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Items: 1 to 50 of 91

1.

Structural biology of laminins.

Hohenester E.

Essays Biochem. 2019 May 15. pii: EBC20180075. doi: 10.1042/EBC20180075. [Epub ahead of print] Review.

2.

Laminin G-like domains: dystroglycan-specific lectins.

Hohenester E.

Curr Opin Struct Biol. 2018 Dec 6;56:56-63. doi: 10.1016/j.sbi.2018.11.007. [Epub ahead of print] Review.

PMID:
30530204
3.

Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1.

Pulido D, Sharma U, Vadon-Le Goff S, Hussain SA, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes DJS.

Structure. 2018 Oct 2;26(10):1384-1392.e3. doi: 10.1016/j.str.2018.06.011. Epub 2018 Aug 2.

4.

Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.

Briggs DC, Hohenester E.

Structure. 2018 Jun 5;26(6):801-809.e3. doi: 10.1016/j.str.2018.03.014. Epub 2018 Apr 19.

5.

Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.

Paracuellos P, Kalamajski S, Bonna A, Bihan D, Farndale RW, Hohenester E.

Matrix Biol. 2017 Nov;63:106-116. doi: 10.1016/j.matbio.2017.02.002. Epub 2017 Feb 17.

6.

Crystal Structure of the Heterotrimeric Integrin-Binding Region of Laminin-111.

Pulido D, Hussain SA, Hohenester E.

Structure. 2017 Mar 7;25(3):530-535. doi: 10.1016/j.str.2017.01.002. Epub 2017 Jan 26.

7.

Structural basis of laminin binding to the LARGE glycans on dystroglycan.

Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP.

Nat Chem Biol. 2016 Oct;12(10):810-4. doi: 10.1038/nchembio.2146. Epub 2016 Aug 15.

8.

Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity.

Ahmed YA, Yates EA, Moss DJ, Loeven MA, Hussain SA, Hohenester E, Turnbull JE, Powell AK.

Mol Biosyst. 2016 Oct 20;12(10):3166-75. doi: 10.1039/c6mb00432f. Epub 2016 Aug 9.

9.

Crystallographic analysis of the laminin β2 short arm reveals how the LF domain is inserted into a regular array of LE domains.

Pulido D, Briggs DC, Hua J, Hohenester E.

Matrix Biol. 2017 Jan;57-58:204-212. doi: 10.1016/j.matbio.2016.06.006. Epub 2016 Jul 16.

10.

Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4.

Paracuellos P, Briggs DC, Carafoli F, Lončar T, Hohenester E.

Structure. 2015 Nov 3;23(11):2133-42. doi: 10.1016/j.str.2015.09.004. Epub 2015 Oct 15.

11.

Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.

Zelina P, Blockus H, Zagar Y, Péres A, Friocourt F, Wu Z, Rama N, Fouquet C, Hohenester E, Tessier-Lavigne M, Schweitzer J, Roest Crollius H, Chédotal A.

Neuron. 2014 Dec 17;84(6):1258-72. doi: 10.1016/j.neuron.2014.11.004. Epub 2014 Nov 26.

12.

Signalling complexes at the cell-matrix interface.

Hohenester E.

Curr Opin Struct Biol. 2014 Dec;29:10-6. doi: 10.1016/j.sbi.2014.08.009. Epub 2014 Sep 1. Review.

PMID:
25181573
13.

Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells.

Horejs CM, Serio A, Purvis A, Gormley AJ, Bertazzo S, Poliniewicz A, Wang AJ, DiMaggio P, Hohenester E, Stevens MM.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5908-13. doi: 10.1073/pnas.1403139111. Epub 2014 Apr 3.

14.

Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications.

Xu H, Abe T, Liu JK, Zalivina I, Hohenester E, Leitinger B.

J Biol Chem. 2014 May 9;289(19):13565-74. doi: 10.1074/jbc.M113.536144. Epub 2014 Mar 26.

15.

Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.

Riese SB, Kuehne C, Tedder TF, Hallmann R, Hohenester E, Buscher K.

J Immunol. 2014 Feb 15;192(4):1862-9. doi: 10.4049/jimmunol.1302147. Epub 2014 Jan 15.

