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Items: 1 to 50 of 141

1.

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies.

Berdenis van Berlekom A, Muflihah CH, Snijders GJLJ, MacGillavry HD, Middeldorp J, Hol EM, Kahn RS, de Witte LD.

Schizophr Bull. 2019 Jun 13. pii: sbz060. doi: 10.1093/schbul/sbz060. [Epub ahead of print]

PMID:
31192350
2.

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease.

Donega V, Burm SM, van Strien ME, van Bodegraven EJ, Paliukhovich I, Geut H, van de Berg WDJ, Li KW, Smit AB, Basak O, Hol EM.

Acta Neuropathol Commun. 2019 Jun 3;7(1):4. doi: 10.1186/s40478-019-0736-0.

3.

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated.

Sneeboer MAM, Snijders GJLJ, Berdowski WM, Fernández-Andreu A; Psychiatric Donor Program of the Netherlands Brain Bank (NBB-Psy), van Mierlo HC, Berdenis van Berlekom A, Litjens M, Kahn RS, Hol EM, de Witte LD.

Transl Psychiatry. 2019 May 24;9(1):153. doi: 10.1038/s41398-019-0490-x.

4.

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data.

He Y, de Witte LD, Houtepen LC, Nispeling DM, Xu Z, Yu Q, Yu Y, Hol EM, Kahn RS, Boks MP.

Clin Epigenetics. 2019 May 16;11(1):80. doi: 10.1186/s13148-019-0680-7.

5.

Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.

He Y, de Witte LD, Schubart CD, Van Gastel WA, Koeleman BPC, de Jong S, Ophoff RA, Hol EM, Boks MP.

Eur Neuropsychopharmacol. 2019 May;29(5):643-652. doi: 10.1016/j.euroneuro.2019.03.004. Epub 2019 Mar 15.

PMID:
30879928
6.

Importance of GFAP isoform-specific analyses in astrocytoma.

van Bodegraven EJ, van Asperen JV, Robe PAJ, Hol EM.

Glia. 2019 Aug;67(8):1417-1433. doi: 10.1002/glia.23594. Epub 2019 Jan 22. Review.

PMID:
30667110
7.

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.

Böttcher C, Schlickeiser S, Sneeboer MAM, Kunkel D, Knop A, Paza E, Fidzinski P, Kraus L, Snijders GJL, Kahn RS, Schulz AR, Mei HE; NBB-Psy, Hol EM, Siegmund B, Glauben R, Spruth EJ, de Witte LD, Priller J.

Nat Neurosci. 2019 Jan;22(1):78-90. doi: 10.1038/s41593-018-0290-2. Epub 2018 Dec 17.

PMID:
30559476
8.

Microglia innately develop within cerebral organoids.

Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ.

Nat Commun. 2018 Oct 9;9(1):4167. doi: 10.1038/s41467-018-06684-2.

9.

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping.

Antonovaite N, Beekmans SV, Hol EM, Wadman WJ, Iannuzzi D.

Sci Rep. 2018 Aug 21;8(1):12517. doi: 10.1038/s41598-018-31035-y.

10.

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

Boks MP, Houtepen LC, Xu Z, He Y, Ursini G, Maihofer AX, Rajarajan P, Yu Q, Xu H, Wu Y, Wang S, Shi JP, Hulshoff Pol HE, Strengman E, Rutten BPF, Jaffe AE, Kleinman JE, Baker DG, Hol EM, Akbarian S, Nievergelt CM, De Witte LD, Vinkers CH, Weinberger DR, Yu J, Kahn RS.

NPJ Schizophr. 2018 Aug 21;4(1):16. doi: 10.1038/s41537-018-0058-4.

11.

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo.

Oosterhof N, Kuil LE, van der Linde HC, Burm SM, Berdowski W, van Ijcken WFJ, van Swieten JC, Hol EM, Verheijen MHG, van Ham TJ.

Cell Rep. 2018 Jul 31;24(5):1203-1217.e6. doi: 10.1016/j.celrep.2018.06.113.

12.

Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.

Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI.

J Thromb Haemost. 2018 Jul;16(7):1413-1422. doi: 10.1111/jth.14136. Epub 2018 Jun 8.

13.

