krishna A, Holden MTG, Peacock SJ, Edwards AM, Wigneshweraraj S.

Microbiology. 2018 Sep;164(9):1189-1195. doi: 10.1099/mic.0.000695. Epub 2018 Jul 20.

9.

Comparative sequence analysis of the capsular polysaccharide loci of Actinobacillus pleuropneumoniae serovars 1-18, and development of two multiplex PCRs for comprehensive capsule typing.

Bossé JT, Li Y, Fernandez Crespo R, Lacouture S, Gottschalk M, Sárközi R, Fodor L, Casas Amoribieta M, Angen Ø, Nedbalcova K, Holden MTG, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR; BRaDP1T consortium.

Vet Microbiol. 2018 Jul;220:83-89. doi: 10.1016/j.vetmic.2018.05.011. Epub 2018 May 20.

10.

An Outbreak of Streptococcus pyogenes in a Mental Health Facility: Advantage of Well-Timed Whole-Genome Sequencing Over emm Typing.

Bergin SM, Periaswamy B, Barkham T, Chua HC, Mok YM, Fung DSS, Su AHC, Lee YL, Chua MLI, Ng PY, Soon WJW, Chu CW, Tan SL, Meehan M, Ang BSP, Leo YS, Holden MTG, De P, Hsu LY, Chen SL, de Sessions PF, Marimuthu K.

Infect Control Hosp Epidemiol. 2018 Jul;39(7):852-860. doi: 10.1017/ice.2018.101. Epub 2018 May 9.

PMID:
29739475
11.

The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis.

Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG.

Br J Dermatol. 2018 Oct;179(4):951-958. doi: 10.1111/bjd.16722. Epub 2018 Jul 24.

12.

Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA.

Hao L, Holden MTG, Wang X, Andrew L, Wellnitz S, Hu F, Whaley M, Sammons S, Knipe K, Frace M, McNamara LA, Liberator P, Anderson AS.

Microb Genom. 2018 Apr;4(4). doi: 10.1099/mgen.0.000155. Epub 2018 Apr 4.

13.

Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis.

Bossé JT, Li Y, Sárközi R, Fodor L, Lacouture S, Gottschalk M, Casas Amoribieta M, Angen Ø, Nedbalcova K, Holden MTG, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR; BRaDP1T consortium.

Vet Microbiol. 2018 Apr;217:1-6. doi: 10.1016/j.vetmic.2018.02.019. Epub 2018 Feb 16.

14.

Pseudomonas aeruginosa intensive care unit outbreak: winnowing of transmissions with molecular and genomic typing.

Parcell BJ, Oravcova K, Pinheiro M, Holden MTG, Phillips G, Turton JF, Gillespie SH.

J Hosp Infect. 2018 Mar;98(3):282-288. doi: 10.1016/j.jhin.2017.12.005. Epub 2017 Dec 8.

15.

Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390.

Casabona MG, Kneuper H, Alferes de Lima D, Harkins CP, Zoltner M, Hjerde E, Holden MTG, Palmer T.

Microbiology. 2017 Dec;163(12):1839-1850. doi: 10.1099/mic.0.000579. Epub 2017 Nov 24.

16.

Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system.

Casabona MG, Buchanan G, Zoltner M, Harkins CP, Holden MTG, Palmer T.

Microbiology. 2017 Nov 22. doi: 10.1099/mic.0.000580. [Epub ahead of print]

17.

Whole-genome sequencing to investigate a non-clonal melioidosis cluster on a remote Australian island.

Sarovich DS, Chapple SNJ, Price EP, Mayo M, Holden MTG, Peacock SJ, Currie BJ.

Microb Genom. 2017 Jun 13;3(8):e000117. doi: 10.1099/mgen.0.000117. eCollection 2017 Aug.

18.

Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns.

Donker T, Reuter S, Scriberras J, Reynolds R, Brown NM, Török ME, James R, Network EOEMR, Aanensen DM, Bentley SD, Holden MTG, Parkhill J, Spratt BG, Peacock SJ, Feil EJ, Grundmann H.

Microb Genom. 2017 Jul 4;3(7):e000113. doi: 10.1099/mgen.0.000113. eCollection 2017 Jul.

19.

The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare.

