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Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL.

Ruscher R, Hogquist KA.

Curr Opin Immunol. 2019 Jun;58:83-88. doi: 10.1016/j.coi.2019.04.010. Epub 2019 May 28. Review.


Measuring Thymic Clonal Deletion at the Population Level.

Breed ER, Watanabe M, Hogquist KA.

J Immunol. 2019 Jun 1;202(11):3226-3233. doi: 10.4049/jimmunol.1900191. Epub 2019 Apr 22.


ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets.

Borges da Silva H, Wang H, Qian LJ, Hogquist KA, Jameson SC.

J Immunol. 2019 Apr 1;202(7):2153-2163. doi: 10.4049/jimmunol.1801613. Epub 2019 Feb 18.


The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.

Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB.

Nat Commun. 2019 Jan 21;10(1):354. doi: 10.1038/s41467-019-08300-3.


CCR7 defines a precursor for murine iNKT cells in thymus and periphery.

Wang H, Hogquist KA.

Elife. 2018 Aug 13;7. pii: e34793. doi: 10.7554/eLife.34793.


Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.

Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18.


How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.

Wang H, Hogquist KA.

Front Immunol. 2018 Jun 26;9:1450. doi: 10.3389/fimmu.2018.01450. eCollection 2018. Review.


The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells.

Borges da Silva H, Beura LK, Wang H, Hanse EA, Gore R, Scott MC, Walsh DA, Block KE, Fonseca R, Yan Y, Hippen KL, Blazar BR, Masopust D, Kelekar A, Vulchanova L, Hogquist KA, Jameson SC.

Nature. 2018 Jul;559(7713):264-268. doi: 10.1038/s41586-018-0282-0. Epub 2018 Jul 4.


For T Cells, the Child Is Father of the Man.

Hogquist KA, Hamilton SE.

Cell. 2018 Jun 28;174(1):16-18. doi: 10.1016/j.cell.2018.06.015.


Intravenous Labeling and Analysis of the Content of Thymic Perivascular Spaces.

Ruscher R, Hogquist KA.

Bio Protoc. 2018 Mar 5;8(5). pii: e2757. doi: 10.21769/bioprotoc.2757.


Wait, Wait … OK Now Go In: iNKT Cells Resolve Liver Inflammation.

Wang H, Hogquist KA.

Immunity. 2017 Oct 17;47(4):609-610. doi: 10.1016/j.immuni.2017.10.002.


Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.

Breed ER, Lee ST, Hogquist KA.

Semin Cell Dev Biol. 2018 Dec;84:2-10. doi: 10.1016/j.semcdb.2017.07.045. Epub 2017 Aug 9. Review.


Corrigendum: Spontaneous partial loss of the OT-I transgene.

Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951b. No abstract available.


Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation.

Schuldt NJ, Auger JL, Spanier JA, Martinov T, Breed ER, Fife BT, Hogquist KA, Binstadt BA.

J Immunol. 2017 Jul 1;199(1):33-38. doi: 10.4049/jimmunol.1700406. Epub 2017 May 24.


CD8αα intraepithelial lymphocytes arise from two main thymic precursors.

Ruscher R, Kummer RL, Lee YJ, Jameson SC, Hogquist KA.

Nat Immunol. 2017 Jul;18(7):771-779. doi: 10.1038/ni.3751. Epub 2017 May 22.


T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.

Smith MJ, Reichenbach DK, Parker SL, Riddle MJ, Mitchell J, Osum KC, Mohtashami M, Stefanski HE, Fife BT, Bhandoola A, Hogquist KA, Holländer GA, Zúñiga-Pflücker JC, Tolar J, Blazar BR.

JCI Insight. 2017 May 18;2(10). pii: 92056. doi: 10.1172/jci.insight.92056. eCollection 2017 May 18.


OKT3 and H57-597: From Discovery, to Commercialization, to the Clinic.

Hogquist KA.

J Immunol. 2016 Nov 1;197(9):3429-3430. No abstract available.


How MAIT cells get their start.

