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Egr2 overexpression in Schwann cells increases myelination frequency in vitro.

Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Höke A, Mao HQ.

Heliyon. 2018 Nov 29;4(11):e00982. doi: 10.1016/j.heliyon.2018.e00982. eCollection 2018 Nov.


NCI Clinical Trials Planning Meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy.

Dorsey SG, Kleckner IR, Barton D, Mustian K, O'Mara A, St Germain D, Cavaletti G, Danhauer SC, Hershman D, Hohmann AG, Hoke A, Hopkins JO, Kelly KP, Loprinzi CL, McLeod HL, Mohile S, Paice J, Rowland JH, Salvemini D, Segal RA, Lavoie Smith E, McCaskill Stevens W, Janelsins MC.

J Natl Cancer Inst. 2019 Jan 31. doi: 10.1093/jnci/djz011. [Epub ahead of print]


Evaluation of select biocompatible markers for labelling peripheral nerves on 11.7 T MRI.

Gullotti D, Mangraviti A, Zhang J, Volpin F, Fink G, Reiss R, Ahlawat S, Olivi A, Hoke A, Tyler B, Belzberg A.

J Neurosci Methods. 2019 Mar 1;315:6-13. doi: 10.1016/j.jneumeth.2018.12.019. Epub 2019 Jan 7.


Peripheral Neuropathy Research Registry: A prospective cohort.

Thomas S, Ajroud-Driss S, Dimachkie MM, Gibbons C, Freeman R, Simpson DM, Singleton JR, Smith AG; PNRR Study Group, Höke A.

J Peripher Nerv Syst. 2019 Jan 10. doi: 10.1111/jns.12301. [Epub ahead of print]


Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination.

Milbreta U, Lin J, Pinese C, Ong W, Chin JS, Shirahama H, Mi R, Williams A, Bechler ME, Wang J, Ffrench-Constant C, Hoke A, Chew SY.

Mol Ther. 2019 Feb 6;27(2):411-423. doi: 10.1016/j.ymthe.2018.11.016. Epub 2018 Dec 1.


Body Mass Index Screening and Follow-Up: A Cross-Sectional Questionnaire Study of Pennsylvania School Nurses.

Francis E, Hoke AM, Kraschnewski JL.

Interact J Med Res. 2018 Dec 21;7(2):e11619. doi: 10.2196/11619.


Muscle-derived stem cells: important players in peripheral nerve repair.

Musavi L, Brandacher G, Hoke A, Darrach H, Lee WPA, Kumar A, Lopez J.

Expert Opin Ther Targets. 2018 Dec;22(12):1009-1016. doi: 10.1080/14728222.2018.1539706. Epub 2018 Oct 28.


Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment.

Allard DE, Wang Y, Li JJ, Conley B, Xu EW, Sailer D, Kimpston C, Notini R, Smith CJ, Koseoglu E, Starmer J, Zeng XL, Howard JF Jr, Hoke A, Scherer SS, Su MA.

J Clin Invest. 2018 Oct 1;128(10):4727-4741. doi: 10.1172/JCI99308. Epub 2018 Sep 17.


Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a case for Novel Signatures for Asymptomatic Nerve Agent Exposure.

Getnet D, Gautam A, Kumar R, Hoke A, Cheema AK, Rossetti F, Schultz CR, Hammamieh R, Lumley LA, Jett M.

Appl Environ Microbiol. 2018 Sep 14. pii: AEM.00978-18. doi: 10.1128/AEM.00978-18. [Epub ahead of print]


Brief Report: Anti-Calponin 3 Autoantibodies: A Newly Identified Specificity in Patients With Sjögren's Syndrome.

Birnbaum J, Hoke A, Lalji A, Calabresi P, Bhargava P, Casciola-Rosen L.

Arthritis Rheumatol. 2018 Oct;70(10):1610-1616. doi: 10.1002/art.40550. Epub 2018 Sep 3.


Different ketogenesis strategies lead to disparate seizure outcomes.

Dolce A, Santos P, Chen W, Hoke A, Hartman AL.

