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Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients: A Nested Randomized Clinical Trial.

Brown CH 4th, Neufeld KJ, Tian J, Probert J, LaFlam A, Max L, Hori D, Nomura Y, Mandal K, Brady K, Hogue CW; and the Cerebral Autoregulation Study Group, Shah A, Zehr K, Cameron D, Conte J, Bienvenu OJ, Gottesman R, Yamaguchi A, Kraut M.

JAMA Surg. 2019 May 22. doi: 10.1001/jamasurg.2019.1163. [Epub ahead of print]


Delirium after Cardiac Surgery and Cognitive Change: Reply.

Brown CH 4th, Hogue CW.

Anesthesiology. 2019 May;130(5):859. doi: 10.1097/ALN.0000000000002699. No abstract available.


Pulse pressure and perioperative stroke.

Al-Qamari A, Adeleke I, Kretzer A, Hogue CW.

Curr Opin Anaesthesiol. 2019 Feb;32(1):57-63. doi: 10.1097/ACO.0000000000000673. Review.


Observational Study Examining the Association of Baseline Frailty and Postcardiac Surgery Delirium and Cognitive Change.

Nomura Y, Nakano M, Bush B, Tian J, Yamaguchi A, Walston J, Hasan R, Zehr K, Mandal K, LaFlam A, Neufeld KJ, Kamath V, Hogue CW, Brown CH 4th.

Anesth Analg. 2019 Aug;129(2):507-514. doi: 10.1213/ANE.0000000000003967.


Aligning nomenclature for cognitive changes associated with anaesthesia and surgery with broader diagnostic classifications of non-surgical populations: a needed first step.

Hogue CW, Grafman J.

Br J Anaesth. 2018 Nov;121(5):991-993. doi: 10.1016/j.bja.2017.12.029. Epub 2018 Jan 17. No abstract available.


Cerebral Neuromonitoring During Cardiac Surgery: A Critical Appraisal With an Emphasis on Near-Infrared Spectroscopy.

Lewis C, Parulkar SD, Bebawy J, Sherwani S, Hogue CW.

J Cardiothorac Vasc Anesth. 2018 Oct;32(5):2313-2322. doi: 10.1053/j.jvca.2018.03.032. Epub 2018 Mar 20. Review.


Glasgow Coma Scale Score Fluctuations are Inversely Associated With a NIRS-based Index of Cerebral Autoregulation in Acutely Comatose Patients.

Healy RJ, Zorrilla-Vaca A, Ziai W, Mirski MA, Hogue CW, Geocadin R, Radzik B, Palmisano C, Rivera-Lara L.

J Neurosurg Anesthesiol. 2019 Jul;31(3):306-310. doi: 10.1097/ANA.0000000000000513.


Cognitive Decline after Delirium in Patients Undergoing Cardiac Surgery.

Brown CH 4th, Probert J, Healy R, Parish M, Nomura Y, Yamaguchi A, Tian J, Zehr K, Mandal K, Kamath V, Neufeld KJ, Hogue CW.

Anesthesiology. 2018 Sep;129(3):406-416. doi: 10.1097/ALN.0000000000002253.


Effect of Body Temperature on Cerebral Autoregulation in Acutely Comatose Neurocritically Ill Patients.

Adatia K, Geocadin RG, Healy R, Ziai W, Ponce-Mejia L, Anderson-White M, Shah D, Radzik BR, Palmisano C, Hogue CW, Brown C, Rivera-Lara L.

Crit Care Med. 2018 Aug;46(8):e733-e741. doi: 10.1097/CCM.0000000000003181.


Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study.

Nomura Y, Faegle R, Hori D, Al-Qamari A, Nemeth AJ, Gottesman R, Yenokyan G, Brown C, Hogue CW.

Anesth Analg. 2018 Dec;127(6):1314-1322. doi: 10.1213/ANE.0000000000003384.


Relationship Between the Ambulatory Arterial Stiffness Index and the Lower Limit of Cerebral Autoregulation During Cardiac Surgery.

Obata Y, Barodka V, Berkowitz DE, Gottschalk A, Hogue CW, Steppan J.

J Am Heart Assoc. 2018 Feb 8;7(4). pii: e007816. doi: 10.1161/JAHA.117.007816.


Peri-operative neurological complications.

Hood R, Budd A, Sorond FA, Hogue CW.

Anaesthesia. 2018 Jan;73 Suppl 1:67-75. doi: 10.1111/anae.14142. Review.


