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Items: 1 to 50 of 100

1.

Characterizing Cellular Responses During Oncolytic Maraba Virus Infection.

Hassanzadeh G, Naing T, Graber T, Jafarnejad SM, Stojdl DF, Alain T, Holcik M.

Int J Mol Sci. 2019 Jan 29;20(3). pii: E580. doi: 10.3390/ijms20030580.

2.

Corrigendum to "Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial" Physiology & Behavior, Volume 191, 1 July 2018, Pages 138-145.

Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay MS, Walsh J, Guerin E, Gunnell KE, D'Angiulli A, Sigal RJ.

Physiol Behav. 2019 Jan 1;198:161. doi: 10.1016/j.physbeh.2018.06.019. Epub 2018 Jun 30. No abstract available.

PMID:
30428994
3.

Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial.

Walsh JJ, D'Angiulli A, Cameron JD, Sigal RJ, Kenny GP, Holcik M, Doucette S, Alberga AS, Prud'homme D, Hadjiyannakis S, Gunnell K, Goldfield GS.

Neural Plast. 2018 Sep 30;2018:7169583. doi: 10.1155/2018/7169583. eCollection 2018.

4.

Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast.

Moteshareie H, Hajikarimlou M, Mulet Indrayanti A, Burnside D, Paula Dias A, Lettl C, Ahmed D, Omidi K, Kazmirchuk T, Puchacz N, Zare N, Takallou S, Naing T, Hernández RB, Willmore WG, Babu M, McKay B, Samanfar B, Holcik M, Golshani A.

PLoS One. 2018 Sep 19;13(9):e0198704. doi: 10.1371/journal.pone.0198704. eCollection 2018.

5.

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial.

Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay MS, Walsh J, Guerin E, Gunnell KE, D'Angiulli A, Sigal RJ.

Physiol Behav. 2018 Jul 1;191:138-145. doi: 10.1016/j.physbeh.2018.04.026. Epub 2018 Apr 19. Erratum in: Physiol Behav. 2019 Jan 1;198:161.

PMID:
29679660
6.

The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A.

Samanfar B, Shostak K, Moteshareie H, Hajikarimlou M, Shaikho S, Omidi K, Hooshyar M, Burnside D, Márquez IG, Kazmirchuk T, Naing T, Ludovico P, York-Lyon A, Szereszewski K, Leung C, Jin JY, Megarbane R, Smith ML, Babu M, Holcik M, Golshani A.

PeerJ. 2017 Nov 14;5:e4037. doi: 10.7717/peerj.4037. eCollection 2017.

7.

Elevated levels of ribosomal proteins eL36 and eL42 control expression of Hsp90 in rhabdomyosarcoma.

Shaikho S, Dobson CC, Naing T, Samanfar B, Moteshareie H, Hajikarimloo M, Golshani A, Holcik M.

Translation (Austin). 2016 Oct 4;4(2):e1244395. doi: 10.1080/21690731.2016.1244395. eCollection 2016.

8.

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model.

Dobson CC, Naing T, Beug ST, Faye MD, Chabot J, St-Jean M, Walker DE, LaCasse EC, Stojdl DF, Korneluk RG, Holcik M.

Oncotarget. 2017 Jan 10;8(2):3495-3508. doi: 10.18632/oncotarget.13849.

9.

Engaging Cell Death Pathways for the Treatment of Rhabdomyosarcoma.

Dobson CC, Langlois S, Grynspan D, Cowan KN, Holcik M.

Crit Rev Oncog. 2016;21(3-4):221-239. Review.

PMID:
27915973
10.

Impaired activity of CCA-adding enzyme TRNT1 impacts OXPHOS complexes and cellular respiration in SIFD patient-derived fibroblasts.

Liwak-Muir U, Mamady H, Naas T, Wylie Q, McBride S, Lines M, Michaud J, Baird SD, Chakraborty PK, Holcik M.

Orphanet J Rare Dis. 2016 Jun 18;11(1):79. doi: 10.1186/s13023-016-0466-3.