Epilepsy Res. 2018 Jul;143:90-97. doi: 10.1016/j.eplepsyres.2018.04.011. Epub 2018 Apr 27.


Altered fecal microbiota composition in all male aggressor-exposed rodent model simulating features of post-traumatic stress disorder.

Gautam A, Kumar R, Chakraborty N, Muhie S, Hoke A, Hammamieh R, Jett M.

J Neurosci Res. 2018 Jul;96(7):1311-1323. doi: 10.1002/jnr.24229. Epub 2018 Apr 6.


Increased Single-Fiber Jitter Level Is Associated With Reduction in Motor Function With Aging.

Chung T, Tian Y, Walston J, Hoke A.

Am J Phys Med Rehabil. 2018 Aug;97(8):551-556. doi: 10.1097/PHM.0000000000000915.


Novel hemizygous nonsense mutation in DRP2 is associated with inherited neuropathy.

Roda RH, McCray BA, Klein CJ, Hoke A.

Neurol Genet. 2018 Jan 24;4(1):e220. doi: 10.1212/NXG.0000000000000220. eCollection 2018 Feb. No abstract available.


Gene-metabolite profile integration to understand the cause of spaceflight induced immunodeficiency.

Chakraborty N, Cheema A, Gautam A, Donohue D, Hoke A, Conley C, Jett M, Hammamieh R.

NPJ Microgravity. 2018 Jan 29;4:4. doi: 10.1038/s41526-017-0038-4. eCollection 2018.


NaV channel variants in patients with painful and nonpainful peripheral neuropathy.

Wadhawan S, Pant S, Golhar R, Kirov S, Thompson J, Jacobsen L, Qureshi I, Ajroud-Driss S, Freeman R, Simpson DM, Smith AG, Hoke A, Bristow LJ.

Neurol Genet. 2017 Dec 15;3(6):e207. doi: 10.1212/NXG.0000000000000207. eCollection 2017 Dec.


Quality of local school wellness policies for physical activity and resultant implementation in Pennsylvania schools.

Francis E, Hivner E, Hoke A, Ricci T, Watach A, Kraschnewski J.

J Public Health (Oxf). 2018 Sep 1;40(3):591-597. doi: 10.1093/pubmed/fdx130.


Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.

Yamaleyeva LM, Sun Y, Bledsoe T, Hoke A, Gurley SB, Brosnihan KB.

FASEB J. 2017 Dec;31(12):5520-5529. doi: 10.1096/fj.201700047RR. Epub 2017 Aug 21.


Molecular indicators of stress-induced neuroinflammation in a mouse model simulating features of post-traumatic stress disorder.

Muhie S, Gautam A, Chakraborty N, Hoke A, Meyerhoff J, Hammamieh R, Jett M.

Transl Psychiatry. 2017 May 23;7(5):e1135. doi: 10.1038/tp.2017.91.


HSP and deafness: Neurocristopathy caused by a novel mosaic SOX10 mutation.

Donkervoort S, Bharucha-Goebel D, Yun P, Hu Y, Mohassel P, Hoke A, Zein WM, Ezzo D, Atherton AM, Modrcin AC, Dasouki M, Foley AR, Bönnemann CG.

Neurol Genet. 2017 May 15;3(3):e151. doi: 10.1212/NXG.0000000000000151. eCollection 2017 Jun.


Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.

Turkiew E, Falconer D, Reed N, Höke A.

J Peripher Nerv Syst. 2017 Sep;22(3):162-171. doi: 10.1111/jns.12219.


Deficiency of adaptive immunity does not interfere with Wallerian degeneration.

Cashman CR, Hoke A.

PLoS One. 2017 May 5;12(5):e0177070. doi: 10.1371/journal.pone.0177070. eCollection 2017.


An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.

Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL.

Neuron. 2017 Apr 19;94(2):337-346.e6. doi: 10.1016/j.neuron.2017.03.034.


Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress.

