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Items: 1 to 50 of 80

1.

Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice.

Oza M, Becker W, Gummadidala PM, Dias T, Omebeyinje MH, Chen L, Mitra C, Jesmin R, Chakraborty P, Sajish M, Hofseth LJ, Banerjee K, Wang Q, Moeller PDR, Nagarkatti M, Nagarkatti P, Chanda A.

Sci Rep. 2019 Jul 19;9(1):10520. doi: 10.1038/s41598-019-46478-0.

2.

Maternal stress and early-onset colorectal cancer.

Zhang Q, Berger FG, Love B, Banister CE, Murphy EA, Hofseth LJ.

Med Hypotheses. 2018 Dec;121:152-159. doi: 10.1016/j.mehy.2018.09.035. Epub 2018 Sep 21.

3.

Getting rigorous with scientific rigor.

Hofseth LJ.

Carcinogenesis. 2018 Jan 12;39(1):21-25. doi: 10.1093/carcin/bgx085. No abstract available.

4.

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation.

Alhasson F, Das S, Seth R, Dattaroy D, Chandrashekaran V, Ryan CN, Chan LS, Testerman T, Burch J, Hofseth LJ, Horner R, Nagarkatti M, Nagarkatti P, Lasley SM, Chatterjee S.

PLoS One. 2017 Mar 22;12(3):e0172914. doi: 10.1371/journal.pone.0172914. eCollection 2017.

5.

Dietary inflammatory index and odds of colorectal cancer in a case-control study from Jordan.

Shivappa N, Hébert JR, Steck SE, Hofseth LJ, Shehadah I, Bani-Hani KE, Al-Jaberi T, Al-Nusairr M, Heath D, Tayyem R.

Appl Physiol Nutr Metab. 2017 Jul;42(7):744-749. doi: 10.1139/apnm-2017-0035. Epub 2017 Feb 22.

PMID:
28226219
6.

Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds.

Chumanevich AA, Chaparala A, Witalison EE, Tashkandi H, Hofseth AB, Lane C, Pena E, Liu P, Pittman DL, Nagarkatti P, Nagarkatti M, Hofseth LJ, Chumanevich AA.

Oncotarget. 2017 Jan 3;8(1):228-237. doi: 10.18632/oncotarget.13894.

7.

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties.

Chumanevich AA, Witalison EE, Chaparala A, Chumanevich A, Nagarkatti P, Nagarkatti M, Hofseth LJ.

Oncotarget. 2016 Aug 16;7(33):52928-52939. doi: 10.18632/oncotarget.10608.

8.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

9.

Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.

Witalison EE, Cui X, Causey CP, Thompson PR, Hofseth LJ.

Oncotarget. 2015 Nov 3;6(34):36053-62. doi: 10.18632/oncotarget.5937.

10.

A multi-targeted approach to suppress tumor-promoting inflammation.

Samadi AK, Bilsland A, Georgakilas AG, Amedei A, Amin A, Bishayee A, Azmi AS, Lokeshwar BL, Grue B, Panis C, Boosani CS, Poudyal D, Stafforini DM, Bhakta D, Niccolai E, Guha G, Vasantha Rupasinghe HP, Fujii H, Honoki K, Mehta K, Aquilano K, Lowe L, Hofseth LJ, Ricciardiello L, Ciriolo MR, Singh N, Whelan RL, Chaturvedi R, Ashraf SS, Shantha Kumara HMC, Nowsheen S, Mohammed SI, Keith WN, Helferich WG, Yang X.

Semin Cancer Biol. 2015 Dec;35 Suppl:S151-S184. doi: 10.1016/j.semcancer.2015.03.006. Epub 2015 May 5. Review.

11.

Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.

Qu C, Li B, Lai Y, Li H, Windust A, Hofseth LJ, Nagarkatti M, Nagarkatti P, Wang XL, Tang D, Janicki JS, Tian X, Cui T.

J Ethnopharmacol. 2015 Jun 20;168:326-36. doi: 10.1016/j.jep.2015.04.004. Epub 2015 Apr 14.

12.

A novel chemopreventive strategy based on therapeutic microRNAs produced in plants.

Mlotshwa S, Pruss GJ, MacArthur JL, Endres MW, Davis C, Hofseth LJ, Peña MM, Vance V.

Cell Res. 2015 Apr;25(4):521-4. doi: 10.1038/cr.2015.25. Epub 2015 Feb 27. No abstract available.

13.
14.

Inhibiting protein arginine deiminases has antioxidant consequences.

Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ.

J Pharmacol Exp Ther. 2015 Apr;353(1):64-70. doi: 10.1124/jpet.115.222745. Epub 2015 Jan 29.

15.

A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng.

Poudyal D, Cui X, Le PM, Hofseth AB, Windust A, Nagarkatti M, Nagarkatti PS, Schetter AJ, Harris CC, Hofseth LJ.