11.

Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization.

Saxena M, Busca A, Holcik M, Kumar A.

J Immunol. 2016 May 1;196(9):3754-67. doi: 10.4049/jimmunol.1402379. Epub 2016 Mar 11.

12.

Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation.

Thakor N, Smith MD, Roberts L, Faye MD, Patel H, Wieden HJ, Cate JHD, Holcik M.

RNA Biol. 2017 May 4;14(5):553-567. doi: 10.1080/15476286.2015.1137419. Epub 2016 Feb 1.

13.

Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?

Holcik M.

Front Oncol. 2015 Nov 26;5:264. doi: 10.3389/fonc.2015.00264. eCollection 2015. Review.

14.

DNM1L-related mitochondrial fission defect presenting as refractory epilepsy.

Vanstone JR, Smith AM, McBride S, Naas T, Holcik M, Antoun G, Harper ME, Michaud J, Sell E, Chakraborty P, Tetreault M; Care4Rare Consortium, Majewski J, Baird S, Boycott KM, Dyment DA, MacKenzie A, Lines MA.

Eur J Hum Genet. 2016 Jul;24(7):1084-8. doi: 10.1038/ejhg.2015.243. Epub 2015 Nov 25.

15.

ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.

Liwak-Muir U, Dobson CC, Naing T, Wylie Q, Chehade L, Baird SD, Chakraborty PK, Holcik M.

Oncotarget. 2016 Jan 12;7(2):1439-50. doi: 10.18632/oncotarget.6363.

16.

Detailed Biochemical and Bioenergetic Characterization of FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion.

Antoun G, McBride S, Vanstone JR, Naas T, Michaud J, Redpath S, McMillan HJ, Brophy J, Daoud H, Chakraborty P, Dyment D, Holcik M, Harper ME, Lines MA.

JIMD Rep. 2016;27:1-9. doi: 10.1007/8904_2015_491. Epub 2015 Sep 25.

17.

Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.

Kernohan KD, Tétreault M, Liwak-Muir U, Geraghty MT, Qin W, Venkateswaran S, Davila J; Care4Rare Canada Consortium, Holcik M, Majewski J, Richer J, Boycott KM.

Hum Mol Genet. 2015 Nov 15;24(22):6293-300. doi: 10.1093/hmg/ddv337. Epub 2015 Aug 24.

18.

Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein.

Courteau L, Crasto J, Hassanzadeh G, Baird SD, Hodgins J, Liwak-Muir U, Fung G, Luo H, Stojdl DF, Screaton RA, Holcik M.

Cell Death Dis. 2015 Aug 6;6:e1837. doi: 10.1038/cddis.2015.209.

19.

Placenta nutrient transport-related gene expression: the impact of maternal obesity and excessive gestational weight gain.

Brett KE, Ferraro ZM, Holcik M, Adamo KB.

J Matern Fetal Neonatal Med. 2016;29(9):1399-405. doi: 10.3109/14767058.2015.1049522. Epub 2015 Jun 11.

PMID:
26067267
20.

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.

Liberman N, Gandin V, Svitkin YV, David M, Virgili G, Jaramillo M, Holcik M, Nagar B, Kimchi A, Sonenberg N.

Nucleic Acids Res. 2015 Apr 20;43(7):3764-75. doi: 10.1093/nar/gkv205. Epub 2015 Mar 16.

21.

Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta.

Brett KE, Ferraro ZM, Holcik M, Adamo KB.

Placenta. 2015 Feb;36(2):204-12. doi: 10.1016/j.placenta.2014.11.015. Epub 2014 Dec 4.

PMID:
25510392
22.

Assessment of selective mRNA translation in mammalian cells by polysome profiling.

Faye MD, Graber TE, Holcik M.

J Vis Exp. 2014 Oct 28;(92):e52295. doi: 10.3791/52295.

23.

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

Roy R, Durie D, Li H, Liu BQ, Skehel JM, Mauri F, Cuorvo LV, Barbareschi M, Guo L, Holcik M, Seckl MJ, Pardo OE.