Karl JP, Margolis LM, Madslien EH, Murphy NE, Castellani JW, Gundersen Y, Hoke AV, Levangie MW, Kumar R, Chakraborty N, Gautam A, Hammamieh R, Martini S, Montain SJ, Pasiakos SM.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G559-G571. doi: 10.1152/ajpgi.00066.2017. Epub 2017 Mar 23.


GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord.

Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, Sockanathan S.

Mol Neurodegener. 2017 Jan 19;12(1):8. doi: 10.1186/s13024-017-0148-1.


Evolutionary perspectives: Introduction to the special issue on Axon Regeneration Across Species.

He Z, Höke A.

Exp Neurol. 2017 Jan;287(Pt 3):299. doi: 10.1016/j.expneurol.2016.11.011. No abstract available.


The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.

Ehmsen JT, Liu Y, Wang Y, Paladugu N, Johnson AE, Rothstein JD, du Lac S, Mattson MP, Höke A.

Sci Rep. 2016 Oct 19;6:35592. doi: 10.1038/srep35592.


Identification of extracellular miRNA in archived serum samples by next-generation sequencing from RNA extracted using multiple methods.

Gautam A, Kumar R, Dimitrov G, Hoke A, Hammamieh R, Jett M.

Mol Biol Rep. 2016 Oct;43(10):1165-78. doi: 10.1007/s11033-016-4043-6. Epub 2016 Aug 10.


A Novel Rodent Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Functional Recovery Resulting From Nerve Regeneration.

Kern B, Budihardjo JD, Mermulla S, Quan A, Cadmi C, Lopez J, Khusheim M, Xiang S, Park J, Furtmüller GJ, Sarhane KA, Schneeberger S, Lee WP, Hoke A, Tuffaha SH, Brandacher G.

Am J Transplant. 2017 Mar;17(3):622-634. doi: 10.1111/ajt.14007. Epub 2016 Sep 12.


A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems.

Zigler JS Jr, Hodgkinson CA, Wright M, Klise A, Sundin O, Broman KW, Hejtmancik F, Huang H, Patek B, Sergeev Y, Hose S, Brayton C, Xaiodong J, Vasquez D, Maragakis N, Mori S, Goldman D, Hoke A, Sinha D.

PLoS One. 2016 Jul 29;11(7):e0160447. doi: 10.1371/journal.pone.0160447. eCollection 2016.


Evidence for dying-back axonal degeneration in age-associated skeletal muscle decline.

Chung T, Park JS, Kim S, Montes N, Walston J, Höke A.

Muscle Nerve. 2017 Jun;55(6):894-901. doi: 10.1002/mus.25267. Epub 2017 Apr 1.


An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats.

Scheib JL, Höke A.

Neurobiol Aging. 2016 Sep;45:1-9. doi: 10.1016/j.neurobiolaging.2016.05.004. Epub 2016 May 11.


Impaired regeneration in aged nerves: Clearing out the old to make way for the new.

Scheib J, Höke A.

Exp Neurol. 2016 Oct;284(Pt A):79-83. doi: 10.1016/j.expneurol.2016.07.010. Epub 2016 Jul 21. Review.


Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion.

Hannan JL, Matsui H, Sopko NA, Liu X, Weyne E, Albersen M, Watson JW, Hoke A, Burnett AL, Bivalacqua TJ.

Sci Rep. 2016 Jul 8;6:29416. doi: 10.1038/srep29416.


Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity.

Zhu J, Carozzi VA, Reed N, Mi R, Marmiroli P, Cavaletti G, Hoke A.

Sci Rep. 2016 Jun 28;6:28861. doi: 10.1038/srep28861.


Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias.

Keller RR, Gestl SA, Lu AQ, Hoke A, Feith DJ, Gunther EJ.

Carcinogenesis. 2016 Aug;37(8):810-816. doi: 10.1093/carcin/bgw061. Epub 2016 May 17.


Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury.

Tuffaha SH, Singh P, Budihardjo JD, Means KR, Higgins JP, Shores JT, Salvatori R, Höke A, Lee WP, Brandacher G.

Expert Opin Ther Targets. 2016 Oct;20(10):1259-65. doi: 10.1080/14728222.2016.1188079. Epub 2016 May 24. Review.


