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Items: 1 to 50 of 114


DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry.

Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML.

J Am Chem Soc. 2018 Aug 29;140(34):10639-10643. doi: 10.1021/jacs.8b04638. Epub 2018 Aug 16.


A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.

Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM.

ACS Infect Dis. 2017 Feb 10;3(2):112-118. doi: 10.1021/acsinfecdis.6b00079. Epub 2016 Dec 6.


Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes.

Groppelli E, Levy HC, Sun E, Strauss M, Nicol C, Gold S, Zhuang X, Tuthill TJ, Hogle JM, Rowlands DJ.

PLoS Pathog. 2017 Feb 6;13(2):e1006197. doi: 10.1371/journal.ppat.1006197. eCollection 2017 Feb.


Getting to and through the inner nuclear membrane during herpesvirus nuclear egress.

Lye MF, Wilkie AR, Filman DJ, Hogle JM, Coen DM.

Curr Opin Cell Biol. 2017 Jun;46:9-16. doi: 10.1016/ Epub 2017 Jan 10. Review.


Covalently circularized nanodiscs for studying membrane proteins and viral entry.

Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G.

Nat Methods. 2017 Jan;14(1):49-52. doi: 10.1038/nmeth.4079. Epub 2016 Nov 21.


Cryo-electron Microscopy Structures of Expanded Poliovirus with VHHs Sample the Conformational Repertoire of the Expanded State.

Strauss M, Schotte L, Karunatilaka KS, Filman DJ, Hogle JM.

J Virol. 2017 Jan 18;91(3). pii: e01443-16. doi: 10.1128/JVI.01443-16. Print 2017 Feb 1.


Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.

Strauss M, Schotte L, Thys B, Filman DJ, Hogle JM.

J Virol. 2016 Jan 13;90(7):3496-505. doi: 10.1128/JVI.03017-15.


Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.

Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM.

EMBO J. 2015 Dec 2;34(23):2937-52. doi: 10.15252/embj.201592651. Epub 2015 Oct 28.


Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.

Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9010-5. doi: 10.1073/pnas.1511140112. Epub 2015 Jul 6.


Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs).

Schotte L, Thys B, Strauss M, Filman DJ, Rombaut B, Hogle JM.

Antimicrob Agents Chemother. 2015 Aug;59(8):4695-706. doi: 10.1128/AAC.00878-15. Epub 2015 May 26.


Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry.

Strauss M, Filman DJ, Belnap DM, Cheng N, Noel RT, Hogle JM.

J Virol. 2015 Apr;89(8):4143-57. doi: 10.1128/JVI.03101-14. Epub 2015 Jan 28.


Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.

Moustafa IM, Korboukh VK, Arnold JJ, Smidansky ED, Marcotte LL, Gohara DW, Yang X, Sánchez-Farrán MA, Filman D, Maranas JK, Boehr DD, Hogle JM, Colina CM, Cameron CE.

J Biol Chem. 2014 Dec 26;289(52):36229-48. doi: 10.1074/jbc.M114.616193. Epub 2014 Nov 6.


Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex.

Sharma M, Bender BJ, Kamil JP, Lye MF, Pesola JM, Reim NI, Hogle JM, Coen DM.

J Virol. 2015 Jan;89(1):523-34. doi: 10.1128/JVI.02426-14. Epub 2014 Oct 22.


Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore.

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ.

PLoS Pathog. 2014 Aug 7;10(8):e1004294. doi: 10.1371/journal.ppat.1004294. eCollection 2014 Aug.


Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity.

Schotte L, Strauss M, Thys B, Halewyck H, Filman DJ, Bostina M, Hogle JM, Rombaut B.

J Virol. 2014 Apr;88(8):4403-13. doi: 10.1128/JVI.03402-13. Epub 2014 Feb 5.


Cryo-electron microscopy reconstruction shows poliovirus 135S particles poised for membrane interaction and RNA release.

Butan C, Filman DJ, Hogle JM.

J Virol. 2014 Feb;88(3):1758-70. doi: 10.1128/JVI.01949-13. Epub 2013 Nov 20.


Conformational shift of a major poliovirus antigen confirmed by immuno-cryogenic electron microscopy.

Lin J, Cheng N, Hogle JM, Steven AC, Belnap DM.

J Immunol. 2013 Jul 15;191(2):884-91. doi: 10.4049/jimmunol.1202014. Epub 2013 Jun 14.


RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors.

Strauss M, Levy HC, Bostina M, Filman DJ, Hogle JM.

J Virol. 2013 Apr;87(7):3903-14. doi: 10.1128/JVI.03209-12. Epub 2013 Jan 30.


A 3D framework for understanding enterovirus 71.

Hogle JM.

Nat Struct Mol Biol. 2012 Apr 4;19(4):367-8. doi: 10.1038/nsmb.2276.


Structure of the Fab-labeled "breathing" state of native poliovirus.

Lin J, Lee LY, Roivainen M, Filman DJ, Hogle JM, Belnap DM.

J Virol. 2012 May;86(10):5959-62. doi: 10.1128/JVI.05990-11. Epub 2012 Mar 7.


An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.

Lin J, Cheng N, Chow M, Filman DJ, Steven AC, Hogle JM, Belnap DM.

J Virol. 2011 Oct;85(19):9974-83. doi: 10.1128/JVI.05013-11. Epub 2011 Jul 20.