16.

The concave face of decorin mediates reversible dimerization and collagen binding.

Islam M, Gor J, Perkins SJ, Ishikawa Y, Bächinger HP, Hohenester E.

J Biol Chem. 2013 Dec 6;288(49):35526-33. doi: 10.1074/jbc.M113.504530. Epub 2013 Oct 29.

17.

A propofol binding site on mammalian GABAA receptors identified by photolabeling.

Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP.

Nat Chem Biol. 2013 Nov;9(11):715-20. doi: 10.1038/nchembio.1340. Epub 2013 Sep 22.

18.

An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens.

Carafoli F, Hamaia SW, Bihan D, Hohenester E, Farndale RW.

PLoS One. 2013 Jul 29;8(7):e69833. doi: 10.1371/journal.pone.0069833. Print 2013.

19.

Laminin network formation studied by reconstitution of ternary nodes in solution.

Purvis A, Hohenester E.

J Biol Chem. 2012 Dec 28;287(53):44270-7. doi: 10.1074/jbc.M112.418426. Epub 2012 Nov 19.

20.

Collagen recognition and transmembrane signalling by discoidin domain receptors.

Carafoli F, Hohenester E.

Biochim Biophys Acta. 2013 Oct;1834(10):2187-94. doi: 10.1016/j.bbapap.2012.10.014. Epub 2012 Nov 2. Review.

21.

Laminins in basement membrane assembly.

Hohenester E, Yurchenco PD.

Cell Adh Migr. 2013 Jan-Feb;7(1):56-63. doi: 10.4161/cam.21831. Epub 2012 Oct 17. Review.

22.

Crystal structures of the network-forming short-arm tips of the laminin β1 and γ1 chains.

Carafoli F, Hussain SA, Hohenester E.

PLoS One. 2012;7(7):e42473. doi: 10.1371/journal.pone.0042473. Epub 2012 Jul 31.

23.

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.

Manka SW, Carafoli F, Visse R, Bihan D, Raynal N, Farndale RW, Murphy G, Enghild JJ, Hohenester E, Nagase H.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12461-6. doi: 10.1073/pnas.1204991109. Epub 2012 Jul 3.

24.

Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.

Carafoli F, Mayer MC, Shiraishi K, Pecheva MA, Chan LY, Nan R, Leitinger B, Hohenester E.

Structure. 2012 Apr 4;20(4):688-97. doi: 10.1016/j.str.2012.02.011. Epub 2012 Apr 3.

25.

Tackling the legs of mannan-binding lectin.

Hohenester E.

Structure. 2011 Nov 9;19(11):1538-40. doi: 10.1016/j.str.2011.10.005.

26.

Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region.

Hussain SA, Carafoli F, Hohenester E.

EMBO Rep. 2011 Mar;12(3):276-82. doi: 10.1038/embor.2011.3. Epub 2011 Feb 11.

27.

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

Thompson O, Moore CJ, Hussain SA, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJ.

J Cell Sci. 2010 Jan 1;123(Pt 1):118-27. doi: 10.1242/jcs.047902.

28.

Crystallographic insight into collagen recognition by discoidin domain receptor 2.

Carafoli F, Bihan D, Stathopoulos S, Konitsiotis AD, Kvansakul M, Farndale RW, Leitinger B, Hohenester E.

Structure. 2009 Dec 9;17(12):1573-1581. doi: 10.1016/j.str.2009.10.012.

29.

Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.

Hu Y, Guimond SE, Travers P, Cadman S, Hohenester E, Turnbull JE, Kim SH, Bouloux PM.

J Biol Chem. 2009 Oct 23;284(43):29905-20. doi: 10.1074/jbc.M109.049155. Epub 2009 Aug 20.

30.

Crystal structure of the LG1-3 region of the laminin alpha2 chain.

Carafoli F, Clout NJ, Hohenester E.

J Biol Chem. 2009 Aug 21;284(34):22786-92. doi: 10.1074/jbc.M109.026658. Epub 2009 Jun 24.

31.

Structural basis of sequence-specific collagen recognition by SPARC.