Harkins CP, Pettigrew KA, Oravcová K, Gardner J, Hearn RMR, Rice D, Mather AE, Parkhill J, Brown SJ, Proby CM, Holden MTG.

J Invest Dermatol. 2018 Feb;138(2):336-343. doi: 10.1016/j.jid.2017.09.023. Epub 2017 Sep 23.

20.

Corrigendum: Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland.

Reuter S, Török ME, Holden MTG, Reynolds R, Raven KE, Blane B, Donker T, Bentley SD, Aanensen DM, Grundmann H, Feil EJ, Spratt BG, Parkhill J, Peacock SJ.

Genome Res. 2017 Sep;27(9):1622. doi: 10.1101/gr.228155.117. No abstract available.

21.

Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases.

Björnsdóttir S, Harris SR, Svansson V, Gunnarsson E, Sigurðardóttir ÓG, Gammeljord K, Steward KF, Newton JR, Robinson C, Charbonneau ARL, Parkhill J, Holden MTG, Waller AS.

MBio. 2017 Aug 1;8(4). pii: e00826-17. doi: 10.1128/mBio.00826-17.

22.

Parallel DNA Synthesis on Poly(ethylene terephthalate).

Holden MT, Carter MCD, Ting SK, Lynn DM, Smith LM.

Chembiochem. 2017 Oct 5;18(19):1914-1916. doi: 10.1002/cbic.201700321. Epub 2017 Aug 30.

23.

Diversity of Streptococcus equi subsp. zooepidemicus strains isolated from the Spanish sheep and goat population and the identification, function and prevalence of a novel arbutin utilisation system.

Steward KF, Robinson C, Holden MTG, Harris SR, Ros AF, Pérez GC, Baselga R, Waller AS.

Vet Microbiol. 2017 Aug;207:231-238. doi: 10.1016/j.vetmic.2017.06.020. Epub 2017 Jul 1.

PMID:
28757029
24.

Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice.

Harkins CP, Pichon B, Doumith M, Parkhill J, Westh H, Tomasz A, de Lencastre H, Bentley SD, Kearns AM, Holden MTG.

Genome Biol. 2017 Jul 20;18(1):130. doi: 10.1186/s13059-017-1252-9.

25.

MRSA Transmission Dynamics Among Interconnected Acute, Intermediate-Term, and Long-Term Healthcare Facilities in Singapore.

Chow A, Lim VW, Khan A, Pettigrew K, Lye DCB, Kanagasabai K, Phua K, Krishnan P, Ang B, Marimuthu K, Hon PY, Koh J, Leong I, Parkhill J, Hsu LY, Holden MTG.

Clin Infect Dis. 2017 May 15;64(suppl_2):S76-S81. doi: 10.1093/cid/cix072. Erratum in: Clin Infect Dis. 2017 Sep 15;65(6):1057.

26.

2015 Epidemic of Severe Streptococcus agalactiae Sequence Type 283 Infections in Singapore Associated With the Consumption of Raw Freshwater Fish: A Detailed Analysis of Clinical, Epidemiological, and Bacterial Sequencing Data.

Kalimuddin S, Chen SL, Lim CTK, Koh TH, Tan TY, Kam M, Wong CW, Mehershahi KS, Chau ML, Ng LC, Tang WY, Badaruddin H, Teo J, Apisarnthanarak A, Suwantarat N, Ip M, Holden MTG, Hsu LY, Barkham T; Singapore Group B Streptococcus Consortium.

Clin Infect Dis. 2017 May 15;64(suppl_2):S145-S152. doi: 10.1093/cid/cix021.

PMID:
28475781
27.

Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus.

Afshar B, Turner CE, Lamagni TL, Smith KC, Al-Shahib A, Underwood A, Holden MTG, Efstratiou A, Sriskandan S.

Virulence. 2017 Oct 3;8(7):1390-1400. doi: 10.1080/21505594.2017.1325070. Epub 2017 May 1.

28.

ST3268: a geographically widespread primate MRSA clone.

Hsu LY, Holden MTG, Koh TH, Pettigrew KA, Cao D, Hon PY, Sergio DM, Pena E, Ogden BE.

J Antimicrob Chemother. 2017 Aug 1;72(8):2401-2403. doi: 10.1093/jac/dkx120. No abstract available.

PMID:
28444294
29.

Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity.