Cell adhesion and matricellular support by astrocytes of the tripartite synapse.

Hillen AEJ, Burbach JPH, Hol EM.

Prog Neurobiol. 2018 Jun - Aug;165-167:66-86. doi: 10.1016/j.pneurobio.2018.02.002. Epub 2018 Feb 11. Review.

14.

Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions.

Hendrickx DAE, van Scheppingen J, van der Poel M, Bossers K, Schuurman KG, van Eden CG, Hol EM, Hamann J, Huitinga I.

Front Immunol. 2017 Dec 21;8:1810. doi: 10.3389/fimmu.2017.01810. eCollection 2017.

15.

Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin.

Hol EM, Capetanaki Y.

Cold Spring Harb Perspect Biol. 2017 Dec 1;9(12). pii: a021642. doi: 10.1101/cshperspect.a021642. Review.

PMID:
29196434
16.

GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile.

Stassen OMJA, van Bodegraven EJ, Giuliani F, Moeton M, Kanski R, Sluijs JA, van Strien ME, Kamphuis W, Robe PAJ, Hol EM.

Oncotarget. 2017 Oct 4;8(50):88104-88121. doi: 10.18632/oncotarget.21540. eCollection 2017 Oct 20.

17.

Characterization of macrophages from schizophrenia patients.

Ormel PR, van Mierlo HC, Litjens M, Strien MEV, Hol EM, Kahn RS, de Witte LD.

NPJ Schizophr. 2017 Nov 14;3(1):41. doi: 10.1038/s41537-017-0042-4.

18.

Clinical and immunological characteristics of the spectrum of GFAP autoimmunity: a case series of 22 patients.

Iorio R, Damato V, Evoli A, Gessi M, Gaudino S, Di Lazzaro V, Spagni G, Sluijs JA, Hol EM.

J Neurol Neurosurg Psychiatry. 2018 Feb;89(2):138-146. doi: 10.1136/jnnp-2017-316583. Epub 2017 Sep 26.

PMID:
28951498
19.

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.

Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Eggen BJL, Möller T, Tamm JA, Abdourahman A, Hol EM, Kamphuis W, Bayer TA, De Deyn PP, Boddeke E.

Neurobiol Aging. 2017 Jul;55:115-122. doi: 10.1016/j.neurobiolaging.2017.03.021. Epub 2017 Mar 27.

PMID:
28434692
20.

Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies.

van Kesteren CF, Gremmels H, de Witte LD, Hol EM, Van Gool AR, Falkai PG, Kahn RS, Sommer IE.

Transl Psychiatry. 2017 Mar 28;7(3):e1075. doi: 10.1038/tp.2017.4.

21.

The Indispensable Roles of Microglia and Astrocytes during Brain Development.

Reemst K, Noctor SC, Lucassen PJ, Hol EM.

Front Hum Neurosci. 2016 Nov 8;10:566. eCollection 2016. Review.

22.

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific.

Jansen AH, van Hal M, Op den Kelder IC, Meier RT, de Ruiter AA, Schut MH, Smith DL, Grit C, Brouwer N, Kamphuis W, Boddeke HW, den Dunnen WF, van Roon WM, Bates GP, Hol EM, Reits EA.

Glia. 2017 Jan;65(1):50-61. doi: 10.1002/glia.23050. Epub 2016 Sep 12.

23.

Characterizing primary human microglia: A comparative study with myeloid subsets and culture models.

Melief J, Sneeboer MA, Litjens M, Ormel PR, Palmen SJ, Huitinga I, Kahn RS, Hol EM, de Witte LD.

Glia. 2016 Nov;64(11):1857-68. doi: 10.1002/glia.23023. Epub 2016 Jul 21.

PMID:
27442614
24.

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.

Kamphuis W, Kooijman L, Schetters S, Orre M, Hol EM.

Biochim Biophys Acta. 2016 Oct;1862(10):1847-60. doi: 10.1016/j.bbadis.2016.07.007. Epub 2016 Jul 15.

25.

GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions.

Moeton M, Stassen OM, Sluijs JA, van der Meer VW, Kluivers LJ, van Hoorn H, Schmidt T, Reits EA, van Strien ME, Hol EM.

