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Influenza challenge models: Ready for prime time?

Bernstein DI, Atmar RL, Hoft DF.

Clin Infect Dis. 2020 Mar 24. pii: ciaa278. doi: 10.1093/cid/ciaa278. [Epub ahead of print] No abstract available.


Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy.

Liu X, Hoft DF, Peng G.

J Clin Invest. 2020 Mar 2;130(3):1073-1083. doi: 10.1172/JCI133679. Review.


Percutaneous BCG enhances innate effector antitumor cytotoxicity during treatment of bladder cancer: a translational clinical trial.

Ji N, Mukherjee N, Morales EE, Tomasini ME, Hurez V, Curiel TJ, Abate G, Hoft DF, Zhao XR, Gelfond J, Maiti S, Cooper LJN, Svatek RS.

Oncoimmunology. 2019 May 25;8(8):1614857. doi: 10.1080/2162402X.2019.1614857. eCollection 2019.


Induction of mycobacterial protective immunity by sublingual BCG vaccination.

Eickhoff CS, Blazevic A, Killoran EA, Morris MS, Hoft DF.

Vaccine. 2019 Aug 23;37(36):5364-5370. doi: 10.1016/j.vaccine.2019.07.034. Epub 2019 Jul 19.


Highly conserved influenza T cell epitopes induce broadly protective immunity.

Eickhoff CS, Terry FE, Peng L, Meza KA, Sakala IG, Van Aartsen D, Moise L, Martin WD, Schriewer J, Buller RM, De Groot AS, Hoft DF.

Vaccine. 2019 Aug 23;37(36):5371-5381. doi: 10.1016/j.vaccine.2019.07.033. Epub 2019 Jul 19.


A Subset of Mycobacteria-Specific CD4+ IFN-γ+ T Cell Expressing Naive Phenotype Confers Protection against Tuberculosis Infection in the Lung.

Yuan J, Tenant J, Pacatte T, Eickhoff C, Blazevic A, Hoft DF, Chatterjee S.

J Immunol. 2019 Aug 15;203(4):972-980. doi: 10.4049/jimmunol.1900209. Epub 2019 Jun 28.


Harnessing donor unrestricted T-cells for new vaccines against tuberculosis.

Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, Seshadri C; Collaboration for Tuberculosis Vaccine Discovery - Donor-Unrestricted T-cells Working Group, Bill and Melinda Gates Foundation.

Vaccine. 2019 May 21;37(23):3022-3030. doi: 10.1016/j.vaccine.2019.04.050. Epub 2019 Apr 27. Review.


BCG Vaccination Induces M. avium and M. abscessus Cross-Protective Immunity.

Abate G, Hamzabegovic F, Eickhoff CS, Hoft DF.

Front Immunol. 2019 Feb 19;10:234. doi: 10.3389/fimmu.2019.00234. eCollection 2019.


Clinical, Virologic, and Immunologic Characteristics of Zika Virus Infection in a Cohort of US Patients: Prolonged RNA Detection in Whole Blood.

El Sahly HM, Gorchakov R, Lai L, Natrajan MS, Patel SM, Atmar RL, Keitel WA, Hoft DF, Barrett J, Bailey J, Edupuganti S, Raabe V, Wu HM, Fairley J, Rouphael N, Murray KO, Mulligan MJ.

Open Forum Infect Dis. 2018 Dec 19;6(1):ofy352. doi: 10.1093/ofid/ofy352. eCollection 2019 Jan.


A scoring strategy for progression risk and rates of treatment completion in subjects with latent tuberculosis.

Scolarici M, Dekitani K, Chen L, Sokol-Anderson M, Hoft DF, Chatterjee S.

PLoS One. 2018 Nov 15;13(11):e0207582. doi: 10.1371/journal.pone.0207582. eCollection 2018.


TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy.

Li L, Liu X, Sanders KL, Edwards JL, Ye J, Si F, Gao A, Huang L, Hsueh EC, Ford DA, Hoft DF, Peng G.

Cell Metab. 2019 Jan 8;29(1):103-123.e5. doi: 10.1016/j.cmet.2018.09.020. Epub 2018 Oct 18.


Thermal and Nutritional Regulation of Ribosome Hibernation in Staphylococcus aureus.

Basu A, Shields KE, Eickhoff CS, Hoft DF, Yap MN.