PLoS One. 2013 Oct 9;8(10):e75034. doi: 10.1371/journal.pone.0075034. eCollection 2013.

16.

D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR.

ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.

17.

The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.

Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ.

PLoS One. 2013;8(1):e53791. doi: 10.1371/journal.pone.0053791. Epub 2013 Jan 7.

18.

Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.

Bicker KL, Subramanian V, Chumanevich AA, Hofseth LJ, Thompson PR.

J Am Chem Soc. 2012 Oct 17;134(41):17015-8. doi: 10.1021/ja308871v. Epub 2012 Oct 3.

19.

Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.

PLoS One. 2012;7(9):e44156. doi: 10.1371/journal.pone.0044156. Epub 2012 Sep 6.

20.

A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis.

Poudyal D, Cui X, Mai Le P, Davis T, Hofseth AB, Jin Y, Chumanevich AA, Wargovich MJ, Nagarkatti M, Nagarkatti PS, Windust A, Hofseth LJ.

J Biomed Biotechnol. 2012;2012:785739. doi: 10.1155/2012/785739. Epub 2012 Jul 30.

21.

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.

Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14007-12. doi: 10.1073/pnas.1211509109. Epub 2012 Aug 14.

22.

Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trial.

Cui X, Jin Y, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Poudyal D, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ.

Mol Nutr Food Res. 2012 Apr;56(4):666-70. doi: 10.1002/mnfr.201100496. Epub 2012 Mar 1.

PMID:
22383296
23.

A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanisms.

Poudyal D, Le PM, Davis T, Hofseth AB, Chumanevich A, Chumanevich AA, Wargovich MJ, Nagarkatti M, Nagarkatti PS, Windust A, Hofseth LJ.

Cancer Prev Res (Phila). 2012 Apr;5(4):685-96. doi: 10.1158/1940-6207.CAPR-11-0421. Epub 2012 Jan 31.

24.

Editorial: an apple a day keeps colitis away.

Hofseth LJ, Matesic LE.

J Leukoc Biol. 2011 Dec;90(6):1037-8. doi: 10.1189/jlb.0511262. No abstract available.

PMID:
22131358
25.

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR.

J Med Chem. 2011 Oct 13;54(19):6919-35. doi: 10.1021/jm2008985. Epub 2011 Sep 16. Erratum in: J Med Chem. 2011 Nov 24;54(22):7942.

26.

Role of resveratrol-induced CD11b(+) Gr-1(+) myeloid derived suppressor cells (MDSCs) in the reduction of CXCR3(+) T cells and amelioration of chronic colitis in IL-10(-/-) mice.

Singh UP, Singh NP, Singh B, Hofseth LJ, Taub DD, Price RL, Nagarkatti M, Nagarkatti PS.

Brain Behav Immun. 2012 Jan;26(1):72-82. doi: 10.1016/j.bbi.2011.07.236. Epub 2011 Jul 23.

27.

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.

Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G929-38. doi: 10.1152/ajpgi.00435.2010. Epub 2011 Mar 17.

28.

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Chumanevich AA, Poudyal D, Cui X, Davis T, Wood PA, Smith CD, Hofseth LJ.

Carcinogenesis. 2010 Oct;31(10):1787-93. doi: 10.1093/carcin/bgq158. Epub 2010 Aug 5.

29.

An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes.

Li J, Ichikawa T, Jin Y, Hofseth LJ, Nagarkatti P, Nagarkatti M, Windust A, Cui T.

J Ethnopharmacol. 2010 Jul 20;130(2):222-30. doi: 10.1016/j.jep.2010.03.040. Epub 2010 May 4.

30.

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer.

Hofseth LJ, Singh UP, Singh NP, Nagarkatti M, Nagarkatti PS.

Aging (Albany NY). 2010 Apr;2(4):183-4. No abstract available.

31.

Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate.

Jin Y, Cui X, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ.

Mol Nutr Food Res. 2010 Oct;54(10):1506-14. doi: 10.1002/mnfr.200900579.

PMID:
20425759
32.

Resveratrol suppresses colitis and colon cancer associated with colitis.

Cui X, Jin Y, Hofseth AB, Pena E, Habiger J, Chumanevich A, Poudyal D, Nagarkatti M, Nagarkatti PS, Singh UP, Hofseth LJ.

Cancer Prev Res (Phila). 2010 Apr;3(4):549-59. doi: 10.1158/1940-6207.CAPR-09-0117. Epub 2010 Mar 23.

33.

American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells.

Jin Y, Hofseth AB, Cui X, Windust AJ, Poudyal D, Chumanevich AA, Matesic LE, Singh NP, Nagarkatti M, Nagarkatti PS, Hofseth LJ.

Cancer Prev Res (Phila). 2010 Mar;3(3):339-47. doi: 10.1158/1940-6207.CAPR-09-0116. Epub 2010 Feb 23.

