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Items: 31


Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response.

Foster JB, Choudhari N, Perazzelli J, Storm J, Hofmann TJ, Jain P, Storm PB, Pardi N, Weissman D, Waanders AJ, Grupp SA, Karikó K, Resnick AC, Barrett DM.

Hum Gene Ther. 2019 Feb;30(2):168-178. doi: 10.1089/hum.2018.145. Epub 2018 Oct 2.


Extracellular vesicles released from mesenchymal stromal cells stimulate bone growth in osteogenesis imperfecta.

Otsuru S, Desbourdes L, Guess AJ, Hofmann TJ, Relation T, Kaito T, Dominici M, Iwamoto M, Horwitz EM.

Cytotherapy. 2018 Jan;20(1):62-73. doi: 10.1016/j.jcyt.2017.09.012. Epub 2017 Oct 26.


Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function.

Singh N, Hofmann TJ, Gershenson Z, Levine BL, Grupp SA, Teachey DT, Barrett DM.

Cytotherapy. 2017 Jul;19(7):867-880. doi: 10.1016/j.jcyt.2017.04.001. Epub 2017 May 11.


Hematopoietic derived cells do not contribute to osteogenesis as osteoblasts.

Otsuru S, Overholt KM, Olson TS, Hofmann TJ, Guess AJ, Velazquez VM, Kaito T, Dominici M, Horwitz EM.

Bone. 2017 Jan;94:1-9. doi: 10.1016/j.bone.2016.10.003. Epub 2016 Oct 7.


Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.

Ruella M, Barrett DM, Kenderian SS, Shestova O, Hofmann TJ, Perazzelli J, Klichinsky M, Aikawa V, Nazimuddin F, Kozlowski M, Scholler J, Lacey SF, Melenhorst JJ, Morrissette JJ, Christian DA, Hunter CA, Kalos M, Porter DL, June CH, Grupp SA, Gill S.

J Clin Invest. 2016 Oct 3;126(10):3814-3826. doi: 10.1172/JCI87366. Epub 2016 Aug 29.


Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, Wu G, Sussman R, Lanauze C, Ruella M, Gazzara MR, Martinez NM, Harrington CT, Chung EY, Perazzelli J, Hofmann TJ, Maude SL, Raman P, Barrera A, Gill S, Lacey SF, Melenhorst JJ, Allman D, Jacoby E, Fry T, Mackall C, Barash Y, Lynch KW, Maris JM, Grupp SA, Thomas-Tikhonenko A.

Cancer Discov. 2015 Dec;5(12):1282-95. doi: 10.1158/2159-8290.CD-15-1020. Epub 2015 Oct 29.


Genomic and functional comparison of mesenchymal stromal cells prepared using two isolation methods.

Otsuru S, Hofmann TJ, Raman P, Olson TS, Guess AJ, Dominici M, Horwitz EM.

Cytotherapy. 2015 Mar;17(3):262-70. doi: 10.1016/j.jcyt.2014.10.013.


Tendon progenitor cells in injured tendons have strong chondrogenic potential: the CD105-negative subpopulation induces chondrogenic degeneration.

Asai S, Otsuru S, Candela ME, Cantley L, Uchibe K, Hofmann TJ, Zhang K, Wapner KL, Soslowsky LJ, Horwitz EM, Enomoto-Iwamoto M.

Stem Cells. 2014 Dec;32(12):3266-77. doi: 10.1002/stem.1847.


Delayed marrow infusion in mice enhances hematopoietic and osteopoietic engraftment by facilitating transient expansion of the osteoblastic niche.

Marino R, Otsuru S, Hofmann TJ, Olson TS, Rasini V, Veronesi E, Boyd K, Gaber MW, Martinez C, Paolucci P, Dominici M, Horwitz EM.

Biol Blood Marrow Transplant. 2013 Nov;19(11):1566-73. doi: 10.1016/j.bbmt.2013.07.025. Epub 2013 Aug 2.


IGF-1-mediated osteoblastic niche expansion enhances long-term hematopoietic stem cell engraftment after murine bone marrow transplantation.

Caselli A, Olson TS, Otsuru S, Chen X, Hofmann TJ, Nah HD, Grisendi G, Paolucci P, Dominici M, Horwitz EM.

Stem Cells. 2013 Oct;31(10):2193-204. doi: 10.1002/stem.1463.


Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning.

Olson TS, Caselli A, Otsuru S, Hofmann TJ, Williams R, Paolucci P, Dominici M, Horwitz EM.

Blood. 2013 Jun 27;121(26):5238-49. doi: 10.1182/blood-2012-10-463414. Epub 2013 May 10.


Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche.

Hofmann TJ, Otsuru S, Marino R, Rasini V, Veronesi E, Murgia A, Lahti J, Boyd K, Dominici M, Horwitz EM.