J Bacteriol. 2018 Nov 26;200(24). pii: e00426-18. doi: 10.1128/JB.00426-18. Print 2018 Dec 15.


Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis.

Bockerstett KA, Osaki LH, Petersen CP, Cai CW, Wong CF, Nguyen TM, Ford EL, Hoft DF, Mills JC, Goldenring JR, DiPaolo RJ.

Cell Mol Gastroenterol Hepatol. 2018 Jan 2;5(4):678-690.e1. doi: 10.1016/j.jcmgh.2017.12.012. eCollection 2018.


Automated generation of immature dendritic cells in a single-use system.

Kozbial A, Bhandary L, Collier BB, Eickhoff CS, Hoft DF, Murthy SK.

J Immunol Methods. 2018 Jun;457:53-65. doi: 10.1016/j.jim.2018.03.010. Epub 2018 Apr 3.


Hepatitis C Virus E2 Envelope Glycoprotein Induces an Immunoregulatory Phenotype in Macrophages.

Kwon YC, Meyer K, Peng G, Chatterjee S, Hoft DF, Ray R.

Hepatology. 2019 May;69(5):1873-1884. doi: 10.1002/hep.29843. Epub 2018 May 24.


Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis.

Kumar M, Singh K, Ngwane AH, Hamzabegovic F, Abate G, Baker B, Wiid I, Hoft DF, Ruminski P, Chibale K.

Bioorg Med Chem. 2018 Feb 15;26(4):833-844. doi: 10.1016/j.bmc.2017.12.047. Epub 2017 Dec 29.


Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition.

Liu X, Mo W, Ye J, Li L, Zhang Y, Hsueh EC, Hoft DF, Peng G.

Nat Commun. 2018 Jan 16;9(1):249. doi: 10.1038/s41467-017-02689-5.


Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials.

Modjarrad K, Lin L, George SL, Stephenson KE, Eckels KH, De La Barrera RA, Jarman RG, Sondergaard E, Tennant J, Ansel JL, Mills K, Koren M, Robb ML, Barrett J, Thompson J, Kosel AE, Dawson P, Hale A, Tan CS, Walsh SR, Meyer KE, Brien J, Crowell TA, Blazevic A, Mosby K, Larocca RA, Abbink P, Boyd M, Bricault CA, Seaman MS, Basil A, Walsh M, Tonwe V, Hoft DF, Thomas SJ, Barouch DH, Michael NL.

Lancet. 2018 Feb 10;391(10120):563-571. doi: 10.1016/S0140-6736(17)33106-9. Epub 2017 Dec 5.


Monocyte chemotactic protein-induced protein 1 controls allergic airway inflammation by suppressing IL-5-producing TH2 cells through the Notch/Gata3 pathway.

Peng H, Ning H, Wang Q, Lu W, Chang Y, Wang TT, Lai J, Kolattukudy PE, Hou R, Hoft DF, Dykewicz MS, Liu J.

J Allergy Clin Immunol. 2018 Aug;142(2):582-594.e10. doi: 10.1016/j.jaci.2017.09.031. Epub 2017 Oct 27.


Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.

Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft DF, Liu J.

Nat Commun. 2017 Oct 11;8(1):867. doi: 10.1038/s41467-017-00892-y.


PO and ID BCG vaccination in humans induce distinct mucosal and systemic immune responses and CD4+ T cell transcriptomal molecular signatures.

Hoft DF, Xia M, Zhang GL, Blazevic A, Tennant J, Kaplan C, Matuschak G, Dube TJ, Hill H, Schlesinger LS, Andersen PL, Brusic V.

Mucosal Immunol. 2018 Mar;11(2):486-495. doi: 10.1038/mi.2017.67. Epub 2017 Aug 30.


The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010-2014.

Brennan MJ, Tanner R, Morris S, Scriba TJ, Achkar JM, Zelmer A, Hokey DA, Izzo A, Sharpe S, Williams A, Penn-Nicholson A, Erasmus M, Stylianou E, Hoft DF, McShane H, Fletcher HA.

Clin Vaccine Immunol. 2017 Sep 5;24(9). pii: e00142-17. doi: 10.1128/CVI.00142-17. Print 2017 Sep. Review.


Pilot studies of a human BCG challenge model.

Blazevic A, Xia M, Turan A, Tennant J, Hoft DF.

Tuberculosis (Edinb). 2017 Jul;105:108-112. doi: 10.1016/ Epub 2017 May 4.