Identification of fluocinolone acetonide to prevent paclitaxel-induced peripheral neuropathy.

Cetinkaya-Fisgin A, Joo MG, Ping X, Thakor NV, Ozturk C, Hoke A, Yang IH.

J Peripher Nerv Syst. 2016 Sep;21(3):128-33. doi: 10.1111/jns.12172.


Longitudinal Assessment of Small Fiber Neuropathy: Evidence of a Non-Length-Dependent Distal Axonopathy.

Khoshnoodi MA, Truelove S, Burakgazi A, Hoke A, Mammen AL, Polydefkis M.

JAMA Neurol. 2016 Jun 1;73(6):684-90. doi: 10.1001/jamaneurol.2016.0057.


Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy following Peripheral Nerve Injury.

Tuffaha SH, Budihardjo JD, Sarhane KA, Khusheim M, Song D, Broyles JM, Salvatori R, Means KR Jr, Higgins JP, Shores JT, Cooney DS, Hoke A, Lee WP, Brandacher G.

Plast Reconstr Surg. 2016 Jun;137(6):1771-80. doi: 10.1097/PRS.0000000000002188.


Immortalized Human Schwann Cell Lines Derived From Tumors of Schwannomatosis Patients.

Ostrow KL, Donaldson K, Blakeley J, Belzberg A, Hoke A.

PLoS One. 2015 Dec 14;10(12):e0144620. doi: 10.1371/journal.pone.0144620. eCollection 2015.


Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards.

Lehmann HC, Höke A.

Brain Res. 2016 May 1;1638(Pt A):97-104. doi: 10.1016/j.brainres.2015.10.040. Epub 2015 Oct 31. Review.


Improving Community Health While Satisfying a Critical Community Need: A Case Study for Nonprofit Hospitals.

Hoke AM, Kephart DK, Dillon JF, McCullough JR, Blatt BJ, Kraschnewski JL.

Prev Chronic Dis. 2015 Oct 29;12:E185. doi: 10.5888/pcd12.150230.


Paclitaxel inhibits mRNA transport in axons.

Bobylev I, Joshi AR, Barham M, Ritter C, Neiss WF, Höke A, Lehmann HC.

Neurobiol Dis. 2015 Oct;82:321-331. doi: 10.1016/j.nbd.2015.07.006. Epub 2015 Jul 15.


An exercise regimen prevents development paclitaxel induced peripheral neuropathy in a mouse model.

Park JS, Kim S, Hoke A.

J Peripher Nerv Syst. 2015 Mar;20(1):7-14. doi: 10.1111/jns.12109.


Temporal changes in neurotrophic factors and neurite outgrowth in the major pelvic ganglion following cavernous nerve injury.

Hannan JL, Albersen M, Stopak BL, Liu X, Burnett AL, Hoke A, Bivalacqua TJ.

J Neurosci Res. 2015 Jun;93(6):954-63. doi: 10.1002/jnr.23553. Epub 2015 Jan 19.


GGF2 is neuroprotective in a rat model of cavernous nerve injury-induced erectile dysfunction.

Burnett AL, Sezen SF, Hoke A, Caggiano AO, Iaci J, Lagoda G, Musicki B, Bella AJ.

J Sex Med. 2015 Apr;12(4):897-905. doi: 10.1111/jsm.12834. Epub 2015 Jan 30.


Mechanisms of distal axonal degeneration in peripheral neuropathies.

Cashman CR, Höke A.

Neurosci Lett. 2015 Jun 2;596:33-50. doi: 10.1016/j.neulet.2015.01.048. Epub 2015 Jan 21. Review.


Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.

Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H.

EMBO J. 2014 Dec 1;33(23):2798-813. doi: 10.15252/embj.201488658. Epub 2014 Oct 27.


Designing innovative therapies for neuropathic pain: preclinical and early clinical development challenges.

Höke A, Simpson DM, Freeman R.

J Peripher Nerv Syst. 2014 Oct;19 Suppl 2:S28-9. doi: 10.1111/jns.12082. No abstract available.


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