Validation of a Real-Time Minute-to-Minute Urine Output Monitor and the Feasibility of Its Clinical Use for Patients Undergoing Cardiac Surgery.

Chang AJ, Nomura Y, Barodka VM, Hori D, Magruder JT, Katz NM, Berkowitz DE, Hogue CW.

Anesth Analg. 2017 Dec;125(6):1883-1886. doi: 10.1213/ANE.0000000000002217.


Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring.

Hori D, Nomura Y, Ono M, Joshi B, Mandal K, Cameron D, Kocherginsky M, Hogue CW.

J Thorac Cardiovasc Surg. 2017 Nov;154(5):1590-1598.e2. doi: 10.1016/j.jtcvs.2017.04.091. Epub 2017 Jul 24.


Lack of benefit of near-infrared spectroscopy monitoring for improving patient outcomes. Case closed?

Lewis C, Hogue CW.

Br J Anaesth. 2017 Sep 1;119(3):347-349. doi: 10.1093/bja/aex214. No abstract available.


Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults.

Wyrobek J, LaFlam A, Max L, Tian J, Neufeld KJ, Kebaish KM, Walston JD, Hogue CW, Riley LH, Everett AD, Brown CH 4th.

Br J Anaesth. 2017 Aug 1;119(2):324-332. doi: 10.1093/bja/aex103.


Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium.

Yoshimura A, Goodson C, Johns JT, Towe MM, Irvine ES, Rendradjaja NA, Max LK, LaFlam A, Ledford EC, Probert J, Tieges Z, Edwin DH, MacLullich AMJ, Hogue CW, Lindquist MA, Gurakar A, Neufeld KJ, Kamiya A.

Sci Rep. 2017 Aug 23;7(1):9258. doi: 10.1038/s41598-017-10024-7.


Impaired cerebral autoregulation and elevation in plasma glial fibrillary acidic protein level during cardiopulmonary bypass surgery for CHD.

Easley RB, Marino BS, Jennings J, Cassedy AE, Kibler KK, Brady KM, Andropoulos DB, Brunetti M, Hogue CW, Heitmiller ES, Lee JK, Spaeth J, Everett AD.

Cardiol Young. 2018 Jan;28(1):55-65. doi: 10.1017/S1047951117001573. Epub 2017 Aug 24.


Predictors of Outcome With Cerebral Autoregulation Monitoring: A Systematic Review and Meta-Analysis.

Rivera-Lara L, Zorrilla-Vaca A, Geocadin R, Ziai W, Healy R, Thompson R, Smielewski P, Czosnyka M, Hogue CW.

Crit Care Med. 2017 Apr;45(4):695-704. doi: 10.1097/CCM.0000000000002251. Review.


Defining oliguria during cardiopulmonary bypass and its relationship with cardiac surgery-associated acute kidney injury.

Hori D, Katz NM, Fine DM, Ono M, Barodka VM, Lester LC, Yenokyan G, Hogue CW.

Br J Anaesth. 2016 Dec;117(6):733-740.


Cerebral Blood Flow Autoregulation in Sepsis for the Intensivist: Why Its Monitoring May Be the Future of Individualized Care.

Goodson CM, Rosenblatt K, Rivera-Lara L, Nyquist P, Hogue CW.

J Intensive Care Med. 2018 Feb;33(2):63-73. doi: 10.1177/0885066616673973. Epub 2016 Oct 25. Review.


Delirium After Spine Surgery in Older Adults: Incidence, Risk Factors, and Outcomes.

Brown CH 4th, LaFlam A, Max L, Wyrobek J, Neufeld KJ, Kebaish KM, Cohen DB, Walston JD, Hogue CW, Riley LH.

J Am Geriatr Soc. 2016 Oct;64(10):2101-2108. doi: 10.1111/jgs.14434. Epub 2016 Oct 3.


Blood Pressure Deviations From Optimal Mean Arterial Pressure During Cardiac Surgery Measured With a Novel Monitor of Cerebral Blood Flow and Risk for Perioperative Delirium: A Pilot Study.

Hori D, Max L, Laflam A, Brown C, Neufeld KJ, Adachi H, Sciortino C, Conte JV, Cameron DE, Hogue CW Jr, Mandal K.

J Cardiothorac Vasc Anesth. 2016 Jun;30(3):606-12. doi: 10.1053/j.jvca.2016.01.012. Epub 2016 Jan 12.



Hori D, Hogue CW.