Cell Mol Life Sci. 2016 Nov;73(21):4101-20. doi: 10.1007/s00018-016-2239-5. Epub 2016 May 3.

26.

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease.

Osborn LM, Kamphuis W, Wadman WJ, Hol EM.

Prog Neurobiol. 2016 Sep;144:121-41. doi: 10.1016/j.pneurobio.2016.01.001. Epub 2016 Jan 12. Review.

PMID:
26797041
27.

Astrocytes: a central element in neurological diseases.

Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A.

Acta Neuropathol. 2016 Mar;131(3):323-45. doi: 10.1007/s00401-015-1513-1. Epub 2015 Dec 15. Review.

PMID:
26671410
28.

Glial cell response after aneurysmal subarachnoid hemorrhage - Functional consequences and clinical implications.

van Dijk BJ, Vergouwen MD, Kelfkens MM, Rinkel GJ, Hol EM.

Biochim Biophys Acta. 2016 Mar;1862(3):492-505. doi: 10.1016/j.bbadis.2015.10.013. Epub 2015 Oct 19. Review. No abstract available.

29.

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes.

Herrera Moro Chao D, Kallemeijn WW, Marques AR, Orre M, Ottenhoff R, van Roomen C, Foppen E, Renner MC, Moeton M, van Eijk M, Boot RG, Kamphuis W, Hol EM, Aten J, Overkleeft HS, Kalsbeek A, Aerts JM.

PLoS One. 2015 Sep 29;10(9):e0138107. doi: 10.1371/journal.pone.0138107. eCollection 2015.

30.

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.

Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ.

Acta Neuropathol Commun. 2015 May 23;3:31. doi: 10.1186/s40478-015-0203-5.

31.

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.

de Vrij J, Maas SL, Kwappenberg KM, Schnoor R, Kleijn A, Dekker L, Luider TM, de Witte LD, Litjens M, van Strien ME, Hol EM, Kroonen J, Robe PA, Lamfers ML, Schilham MW, Broekman ML.

Int J Cancer. 2015 Oct 1;137(7):1630-42. doi: 10.1002/ijc.29521. Epub 2015 Apr 7.

32.

Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release.

Cuadrado E, Michailidou I, van Bodegraven EJ, Jansen MH, Sluijs JA, Geerts D, Couraud PO, De Filippis L, Vescovi AL, Kuijpers TW, Hol EM.

J Immunol. 2015 Apr 15;194(8):3623-33. doi: 10.4049/jimmunol.1401334. Epub 2015 Mar 13.

33.

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease.

Kamphuis W, Kooijman L, Orre M, Stassen O, Pekny M, Hol EM.

Glia. 2015 Jun;63(6):1036-56. doi: 10.1002/glia.22800. Epub 2015 Mar 2.

PMID:
25731615
34.

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system.

Hol EM, Pekny M.

Curr Opin Cell Biol. 2015 Feb;32:121-30. doi: 10.1016/j.ceb.2015.02.004. Epub 2015 Mar 2. Review.

PMID:
25726916
35.

Editorial overview: cell architecture: intermediate filaments - from molecules to patients.

Hol EM, Etienne-Manneville S.

Curr Opin Cell Biol. 2015 Feb;32:v-vi. doi: 10.1016/j.ceb.2015.01.007. Epub 2015 Feb 6. No abstract available.

PMID:
25666354
36.

Activation of endogenous neural stem cells for multiple sclerosis therapy.

Michailidou I, de Vries HE, Hol EM, van Strien ME.

Front Neurosci. 2015 Jan 20;8:454. doi: 10.3389/fnins.2014.00454. eCollection 2014.

37.

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases.

Kreft KL, van Meurs M, Wierenga-Wolf AF, Melief MJ, van Strien ME, Hol EM, Oostra BA, Laman JD, Hintzen RQ.

Acta Neuropathol Commun. 2014 Oct 3;2:144. doi: 10.1186/s40478-014-0144-4.

38.

The ubiquitin proteasome system in glia and its role in neurodegenerative diseases.

Jansen AH, Reits EA, Hol EM.

Front Mol Neurosci. 2014 Aug 8;7:73. doi: 10.3389/fnmol.2014.00073. eCollection 2014. Review.

39.

Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network.