Potential High-Risk Areas for Zika Virus Transmission in the Contiguous United States.

Shacham E, Nelson EJ, Hoft DF, Schootman M, Garza A.

Am J Public Health. 2017 May;107(5):724-731. doi: 10.2105/AJPH.2017.303670. Epub 2017 Mar 21.


Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults.

Hoft DF, Lottenbach KR, Blazevic A, Turan A, Blevins TP, Pacatte TP, Yu Y, Mitchell MC, Hoft SG, Belshe RB.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00414-16. doi: 10.1128/CVI.00414-16. Print 2017 Jan.


Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis.

Kumar M, Singh K, Naran K, Hamzabegovic F, Hoft DF, Warner DF, Ruminski P, Abate G, Chibale K.

ACS Infect Dis. 2016 Oct 14;2(10):714-725. Epub 2016 Sep 6.


Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi.

Cai CW, Blase JR, Zhang X, Eickhoff CS, Hoft DF.

PLoS Pathog. 2016 Oct 3;12(10):e1005902. doi: 10.1371/journal.ppat.1005902. eCollection 2016 Oct.


Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity.

Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O'Shea K, Pozzi N, Gohara DW, Blase JR, Di Cera E, Hoft DF.

PLoS Pathog. 2016 Sep 19;12(9):e1005896. doi: 10.1371/journal.ppat.1005896. eCollection 2016 Sep.


Immunotherapy for tuberculosis: future prospects.

Abate G, Hoft DF.

Immunotargets Ther. 2016 Apr 20;5:37-45. doi: 10.2147/ITT.S81892. eCollection 2016. Review.


Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination.

Hoft DF, Lottenbach K, Goll JB, Hill H, Winokur PL, Patel SM, Brady RC, Chen WH, Edwards K, Creech CB, Frey SE, Blevins TP, Salomon R, Belshe RB.

J Infect Dis. 2016 Oct 1;214(7):1020-9. doi: 10.1093/infdis/jiw310. Epub 2016 Jul 20.


Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses.

Suliman S, Geldenhuys H, Johnson JL, Hughes JE, Smit E, Murphy M, Toefy A, Lerumo L, Hopley C, Pienaar B, Chheng P, Nemes E, Hoft DF, Hanekom WA, Boom WH, Hatherill M, Scriba TJ.

J Immunol. 2016 Aug 15;197(4):1100-1110. doi: 10.4049/jimmunol.1501996. Epub 2016 Jul 13.


Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial.

Hoft DF, Blazevic A, Selimovic A, Turan A, Tennant J, Abate G, Fulkerson J, Zak DE, Walker R, McClain B, Sadoff J, Scott J, Shepherd B, Ishmukhamedov J, Hokey DA, Dheenadhayalan V, Shankar S, Amon L, Navarro G, Podyminogin R, Aderem A, Barker L, Brennan M, Wallis RS, Gershon AA, Gershon MD, Steinberg S.

EBioMedicine. 2016 May;7:278-86. doi: 10.1016/j.ebiom.2016.04.010. Epub 2016 Apr 19.


A Subset of Protective γ9δ2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components.

Xia M, Hesser DC, De P, Sakala IG, Spencer CT, Kirkwood JS, Abate G, Chatterjee D, Dobos KM, Hoft DF.

Infect Immun. 2016 Aug 19;84(9):2449-62. doi: 10.1128/IAI.01322-15. Print 2016 Sep.


Mice with Genetic Deletion of Group VIA Phospholipase A2β Exhibit Impaired Macrophage Function and Increased Parasite Load in Trypanosoma cruzi-Induced Myocarditis.

Sharma J, Blase JR, Hoft DF, Marentette JO, Turk J, McHowat J.

Infect Immun. 2016 Mar 24;84(4):1137-1142. doi: 10.1128/IAI.01564-15. Print 2016 Apr.


MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression.

Lu W, Ning H, Gu L, Peng H, Wang Q, Hou R, Fu M, Hoft DF, Liu J.

Cancer Res. 2016 Mar 15;76(6):1429-40. doi: 10.1158/0008-5472.CAN-15-1115. Epub 2016 Feb 1.


Mycobacterium-Specific γ9δ2 T Cells Mediate Both Pathogen-Inhibitory and CD40 Ligand-Dependent Antigen Presentation Effects Important for Tuberculosis Immunity.