Mol Ther. 2013 Jun;21(6):1224-31. doi: 10.1038/mt.2013.36. Epub 2013 Apr 16.


Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filter device.

Otsuru S, Hofmann TJ, Olson TS, Dominici M, Horwitz EM.

Cytotherapy. 2013 Feb;15(2):146-53. doi: 10.1016/j.jcyt.2012.10.012. Epub 2012 Dec 6.


Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms.

Otsuru S, Gordon PL, Shimono K, Jethva R, Marino R, Phillips CL, Hofmann TJ, Veronesi E, Dominici M, Iwamoto M, Horwitz EM.

Blood. 2012 Aug 30;120(9):1933-41. doi: 10.1182/blood-2011-12-400085. Epub 2012 Jul 24.


Cytokine-induced osteopoietic differentiation of transplanted marrow cells.

Otsuru S, Rasini V, Bussolari R, Hofmann TJ, Dominici M, Horwitz EM.

Blood. 2011 Aug 25;118(8):2358-61. doi: 10.1182/blood-2011-01-331397. Epub 2011 Jun 29.


Osteopoietic engraftment after bone marrow transplantation: effect of inbred strain of mice.

Otsuru S, Hofmann TJ, Rasini V, Veronesi E, Dominici M, Horwitz EM.

Exp Hematol. 2010 Sep;38(9):836-44. doi: 10.1016/j.exphem.2010.04.015. Epub 2010 May 4.


A strategy for single nucleotide polymorphism analysis of chimerism for somatic cell therapy.

Chen X, Hofmann TJ, Otsuru S, Jethva R, Lind C, Monos D, Horwitz EM.

Cytotherapy. 2010 Dec;12(8):1035-43. doi: 10.3109/14653241003774029. Epub 2010 Apr 29.


Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation.

Dominici M, Rasini V, Bussolari R, Chen X, Hofmann TJ, Spano C, Bernabei D, Veronesi E, Bertoni F, Paolucci P, Conte P, Horwitz EM.

Blood. 2009 Sep 10;114(11):2333-43. doi: 10.1182/blood-2008-10-183459. Epub 2009 May 11.


Donor cell-derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation.

Dominici M, Marino R, Rasini V, Spano C, Paolucci P, Conte P, Hofmann TJ, Horwitz EM.

Blood. 2008 Apr 15;111(8):4386-91. doi: 10.1182/blood-2007-10-115725. Epub 2008 Jan 8.


Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment.

Marino R, Martinez C, Boyd K, Dominici M, Hofmann TJ, Horwitz EM.

Exp Hematol. 2008 Mar;36(3):360-8. doi: 10.1016/j.exphem.2007.11.002. Epub 2008 Jan 7.


Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs.

Martinez C, Hofmann TJ, Marino R, Dominici M, Horwitz EM.

Blood. 2007 May 15;109(10):4245-8. Epub 2007 Jan 30. Erratum in: Blood. 2007 Aug 1;110(3):826.


Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation.

Dominici M, Pritchard C, Garlits JE, Hofmann TJ, Persons DA, Horwitz EM.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11761-6. Epub 2004 Jul 28.


Clinical gene-marking of mesenchymal cells.

Horwitz EM, Kasow KA, Hofmann TJ.

Cytotherapy. 2003;5(3):194-6. No abstract available.


On the development of cell therapy for genetic disorders.

Horwitz EM, Hofmann TJ, Garlits JE, Campioni D, Dominici M.

Cytotherapy. 2002;4(6):511-2. Review. No abstract available.


Bone marrow mesenchymal cells: biological properties and clinical applications.

Dominici M, Hofmann TJ, Horwitz EM.

J Biol Regul Homeost Agents. 2001 Jan-Mar;15(1):28-37. Review. No abstract available.


An essential domain of the c-myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation.

Brough DE, Hofmann TJ, Ellwood KB, Townley RA, Cole MD.

Mol Cell Biol. 1995 Mar;15(3):1536-44.


Purification and properties of the major nuclease from mitochondria of Saccharomyces cerevisiae.

Dake E, Hofmann TJ, McIntire S, Hudson A, Zassenhaus HP.

J Biol Chem. 1988 Jun 5;263(16):7691-702.


Sequence and expression of NUC1, the gene encoding the mitochondrial nuclease in Saccharomyces cerevisiae.

Vincent RD, Hofmann TJ, Zassenhaus HP.

Nucleic Acids Res. 1988 Apr 25;16(8):3297-312.


Construction of a yeast mutant lacking the mitochondrial nuclease.

Zassenhaus HP, Hofmann TJ, Uthayashanker R, Vincent RD, Zona M.

Nucleic Acids Res. 1988 Apr 25;16(8):3283-96.

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