Nucleic Acids Res. 2014 Nov 10;42(20):12483-97. doi: 10.1093/nar/gku953. Epub 2014 Oct 16.

24.

The role of IRES trans-acting factors in carcinogenesis.

Faye MD, Holcik M.

Biochim Biophys Acta. 2015 Jul;1849(7):887-97. doi: 10.1016/j.bbagrm.2014.09.012. Epub 2014 Sep 23. Review.

PMID:
25257759
25.

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD).

Chakraborty PK, Schmitz-Abe K, Kennedy EK, Mamady H, Naas T, Durie D, Campagna DR, Lau A, Sendamarai AK, Wiseman DH, May A, Jolles S, Connor P, Powell C, Heeney MM, Giardina PJ, Klaassen RJ, Kannengiesser C, Thuret I, Thompson AA, Marques L, Hughes S, Bonney DK, Bottomley SS, Wynn RF, Laxer RM, Minniti CP, Moppett J, Bordon V, Geraghty M, Joyce PB, Markianos K, Rudner AD, Holcik M, Fleming MD.

Blood. 2014 Oct 30;124(18):2867-71. doi: 10.1182/blood-2014-08-591370. Epub 2014 Sep 5.

26.

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.

Faye MD, Beug ST, Graber TE, Earl N, Xiang X, Wild B, Langlois S, Michaud J, Cowan KN, Korneluk RG, Holcik M.

Oncogene. 2015 Mar 19;34(12):1532-41. doi: 10.1038/onc.2014.90. Epub 2014 Apr 7.

PMID:
24704827
27.

VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models.

Hadwen J, MacKenzie D, Shamim F, Mongeon K, Holcik M, MacKenzie A, Farooq F.

Orphanet J Rare Dis. 2014 Jan 9;9:4. doi: 10.1186/1750-1172-9-4.

28.

Loss of cellular inhibitor of apoptosis protein 2 reduces atherosclerosis in atherogenic apoE-/- C57BL/6 mice on high-fat diet.

Sleiman L, Beanlands R, Hasu M, Thabet M, Norgaard A, Chen YX, Holcik M, Whitman S.

J Am Heart Assoc. 2013 Sep 26;2(5):e000259. doi: 10.1161/JAHA.113.000259.

29.

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid.

Silva A, Sampaio-Marques B, Fernandes A, Carreto L, Rodrigues F, Holcik M, Santos MA, Ludovico P.

PLoS One. 2013 Aug 15;8(8):e71294. doi: 10.1371/journal.pone.0071294. eCollection 2013.

30.

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma multiforme through de-repression of Bcl-xL translation.

Liwak U, Jordan LE, Von-Holt SD, Singh P, Hanson JE, Lorimer IA, Roncaroli F, Holcik M.

Oncotarget. 2013 Sep;4(9):1365-72.

31.

Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation.

Farooq F, Abadía-Molina F, MacKenzie D, Hadwen J, Shamim F, O'Reilly S, Holcik M, MacKenzie A.

Hum Mol Genet. 2013 Sep 1;22(17):3415-24. doi: 10.1093/hmg/ddt191. Epub 2013 May 7.

PMID:
23656793
32.

A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression.

Melanson BD, Cabrita MA, Bose R, Hamill JD, Pan E, Brochu C, Marcellus KA, Zhao TT, Holcik M, McKay BC.

Nucleic Acids Res. 2013 Jun;41(11):5692-703. doi: 10.1093/nar/gkt279. Epub 2013 Apr 19.

33.

HuR controls mitochondrial morphology through the regulation of BclxL translation.

Durie D, Hatzoglou M, Chakraborty P, Holcik M.

Translation (Austin). 2013 Apr 1;1(1). pii: e23980.

34.

Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon.

Faye MD, Graber TE, Liu P, Thakor N, Baird SD, Durie D, Holcik M.