Chapple SNJ, Sarovich DS, Holden MTG, Peacock SJ, Buller N, Golledge C, Mayo M, Currie BJ, Price EP.

Microb Genom. 2016 Jul 11;2(7):e000067. doi: 10.1099/mgen.0.000067. eCollection 2016 Jul.

30.

Pan-genomic perspective on the evolution of the Staphylococcus aureus USA300 epidemic.

Jamrozy DM, Harris SR, Mohamed N, Peacock SJ, Tan CY, Parkhill J, Anderson AS, Holden MTG.

Microb Genom. 2016 May 31;2(5):e000058. doi: 10.1099/mgen.0.000058. eCollection 2016 May.

31.

Microreact: visualizing and sharing data for genomic epidemiology and phylogeography.

Argimón S, Abudahab K, Goater RJE, Fedosejev A, Bhai J, Glasner C, Feil EJ, Holden MTG, Yeats CA, Grundmann H, Spratt BG, Aanensen DM.

Microb Genom. 2016 Nov 30;2(11):e000093. doi: 10.1099/mgen.0.000093. eCollection 2016 Nov.

32.

Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Actinobacillus pleuropneumoniae.

Bossé JT, Li Y, Rogers J, Fernandez Crespo R, Li Y, Chaudhuri RR, Holden MT, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR.

Front Microbiol. 2017 Mar 6;8:311. doi: 10.3389/fmicb.2017.00311. eCollection 2017.

33.

Global and regional dissemination and evolution of Burkholderia pseudomallei.

Chewapreecha C, Holden MT, Vehkala M, Välimäki N, Yang Z, Harris SR, Mather AE, Tuanyok A, De Smet B, Le Hello S, Bizet C, Mayo M, Wuthiekanun V, Limmathurotsakul D, Phetsouvanh R, Spratt BG, Corander J, Keim P, Dougan G, Dance DA, Currie BJ, Parkhill J, Peacock SJ.

Nat Microbiol. 2017 Jan 23;2:16263. doi: 10.1038/nmicrobiol.2016.263.

34.

The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee.

Ellington MJ, Ekelund O, Aarestrup FM, Canton R, Doumith M, Giske C, Grundman H, Hasman H, Holden MTG, Hopkins KL, Iredell J, Kahlmeter G, Köser CU, MacGowan A, Mevius D, Mulvey M, Naas T, Peto T, Rolain JM, Samuelsen Ø, Woodford N.

Clin Microbiol Infect. 2017 Jan;23(1):2-22. doi: 10.1016/j.cmi.2016.11.012. Epub 2016 Nov 23. Review.

35.

Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: Blurring of the traditional definitions.

Bal AM, Coombs GW, Holden MTG, Lindsay JA, Nimmo GR, Tattevin P, Skov RL.

J Glob Antimicrob Resist. 2016 Sep;6:95-101. doi: 10.1016/j.jgar.2016.04.004. Epub 2016 May 17. Review.

PMID:
27530849
36.

Genomics of Natural Populations of Staphylococcus aureus.

Fitzgerald JR, Holden MT.

Annu Rev Microbiol. 2016 Sep 8;70:459-78. doi: 10.1146/annurev-micro-102215-095547. Epub 2016 Jul 29. Review.

37.

ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae.

Bossé JT, Li Y, Fernandez Crespo R, Chaudhuri RR, Rogers J, Holden MT, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR; the BRaDP1T Consortium.

Front Microbiol. 2016 Jun 15;7:810. doi: 10.3389/fmicb.2016.00810. eCollection 2016.

38.

Whole-Genome Sequencing for Routine Pathogen Surveillance in Public Health: a Population Snapshot of Invasive Staphylococcus aureus in Europe.

Aanensen DM, Feil EJ, Holden MT, Dordel J, Yeats CA, Fedosejev A, Goater R, Castillo-Ramírez S, Corander J, Colijn C, Chlebowicz MA, Schouls L, Heck M, Pluister G, Ruimy R, Kahlmeter G, Åhman J, Matuschek E, Friedrich AW, Parkhill J, Bentley SD, Spratt BG, Grundmann H; European SRL Working Group.

MBio. 2016 May 5;7(3). pii: e00444-16. doi: 10.1128/mBio.00444-16.

39.

The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity.

