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Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).

Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y.

Eur J Nucl Med Mol Imaging. 2019 Jun 7. doi: 10.1007/s00259-019-04357-w. [Epub ahead of print]


Imaging histamine H3 receptors with [18 F]FMH3: Test-retest and occupancy studies in the non-human primate.

Sandiego CM, Barret O, Lee H, Alagille D, Amenta A, Fowles K, Holden D, Seibyl JP, Tamagnan G.

Synapse. 2019 Jul;73(7):e22096. doi: 10.1002/syn.22096. Epub 2019 Mar 23.


Top-Down Analysis of Proteins in Low Charge States.

Bashyal A, Sanders JD, Holden DD, Brodbelt JS.

J Am Soc Mass Spectrom. 2019 Apr;30(4):704-717. doi: 10.1007/s13361-019-02146-1. Epub 2019 Feb 22.


Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function.

Cerny O, Holden DW.

Immunol Lett. 2019 Feb 13. pii: S0165-2478(18)30544-3. doi: 10.1016/j.imlet.2019.01.006. [Epub ahead of print] Review.


Evaluation of 11C-LSN3172176 as a novel PET tracer for imaging M1 muscarinic acetylcholine receptors in non-human primates.

Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker LJ, Jesudason CD, Barth VN, Navarro A, Kant N, Carson RE, Huang H.

J Nucl Med. 2019 Feb 7. pii: jnumed.118.222034. doi: 10.2967/jnumed.118.222034. [Epub ahead of print]


A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates.

Baum E, Zhang W, Li S, Cai Z, Holden D, Huang Y.

ACS Chem Neurosci. 2019 May 15;10(5):2450-2458. doi: 10.1021/acschemneuro.8b00715. Epub 2019 Feb 19.


SrcA is a chaperone for the Salmonella SPI-2 type three secretion system effector SteD.

Godlee C, Cerny O, Durkin CH, Holden DW.

Microbiology. 2019 Jan;165(1):15-25. doi: 10.1099/mic.0.000732. Epub 2018 Nov 20.


Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y.

ACS Chem Neurosci. 2019 Mar 20;10(3):1544-1554. doi: 10.1021/acschemneuro.8b00526. Epub 2018 Nov 16.


A Taxonomy of Integration Interventions Between Health Care and Public Health [Internet].

Porterfield DS, Rojas-Smith L, Lewis M, McCormack LA, Hoerger TJ, Holden DJ.

Research Triangle Park (NC): RTI Press; 2015 Jul.


Arc/Arg3.1 has an activity-regulated interaction with PICK1 that results in altered spatial dynamics.

Goo BMSS, Sanstrum BJ, Holden DZY, Yu Y, James NG.

Sci Rep. 2018 Oct 2;8(1):14675. doi: 10.1038/s41598-018-32821-4.


SsaV Interacts with SsaL to Control the Translocon-to-Effector Switch in the Salmonella SPI-2 Type Three Secretion System.

Yu XJ, Grabe GJ, Liu M, Mota LJ, Holden DW.

MBio. 2018 Oct 2;9(5). pii: e01149-18. doi: 10.1128/mBio.01149-18.


Type II Toxin-Antitoxin Systems and Persister Cells.

Holden DW, Errington J.

MBio. 2018 Sep 25;9(5). pii: e01574-18. doi: 10.1128/mBio.01574-18. No abstract available.


Epstein Barr virus shedding in multiple sclerosis: Similar frequencies of EBV in saliva across separate patient cohorts.

Holden DW, Gold J, Hawkes CH, Giovannoni G, Saxton JM, Carter A, Sharrack B.

Mult Scler Relat Disord. 2018 Oct;25:197-199. doi: 10.1016/j.msard.2018.07.041. Epub 2018 Jul 27.


Multistage Ultraviolet Photodissociation Mass Spectrometry To Characterize Single Amino Acid Variants of Human Mitochondrial BCAT2.

Mehaffey MR, Sanders JD, Holden DD, Nilsson CL, Brodbelt JS.

Anal Chem. 2018 Aug 21;90(16):9904-9911. doi: 10.1021/acs.analchem.8b02099. Epub 2018 Aug 1.


