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Items: 36

1.

CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability.

Kapplusch F, Schulze F, Rabe-Matschewsky S, Russ S, Herbig M, Heymann MC, Schoepf K, Stein R, Range U, Rösen-Wolff A, Winkler S, Hedrich CM, Guck J, Hofmann SR.

Clin Immunol. 2019 Jun 26;208:108232. doi: 10.1016/j.clim.2019.06.008. [Epub ahead of print]

PMID:
31252176
2.

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar PE, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL.

J Allergy Clin Immunol. 2018 Dec;142(6):1956-1967.e6. doi: 10.1016/j.jaci.2018.04.033. Epub 2018 May 17.

3.

CD14+ monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression.

Brandt D, Sohr E, Pablik J, Schnabel A, Kapplusch F, Mäbert K, Girschick JH, Morbach H, Thielemann F, Hofmann SR, Hedrich CM.

Clin Immunol. 2018 Nov;196:77-84. doi: 10.1016/j.clim.2018.04.011. Epub 2018 Apr 30.

PMID:
29723617
4.

IL10 promoter haplotypes may contribute to altered cytokine expression and systemic inflammation in celiac disease.

Hofmann SR, Laass MW, Fehrs A, Schuppan D, Zevallos VF, Salminger D, Mäbert K, Hedrich CM.

Clin Immunol. 2018 May;190:15-21. doi: 10.1016/j.clim.2018.02.010. Epub 2018 Feb 24.

PMID:
29481982
5.

Development of a Diagnostic Clinical Score for Hemodynamically Significant Patent Ductus Arteriosus.

Kindler A, Seipolt B, Heilmann A, Range U, Rüdiger M, Hofmann SR.

Front Pediatr. 2017 Dec 22;5:280. doi: 10.3389/fped.2017.00280. eCollection 2017.

6.

Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis.

Hofmann SR, Böttger F, Range U, Lück C, Morbach H, Girschick HJ, Suttorp M, Hedrich CM.

Front Pediatr. 2017 Dec 1;5:256. doi: 10.3389/fped.2017.00256. eCollection 2017.

7.

Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment.

Hofmann SR, Kapplusch F, Girschick HJ, Morbach H, Pablik J, Ferguson PJ, Hedrich CM.

Curr Osteoporos Rep. 2017 Dec;15(6):542-554. doi: 10.1007/s11914-017-0405-9. Review.

8.

The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review.

Hofmann SR, Kapplusch F, Mäbert K, Hedrich CM.

Mol Cell Pediatr. 2017 Dec;4(1):7. doi: 10.1186/s40348-017-0073-y. Epub 2017 Jul 6. Review.

9.

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

van den Bruck R, Weil PP, Ziegenhals T, Schreiner P, Juranek S, Gödde D, Vogel S, Schuster F, Orth V, Dörner J, Pembaur D, Röper M, Störkel S, Zirngibl H, Wirth S, Jenke ACW, Postberg J, Boy N, Heringer J, Haege G, Glahn EM, Hoffmann GF, Garbade SF, Burgard P, Kölker S, Chao CM, Yahya F, Moiseenko A, Shrestha A, Ahmadvand N, Quantius J, Wilhelm J, El-Agha E, Zimmer KP, Bellusci S, Staufner C, Kölker S, Prokisch H, Hoffmann GF, Seeliger S, Müller M, Hippe A, Steinkraus H, Wauer R, Lachmann B, Hofmann SR, Hedrich CM, Zierk J, Arzideh F, Haeckel R, Rascher W, Rauh M, Metzler M, Thieme S, Bandoła J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Hedrich CM, Bonifacio E, Berner R, Brenner S, Hammersen J, Has C, Naumann-Bartsch N, Stachel D, Kiritsi D, Söder S, Tardieu M, Metzler M, Bruckner-Tuderman L, Schneider H, Bohne F, Langer D, Cencic R, Eggermann T, Zechner U, Pelletier J, Zepp F, Enklaar T, Prawitt D, Pech M, Weckmann M, Heinsen FA, Franke A, Happle C, Dittrich AM, Hansen G, Fuchs O, von Mutius E, Oliver BG, Kopp MV, Paret C, Russo A, Theruvath J, Keller B, El Malki K, Lehmann N, Wingerter A, Neu MA, Aslihan GA, Wagner W, Sommer C, Pietsch T, Seidmann L, Faber J, Schreiner F, Ackermann M, Michalik M, Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J, Fischer HS, Ullrich TL, Bührer C, Czernik C, Schmalisch G, Stein R, Hofmann SR, Hagenbuchner J, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ, Loges NT, Frommer AT, Wallmeier J, Omran H, Öner-Sieben S, Gimpfl M, Rozman J, Irmler M, Beckers J, De Angelis MH, Roscher A, Wolf E, Ensenauer R, Nemes K, Frühwald M, Hasselblatt M, Siebert R, Kordes U, Kool M, Wang H, Hardy H, Refai O, Barwick KES, Zimmerman HH, Weis J, Baple EL, Crosby AH, Cirak S, Hellmuth C, Uhl O, Standl M, Heinrich J, Thiering E, Koletzko B, Blümel L, Kerl K, Picard D, Frühwald MC, Liebau MC, Reifenberger G, Borkhardt A, Hasselblatt M, Remke M, Tews D, Wabitsch M, Fischer-Posovszky P, Westhoff MA, Nonnenmacher L, Langhans J, Schneele L, Trenkler N, Debatin KM.