34.

Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis.

Singh UP, Singh NP, Singh B, Hofseth LJ, Price RL, Nagarkatti M, Nagarkatti PS.

J Pharmacol Exp Ther. 2010 Mar;332(3):829-39. doi: 10.1124/jpet.109.160838. Epub 2009 Nov 25.

35.

Circadian disruption, Per3, and human cytokine secretion.

Guess J, Burch JB, Ogoussan K, Armstead CA, Zhang H, Wagner S, Hebert JR, Wood P, Youngstedt SD, Hofseth LJ, Singh UP, Xie D, Hrushesky WJ.

Integr Cancer Ther. 2009 Dec;8(4):329-36. doi: 10.1177/1534735409352029. Epub 2009 Nov 18.

36.

Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.

Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD.

Carcinogenesis. 2009 Dec;30(12):2123-9. doi: 10.1093/carcin/bgp256.

37.

Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.

Yoshizawa K, Jelezcova E, Brown AR, Foley JF, Nyska A, Cui X, Hofseth LJ, Maronpot RM, Wilson SH, Sepulveda AR, Sobol RW.

PLoS One. 2009 Aug 5;4(8):e6493. doi: 10.1371/journal.pone.0006493.

38.

American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages.

Ichikawa T, Li J, Nagarkatti P, Nagarkatti M, Hofseth LJ, Windust A, Cui T.

J Ethnopharmacol. 2009 Aug 17;125(1):145-50. doi: 10.1016/j.jep.2009.05.032. Epub 2009 Jun 6.

39.

American ginseng suppresses inflammation and DNA damage associated with mouse colitis.

Jin Y, Kotakadi VS, Ying L, Hofseth AB, Cui X, Wood PA, Windust A, Matesic LE, Pena EA, Chiuzan C, Singh NP, Nagarkatti M, Nagarkatti PS, Wargovich MJ, Hofseth LJ.

Carcinogenesis. 2008 Dec;29(12):2351-9. doi: 10.1093/carcin/bgn211. Epub 2008 Sep 18.

40.

Nitric oxide is a key component in inflammation-accelerated tumorigenesis.

Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, Gruys E, Laubach VE, Wiltrout RH, Harris CC.

Cancer Res. 2008 Sep 1;68(17):7130-6. doi: 10.1158/0008-5472.CAN-08-0410.

41.

Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.

Kotakadi VS, Jin Y, Hofseth AB, Ying L, Cui X, Volate S, Chumanevich A, Wood PA, Price RL, McNeal A, Singh UP, Singh NP, Nagarkatti M, Nagarkatti PS, Matesic LE, Auclair K, Wargovich MJ, Hofseth LJ.

Carcinogenesis. 2008 Sep;29(9):1799-806. doi: 10.1093/carcin/bgn143. Epub 2008 Jun 20.

42.

Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.

Hofseth LJ.

Cancer Lett. 2008 Sep 8;268(1):10-30. doi: 10.1016/j.canlet.2008.03.024. Epub 2008 Apr 25. Review.

43.

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.

Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, Nagarkatti PS.

Mol Pharmacol. 2008 Jul;74(1):20-33. doi: 10.1124/mol.108.047035. Epub 2008 Apr 3.

44.

Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.

Ying L, Hofseth AB, Browning DD, Nagarkatti M, Nagarkatti PS, Hofseth LJ.

Cancer Res. 2007 Oct 1;67(19):9286-93.

46.

Colorectal cancer disparities in South Carolina: descriptive epidemiology, screening, special programs, and future direction.

Daguise VG, Burch JB, Horner MJ, Mosley C, Hofseth LJ, Wargovich MJ, Lloyd SC, Hebert JR.

J S C Med Assoc. 2006 Aug;102(7):212-20. Review. No abstract available.

PMID:
17319233
47.

An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer.

Ying L, Hofseth LJ.

Cancer Res. 2007 Feb 15;67(4):1407-10. Review.

48.

Inflammation, cancer, and targets of ginseng.

Hofseth LJ, Wargovich MJ.

J Nutr. 2007 Jan;137(1 Suppl):183S-185S. doi: 10.1093/jn/137.1.183S. Review.

PMID:
17182823
49.

Inflammation and IGF-I activate the Akt pathway in breast cancer.

Prueitt RL, Boersma BJ, Howe TM, Goodman JE, Thomas DD, Ying L, Pfiester CM, Yfantis HG, Cottrell JR, Lee DH, Remaley AT, Hofseth LJ, Wink DA, Ambs S.

Int J Cancer. 2007 Feb 15;120(4):796-805.

50.

Nitric oxide is a signaling molecule that regulates gene expression.

Hofseth LJ, Robles AI, Espey MG, Harris CC.

Methods Enzymol. 2005;396:326-40.

PMID:
16291242

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