A phase II baseline versus treatment study to determine the efficacy of raltegravir (Isentress) in preventing progression of relapsing remitting multiple sclerosis as determined by gadolinium-enhanced MRI: The INSPIRE study.

Gold J, Marta M, Meier UC, Christensen T, Miller D, Altmann D, Holden D, Bianchi L, Adiutori R, MacManus D, Yousry T, Schmierer K, Turner B, Giovannoni G.

Mult Scler Relat Disord. 2018 Aug;24:123-128. doi: 10.1016/j.msard.2018.06.002. Epub 2018 Jun 28.


Implementation of Fragment Ion Protection (FIP) during Ultraviolet Photodissociation (UVPD) Mass Spectrometry.

Holden DD, Sanders JD, Weisbrod CR, Mullen C, Schwartz JC, Brodbelt JS.

Anal Chem. 2018 Jul 17;90(14):8583-8591. doi: 10.1021/acs.analchem.8b01723. Epub 2018 Jul 6.


Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer.

Sanders JD, Grinfeld D, Aizikov K, Makarov A, Holden DD, Brodbelt JS.

Anal Chem. 2018 May 1;90(9):5896-5902. doi: 10.1021/acs.analchem.8b00724. Epub 2018 Apr 18.


Invasion history alters the behavioural consequences of immune system activation in cane toads.

Brown GP, Holden D, Shine R, Phillips BL.

J Anim Ecol. 2018 May;87(3):716-726. doi: 10.1111/1365-2656.12799. Epub 2018 Feb 28.


Post-operative telephone review is safe and effective: prospective study - Monash outpatient review by phone trial.

Ma Y, Jones G, Tay YK, Hunter T, Holden D, Rodgers-Wilson S, Cashin P, Tan PY, Croagh D.

ANZ J Surg. 2018 May;88(5):434-439. doi: 10.1111/ans.14280. Epub 2017 Dec 5.


Inside information on xenon adsorption in porous organic cages by NMR.

Komulainen S, Roukala J, Zhivonitko VV, Javed MA, Chen L, Holden D, Hasell T, Cooper A, Lantto P, Telkki VV.

Chem Sci. 2017 Aug 1;8(8):5721-5727. doi: 10.1039/c7sc01990d. Epub 2017 Jun 14.


The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates.

Lin SF, Bois F, Holden D, Nabulsi N, Pracitto R, Gao H, Kapinos M, Teng JK, Shirali A, Ropchan J, Carson RE, Elmore CS, Vasdev N, Huang Y.

Mol Imaging. 2017 Jan-Dec;16:1536012117731258. doi: 10.1177/1536012117731258.


Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys.

Gallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE.

J Nucl Med. 2018 Feb;59(2):327-333. doi: 10.2967/jnumed.117.195073. Epub 2017 Sep 1.


Fast Neural Style Transfer for Motion Data.

Holden D, Habibie I, Kusajima I, Komura T.

IEEE Comput Graph Appl. 2017;37(4):42-49. doi: 10.1109/MCG.2017.3271464.


Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences.

Jennings E, Thurston TLM, Holden DW.

Cell Host Microbe. 2017 Aug 9;22(2):217-231. doi: 10.1016/j.chom.2017.07.009. Review.


Computationally-Guided Synthetic Control over Pore Size in Isostructural Porous Organic Cages.

Slater AG, Reiss PS, Pulido A, Little MA, Holden DL, Chen L, Chong SY, Alston BM, Clowes R, Haranczyk M, Briggs ME, Hasell T, Day GM, Cooper AI.

ACS Cent Sci. 2017 Jul 26;3(7):734-742. doi: 10.1021/acscentsci.7b00145. Epub 2017 Jun 20.


Novel 18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates.

Li S, Cai Z, Zheng MQ, Holden D, Naganawa M, Lin SF, Ropchan J, Labaree D, Kapinos M, Lara-Jaime T, Navarro A, Huang Y.

J Nucl Med. 2018 Jan;59(1):140-146. doi: 10.2967/jnumed.117.195586. Epub 2017 Jul 26.


Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates.

Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP.

