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Phase-I trial of donor-derived modified immune cell infusion in kidney transplantation.

Morath C, Schmitt A, Kleist C, Daniel V, Opelz G, Süsal C, Ibrahim EH, Kälble F, Speer C, Nusshag C, Pego da Silva L, Sommerer C, Wang L, Ni M, Hückelhoven-Krauss A, Czock D, Merle U, Mehrabi A, Sander A, Hackbusch M, Eckert C, Waldherr R, Schnitzler P, Müller-Tidow C, Hoheisel JD, Mustafa SA, Alhamdani MS, Bauer AS, Reiser J, Zeier M, Schmitt M, Schaier M, Terness P.

J Clin Invest. 2020 Jan 28. pii: 133595. doi: 10.1172/JCI133595. [Epub ahead of print]


A Diagnostic Panel of DNA Methylation Biomarkers for Lung Adenocarcinoma.

Shen N, Du J, Zhou H, Chen N, Pan Y, Hoheisel JD, Jiang Z, Xiao L, Tao Y, Mo X.

Front Oncol. 2019 Dec 3;9:1281. doi: 10.3389/fonc.2019.01281. eCollection 2019.


The transcription factor FLI1 promotes cancer progression by affecting cell cycle regulation.

Miao B, Bauer AS, Hufnagel K, Wu Y, Trajkovic-Arsic M, Pirona AC, Giese N, Taipale J, Siveke JT, Hoheisel JD, Lueong S.

Int J Cancer. 2019 Dec 17. doi: 10.1002/ijc.32831. [Epub ahead of print]


Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer.

Al Alawi R, Alhamdani MSS, Hoheisel JD, Baqi Y.

Biomed Pharmacother. 2020 Jan;121:109522. doi: 10.1016/j.biopha.2019.109522. Epub 2019 Oct 29.


Nanobody stability engineering by employing the ΔTm shift; a comparison with apparent rate constants of heat-induced aggregation.

Kunz P, Ortale A, Mücke N, Zinner K, Hoheisel JD.

Protein Eng Des Sel. 2019 Dec 31;32(5):241-249. doi: 10.1093/protein/gzz017.


The potential of dopamine receptor D2 (DRD2) as a therapeutic target for tackling pancreatic cancer.

Bakadlag R, Jandaghi P, Hoheisel JD, Riazalhosseini Y.

Expert Opin Ther Targets. 2019 May;23(5):365-367. doi: 10.1080/14728222.2019.1606904. Epub 2019 Apr 26. No abstract available.


Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells.

Marzoq AJ, Mustafa SA, Heidrich L, Hoheisel JD, Alhamdani MSS.

Sci Rep. 2019 Mar 28;9(1):5303. doi: 10.1038/s41598-019-41740-x.


Copying Life: Synthesis of an Enzymatically Active Mirror-Image DNA-Ligase Made of D-Amino Acids.

Weidmann J, Schnölzer M, Dawson PE, Hoheisel JD.

Cell Chem Biol. 2019 May 16;26(5):645-651.e3. doi: 10.1016/j.chembiol.2019.02.008. Epub 2019 Mar 14.


N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling.

Visvanathan A, Patil V, Abdulla S, Hoheisel JD, Somasundaram K.

Genes (Basel). 2019 Feb 13;10(2). pii: E141. doi: 10.3390/genes10020141.


GHSR DNA hypermethylation is a new epigenetic biomarker for gastric adenocarcinoma and beyond.

Amini M, Foroughi K, Talebi F, Aghagolzade Haji H, Kamali F, Jandaghi P, Hoheisel JD, Manoochehri M.

J Cell Physiol. 2019 Jan 24. doi: 10.1002/jcp.28179. [Epub ahead of print]


Function, clinical application, and strategies of Pre-mRNA splicing in cancer.

Di C, Syafrizayanti, Zhang Q, Chen Y, Wang Y, Zhang X, Liu Y, Sun C, Zhang H, Hoheisel JD.

Cell Death Differ. 2019 Jul;26(7):1181-1194. doi: 10.1038/s41418-018-0231-3. Epub 2018 Nov 21.


Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns.

Bure I, Geer S, Knopf J, Roas M, Henze S, Ströbel P, Agaimy A, Wiemann S, Hoheisel JD, Hartmann A, Haller F, Moskalev EA.

Genes Chromosomes Cancer. 2018 Nov;57(11):584-597. doi: 10.1002/gcc.22672. Epub 2018 Sep 24.


Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer.

Bermejo JL, Huang G, Manoochehri M, Mesa KG, Schick M, Silos RG, Ko YD, Brüning T, Brauch H, Lo WY, Hoheisel JD, Hamann U.