Mol Cell Pediatr. 2017 May;4(Suppl 1):5. doi: 10.1186/s40348-017-0071-0. No abstract available.

10.

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies.

Hofmann SR, Schnabel A, Rösen-Wolff A, Morbach H, Girschick HJ, Hedrich CM.

J Rheumatol. 2016 Nov;43(11):1956-1964. Epub 2016 Sep 1. Review.

PMID:
27585682
11.

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division.

Stein R, Kapplusch F, Heymann MC, Russ S, Staroske W, Hedrich CM, Rösen-Wolff A, Hofmann SR.

J Biol Chem. 2016 Aug 26;291(35):18419-29. doi: 10.1074/jbc.M116.718668. Epub 2016 Jul 8.

12.

Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO).

Hofmann SR, Kubasch AS, Range U, Laass MW, Morbach H, Girschick HJ, Hedrich CM.

Rheumatol Int. 2016 Jun;36(6):769-79. doi: 10.1007/s00296-016-3466-7. Epub 2016 Mar 21.

PMID:
27000045
13.

Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1β expression and release.

Hofmann SR, Kubasch AS, Ioannidis C, Rösen-Wolff A, Girschick HJ, Morbach H, Hedrich CM.

Clin Immunol. 2015 Dec;161(2):300-7. doi: 10.1016/j.clim.2015.09.013. Epub 2015 Sep 25.

PMID:
26404542
14.

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1.

Heymann MC, Rabe S, Ruß S, Kapplusch F, Schulze F, Stein R, Winkler S, Hedrich CM, Rösen-Wolff A, Hofmann SR.

Clin Immunol. 2015 Oct;160(2):172-9. doi: 10.1016/j.clim.2015.05.011. Epub 2015 May 27.

PMID:
26025004
15.

Current knowledge on procaspase-1 variants with reduced or abrogated enzymatic activity in autoinflammatory disease.

Luksch H, Winkler S, Heymann MC, Schulze F, Hofmann SR, Roesler J, Rösen-Wolff A.

Curr Rheumatol Rep. 2015 Jul;17(7):45. doi: 10.1007/s11926-015-0520-5. Review.

PMID:
26003867
16.

Successful thrombolytic treatment of neonatal arterial thromboses.

Stächele J, Dinger J, Brenner S, Hofmann SR, Ifflaender S, Knöfler R.

Hamostaseologie. 2014;34 Suppl 1:S57-9. doi: 10.5482/HAMO-14-02-0014.

PMID:
25382773
17.

Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.

Heymann MC, Winkler S, Luksch H, Flecks S, Franke M, Ruß S, Ozen S, Yilmaz E, Klein C, Kallinich T, Lindemann D, Brenner S, Ganser G, Roesler J, Rösen-Wolff A, Hofmann SR.

J Immunol. 2014 May 1;192(9):4379-85. doi: 10.4049/jimmunol.1203524. Epub 2014 Apr 4.

18.

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO).

Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ.

Pediatr Rheumatol Online J. 2013 Dec 23;11(1):47. doi: 10.1186/1546-0096-11-47.

19.

Agenesis of the ductus venosus-A case with favorable outcome after early signs of cardiac failure.

Hofmann SR, Heilmann A, Häusler HJ, Kamin G, Nitzsche KI.

J Clin Ultrasound. 2013 Mar-Apr;41(3):187-90. doi: 10.1002/jcu.21917. Epub 2012 Apr 17.

PMID:
23475499
20.

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression.

Hofmann SR, Morbach H, Schwarz T, Rösen-Wolff A, Girschick HJ, Hedrich CM.

Clin Immunol. 2012 Oct;145(1):69-76. doi: 10.1016/j.clim.2012.07.012. Epub 2012 Aug 4.

PMID:
22940633
21.

Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β.

Luksch H, Romanowski MJ, Chara O, Tüngler V, Caffarena ER, Heymann MC, Lohse P, Aksentijevich I, Remmers EF, Flecks S, Quoos N, Gramatté J, Petzold C, Hofmann SR, Winkler S, Pessler F, Kallinich T, Ganser G, Nimtz-Talaska A, Baumann U, Runde V, Grimbacher B, Birmelin J, Gahr M, Roesler J, Rösen-Wolff A.

Hum Mutat. 2013 Jan;34(1):122-31. doi: 10.1002/humu.22169. Epub 2012 Aug 10.

PMID:
22833538
22.

