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Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function.

Cerny O, Holden DW.

Immunol Lett. 2019 Nov;215:35-39. doi: 10.1016/j.imlet.2019.01.006. Epub 2019 Feb 13. Review.


SrcA is a chaperone for the Salmonella SPI-2 type three secretion system effector SteD.

Godlee C, Cerny O, Durkin CH, Holden DW.

Microbiology. 2019 Jan;165(1):15-25. doi: 10.1099/mic.0.000732. Epub 2018 Nov 20.


SsaV Interacts with SsaL to Control the Translocon-to-Effector Switch in the Salmonella SPI-2 Type Three Secretion System.

Yu XJ, Grabe GJ, Liu M, Mota LJ, Holden DW.

MBio. 2018 Oct 2;9(5). pii: e01149-18. doi: 10.1128/mBio.01149-18.


Type II Toxin-Antitoxin Systems and Persister Cells.

Holden DW, Errington J.

MBio. 2018 Sep 25;9(5). pii: e01574-18. doi: 10.1128/mBio.01574-18. No abstract available.


Epstein Barr virus shedding in multiple sclerosis: Similar frequencies of EBV in saliva across separate patient cohorts.

Holden DW, Gold J, Hawkes CH, Giovannoni G, Saxton JM, Carter A, Sharrack B.

Mult Scler Relat Disord. 2018 Oct;25:197-199. doi: 10.1016/j.msard.2018.07.041. Epub 2018 Jul 27.


Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences.

Jennings E, Thurston TLM, Holden DW.

Cell Host Microbe. 2017 Aug 9;22(2):217-231. doi: 10.1016/j.chom.2017.07.009. Review.


Correction for Günster et al., "SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages".

Günster RA, Matthews SA, Holden DW, Thurston TLM.

Infect Immun. 2017 May 23;85(6). pii: e00242-17. doi: 10.1128/IAI.00242-17. Print 2017 Jun. No abstract available.


SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages.

Günster RA, Matthews SA, Holden DW, Thurston TLM.

Infect Immun. 2017 Feb 23;85(3). pii: e00010-17. doi: 10.1128/IAI.00010-17. Print 2017 Mar. Erratum in: Infect Immun. 2017 May 23;85(6):.


The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation.

Bayer-Santos E, Durkin CH, Rigano LA, Kupz A, Alix E, Cerny O, Jennings E, Liu M, Ryan AS, Lapaque N, Kaufmann SHE, Holden DW.

Cell Host Microbe. 2016 Nov 9;20(5):584-595. doi: 10.1016/j.chom.2016.10.007.


Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death.

Thurston TL, Matthews SA, Jennings E, Alix E, Shao F, Shenoy AR, Birrell MA, Holden DW.

Nat Commun. 2016 Nov 3;7:13292. doi: 10.1038/ncomms13292.


The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.

Grabe GJ, Zhang Y, Przydacz M, Rolhion N, Yang Y, Pruneda JN, Komander D, Holden DW, Hare SA.

J Biol Chem. 2016 Dec 9;291(50):25853-25863. Epub 2016 Oct 27.


The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.

Pruneda JN, Durkin CH, Geurink PP, Ovaa H, Santhanam B, Holden DW, Komander D.

Mol Cell. 2016 Jul 21;63(2):261-276. doi: 10.1016/j.molcel.2016.06.015. Epub 2016 Jul 14.


Erratum for O'Neill et al., Cytosolic Replication of Group A Streptococcus in Human Macrophages.

O'Neill AM, Thurston TL, Holden DW.

MBio. 2016 Jun 28;7(3). pii: e00931-16. doi: 10.1128/mBio.00931-16. No abstract available.


Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD.

Rolhion N, Furniss RC, Grabe G, Ryan A, Liu M, Matthews SA, Holden DW.

PLoS Pathog. 2016 May 27;12(5):e1005653. doi: 10.1371/journal.ppat.1005653. eCollection 2016 May.


Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis.

Santos AJM, Durkin CH, Helaine S, Boucrot E, Holden DW.

Infect Immun. 2016 Jun 23;84(7):2149-2158. doi: 10.1128/IAI.00062-16. Print 2016 Jul.


Cytosolic Replication of Group A Streptococcus in Human Macrophages.