Hohenester E, Sasaki T, Giudici C, Farndale RW, Bächinger HP.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18273-7. doi: 10.1073/pnas.0808452105. Epub 2008 Nov 14.

32.

Structural insight into Slit-Robo signalling.

Hohenester E.

Biochem Soc Trans. 2008 Apr;36(Pt 2):251-6. doi: 10.1042/BST0360251. Review.

PMID:
18363568
33.

Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo.

Fukuhara N, Howitt JA, Hussain SA, Hohenester E.

J Biol Chem. 2008 Jun 6;283(23):16226-34. doi: 10.1074/jbc.M800688200. Epub 2008 Mar 20.

34.

Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region.

Adams JC, Bentley AA, Kvansakul M, Hatherley D, Hohenester E.

J Cell Sci. 2008 Mar 15;121(Pt 6):784-95. doi: 10.1242/jcs.021006. Epub 2008 Feb 19.

35.

Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.

Carafoli F, Saffell JL, Hohenester E.

J Mol Biol. 2008 Mar 21;377(2):524-34. doi: 10.1016/j.jmb.2008.01.030. Epub 2008 Jan 17.

36.

Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen.

Konitsiotis AD, Raynal N, Bihan D, Hohenester E, Farndale RW, Leitinger B.

J Biol Chem. 2008 Mar 14;283(11):6861-8. doi: 10.1074/jbc.M709290200. Epub 2008 Jan 16.

37.

Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5.

Harrison D, Hussain SA, Combs AC, Ervasti JM, Yurchenco PD, Hohenester E.

J Biol Chem. 2007 Apr 13;282(15):11573-81. Epub 2007 Feb 15.

38.

Mammalian collagen receptors.

Leitinger B, Hohenester E.

Matrix Biol. 2007 Apr;26(3):146-55. Epub 2006 Nov 10. Review.

PMID:
17141492
39.

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.

Hussain SA, Piper M, Fukuhara N, Strochlic L, Cho G, Howitt JA, Ahmed Y, Powell AK, Turnbull JE, Holt CE, Hohenester E.

J Biol Chem. 2006 Dec 22;281(51):39693-8. Epub 2006 Oct 24.

40.

A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1.

Noordeen NA, Carafoli F, Hohenester E, Horton MA, Leitinger B.

J Biol Chem. 2006 Aug 11;281(32):22744-51. Epub 2006 Jun 14.

41.

Interaction of the guidance molecule Slit with cellular receptors.

Hohenester E, Hussain S, Howitt JA.

Biochem Soc Trans. 2006 Jun;34(Pt 3):418-21. Review.

PMID:
16709176
42.

Structural basis for Gas6-Axl signalling.

Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Göhring W, Ullrich A, Timpl R, Hohenester E.

EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15.

43.

A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival.

Anderson AA, Kendal CE, Garcia-Maya M, Kenny AV, Morris-Triggs SA, Wu T, Reynolds R, Hohenester E, Saffell JL.

J Neurochem. 2005 Oct;95(2):570-83. Epub 2005 Aug 31.

44.

A simplified laminin nomenclature.

Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD.

Matrix Biol. 2005 Aug;24(5):326-32. Review.

PMID:
15979864
45.

Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit.

Howitt JA, Clout NJ, Hohenester E.

EMBO J. 2004 Nov 10;23(22):4406-12. Epub 2004 Oct 21.

46.

Laminin: the crux of basement membrane assembly.

Sasaki T, Fässler R, Hohenester E.

J Cell Biol. 2004 Mar 29;164(7):959-63. Epub 2004 Mar 22. Review.

47.

Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats.

Kvansakul M, Adams JC, Hohenester E.

EMBO J. 2004 Mar 24;23(6):1223-33. Epub 2004 Mar 11.

48.
49.

Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair.

Wizemann H, Garbe JH, Friedrich MV, Timpl R, Sasaki T, Hohenester E.

J Mol Biol. 2003 Sep 19;332(3):635-42.

PMID:
12963372
50.

Crystal structure of the collagen alpha1(VIII) NC1 trimer.

Kvansakul M, Bogin O, Hohenester E, Yayon A.

Matrix Biol. 2003 Apr;22(2):145-52.

PMID:
12782141

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