Abate G, Spencer CT, Hamzabegovic F, Blazevic A, Xia M, Hoft DF.

Infect Immun. 2015 Dec 7;84(2):580-9. doi: 10.1128/IAI.01262-15. Print 2016 Feb.


New Verapamil Analogs Inhibit Intracellular Mycobacteria without Affecting the Functions of Mycobacterium-Specific T Cells.

Abate G, Ruminiski PG, Kumar M, Singh K, Hamzabegovic F, Hoft DF, Eickhoff CS, Selimovic A, Campbell M, Chibale K.

Antimicrob Agents Chemother. 2015 Dec 7;60(3):1216-25. doi: 10.1128/AAC.01567-15.


An immunoinformatic approach for identification of Trypanosoma cruzi HLA-A2-restricted CD8(+) T cell epitopes.

Eickhoff CS, Van Aartsen D, Terry FE, Meymandi SK, Traina MM, Hernandez S, Martin WD, Moise L, De Groot AS, Hoft DF.

Hum Vaccin Immunother. 2015;11(9):2322-8. doi: 10.1080/21645515.2015.1061160. Epub 2015 Jun 24.


Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Sakala IG, Kjer-Nielsen L, Eickhoff CS, Wang X, Blazevic A, Liu L, Fairlie DP, Rossjohn J, McCluskey J, Fremont DH, Hansen TH, Hoft DF.

J Immunol. 2015 Jul 15;195(2):587-601. doi: 10.4049/jimmunol.1402545. Epub 2015 Jun 10.


CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome.

Huang Y, Ma C, Zhang Q, Ye J, Wang F, Zhang Y, Hunborg P, Varvares MA, Hoft DF, Hsueh EC, Peng G.

Oncotarget. 2015 Jul 10;6(19):17462-78.


Deficiency of antigen-specific B cells results in decreased Trypanosoma cruzi systemic but not mucosal immunity due to CD8 T cell exhaustion.

Sullivan NL, Eickhoff CS, Sagartz J, Hoft DF.

J Immunol. 2015 Feb 15;194(4):1806-18. doi: 10.4049/jimmunol.1303163. Epub 2015 Jan 16.


TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence.

Ye J, Ma C, Hsueh EC, Dou J, Mo W, Liu S, Han B, Huang Y, Zhang Y, Varvares MA, Hoft DF, Peng G.

EMBO Mol Med. 2014 Oct;6(10):1294-311. doi: 10.15252/emmm.201403918.


Progress toward the development of universal influenza vaccines.

Hoft DF, Belshe RB.

Mo Med. 2014 Jul-Aug;111(4):321-5.


Variations between bacillus Calmette-Guérin strains: lessons from tuberculosis prevention.

Abate G, Hoft DF.

Eur Urol. 2014 Oct;66(4):692-3. doi: 10.1016/j.eururo.2014.06.006. Epub 2014 Jun 27. No abstract available.


Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults.

Hatherill M, Geldenhuys H, Pienaar B, Suliman S, Chheng P, Debanne SM, Hoft DF, Boom WH, Hanekom WA, Johnson JL.

Vaccine. 2014 Jun 30;32(31):3982-8. doi: 10.1016/j.vaccine.2014.04.084. Epub 2014 May 9.


Absence of calcium-independent phospholipase A2 β impairs platelet-activating factor production and inflammatory cell recruitment in Trypanosoma cruzi-infected endothelial cells.

Sharma J, Eickhoff CS, Hoft DF, Marentette JO, Turk J, McHowat J.

Physiol Rep. 2014 Jan 6;2(1):e00196. doi: 10.1002/phy2.196. eCollection 2014 Jan 1.


Multidrug-resistant tuberculosis. Recommendations for reducing risk during travel for healthcare and humanitarian work.

Seaworth BJ, Armitige LY, Aronson NE, Hoft DF, Fleenor ME, Gardner AF, Harris DA, Stricof RL, Nardell EA.

Ann Am Thorac Soc. 2014 Mar;11(3):286-95. doi: 10.1513/AnnalsATS.201309-312PS.


Investigations of TB vaccine-induced mucosal protection in mice.

Blazevic A, Eickhoff CS, Stanley J, Buller MR, Schriewer J, Kettelson EM, Hoft DF.

Microbes Infect. 2014 Jan;16(1):73-9. doi: 10.1016/j.micinf.2013.09.006. Epub 2013 Oct 8.

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