Epigenomics. 2019 Jan;11(1):81-93. doi: 10.2217/epi-2018-0121. Epub 2018 Sep 13.


The structural basis of nanobody unfolding reversibility and thermoresistance.

Kunz P, Zinner K, Mücke N, Bartoschik T, Muyldermans S, Hoheisel JD.

Sci Rep. 2018 May 21;8(1):7934. doi: 10.1038/s41598-018-26338-z.


Immunoprofiling of Chlamydia trachomatis using whole-proteome microarrays generated by on-chip in situ expression.

Hufnagel K, Lueong S, Willhauck-Fleckenstein M, Hotz-Wagenblatt A, Miao B, Bauer A, Michel A, Butt J, Pawlita M, Hoheisel JD, Waterboer T.

Sci Rep. 2018 May 14;8(1):7503. doi: 10.1038/s41598-018-25918-3.


Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy.

García-Salum T, Villablanca A, Matthäus F, Tittarelli A, Baeza M, Pereda C, Gleisner MA, González FE, López MN, Hoheisel JD, Norgauer J, Gebicke-Haerter PJ, Salazar-Onfray F.

Oncotarget. 2018 Mar 30;9(24):17014-17027. doi: 10.18632/oncotarget.24795. eCollection 2018 Mar 30.


The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators.

Kaistha BP, Krattenmacher A, Fredebohm J, Schmidt H, Behrens D, Widder M, Hackert T, Strobel O, Hoheisel JD, Gress TM, Buchholz M.

Oncotarget. 2017 Aug 3;8(39):66215-66225. doi: 10.18632/oncotarget.19882. eCollection 2017 Sep 12.


Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

Bauer AS, Nazarov PV, Giese NA, Beghelli S, Heller A, Greenhalf W, Costello E, Muller A, Bier M, Strobel O, Hackert T, Vallar L, Scarpa A, Büchler MW, Neoptolemos JP, Kreis S, Hoheisel JD.

Int J Cancer. 2018 Mar 1;142(5):1010-1021. doi: 10.1002/ijc.31087. Epub 2017 Oct 17.


Exploiting sequence and stability information for directing nanobody stability engineering.

Kunz P, Flock T, Soler N, Zaiss M, Vincke C, Sterckx Y, Kastelic D, Muyldermans S, Hoheisel JD.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2196-2205. doi: 10.1016/j.bbagen.2017.06.014. Epub 2017 Jun 20.


Comparison of the tumor cell secretome and patient sera for an accurate serum-based diagnosis of pancreatic ductal adenocarcinoma.

Mustafa S, Pan L, Marzoq A, Fawaz M, Sander L, Rückert F, Schrenk A, Hartl C, Uhler R, Yildirim A, Strobel O, Hackert T, Giese N, Büchler MW, Hoheisel JD, Alhamdani MS.

Oncotarget. 2017 Feb 14;8(7):11963-11976. doi: 10.18632/oncotarget.14449.


Personalised proteome analysis by means of protein microarrays made from individual patient samples.

Syafrizayanti, Lueong SS, Di C, Schaefer JV, Plückthun A, Hoheisel JD.

Sci Rep. 2017 Jan 3;7:39756. doi: 10.1038/srep39756.


Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice.

Jandaghi P, Najafabadi HS, Bauer AS, Papadakis AI, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, Park M, Büchler MW, Strobel O, Hackert T, Giese NA, Zogopoulos G, Sangwan V, Huang S, Riazalhosseini Y, Hoheisel JD.

Gastroenterology. 2016 Dec;151(6):1218-1231. doi: 10.1053/j.gastro.2016.08.040. Epub 2016 Aug 28.


CRISPR RNA-guided FokI nucleases repair a PAH variant in a phenylketonuria model.

Pan Y, Shen N, Jung-Klawitter S, Betzen C, Hoffmann GF, Hoheisel JD, Blau N.

Sci Rep. 2016 Oct 27;6:35794. doi: 10.1038/srep35794.


Secretome profiling of apheresis platelet supernatants during routine storage via antibody-based microarray.

Kamhieh-Milz J, Mustafa SA, Sterzer V, Celik H, Keski S, Khorramshahi O, Movassaghi K, Hoheisel JD, Alhamdani MS, Salama A.

J Proteomics. 2017 Jan 6;150:74-85. doi: 10.1016/j.jprot.2016.07.028. Epub 2016 Jul 28.


Protein Profiling Gastric Cancer and Neighboring Control Tissues Using High-Content Antibody Microarrays.

Sill M, Schröder C, Shen Y, Marzoq A, Komel R, Hoheisel JD, Nienhüser H, Schmidt T, Kastelic D.