Mol Cell Biol. 2013 Jan;33(2):307-18. doi: 10.1128/MCB.00546-12. Epub 2012 Nov 5.

35.

Translation control in apoptosis.

Liwak U, Faye MD, Holcik M.

Exp Oncol. 2012 Oct;34(3):218-30. Review.

PMID:
23070007
36.

An oxygen-regulated switch in the protein synthesis machinery.

Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S.

Nature. 2012 May 6;486(7401):126-9. doi: 10.1038/nature11055.

37.

Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.

Liwak U, Thakor N, Jordan LE, Roy R, Lewis SM, Pardo OE, Seckl M, Holcik M.

Mol Cell Biol. 2012 May;32(10):1818-29. doi: 10.1128/MCB.06317-11. Epub 2012 Mar 19.

38.

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.

Thakor N, Holcik M.

Nucleic Acids Res. 2012 Jan;40(2):541-52. doi: 10.1093/nar/gkr701. Epub 2011 Sep 14.

39.

Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway.

Farooq F, Molina FA, Hadwen J, MacKenzie D, Witherspoon L, Osmond M, Holcik M, MacKenzie A.

J Clin Invest. 2011 Aug;121(8):3042-50. doi: 10.1172/JCI46276. Epub 2011 Jul 25. Erratum in: J Clin Invest. 2011 Sep 1;121(9):3763.

40.

Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2.

Graber TE, Holcik M.

Cell Death Dis. 2011 Mar 24;2:e135. doi: 10.1038/cddis.2011.20. Review. No abstract available.

41.

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.

Durie D, Lewis SM, Liwak U, Kisilewicz M, Gorospe M, Holcik M.

Oncogene. 2011 Mar 24;30(12):1460-9. doi: 10.1038/onc.2010.527. Epub 2010 Nov 22.

42.

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE.

Mol Biol Cell. 2010 Sep 15;21(18):3220-31. doi: 10.1091/mbc.E10-01-0023. Epub 2010 Jul 21.

43.

Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress.

Riley A, Jordan LE, Holcik M.

Nucleic Acids Res. 2010 Aug;38(14):4665-74. doi: 10.1093/nar/gkq241. Epub 2010 Apr 12.

44.

eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.

Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M.

J Biol Chem. 2010 May 28;285(22):17098-111. doi: 10.1074/jbc.M110.109439. Epub 2010 Mar 25.

45.

The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2.

Miura P, Coriati A, Bélanger G, De Repentigny Y, Lee J, Kothary R, Holcik M, Jasmin BJ.

Hum Mol Genet. 2010 Apr 1;19(7):1211-20. doi: 10.1093/hmg/ddp591. Epub 2010 Jan 6.

PMID:
20053670
46.

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.

Li W, Thakor N, Xu EY, Huang Y, Chen C, Yu R, Holcik M, Kong AN.

Nucleic Acids Res. 2010 Jan;38(3):778-88. doi: 10.1093/nar/gkp1048. Epub 2009 Nov 24.

47.

NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response.

Graber TE, Baird SD, Kao PN, Mathews MB, Holcik M.

Cell Death Differ. 2010 Apr;17(4):719-29. doi: 10.1038/cdd.2009.164. Epub 2009 Nov 6.

48.

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

Farooq F, Balabanian S, Liu X, Holcik M, MacKenzie A.

Hum Mol Genet. 2009 Nov 1;18(21):4035-45. doi: 10.1093/hmg/ddp352. Epub 2009 Jul 31.

PMID:
19648294
49.

RNA structure: new messages in translation, replication and disease. Workshop on the role of RNA structures in the translation of viral and cellular RNAs.

Roberts L, Holcik M.

EMBO Rep. 2009 May;10(5):449-53. doi: 10.1038/embor.2009.56. Epub 2009 Apr 3. Review. No abstract available.

50.

Strong eukaryotic IRESs have weak secondary structure.

Xia X, Holcik M.

PLoS One. 2009;4(1):e4136. doi: 10.1371/journal.pone.0004136. Epub 2009 Jan 6.

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