EJNMMI Res. 2017 Dec;7(1):59. doi: 10.1186/s13550-017-0305-0. Epub 2017 Jul 24.


Safety Considerations and Guideline-Based Safe Use Recommendations for "Bolus-Dose" Vasopressors in the Emergency Department.

Holden D, Ramich J, Timm E, Pauze D, Lesar T.

Ann Emerg Med. 2018 Jan;71(1):83-92. doi: 10.1016/j.annemergmed.2017.04.021.


Understanding gas capacity, guest selectivity, and diffusion in porous liquids.

Greenaway RL, Holden D, Eden EGB, Stephenson A, Yong CW, Bennison MJ, Hasell T, Briggs ME, James SL, Cooper AI.

Chem Sci. 2017 Apr 1;8(4):2640-2651. doi: 10.1039/c6sc05196k. Epub 2017 Jan 31.


Correction for Günster et al., "SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages".

Günster RA, Matthews SA, Holden DW, Thurston TLM.

Infect Immun. 2017 May 23;85(6). pii: e00242-17. doi: 10.1128/IAI.00242-17. Print 2017 Jun. No abstract available.


Modulation of Protein Fragmentation Through Carbamylation of Primary Amines.

Greer SM, Holden DD, Fellers R, Kelleher NL, Brodbelt JS.

J Am Soc Mass Spectrom. 2017 Aug;28(8):1587-1599. doi: 10.1007/s13361-017-1648-5. Epub 2017 Apr 3.


Functional materials discovery using energy-structure-function maps.

Pulido A, Chen L, Kaczorowski T, Holden D, Little MA, Chong SY, Slater BJ, McMahon DP, Bonillo B, Stackhouse CJ, Stephenson A, Kane CM, Clowes R, Hasell T, Cooper AI, Day GM.

Nature. 2017 Mar 30;543(7647):657-664. doi: 10.1038/nature21419. Epub 2017 Mar 22.


Comprehensive de Novo Peptide Sequencing from MS/MS Pairs Generated through Complementary Collision Induced Dissociation and 351 nm Ultraviolet Photodissociation.

Horton AP, Robotham SA, Cannon JR, Holden DD, Marcotte EM, Brodbelt JS.

Anal Chem. 2017 Mar 21;89(6):3747-3753. doi: 10.1021/acs.analchem.7b00130. Epub 2017 Mar 8.


PET Imaging Evaluation of Four σ1 Radiotracers in Nonhuman Primates.

Baum E, Cai Z, Bois F, Holden D, Lin SF, Lara-Jaime T, Kapinos M, Chen Y, Deuther-Conrad W, Fischer S, Dukic-Stefanovic S, Bunse P, Wünsch B, Brust P, Jia H, Huang Y.

J Nucl Med. 2017 Jun;58(6):982-988. doi: 10.2967/jnumed.116.188052. Epub 2017 Feb 23.


Ultraviolet Photodissociation of Native Proteins Following Proton Transfer Reactions in the Gas Phase.

Holden DD, Brodbelt JS.

Anal Chem. 2016 Dec 20;88(24):12354-12362. doi: 10.1021/acs.analchem.6b03565. Epub 2016 Dec 7.


Structural Characterization of Native Proteins and Protein Complexes by Electron Ionization Dissociation-Mass Spectrometry.

Li H, Sheng Y, McGee W, Cammarata M, Holden D, Loo JA.

Anal Chem. 2017 Mar 7;89(5):2731-2738. doi: 10.1021/acs.analchem.6b02377. Epub 2017 Feb 22.


A multi species evaluation of the radiation dosimetry of [11C]erlotinib, the radiolabeled analog of a clinically utilized tyrosine kinase inhibitor.

Petrulli JR, Hansen SB, Abourbeh G, Yaqub M, Bahce I, Holden D, Huang Y, Nabulsi NB, Contessa JN, Mishani E, Lammertsma AA, Morris ED.

Nucl Med Biol. 2017 Apr;47:56-61. doi: 10.1016/j.nucmedbio.2016.12.009. Epub 2017 Jan 2.


PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans.