Microarrays (Basel). 2016 Jul 8;5(3). pii: E19. doi: 10.3390/microarrays5030019.


Melanoma miRNA trafficking controls tumour primary niche formation.

Dror S, Sander L, Schwartz H, Sheinboim D, Barzilai A, Dishon Y, Apcher S, Golan T, Greenberger S, Barshack I, Malcov H, Zilberberg A, Levin L, Nessling M, Friedmann Y, Igras V, Barzilay O, Vaknine H, Brenner R, Zinger A, Schroeder A, Gonen P, Khaled M, Erez N, Hoheisel JD, Levy C.

Nat Cell Biol. 2016 Sep;18(9):1006-17. doi: 10.1038/ncb3399. Epub 2016 Aug 22.


Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression.

Botla SK, Savant S, Jandaghi P, Bauer AS, Mücke O, Moskalev EA, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Gaida MM, Büchler MW, Strobel O, Hackert T, Giese NA, Augustin HG, Hoheisel JD.

Cancer Res. 2016 Jul 15;76(14):4149-59. doi: 10.1158/0008-5472.CAN-15-0390. Epub 2016 May 23.


Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.

Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S.

Mol Oncol. 2016 Jun;10(6):806-24. doi: 10.1016/j.molonc.2016.01.008. Epub 2016 Feb 4.


Gene expression regulatory networks in Trypanosoma brucei: insights into the role of the mRNA-binding proteome.

Lueong S, Merce C, Fischer B, Hoheisel JD, Erben ED.

Mol Microbiol. 2016 May;100(3):457-71. doi: 10.1111/mmi.13328. Epub 2016 Mar 10.


Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.

Kibat J, Schirrmann T, Knape MJ, Helmsing S, Meier D, Hust M, Schröder C, Bertinetti D, Winter G, Pardes K, Funk M, Vala A, Giese N, Herberg FW, Dübel S, Hoheisel JD.

N Biotechnol. 2016 Sep 25;33(5 Pt A):574-81. doi: 10.1016/j.nbt.2015.12.003. Epub 2015 Dec 17.


Boc-SPPS: Compatible Linker for the Synthesis of Peptide o-Aminoanilides.

Weidmann J, Dimitrijević E, Hoheisel JD, Dawson PE.

Org Lett. 2016 Jan 15;18(2):164-7. doi: 10.1021/acs.orglett.5b03111. Epub 2015 Dec 24.


Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling.

Bal G, Futschik ME, Hartl D, Ringel F, Kamhieh-Milz J, Sterzer V, Hoheisel JD, Alhamdani MS, Salama A.

Br J Haematol. 2016 Feb;172(4):602-15. doi: 10.1111/bjh.13861. Epub 2015 Dec 2.


Definition of a serum marker panel for glioblastoma discrimination and identification of Interleukin 1β in the microglial secretome as a novel mediator of endothelial cell survival induced by C-reactive protein.

Nijaguna MB, Schröder C, Patil V, Shwetha SD, Hegde AS, Chandramouli BA, Arivazhagan A, Santosh V, Hoheisel JD, Somasundaram K.

J Proteomics. 2015 Oct 14;128:251-61. doi: 10.1016/j.jprot.2015.07.026. Epub 2015 Jul 29.


Stratification of pancreatic tissue samples for molecular studies: RNA-based cellular annotation procedure.

Heller A, Gaida MM, Männle D, Giese T, Scarpa A, Neoptolemos JP, Hackert T, Strobel O, Hoheisel JD, Giese NA, Bauer AS.

Pancreatology. 2015 Jul-Aug;15(4):423-31. doi: 10.1016/j.pan.2015.05.480. Epub 2015 Jun 15.


Micro RNA expression profiles in peripheral blood cells of rats that were experimentally infected with Trypanosoma congolense and different Trypanosoma brucei subspecies.

Simo G, Lueong S, Grebaut P, Guny G, Hoheisel JD.

Microbes Infect. 2015 Aug;17(8):596-608. doi: 10.1016/j.micinf.2015.03.004. Epub 2015 Mar 19.


GHSR hypermethylation: a promising pan-cancer marker.

Jandaghi P, Hoheisel JD, Riazalhosseini Y.

Cell Cycle. 2015;14(5):689-90. doi: 10.1080/15384101.2015.1006051. No abstract available.


Clinical proteomics: promises, challenges and limitations of affinity arrays.

Betzen C, Alhamdani MS, Lueong S, Schröder C, Stang A, Hoheisel JD.

Proteomics Clin Appl. 2015 Apr;9(3-4):342-7. doi: 10.1002/prca.201400156. Epub 2015 Mar 2. Review.


Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications.

Ragusa M, Statello L, Maugeri M, Barbagallo C, Passanisi R, Alhamdani MS, Li Destri G, Cappellani A, Barbagallo D, Scalia M, Valadi H, Hoheisel JD, Di Pietro C, Purrello M.

Oncoscience. 2014 Mar 16;1(2):132-157. eCollection 2014.


GHSR DNA hypermethylation is a common epigenetic alteration of high diagnostic value in a broad spectrum of cancers.

Moskalev EA, Jandaghi P, Fallah M, Manoochehri M, Botla SK, Kolychev OV, Nikitin EA, Bubnov VV, von Knebel Doeberitz M, Strobel O, Hackert T, Büchler MW, Giese N, Bauer A, Muley T, Warth A, Schirmacher P, Haller F, Hoheisel JD, Riazalhosseini Y.

Oncotarget. 2015 Feb 28;6(6):4418-27.


Differentially regulated miRNAs as prognostic biomarkers in the blood of primary CNS lymphoma patients.

Roth P, Keller A, Hoheisel JD, Codo P, Bauer AS, Backes C, Leidinger P, Meese E, Thiel E, Korfel A, Weller M.

Eur J Cancer. 2015 Feb;51(3):382-90. doi: 10.1016/j.ejca.2014.10.028. Epub 2014 Dec 17.


Intracerebral interleukin-10 injection modulates post-ischemic neuroinflammation: an experimental microarray study.

Liesz A, Bauer A, Hoheisel JD, Veltkamp R.

Neurosci Lett. 2014 Sep 5;579:18-23. doi: 10.1016/j.neulet.2014.07.003. Epub 2014 Jul 11.


A genome-wide tethering screen reveals novel potential post-transcriptional regulators in Trypanosoma brucei.

Erben ED, Fadda A, Lueong S, Hoheisel JD, Clayton C.

PLoS Pathog. 2014 Jun 12;10(6):e1004178. doi: 10.1371/journal.ppat.1004178. eCollection 2014 Jun.


Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.

Srinivasan H, Allory Y, Sill M, Vordos D, Alhamdani MS, Radvanyi F, Hoheisel JD, Schröder C.

Proteomics. 2014 Jun;14(11):1333-42. doi: 10.1002/pmic.201300320. Epub 2014 Apr 29.


High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells.

Boettcher M, Lawson A, Ladenburger V, Fredebohm J, Wolf J, Hoheisel JD, Frezza C, Shlomi T.

BMC Genomics. 2014 Feb 25;15:158. doi: 10.1186/1471-2164-15-158.


EU Pancreas: an integrated European platform for pancreas cancer research--from basic science to clinical and public health interventions for a rare disease.

Milne R, La Vecchia C, Van Steen K, Hahn S, Buchholz M, Costello E, Esposito I, Hoheisel JD, Lange B, Lopez-Bigas N, Michalski CW, Real FX, Brand A, Malats N.

Public Health Genomics. 2013;16(6):305-12. doi: 10.1159/000355937. Epub 2014 Feb 3.


Methods for analyzing and quantifying protein-protein interaction.

Syafrizayanti, Betzen C, Hoheisel JD, Kastelic D.

Expert Rev Proteomics. 2014 Feb;11(1):107-20. doi: 10.1586/14789450.2014.875857. Epub 2014 Jan 6. Review.


Plasma protein analysis of patients with different B-cell lymphomas using high-content antibody microarrays.

Schröder C, Srinivasan H, Sill M, Linseisen J, Fellenberg K, Becker N, Nieters A, Hoheisel JD.

Proteomics Clin Appl. 2013 Dec;7(11-12):802-12. doi: 10.1002/prca.201300048.


An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation.

Wolf J, Müller-Decker K, Flechtenmacher C, Zhang F, Shahmoradgoli M, Mills GB, Hoheisel JD, Boettcher M.

Oncogene. 2014 Aug 14;33(33):4273-8. doi: 10.1038/onc.2013.515. Epub 2013 Dec 2.


A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype.

Wolf J, Dewi DL, Fredebohm J, Müller-Decker K, Flechtenmacher C, Hoheisel JD, Boettcher M.

Breast Cancer Res. 2013 Nov 14;15(6):R109. doi: 10.1186/bcr3576.


Proteome variations in pancreatic stellate cells upon stimulation with proinflammatory factors.

Marzoq AJ, Giese N, Hoheisel JD, Alhamdani MS.

J Biol Chem. 2013 Nov 8;288(45):32517-27. doi: 10.1074/jbc.M113.488387. Epub 2013 Oct 2.

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