Warne B, Harkins CP, Harris SR, Vatsiou A, Stanley-Wall N, Parkhill J, Peacock SJ, Palmer T, Holden MT.

BMC Genomics. 2016 Mar 11;17:222. doi: 10.1186/s12864-016-2426-7.

40.

Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae.

Bossé JT, Chaudhuri RR, Li Y, Leanse LG, Fernandez Crespo R, Coupland P, Holden MT, Bazzolli DM, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR.

Genome Announc. 2016 Jan 28;4(1). pii: e01667-15. doi: 10.1128/genomeA.01667-15.

41.

Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland.

Reuter S, Török ME, Holden MT, Reynolds R, Raven KE, Blane B, Donker T, Bentley SD, Aanensen DM, Grundmann H, Feil EJ, Spratt BG, Parkhill J, Peacock SJ.

Genome Res. 2016 Feb;26(2):263-70. doi: 10.1101/gr.196709.115. Epub 2015 Dec 15. Erratum in: Genome Res. 2017 Sep;27(9):1622.

42.

Turner et al. Reply to "Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions".

Turner CE, Lamagni T, Holden MT, David S, Jones MD, Game L, Efstratiou A, Sriskandan S.

MBio. 2015 Dec 1;6(6):e01883-15. doi: 10.1128/mBio.01883-15. No abstract available.

43.

Whole genome investigation of a divergent clade of the pathogen Streptococcus suis.

Baig A, Weinert LA, Peters SE, Howell KJ, Chaudhuri RR, Wang J, Holden MT, Parkhill J, Langford PR, Rycroft AN, Wren BW, Tucker AW, Maskell DJ.

Front Microbiol. 2015 Nov 4;6:1191. doi: 10.3389/fmicb.2015.01191. eCollection 2015.

44.

Photolithographic Synthesis of High-Density DNA and RNA Arrays on Flexible, Transparent, and Easily Subdivided Plastic Substrates.

Holden MT, Carter MC, Wu CH, Wolfer J, Codner E, Sussman MR, Lynn DM, Smith LM.

Anal Chem. 2015 Nov 17;87(22):11420-8. doi: 10.1021/acs.analchem.5b02893. Epub 2015 Nov 5.

45.

Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.

Ba X, Harrison EM, Lovering AL, Gleadall N, Zadoks R, Parkhill J, Peacock SJ, Holden MT, Paterson GK, Holmes MA.

Antimicrob Agents Chemother. 2015 Dec;59(12):7396-404. doi: 10.1128/AAC.01469-15. Epub 2015 Sep 21.

46.

Development of a Multilocus Sequence Typing Scheme for Molecular Typing of Mycoplasma pneumoniae.

Brown RJ, Holden MT, Spiller OB, Chalker VJ.

J Clin Microbiol. 2015 Oct;53(10):3195-203. doi: 10.1128/JCM.01301-15. Epub 2015 Jul 22.

47.

Roary: rapid large-scale prokaryote pan genome analysis.

Page AJ, Cummins CA, Hunt M, Wong VK, Reuter S, Holden MT, Fookes M, Falush D, Keane JA, Parkhill J.

Bioinformatics. 2015 Nov 15;31(22):3691-3. doi: 10.1093/bioinformatics/btv421. Epub 2015 Jul 20.

48.

Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the United Kingdom.

Turner CE, Abbott J, Lamagni T, Holden MT, David S, Jones MD, Game L, Efstratiou A, Sriskandan S.

MBio. 2015 Jul 14;6(4):e00622. doi: 10.1128/mBio.00622-15.

49.

Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection.

Harris SR, Robinson C, Steward KF, Webb KS, Paillot R, Parkhill J, Holden MT, Waller AS.

Genome Res. 2015 Sep;25(9):1360-71. doi: 10.1101/gr.189803.115. Epub 2015 Jul 9.

50.

Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae.

Bossé JT, Li Y, Atherton TG, Walker S, Williamson SM, Rogers J, Chaudhuri RR, Weinert LA, Holden MT, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR; BRaDP1T consortium.

Vet Microbiol. 2015 Aug 5;178(3-4):279-82. doi: 10.1016/j.vetmic.2015.05.020. Epub 2015 May 28. Erratum in: Vet Microbiol. 2015 Sep 30;179(3-4):341. BRaDP1T consortium [added].

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