Wang H, Hogquist KA.

Nat Immunol. 2016 Oct 19;17(11):1238-1240. doi: 10.1038/ni.3584. No abstract available.


Prospective studies of infectious mononucleosis in university students.

Grimm JM, Schmeling DO, Dunmire SK, Knight JA, Mullan BD, Ed JA, Brundage RC, Hogquist KA, Balfour HH Jr.

Clin Transl Immunology. 2016 Aug 12;5(8):e94. doi: 10.1038/cti.2016.48. eCollection 2016 Aug.


Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst γδ T, Innate Lymphoid, and Th Cells.

Lee YJ, Starrett GJ, Lee ST, Yang R, Henzler CM, Jameson SC, Hogquist KA.

J Immunol. 2016 Aug 15;197(4):1460-70. doi: 10.4049/jimmunol.1600643. Epub 2016 Jul 6.


IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection.

Renkema KR, Lee JY, Lee YJ, Hamilton SE, Hogquist KA, Jameson SC.

J Exp Med. 2016 Jun 27;213(7):1319-29. doi: 10.1084/jem.20151359. Epub 2016 Jun 13.


Spontaneous partial loss of the OT-I transgene.

Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.

Nat Immunol. 2016 May;17(5):471. doi: 10.1038/ni.3411. No abstract available. Erratum in: Nat Immunol. 2017 Jul 19;18(8):951.


Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.

Xing Y, Wang X, Jameson SC, Hogquist KA.

Nat Immunol. 2016 May;17(5):565-73. doi: 10.1038/ni.3419. Epub 2016 Apr 4.


CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL.

Nat Immunol. 2016 Mar;17(3):304-14. doi: 10.1038/ni.3331. Epub 2016 Feb 1.


Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.

Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK.

Nat Immunol. 2016 Feb;17(2):187-95. doi: 10.1038/ni.3327. Epub 2016 Jan 4.


Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.

Schuldt NJ, Auger JL, Hogquist KA, Binstadt BA.

PLoS One. 2015 Dec 22;10(12):e0145762. doi: 10.1371/journal.pone.0145762. eCollection 2015.


The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events.

Dunmire SK, Grimm JM, Schmeling DO, Balfour HH Jr, Hogquist KA.

PLoS Pathog. 2015 Dec 1;11(12):e1005286. doi: 10.1371/journal.ppat.1005286. eCollection 2015 Dec.


Infectious Mononucleosis.

Dunmire SK, Hogquist KA, Balfour HH.

Curr Top Microbiol Immunol. 2015;390(Pt 1):211-40. doi: 10.1007/978-3-319-22822-8_9. Review.


Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.

Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA.

Immunity. 2015 Sep 15;43(3):566-78. doi: 10.1016/j.immuni.2015.06.025. Epub 2015 Sep 8.


T Cell Adolescence: Maturation Events Beyond Positive Selection.

Hogquist KA, Xing Y, Hsu FC, Shapiro VS.

J Immunol. 2015 Aug 15;195(4):1351-7. doi: 10.4049/jimmunol.1501050. Review.


Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction.

Panikkar A, Smith C, Hislop A, Tellam N, Dasari V, Hogquist KA, Wykes M, Moss DJ, Rickinson A, Balfour HH Jr, Khanna R.

J Virol. 2015 Sep;89(17):9137-41. doi: 10.1128/JVI.01293-15. Epub 2015 Jun 24.


Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation.

Panikkar A, Smith C, Hislop A, Tellam N, Dasari V, Hogquist KA, Wykes M, Moss DJ, Rickinson A, Balfour HH Jr, Khanna R.

J Infect Dis. 2015 Dec 15;212(12):1957-61. doi: 10.1093/infdis/jiv340. Epub 2015 Jun 16.


Infectious mononucleosis.

Balfour HH Jr, Dunmire SK, Hogquist KA.

Clin Transl Immunology. 2015 Feb 27;4(2):e33. doi: 10.1038/cti.2015.1. eCollection 2015 Feb. Review.