Stabilisation of cardiopulmonary function in newborns with congenital diaphragmatic hernia using lung function parameters and hemodynamic management.

Hofmann SR, Stadler K, Heilmann A, Häusler HJ, Fitze G, Kamin G, Nitzsche KI, Hahn G, Dinger J.

Klin Padiatr. 2012 Jul;224(4):e1-e10. Epub 2012 Jul 10.

PMID:
22782443
23.

Congenital idiopathic dilatation of the right atrium: antenatal appearance, postnatal management, long-term follow-up and possible pathomechanism.

Hofmann SR, Heilmann A, Häusler HJ, Dähnert I, Kamin G, Lachmann R.

Fetal Diagn Ther. 2012;32(4):256-61. doi: 10.1159/000338661. Epub 2012 Jun 21.

24.

Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO).

Hofmann SR, Roesen-Wolff A, Hahn G, Hedrich CM.

Int J Rheumatol. 2012;2012:310206. doi: 10.1155/2012/310206. Epub 2012 May 21.

25.

Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury.

Hofmann SR, Rösen-Wolff A, Tsokos GC, Hedrich CM.

Clin Immunol. 2012 May;143(2):116-27. doi: 10.1016/j.clim.2012.02.005. Epub 2012 Mar 5. Review.

PMID:
22459704
26.

Dynamic CpG-DNA methylation of Il10 and Il19 in CD4+ T lymphocytes and macrophages: effects on tissue-specific gene expression.

Hofmann SR, Möller J, Rauen T, Paul D, Gahr M, Rösen-Wolff Z, Brenner S, Hedrich CM.

Klin Padiatr. 2012 Mar;224(2):53-60. doi: 10.1055/s-0031-1291359. Epub 2011 Dec 20.

PMID:
22187331
27.

Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression.

Hofmann SR, Schwarz T, Möller JC, Morbach H, Schnabel A, Rösen-Wolff A, Girschick HJ, Hedrich CM.

Clin Immunol. 2011 Dec;141(3):317-27. doi: 10.1016/j.clim.2011.08.012. Epub 2011 Aug 30.

PMID:
21925952
28.

An intrathoracic arteriovenous malformation discovered as an extremely uncommon reason of neonatal congestive cardiac failure.

Hofmann SR, Weise M, Nitzsche KI.

Cardiol Young. 2009 Sep;19(5):530-3. doi: 10.1017/S1047951109991375. Epub 2009 Aug 13.

PMID:
19674502
29.

Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.

Watford WT, Li D, Agnello D, Durant L, Yamaoka K, Yao ZJ, Ahn HJ, Cheng TP, Hofmann SR, Cogliati T, Chen A, Hissong BD, Husa MR, Schwartzberg P, O'Shea JJ, Gadina M.

Mol Cell Biol. 2006 Sep;26(17):6623-32.

30.

Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.

Pesu M, Candotti F, Husa M, Hofmann SR, Notarangelo LD, O'Shea JJ.

Immunol Rev. 2005 Feb;203:127-42. Review.

PMID:
15661026
31.

Jak3 and the pathogenesis of severe combined immunodeficiency.

O'Shea JJ, Husa M, Li D, Hofmann SR, Watford W, Roberts JL, Buckley RH, Changelian P, Candotti F.

Mol Immunol. 2004 Jul;41(6-7):727-37. Review.

PMID:
15220007
32.

Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.

Hofmann SR, Lam AQ, Frank S, Zhou YJ, Ramos HL, Kanno Y, Agnello D, Youle RJ, O'Shea JJ.

Mol Cell Biol. 2004 Jun;24(11):5039-49.

33.

Cytokines and their role in lymphoid development, differentiation and homeostasis.

Hofmann SR, Ettinger R, Zhou YJ, Gadina M, Lipsky P, Siegel R, Candotti F, O'Shea JJ.

Curr Opin Allergy Clin Immunol. 2002 Dec;2(6):495-506. Review.

PMID:
14752332
34.

Characterization and analysis of the proximal Janus kinase 3 promoter.

Aringer M, Hofmann SR, Frucht DM, Chen M, Centola M, Morinobu A, Visconti R, Kastner DL, Smolen JS, O'Shea JJ.

J Immunol. 2003 Jun 15;170(12):6057-64.

35.

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, Stein L, Russo R, Goldsmith D, Dent P, Rosenberg HF, Austin F, Remmers EF, Balow JE Jr, Rosenzweig S, Komarow H, Shoham NG, Wood G, Jones J, Mangra N, Carrero H, Adams BS, Moore TL, Schikler K, Hoffman H, Lovell DJ, Lipnick R, Barron K, O'Shea JJ, Kastner DL, Goldbach-Mansky R.

Arthritis Rheum. 2002 Dec;46(12):3340-8.

36.

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.

Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, Morinobu A, Gadina M, O'Shea JJ, Biron CA.

Science. 2002 Sep 20;297(5589):2063-6.

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