Ann Thorac Surg. 2016 May;101(5):2027. doi: 10.1016/j.athoracsur.2015.11.053. No abstract available.


The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery.

Brown CH 4th, Max L, LaFlam A, Kirk L, Gross A, Arora R, Neufeld K, Hogue CW, Walston J, Pustavoitau A.

Anesth Analg. 2016 Aug;123(2):430-5. doi: 10.1213/ANE.0000000000001271.


The Impact of Delirium After Cardiac Surgical Procedures on Postoperative Resource Use.

Brown CH 4th, Laflam A, Max L, Lymar D, Neufeld KJ, Tian J, Shah AS, Whitman GJ, Hogue CW.

Ann Thorac Surg. 2016 May;101(5):1663-9. doi: 10.1016/j.athoracsur.2015.12.074. Epub 2016 Mar 31.


A Multicenter Pilot Study Assessing Regional Cerebral Oxygen Desaturation Frequency During Cardiopulmonary Bypass and Responsiveness to an Intervention Algorithm.

Subramanian B, Nyman C, Fritock M, Klinger RY, Sniecinski R, Roman P, Huffmyer J, Parish M, Yenokyan G, Hogue CW.

Anesth Analg. 2016 Jun;122(6):1786-93. doi: 10.1213/ANE.0000000000001275.


Evidence of an association between brain cellular injury and cognitive decline after non-cardiac surgery.

Rappold T, Laflam A, Hori D, Brown C, Brandt J, Mintz CD, Sieber F, Gottschalk A, Yenokyan G, Everett A, Hogue CW.

Br J Anaesth. 2016 Jan;116(1):83-9. doi: 10.1093/bja/aev415.


The Association of Brain MRI Characteristics and Postoperative Delirium in Cardiac Surgery Patients.

Brown CH 4th, Faigle R, Klinker L, Bahouth M, Max L, LaFlam A, Neufeld KJ, Mandal K, Gottesman RF, Hogue CW Jr.

Clin Ther. 2015 Dec 1;37(12):2686-2699.e9. doi: 10.1016/j.clinthera.2015.10.021. Epub 2015 Nov 29.


Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans.

Mohanty S, Jobichen C, Chichili VP, Velázquez-Campoy A, Low BC, Hogue CW, Sivaraman J.

J Biol Chem. 2015 Nov 6;290(45):27280-96. doi: 10.1074/jbc.M115.677492. Epub 2015 Sep 14.


Cerebral Autoregulation Monitoring with Ultrasound-Tagged Near-Infrared Spectroscopy in Cardiac Surgery Patients.

Hori D, Hogue CW Jr, Shah A, Brown C, Neufeld KJ, Conte JV, Price J, Sciortino C, Max L, Laflam A, Adachi H, Cameron DE, Mandal K.

Anesth Analg. 2015 Nov;121(5):1187-93. doi: 10.1213/ANE.0000000000000930.


Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein.

Hori D, Everett AD, Lee JK, Ono M, Brown CH, Shah AS, Mandal K, Price JE, Lester LC, Hogue CW.

Ann Thorac Surg. 2015 Oct;100(4):1353-8. doi: 10.1016/j.athoracsur.2015.04.006. Epub 2015 Jul 7.


Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury.

Hori D, Ono M, Rappold TE, Conte JV, Shah AS, Cameron DE, Adachi H, Everett AD, Hogue CW.

Ann Thorac Surg. 2015 Aug;100(2):487-93. doi: 10.1016/j.athoracsur.2015.03.036. Epub 2015 Jun 16.


Does it matter who the anesthesiologist is for my heart surgery?

Maxwell BG, Hogue CW Jr, Pronovost PJ.

Anesth Analg. 2015 Mar;120(3):499-501. doi: 10.1213/ANE.0000000000000566. No abstract available.


Effect of carotid revascularization on cerebral autoregulation in combined cardiac surgery†.

Hori D, Ono M, Adachi H, Hogue CW.

Eur J Cardiothorac Surg. 2016 Jan;49(1):281-7. doi: 10.1093/ejcts/ezv018. Epub 2015 Feb 1.


Impaired olfaction and risk of delirium or cognitive decline after cardiac surgery.

Brown CH 4th, Morrissey C, Ono M, Yenokyan G, Selnes OA, Walston J, Max L, LaFlam A, Neufeld K, Gottesman RF, Hogue CW.

J Am Geriatr Soc. 2015 Jan;63(1):16-23. doi: 10.1111/jgs.13198.