O'Neill AM, Thurston TL, Holden DW.

MBio. 2016 Apr 12;7(2):e00020-16. doi: 10.1128/mBio.00020-16. Erratum in: MBio. 2016;7(3). pii: e00931-16. doi: 10.1128/mBio.00931-16.


Elucidating population-wide mycobacterial replication dynamics at the single-cell level.

Mouton JM, Helaine S, Holden DW, Sampson SL.

Microbiology. 2016 Jun;162(6):966-978. doi: 10.1099/mic.0.000288. Epub 2016 Mar 30.


The Salmonella effector SteA binds phosphatidylinositol 4-phosphate for subcellular targeting within host cells.

Domingues L, Ismail A, Charro N, Rodríguez-Escudero I, Holden DW, Molina M, Cid VJ, Mota LJ.

Cell Microbiol. 2016 Jul;18(7):949-69. doi: 10.1111/cmi.12558. Epub 2016 Mar 11.


Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

Scanu T, Spaapen RM, Bakker JM, Pratap CB, Wu LE, Hofland I, Broeks A, Shukla VK, Kumar M, Janssen H, Song JY, Neefjes-Borst EA, te Riele H, Holden DW, Nath G, Neefjes J.

Cell Host Microbe. 2015 Jun 10;17(6):763-74. doi: 10.1016/j.chom.2015.05.002. Epub 2015 May 28.


Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection.

Almeida MT, Mesquita FS, Cruz R, Osório H, Custódio R, Brito C, Vingadassalom D, Martins M, Leong JM, Holden DW, Cabanes D, Sousa S.

J Biol Chem. 2015 Mar 27;290(13):8383-95. doi: 10.1074/jbc.M114.591313. Epub 2015 Jan 29.


Editorial overview: Host-microbe interactions: bacteria.

Holden DW, Philpott DJ.

Curr Opin Microbiol. 2015 Feb;23:v-viii. doi: 10.1016/j.mib.2014.12.002. Epub 2015 Jan 2. No abstract available.


Microbiology. Persisters unmasked.

Holden DW.

Science. 2015 Jan 2;347(6217):30-2. doi: 10.1126/science.1262033. No abstract available.


PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.

McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I.

Cell Host Microbe. 2015 Jan 14;17(1):58-71. doi: 10.1016/j.chom.2014.11.011. Epub 2014 Dec 11.


Edwardsiella tarda-Induced cytotoxicity depends on its type III secretion system and flagellin.

Xie HX, Lu JF, Rolhion N, Holden DW, Nie P, Zhou Y, Yu XJ.

Infect Immun. 2014 Aug;82(8):3436-45. doi: 10.1128/IAI.01065-13. Epub 2014 Jun 2.


The Salmonella effector SteA contributes to the control of membrane dynamics of Salmonella-containing vacuoles.

Domingues L, Holden DW, Mota LJ.

Infect Immun. 2014 Jul;82(7):2923-34. doi: 10.1128/IAI.01385-13. Epub 2014 Apr 28.


Internalization of Salmonella by macrophages induces formation of nonreplicating persisters.

Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW.

Science. 2014 Jan 10;343(6167):204-8. doi: 10.1126/science.1244705.


Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase.

Santos AJ, Meinecke M, Fessler MB, Holden DW, Boucrot E.

J Cell Sci. 2013 Jul 15;126(Pt 14):2990-6. doi: 10.1242/jcs.115253. Epub 2013 May 17.


Heterogeneity of intracellular replication of bacterial pathogens.

Helaine S, Holden DW.

Curr Opin Microbiol. 2013 Apr;16(2):184-91. doi: 10.1016/j.mib.2012.12.004. Epub 2013 Feb 26. Review.


Lack of effect of the Salmonella deubiquitinase SseL on the NF-κB pathway.

Mesquita FS, Holden DW, Rolhion N.

PLoS One. 2013;8(1):e53064. doi: 10.1371/journal.pone.0053064. Epub 2013 Jan 8.


Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.

McGourty K, Thurston TL, Matthews SA, Pinaud L, Mota LJ, Holden DW.

Science. 2012 Nov 16;338(6109):963-7. doi: 10.1126/science.1227037. Erratum in: Science. 2012 Dec 7;338(6112):1287.


The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton.

