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Items: 16

1.

Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.

Burkey BF, Hoglen NC, Inskeep P, Wyman M, Hughes TE, Vath JE.

J Pharmacol Exp Ther. 2018 May;365(2):301-313. doi: 10.1124/jpet.117.246272. Epub 2018 Feb 28.

PMID:
29491038
2.

Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.

Egemnazarov B, Schermuly RT, Dahal BK, Elliott GT, Hoglen NC, Surber MW, Weissmann N, Grimminger F, Seeger W, Ghofrani HA.

Respir Res. 2010 Jun 21;11:81. doi: 10.1186/1465-9921-11-81.

3.

A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia.

Hoglen NC, Anselmo DM, Katori M, Kaldas M, Shen XD, Valentino KL, Lassman C, Busuttil RW, Kupiec-Weglinski JW, Farmer DG.

Liver Transpl. 2007 Mar;13(3):361-6.

4.

First-in-class pan caspase inhibitor developed for the treatment of liver disease.

Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ.

J Med Chem. 2005 Nov 3;48(22):6779-82.

PMID:
16250635
5.

Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor.

Hoglen NC, Chen LS, Fisher CD, Hirakawa BP, Groessl T, Contreras PC.

J Pharmacol Exp Ther. 2004 May;309(2):634-40. Epub 2004 Jan 23.

PMID:
14742742
6.

Modes of cell death in rat liver after monocrotaline exposure.

Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA.

Toxicol Sci. 2004 Jan;77(1):172-82. Epub 2003 Nov 4.

PMID:
14600277
7.

Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.

Hoglen NC, Hirakawa BP, Fisher CD, Weeks S, Srinivasan A, Wong AM, Valentino KL, Tomaselli KJ, Bai X, Karanewsky DS, Contreras PC.

J Pharmacol Exp Ther. 2001 May;297(2):811-8.

PMID:
11303074
8.
9.

1,2-Dichlorobenzene-mediated hepatocellular oxidative stress in Fischer-344 and Sprague-Dawley rats.

Younis HS, Hoglen NC, Kuester RK, Gunawardhana L, Sipes IG.

Toxicol Appl Pharmacol. 2000 Mar 1;163(2):141-8.

PMID:
10698672
10.

1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent.

Hoglen NC, Younis HS, Hartley DP, Gunawardhana L, Lantz RC, Sipes IG.

Toxicol Sci. 1998 Dec;46(2):376-85.

PMID:
10048141
11.

Alteration of Kupffer cell function and morphology by low melt point paraffin wax in female Fischer-344 but not Sprague-Dawley rats.

Hoglen NC, Regan SP, Hensel JL, Younis HS, Sauer JM, Steup DR, Miller MJ, Waterman SJ, Twerdok LE, Sipes IG.

Toxicol Sci. 1998 Nov;46(1):176-84. Erratum in: Toxicol Sci 1999 Mar;48(1):142.

PMID:
9928681
12.

Products from reaction of peroxynitrite with gamma-tocopherol.

Hoglen NC, Liebler DC.

Methods Enzymol. 1999;301:483-90. Review. No abstract available.

PMID:
9919596
13.

Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol.

Hoglen NC, Abril EA, Sauer JM, Earnest DL, McCuskey RS, Lantz RC, Mobley SA, Sipes IG.

Liver. 1997 Jun;17(3):157-65.

PMID:
9249731
14.

Reactions of peroxynitrite with gamma-tocopherol.

Hoglen NC, Waller SC, Sipes IG, Liebler DC.

Chem Res Toxicol. 1997 Apr;10(4):401-7.

PMID:
9114976
15.

The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol.

Badger DA, Sauer JM, Hoglen NC, Jolley CS, Sipes IG.

Toxicol Appl Pharmacol. 1996 Dec;141(2):507-19.

PMID:
8975775
16.

3,3',4,4'-Tetrabromobiphenyl sensitizes rats to the hepatotoxic effects of endotoxin by a mechanism that involves more than tumor necrosis factor.

Shedlofsky SI, Hoglen NC, Rodman LE, Honchel R, Robinson FR, Swim AT, McClain CJ, Robertson LW.

Hepatology. 1991 Dec;14(6):1201-8.

PMID:
1660020

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