Kanski R, Sneeboer MA, van Bodegraven EJ, Sluijs JA, Kropff W, Vermunt MW, Creyghton MP, De Filippis L, Vescovi A, Aronica E, van Tijn P, van Strien ME, Hol EM.

J Cell Sci. 2014 Oct 15;127(Pt 20):4368-80. doi: 10.1242/jcs.145912. Epub 2014 Aug 15.

40.

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.

Orre M, Kamphuis W, Osborn LM, Jansen AHP, Kooijman L, Bossers K, Hol EM.

Neurobiol Aging. 2014 Dec;35(12):2746-2760. doi: 10.1016/j.neurobiolaging.2014.06.004. Epub 2014 Jun 14.

PMID:
25002035
41.

Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer's disease.

Végh MJ, Heldring CM, Kamphuis W, Hijazi S, Timmerman AJ, Li KW, van Nierop P, Mansvelder HD, Hol EM, Smit AB, van Kesteren RE.

Acta Neuropathol Commun. 2014 Jun 29;2:76. doi: 10.1186/s40478-014-0076-z.

42.

Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies.

Cuadrado E, Vanderver A, Brown KJ, Sandza A, Takanohashi A, Jansen MH, Anink J, Herron B, Orcesi S, Olivieri I, Rice GI, Aronica E, Lebon P, Crow YJ, Hol EM, Kuijpers TW.

Ann Rheum Dis. 2015 Oct;74(10):1931-9. doi: 10.1136/annrheumdis-2014-205396. Epub 2014 Jun 6.

PMID:
24906636
43.

Enteric GFAP expression and phosphorylation in Parkinson's disease.

Clairembault T, Kamphuis W, Leclair-Visonneau L, Rolli-Derkinderen M, Coron E, Neunlist M, Hol EM, Derkinderen P.

J Neurochem. 2014 Sep;130(6):805-15. doi: 10.1111/jnc.12742. Epub 2014 Jun 6.

44.

Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion.

Moeton M, Kanski R, Stassen OM, Sluijs JA, Geerts D, van Tijn P, Wiche G, van Strien ME, Hol EM.

FASEB J. 2014 Jul;28(7):2942-54. doi: 10.1096/fj.13-245837. Epub 2014 Apr 2.

PMID:
24696300
45.

Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker CD271.

van Strien ME, Sluijs JA, Reynolds BA, Steindler DA, Aronica E, Hol EM.

Stem Cells Transl Med. 2014 Apr;3(4):470-80. doi: 10.5966/sctm.2013-0038. Epub 2014 Mar 6.

46.

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease.

Kamphuis W, Middeldorp J, Kooijman L, Sluijs JA, Kooi EJ, Moeton M, Freriks M, Mizee MR, Hol EM.

Neurobiol Aging. 2014 Mar;35(3):492-510. doi: 10.1016/j.neurobiolaging.2013.09.035. Epub 2013 Oct 23.

47.

Shades of gray: The delineation of marker expression within the adult rodent subventricular zone.

Mamber C, Kozareva DA, Kamphuis W, Hol EM.

Prog Neurobiol. 2013 Dec;111:1-16. doi: 10.1016/j.pneurobio.2013.07.003. Epub 2013 Aug 28. Review.

PMID:
23994259
48.

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice.

Orre M, Kamphuis W, Osborn LM, Melief J, Kooijman L, Huitinga I, Klooster J, Bossers K, Hol EM.

Neurobiol Aging. 2014 Jan;35(1):1-14. doi: 10.1016/j.neurobiolaging.2013.07.008. Epub 2013 Aug 15.

PMID:
23954174
49.

A star is born: new insights into the mechanism of astrogenesis.

Kanski R, van Strien ME, van Tijn P, Hol EM.

Cell Mol Life Sci. 2014 Feb;71(3):433-47. doi: 10.1007/s00018-013-1435-9. Epub 2013 Aug 2. Review.

PMID:
23907612
50.

Resident adult neural stem cells in Parkinson's disease--the brain's own repair system?

van den Berge SA, van Strien ME, Hol EM.

Eur J Pharmacol. 2013 Nov 5;719(1-3):117-27. doi: 10.1016/j.ejphar.2013.04.058. Epub 2013 Jul 18. Review.

PMID:
23872414

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