Odendall C, Rolhion N, Förster A, Poh J, Lamont DJ, Liu M, Freemont PS, Catling AD, Holden DW.

Cell Host Microbe. 2012 Nov 15;12(5):657-68. doi: 10.1016/j.chom.2012.09.011.


The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates.

Mesquita FS, Thomas M, Sachse M, Santos AJ, Figueira R, Holden DW.

PLoS Pathog. 2012;8(6):e1002743. doi: 10.1371/journal.ppat.1002743. Epub 2012 Jun 14.


Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.

Dart AE, Donnelly SK, Holden DW, Way M, Caron E.

J Cell Sci. 2012 Jun 15;125(Pt 12):2825-30. doi: 10.1242/jcs.106583. Epub 2012 Mar 27.


Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors.

Figueira R, Holden DW.

Microbiology. 2012 May;158(Pt 5):1147-61. doi: 10.1099/mic.0.058115-0. Epub 2012 Mar 15. Review.


Tandem translation generates a chaperone for the Salmonella type III secretion system protein SsaQ.

Yu XJ, Liu M, Matthews S, Holden DW.

J Biol Chem. 2011 Oct 14;286(41):36098-107. doi: 10.1074/jbc.M111.278663. Epub 2011 Aug 30.


Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages.

Thompson JA, Liu M, Helaine S, Holden DW.

Microbiology. 2011 Jul;157(Pt 7):2084-93. doi: 10.1099/mic.0.048926-0. Epub 2011 Apr 21.


Dynamics of growth and dissemination of Salmonella in vivo.

Watson KG, Holden DW.

Cell Microbiol. 2010 Oct;12(10):1389-97. doi: 10.1111/j.1462-5822.2010.01511.x. Review.


SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1-dependent vacuolar membrane exchanges.

Dumont A, Boucrot E, Drevensek S, Daire V, Gorvel JP, Poüs C, Holden DW, Méresse S.

Traffic. 2010 Jul 1;11(7):899-911. doi: 10.1111/j.1600-0854.2010.01069.x. Epub 2010 Apr 6.


pH sensing by intracellular Salmonella induces effector translocation.

Yu XJ, McGourty K, Liu M, Unsworth KE, Holden DW.

Science. 2010 May 21;328(5981):1040-3. doi: 10.1126/science.1189000. Epub 2010 Apr 15.


Dynamics of intracellular bacterial replication at the single cell level.

Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DW.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3746-51. doi: 10.1073/pnas.1000041107. Epub 2010 Feb 2.


Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis.

Groves E, Rittinger K, Amstutz M, Berry S, Holden DW, Cornelis GR, Caron E.

J Biol Chem. 2010 Feb 5;285(6):4087-98. doi: 10.1074/jbc.M109.071035. Epub 2009 Nov 19.


Salmonella regulates polyubiquitination and surface expression of MHC class II antigens.

Lapaque N, Hutchinson JL, Jones DC, Méresse S, Holden DW, Trowsdale J, Kelly AP.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14052-7. doi: 10.1073/pnas.0906735106. Epub 2009 Aug 5.


SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.

Mota LJ, Ramsden AE, Liu M, Castle JD, Holden DW.

Cell Microbiol. 2009 Aug;11(8):1236-53. doi: 10.1111/j.1462-5822.2009.01329.x. Epub 2009 Apr 27.


Ubiquitination - a bacterial effector's ticket to ride.

Thomas M, Holden DW.

Cell Host Microbe. 2009 Apr 23;5(4):309-11. doi: 10.1016/j.chom.2009.03.010.


The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid : cholesterol acyltransferase activity.

Lossi NS, Rolhion N, Magee AI, Boyle C, Holden DW.

Microbiology. 2008 Sep;154(Pt 9):2680-8. doi: 10.1099/mic.0.2008/019075-0.


SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases.

Mazurkiewicz P, Thomas J, Thompson JA, Liu M, Arbibe L, Sansonetti P, Holden DW.

Mol Microbiol. 2008 Mar;67(6):1371-83. doi: 10.1111/j.1365-2958.2008.06134.x. Epub 2008 Feb 15.


Bacterial interference of ubiquitination and deubiquitination.

Rytkönen A, Holden DW.

Cell Host Microbe. 2007 Mar 15;1(1):13-22. Review.

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