Hillmer AT, Li S, Zheng MQ, Scheunemann M, Lin SF, Nabulsi N, Holden D, Pracitto R, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Esterlis I, Cosgrove KP, Brust P, Carson RE, Huang Y.

Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1042-1050. doi: 10.1007/s00259-017-3621-8. Epub 2017 Jan 24.


Microbial recognition and danger signals in sepsis and trauma.

Raymond SL, Holden DC, Mira JC, Stortz JA, Loftus TJ, Mohr AM, Moldawer LL, Moore FA, Larson SD, Efron PA.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2564-2573. doi: 10.1016/j.bbadis.2017.01.013. Epub 2017 Jan 20. Review.


Learning Inverse Rig Mappings by Nonlinear Regression.

Holden D, Saito J, Komura T.

IEEE Trans Vis Comput Graph. 2017 Mar;23(3):1167-1178. doi: 10.1109/TVCG.2016.2628036. Epub 2016 Nov 11.


Improving Performance Metrics of Ultraviolet Photodissociation Mass Spectrometry by Selective Precursor Ejection.

Holden DD, Brodbelt JS.

Anal Chem. 2017 Jan 3;89(1):837-846. doi: 10.1021/acs.analchem.6b03777. Epub 2016 Dec 20.


SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages.

Günster RA, Matthews SA, Holden DW, Thurston TLM.

Infect Immun. 2017 Feb 23;85(3). pii: e00010-17. doi: 10.1128/IAI.00010-17. Print 2017 Mar. Erratum in: Infect Immun. 2017 May 23;85(6):.


Reticular synthesis of porous molecular 1D nanotubes and 3D networks.

Slater AG, Little MA, Pulido A, Chong SY, Holden D, Chen L, Morgan C, Wu X, Cheng G, Clowes R, Briggs ME, Hasell T, Jelfs KE, Day GM, Cooper AI.

Nat Chem. 2017 Jan;9(1):17-25. doi: 10.1038/nchem.2663. Epub 2016 Nov 21.


The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation.

Bayer-Santos E, Durkin CH, Rigano LA, Kupz A, Alix E, Cerny O, Jennings E, Liu M, Ryan AS, Lapaque N, Kaufmann SHE, Holden DW.

Cell Host Microbe. 2016 Nov 9;20(5):584-595. doi: 10.1016/j.chom.2016.10.007.


Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death.

Thurston TL, Matthews SA, Jennings E, Alix E, Shao F, Shenoy AR, Birrell MA, Holden DW.

Nat Commun. 2016 Nov 3;7:13292. doi: 10.1038/ncomms13292.


The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.

Grabe GJ, Zhang Y, Przydacz M, Rolhion N, Yang Y, Pruneda JN, Komander D, Holden DW, Hare SA.

J Biol Chem. 2016 Dec 9;291(50):25853-25863. Epub 2016 Oct 27.


The new bacteriology.

Cossart P, Holden D, Busby S.

Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707). pii: 20150507. doi: 10.1098/rstb.2015.0507. No abstract available.


Ultraviolet Photodissociation Induced by Light-Emitting Diodes in a Planar Ion Trap.

Holden DD, Makarov A, Schwartz JC, Sanders JD, Zhuk E, Brodbelt JS.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12417-21. doi: 10.1002/anie.201605850. Epub 2016 Sep 8.


A Multi-Species TaqMan PCR Assay for the Identification of Asian Gypsy Moths (Lymantria spp.) and Other Invasive Lymantriines of Biosecurity Concern to North America.

Stewart D, Zahiri R, Djoumad A, Freschi L, Lamarche J, Holden D, Cervantes S, Ojeda DI, Potvin A, Nisole A, Béliveau C, Capron A, Kimoto T, Day B, Yueh H, Duff C, Levesque RC, Hamelin RC, Cusson M.

PLoS One. 2016 Aug 11;11(8):e0160878. doi: 10.1371/journal.pone.0160878. eCollection 2016.


Understanding static, dynamic and cooperative porosity in molecular materials.

Holden D, Chong SY, Chen L, Jelfs KE, Hasell T, Cooper AI.

Chem Sci. 2016 Aug 1;7(8):4875-4879. doi: 10.1039/c6sc00713a. Epub 2016 Apr 13.

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