Cerebral and tissue oximetry.

Steppan J, Hogue CW Jr.

Best Pract Res Clin Anaesthesiol. 2014 Dec;28(4):429-39. doi: 10.1016/j.bpa.2014.09.002. Epub 2014 Sep 28. Review.


Arterial pressure above the upper cerebral autoregulation limit during cardiopulmonary bypass is associated with postoperative delirium.

Hori D, Brown C, Ono M, Rappold T, Sieber F, Gottschalk A, Neufeld KJ, Gottesman R, Adachi H, Hogue CW.

Br J Anaesth. 2014 Dec;113(6):1009-17. doi: 10.1093/bja/aeu319. Epub 2014 Sep 25.


Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury.

Tekes A, Poretti A, Scheurkogel MM, Huisman TA, Howlett JA, Alqahtani E, Lee JH, Parkinson C, Shapiro K, Chung SE, Jennings JM, Gilmore MM, Hogue CW, Martin LJ, Koehler RC, Northington FJ, Lee JK.

AJNR Am J Neuroradiol. 2015 Jan;36(1):188-93. doi: 10.3174/ajnr.A4083. Epub 2014 Aug 28.


A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest.

Lee JK, Brady KM, Chung SE, Jennings JM, Whitaker EE, Aganga D, Easley RB, Heitmiller K, Jamrogowicz JL, Larson AC, Lee JH, Jordan LC, Hogue CW, Lehmann CU, Bembea MM, Hunt EA, Koehler RC, Shaffner DH.

Resuscitation. 2014 Oct;85(10):1387-93. doi: 10.1016/j.resuscitation.2014.07.006. Epub 2014 Jul 18.


A cooperative jack model of random coil-to-elongation transition of the FH1 domain by profilin binding explains formin motor behavior in actin polymerization.

Zhao C, Liu C, Hogue CW, Low BC.

FEBS Lett. 2014 Jun 27;588(14):2288-93. doi: 10.1016/j.febslet.2014.05.016. Epub 2014 May 23.


Length of red cell unit storage and risk for delirium after cardiac surgery.

Brown CH 4th, Grega M, Selnes OA, McKhann GM, Shah AS, LaFlam A, Savage WJ, Frank SM, Hogue CW, Gottesman RF.

Anesth Analg. 2014 Aug;119(2):242-50. doi: 10.1213/ANE.0000000000000134.


Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients.

Salaria ON, Barodka VM, Hogue CW, Berkowitz DE, Ness PM, Wasey JO, Frank SM.

Anesth Analg. 2014 Jun;118(6):1179-87. doi: 10.1213/ANE.0000000000000227.


In reply.

Brady K, Rhee CJ, Hogue CW.

Anesthesiology. 2014 May;120(5):1281-2. doi: 10.1097/ALN.0000000000000167. No abstract available.


Biophysical properties of intrinsically disordered p130Cas substrate domain--implication in mechanosensing.

Hotta K, Ranganathan S, Liu R, Wu F, Machiyama H, Gao R, Hirata H, Soni N, Ohe T, Hogue CW, Madhusudhan MS, Sawada Y.

PLoS Comput Biol. 2014 Apr 10;10(4):e1003532. doi: 10.1371/journal.pcbi.1003532. eCollection 2014 Apr.


Reply to the editor.

Ono M, Brady K, Hogue CW.

J Thorac Cardiovasc Surg. 2014 Apr;147(4):1431-2. doi: 10.1016/j.jtcvs.2013.12.004. Epub 2013 Dec 18. No abstract available.


Cerebral blood flow autoregulation is preserved after hypothermic circulatory arrest.

Ono M, Brown C, Lee JK, Gottesman RF, Kraut M, Black J, Shah A, Cameron DE, Baumgartner W, Hogue CW.

Ann Thorac Surg. 2013 Dec;96(6):2045.


Often overlooked problems with handoffs: from the intensive care unit to the operating room.

Evans AS, Yee MS, Hogue CW.

Anesth Analg. 2014 Mar;118(3):687-9. doi: 10.1213/ANE.0000000000000075. Review. No abstract available.


Odds of transfusion for older adults compared to younger adults undergoing surgery.

Brown CH 4th, Savage WJ, Masear CG, Walston JD, Tian J, Colantuoni E, Hogue CW, Frank SM.

Anesth Analg. 2014 Jun;118(6):1168-78. doi: 10.1213/ANE.0000000000000033.

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