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High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis.

Zhai B, Ola M, Rolling T, Tosini NL, Joshowitz S, Littmann ER, Amoretti LA, Fontana E, Wright RJ, Miranda E, Veelken CA, Morjaria SM, Peled JU, van den Brink MRM, Babady NE, Butler G, Taur Y, Hohl TM.

Nat Med. 2020 Jan;26(1):59-64. doi: 10.1038/s41591-019-0709-7. Epub 2020 Jan 6.


Pathology Principles and Practices for Analysis of Animal Models.

Knoblaugh SE, Hohl TM, La Perle KMD.

ILAR J. 2018 Dec 1;59(1):40-50. doi: 10.1093/ilar/ilz001.


CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.

Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, Lionakis MS.

Nat Immunol. 2019 May;20(5):559-570. doi: 10.1038/s41590-019-0377-2. Epub 2019 Apr 17.


Menacing Mold: Recent Advances in Aspergillus Pathogenesis and Host Defense.

Tischler BY, Hohl TM.

J Mol Biol. 2019 Oct 4;431(21):4229-4246. doi: 10.1016/j.jmb.2019.03.027. Epub 2019 Apr 4. Review.


Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans.

Heung LJ, Hohl TM.

PLoS Pathog. 2019 Mar 21;15(3):e1007627. doi: 10.1371/journal.ppat.1007627. eCollection 2019 Mar.


Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer RA, Braus GH, Sharon A, Hohl TM.

Science. 2018 Jun 22;360(6395). pii: eaas9457. doi: 10.1126/science.aas9457.


Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Cancer.

Varughese T, Taur Y, Cohen N, Palomba ML, Seo SK, Hohl TM, Redelman-Sidi G.

Clin Infect Dis. 2018 Aug 16;67(5):687-692. doi: 10.1093/cid/ciy175.


Cytokine Release Syndrome Grade as a Predictive Marker for Infections in Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Treated With Chimeric Antigen Receptor T Cells.

Park JH, Romero FA, Taur Y, Sadelain M, Brentjens RJ, Hohl TM, Seo SK.

Clin Infect Dis. 2018 Aug 1;67(4):533-540. doi: 10.1093/cid/ciy152.


Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates.

Caffrey-Carr AK, Kowalski CH, Beattie SR, Blaseg NA, Upshaw CR, Thammahong A, Lust HE, Tang YW, Hohl TM, Cramer RA, Obar JJ.

Infect Immun. 2017 Nov 17;85(12). pii: e00661-17. doi: 10.1128/IAI.00661-17. Print 2017 Dec.


Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.

Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer RA, Braus GH, Sharon A, Hohl TM.

Science. 2017 Sep 8;357(6355):1037-1041. doi: 10.1126/science.aan0365.


A CCR2+ myeloid cell niche required for pancreatic β cell growth.

Mussar K, Pardike S, Hohl TM, Hardiman G, Cirulli V, Crisa L.

JCI Insight. 2017 Aug 3;2(15). pii: 93834. doi: 10.1172/jci.insight.93834. eCollection 2017 Aug 3.


Flow Cytometry of Lung and Bronchoalveolar Lavage Fluid Cells from Mice Challenged with Fluorescent Aspergillus Reporter (FLARE) Conidia.

Jhingran A, Kasahara S, Hohl TM.

Bio Protoc. 2016 Sep 20;6(18). pii: e1927. doi: 10.21769/BioProtoc.1927.


Immunity against fungi.

Lionakis MS, Iliev ID, Hohl TM.

JCI Insight. 2017 Jun 2;2(11). pii: 93156. doi: 10.1172/jci.insight.93156. eCollection 2017 Jun 2. Review.


Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities.

Hohl TM.

Curr Opin Infect Dis. 2017 Aug;30(4):364-371. doi: 10.1097/QCO.0000000000000381. Review.


Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus.

Brunel SF, Bain JM, King J, Heung LJ, Kasahara S, Hohl TM, Warris A.

J Vis Exp. 2017 Apr 19;(122). doi: 10.3791/55444.


Validation of single nucleotide polymorphisms in invasive aspergillosis following hematopoietic cell transplantation.

Fisher CE, Hohl TM, Fan W, Storer BE, Levine DM, Zhao LP, Martin PJ, Warren EH, Boeckh M, Hansen JA.

Blood. 2017 May 11;129(19):2693-2701. doi: 10.1182/blood-2016-10-743294. Epub 2017 Mar 7.


BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.

Duggan JM, Buechler MB, Olson RM, Hohl TM, Hamerman JA.

Blood. 2017 Mar 16;129(11):1503-1513. doi: 10.1182/blood-2016-06-719823. Epub 2017 Jan 13.


Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence.

Kowalski CH, Beattie SR, Fuller KK, McGurk EA, Tang YW, Hohl TM, Obar JJ, Cramer RA Jr.

mBio. 2016 Sep 20;7(5). pii: e01515-16. doi: 10.1128/mBio.01515-16.


New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches.

Obar JJ, Hohl TM, Cramer RA.

Cytokine. 2016 Aug;84:63-73. doi: 10.1016/j.cyto.2016.05.015. Epub 2016 May 30. Review.


DAP12 Inhibits Pulmonary Immune Responses to Cryptococcus neoformans.

Heung LJ, Hohl TM.

Infect Immun. 2016 May 24;84(6):1879-86. doi: 10.1128/IAI.00222-16. Print 2016 Jun.


Monocyte-mediated defense against bacteria, fungi, and parasites.

Lauvau G, Loke P, Hohl TM.

Semin Immunol. 2015 Dec;27(6):397-409. doi: 10.1016/j.smim.2016.03.014. Epub 2016 Mar 25. Review.


Role of Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Regulating Neutrophil Antifungal Activity and the Oxidative Burst During Respiratory Fungal Challenge.

Kasahara S, Jhingran A, Dhingra S, Salem A, Cramer RA, Hohl TM.

J Infect Dis. 2016 Apr 15;213(8):1289-98. doi: 10.1093/infdis/jiw054. Epub 2016 Feb 9.


CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System.

Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, Fink DL, Hsu AP, Zhai B, Karauzum H, Mikelis CM, Rose SR, Ferre EM, Yockey L, Lemberg K, Kuehn HS, Rosenzweig SD, Lin X, Chittiboina P, Datta SK, Belhorn TH, Weimer ET, Hernandez ML, Hohl TM, Kuhns DB, Lionakis MS.

PLoS Pathog. 2015 Dec 17;11(12):e1005293. doi: 10.1371/journal.ppat.1005293. eCollection 2015 Dec.


Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.

Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E.

J Immunol. 2016 Jan 1;196(1):336-44. doi: 10.4049/jimmunol.1502037. Epub 2015 Nov 18.


Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.

Panea C, Farkas AM, Goto Y, Abdollahi-Roodsaz S, Lee C, Koscsó B, Gowda K, Hohl TM, Bogunovic M, Ivanov II.

Cell Rep. 2015 Aug 25;12(8):1314-24. doi: 10.1016/j.celrep.2015.07.040. Epub 2015 Aug 13.


Deploying FLAREs to Visualize Functional Outcomes of Host-Pathogen Encounters.

Heung LJ, Jhingran A, Hohl TM.

PLoS Pathog. 2015 Jul 9;11(7):e1004912. doi: 10.1371/journal.ppat.1004912. eCollection 2015 Jul. Review. No abstract available.


Calnexin bridges the gap toward a pan-fungal vaccine.

Rivera A, Hohl TM.

Cell Host Microbe. 2015 Apr 8;17(4):421-3. doi: 10.1016/j.chom.2015.03.012.


Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection.

Jhingran A, Kasahara S, Shepardson KM, Junecko BA, Heung LJ, Kumasaka DK, Knoblaugh SE, Lin X, Kazmierczak BI, Reinhart TA, Cramer RA, Hohl TM.

PLoS Pathog. 2015 Jan 26;11(1):e1004589. doi: 10.1371/journal.ppat.1004589. eCollection 2015 Jan.


Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection.

Shepardson KM, Jhingran A, Caffrey A, Obar JJ, Suratt BT, Berwin BL, Hohl TM, Cramer RA.

PLoS Pathog. 2014 Sep 25;10(9):e1004378. doi: 10.1371/journal.ppat.1004378. eCollection 2014 Sep.


Nitric oxide regulates BAFF expression and T cell-independent antibody responses.

Giordano D, Draves KE, Li C, Hohl TM, Clark EA.

J Immunol. 2014 Aug 1;193(3):1110-20. doi: 10.4049/jimmunol.1303158. Epub 2014 Jun 20.


Independent contribution of bronchoalveolar lavage and serum galactomannan in the diagnosis of invasive pulmonary aspergillosis.

Fisher CE, Stevens AM, Leisenring W, Pergam SA, Boeckh M, Hohl TM.

Transpl Infect Dis. 2014 Jun;16(3):505-10. doi: 10.1111/tid.12211. Epub 2014 Apr 12.


Overview of vertebrate animal models of fungal infection.

Hohl TM.

J Immunol Methods. 2014 Aug;410:100-12. doi: 10.1016/j.jim.2014.03.022. Epub 2014 Apr 4. Review.