Poliovirus RNA is released from the capsid near a twofold symmetry axis.

Bostina M, Levy H, Filman DJ, Hogle JM.

J Virol. 2011 Jan;85(2):776-83. doi: 10.1128/JVI.00531-10. Epub 2010 Oct 27.


Nicotine withdrawal increases threat-induced anxiety but not fear: neuroadaptation in human addiction.

Hogle JM, Kaye JT, Curtin JJ.

Biol Psychiatry. 2010 Oct 15;68(8):719-25. doi: 10.1016/j.biopsych.2010.06.003. Epub 2010 Jul 31.



Tuthill TJ, Groppelli E, Hogle JM, Rowlands DJ.

Curr Top Microbiol Immunol. 2010;343:43-89. doi: 10.1007/82_2010_37.


Catching a virus in the act of RNA release: a novel poliovirus uncoating intermediate characterized by cryo-electron microscopy.

Levy HC, Bostina M, Filman DJ, Hogle JM.

J Virol. 2010 May;84(9):4426-41. doi: 10.1128/JVI.02393-09. Epub 2010 Feb 24.


The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.

Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM.

J Virol. 2009 Dec;83(23):12215-28. doi: 10.1128/JVI.01158-09. Epub 2009 Sep 16.


Rapid actin-dependent viral motility in live cells.

Vaughan JC, Brandenburg B, Hogle JM, Zhuang X.

Biophys J. 2009 Sep 16;97(6):1647-56. doi: 10.1016/j.bpj.2009.07.011.


Multiplexed plasmonic sensing based on small-dimension nanohole arrays and intensity interrogation.

Yang JC, Ji J, Hogle JM, Larson DN.

Biosens Bioelectron. 2009 Apr 15;24(8):2334-8. doi: 10.1016/j.bios.2008.12.011. Epub 2008 Dec 13.


Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex.

Sam MD, Evans BT, Coen DM, Hogle JM.

J Virol. 2009 Apr;83(7):2996-3006. doi: 10.1128/JVI.02441-08. Epub 2009 Jan 19.


Metallic nanohole arrays on fluoropolymer substrates as small label-free real-time bioprobes.

Yang JC, Ji J, Hogle JM, Larson DN.

Nano Lett. 2008 Sep;8(9):2718-24. doi: 10.1021/nl801043t. Epub 2008 Aug 19.


The human cytomegalovirus UL44 C clamp wraps around DNA.

Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM.

Structure. 2008 Aug 6;16(8):1214-25. doi: 10.1016/j.str.2008.05.008.


Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry.

Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM.

J Struct Biol. 2008 Jun;162(3):480-90. doi: 10.1016/j.jsb.2008.03.006. Epub 2008 Mar 25.


The positively charged surface of herpes simplex virus UL42 mediates DNA binding.

Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM.

J Biol Chem. 2008 Mar 7;283(10):6154-61. doi: 10.1074/jbc.M708691200. Epub 2008 Jan 4.


Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 A resolution.

Bostina M, Bubeck D, Schwartz C, Nicastro D, Filman DJ, Hogle JM.

J Struct Biol. 2007 Nov;160(2):200-10. Epub 2007 Aug 24.


Imaging poliovirus entry in live cells.

Brandenburg B, Lee LY, Lakadamyali M, Rust MJ, Zhuang X, Hogle JM.

PLoS Biol. 2007 Jul;5(7):e183. Epub 2007 Jul 10.


Identification of a glycosaminoglycan binding region of the alpha C protein that mediates entry of group B Streptococci into host cells.

Baron MJ, Filman DJ, Prophete GA, Hogle JM, Madoff LC.

J Biol Chem. 2007 Apr 6;282(14):10526-36. Epub 2007 Jan 26.


Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase.

Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM.

J Virol. 2007 Apr;81(7):3583-96. Epub 2007 Jan 24.


Sex differences in negative affective response during nicotine withdrawal.

Hogle JM, Curtin JJ.

Psychophysiology. 2006 Jul;43(4):344-56.


Binding of herpes simplex virus-1 US11 to specific RNA sequences.

Bryant KF, Cox JC, Wang H, Hogle JM, Ellington AD, Coen DM.

Nucleic Acids Res. 2005 Oct 24;33(19):6090-100. Print 2005.


Multiple conformations in the ligand-binding site of the yeast nuclear pore-targeting domain of Nup116p.

Robinson MA, Park S, Sun ZY, Silver PA, Wagner G, Hogle JM.

J Biol Chem. 2005 Oct 21;280(42):35723-32. Epub 2005 Aug 16.


Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex.

Bubeck D, Filman DJ, Hogle JM.

Nat Struct Mol Biol. 2005 Jul;12(7):615-8. Epub 2005 Jun 19.


Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein.

Aupérin TC, Bolduc GR, Baron MJ, Heroux A, Filman DJ, Madoff LC, Hogle JM.

J Biol Chem. 2005 May 6;280(18):18245-52. Epub 2005 Mar 6.


Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication.

Guogas LM, Filman DJ, Hogle JM, Gehrke L.

Science. 2004 Dec 17;306(5704):2108-11.


Ligand-induced conformational changes in poliovirus-antiviral drug complexes.

Hiremath CN, Filman DJ, Grant RA, Hogle JM.

Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):558-70.


The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.

Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM.

Mol Cell. 2004 Jul 23;15(2):233-44.

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