Innate memory T cells.

Jameson SC, Lee YJ, Hogquist KA.

Adv Immunol. 2015;126:173-213. doi: 10.1016/ Epub 2015 Feb 7. Review.


The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.

Lee JY, Skon CN, Lee YJ, Oh S, Taylor JJ, Malhotra D, Jenkins MK, Rosenfeld MG, Hogquist KA, Jameson SC.

Immunity. 2015 Feb 17;42(2):252-264. doi: 10.1016/j.immuni.2015.01.013.


The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.

Fulton RB, Hamilton SE, Xing Y, Best JA, Goldrath AW, Hogquist KA, Jameson SC.

Nat Immunol. 2015 Jan;16(1):107-17. doi: 10.1038/ni.3043. Epub 2014 Nov 24.


Isolation, identification, and purification of murine thymic epithelial cells.

Xing Y, Hogquist KA.

J Vis Exp. 2014 Aug 8;(90):e51780. doi: 10.3791/51780.


The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.

Hogquist KA, Jameson SC.

Nat Immunol. 2014 Sep;15(9):815-23. doi: 10.1038/ni.2938. Review.


TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.

Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer MP, Zhang H, Hogquist KA, Evavold BD, Vignali DA.

J Immunol. 2014 Jul 15;193(2):571-9. doi: 10.4049/jimmunol.1400043. Epub 2014 Jun 18.


Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).

Klein L, Kyewski B, Allen PM, Hogquist KA.

Nat Rev Immunol. 2014 Jun;14(6):377-91. doi: 10.1038/nri3667. Epub 2014 May 16. Review.


Antigen-dependent versus -independent activation of invariant NKT cells during infection.

Holzapfel KL, Tyznik AJ, Kronenberg M, Hogquist KA.

J Immunol. 2014 Jun 15;192(12):5490-8. doi: 10.4049/jimmunol.1400722. Epub 2014 May 9.


Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.

Hendricks DW, Balfour HH Jr, Dunmire SK, Schmeling DO, Hogquist KA, Lanier LL.

J Immunol. 2014 May 15;192(10):4492-6. doi: 10.4049/jimmunol.1303211. Epub 2014 Apr 16.


Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA.

Nat Immunol. 2014 May;15(5):473-81. doi: 10.1038/ni.2849. Epub 2014 Mar 16.


From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection.

Sawicka M, Stritesky GL, Reynolds J, Abourashchi N, Lythe G, Molina-París C, Hogquist KA.

Front Immunol. 2014 Feb 14;5:19. doi: 10.3389/fimmu.2014.00019. eCollection 2014.


Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes.

Dunmire SK, Odumade OA, Porter JL, Reyes-Genere J, Schmeling DO, Bilgic H, Fan D, Baechler EC, Balfour HH Jr, Hogquist KA.

PLoS One. 2014 Jan 17;9(1):e85422. doi: 10.1371/journal.pone.0085422. eCollection 2014.


Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.

Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA, Jameson SC.

Nat Immunol. 2013 Dec;14(12):1285-93. doi: 10.1038/ni.2745. Epub 2013 Oct 27.


Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ.

Melichar HJ, Ross JO, Herzmark P, Hogquist KA, Robey EA.

Sci Signal. 2013 Oct 15;6(297):ra92. doi: 10.1126/scisignal.2004400.


Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.

Lee YJ, Holzapfel KL, Zhu J, Jameson SC, Hogquist KA.

Nat Immunol. 2013 Nov;14(11):1146-54. doi: 10.1038/ni.2731. Epub 2013 Oct 6. Erratum in: Nat Immunol. 2014 Mar;15(3):305.


Virtual memory CD8 T cells display unique functional properties.

Lee JY, Hamilton SE, Akue AD, Hogquist KA, Jameson SC.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13498-503. doi: 10.1073/pnas.1307572110. Epub 2013 Jul 29.


Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.

Xing Y, Jameson SC, Hogquist KA.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6979-84. doi: 10.1073/pnas.1222244110. Epub 2013 Apr 8.

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