Inflammatory monocytes orchestrate innate antifungal immunity in the lung.

Espinosa V, Jhingran A, Dutta O, Kasahara S, Donnelly R, Du P, Rosenfeld J, Leiner I, Chen CC, Ron Y, Hohl TM, Rivera A.

PLoS Pathog. 2014 Feb 20;10(2):e1003940. doi: 10.1371/journal.ppat.1003940. eCollection 2014 Feb.


Reply to King and Stover.

Fisher CE, Boeckh M, Hohl TM.

Clin Infect Dis. 2014 Mar;58(5):752. doi: 10.1093/cid/cit784. Epub 2013 Nov 26. No abstract available.


Reply to Mikulska et al.

Fisher CE, Leisenring W, Boeckh M, Hohl TM.

Clin Infect Dis. 2013 Dec;57(12):1787-8. doi: 10.1093/cid/cit568. Epub 2013 Sep 17. No abstract available.


Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions.

Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS.

J Immunol. 2013 Sep 15;191(6):3358-72. doi: 10.4049/jimmunol.1300342. Epub 2013 Aug 16.


Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis.

Ngo LY, Kasahara S, Kumasaka DK, Knoblaugh SE, Jhingran A, Hohl TM.

J Infect Dis. 2014 Jan 1;209(1):109-19. doi: 10.1093/infdis/jit413. Epub 2013 Aug 6.


The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis.

Fisher CE, Stevens AM, Leisenring W, Pergam SA, Boeckh M, Hohl TM.

Clin Infect Dis. 2013 Oct;57(7):1001-4. doi: 10.1093/cid/cit393. Epub 2013 Jun 11.


Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.

Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D'Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH.

J Immunol. 2013 Apr 15;190(8):4175-84. doi: 10.4049/jimmunol.1202800. Epub 2013 Mar 15.


Some fungi in the air. Interview by Sophia Häfner.

Cramer RA, Hohl TM.

Microbes Infect. 2013 Apr;15(4):255-8. doi: 10.1016/j.micinf.2013.01.002. Epub 2013 Jan 29. No abstract available.


Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.

Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, Joyce JA, Fagin JA.

PLoS One. 2013;8(1):e54302. doi: 10.1371/journal.pone.0054302. Epub 2013 Jan 23.


Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.

Shepardson KM, Ngo LY, Aimanianda V, Latgé JP, Barker BM, Blosser SJ, Iwakura Y, Hohl TM, Cramer RA.

Microbes Infect. 2013 Apr;15(4):259-69. doi: 10.1016/j.micinf.2012.11.010. Epub 2012 Dec 4.


Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung.

Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM.

Cell Rep. 2012 Dec 27;2(6):1762-73. doi: 10.1016/j.celrep.2012.10.026. Epub 2012 Nov 29.


Immunity to fungi.

LeibundGut-Landmann S, Wüthrich M, Hohl TM.

Curr Opin Immunol. 2012 Aug;24(4):449-58. doi: 10.1016/j.coi.2012.04.007. Epub 2012 May 19. Review.


Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.

Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG.

Immunity. 2012 Feb 24;36(2):276-87. doi: 10.1016/j.immuni.2011.12.011. Epub 2012 Feb 2.


Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment.

Lesokhin AM, Hohl TM, Kitano S, Cortez C, Hirschhorn-Cymerman D, Avogadri F, Rizzuto GA, Lazarus JJ, Pamer EG, Houghton AN, Merghoub T, Wolchok JD.

Cancer Res. 2012 Feb 15;72(4):876-86. doi: 10.1158/0008-5472.CAN-11-1792. Epub 2011 Dec 15.


iNKTs foil fungi.

Prlic M, Hohl TM.

Cell Host Microbe. 2011 Nov 17;10(5):421-2. doi: 10.1016/j.chom.2011.11.003.


Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection.

Shi C, Hohl TM, Leiner I, Equinda MJ, Fan X, Pamer EG.

J Immunol. 2011 Nov 15;187(10):5293-8. doi: 10.4049/jimmunol.1101721. Epub 2011 Oct 5.


In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis.

Grahl N, Puttikamonkul S, Macdonald JM, Gamcsik MP, Ngo LY, Hohl TM, Cramer RA.

PLoS Pathog. 2011 Jul;7(7):e1002145. doi: 10.1371/journal.ppat.1002145. Epub 2011 Jul 21.


Immune responses against Aspergillus fumigatus: what have we learned?

Cramer RA, Rivera A, Hohl TM.

Curr Opin Infect Dis. 2011 Aug;24(4):315-22. doi: 10.1097/QCO.0b013e328348b159. Review.

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