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Items: 1 to 50 of 55

1.

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.

Gerlach D, Tontsch-Grunt U, Baum A, Popow J, Scharn D, Hofmann MH, Engelhardt H, Kaya O, Beck J, Schweifer N, Gerstberger T, Zuber J, Savarese F, Kraut N.

Oncogene. 2018 May;37(20):2687-2701. doi: 10.1038/s41388-018-0150-2. Epub 2018 Mar 1.

2.

The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy.

Sanderson MP, Hofmann MH, Garin-Chesa P, Schweifer N, Wernitznig A, Fischer S, Jeschko A, Meyer R, Moll J, Pecina T, Arnhof H, Weyer-Czernilofsky U, Zahn SK, Adolf GR, Kraut N.

Mol Cancer Ther. 2017 Oct;16(10):2223-2233. doi: 10.1158/1535-7163.MCT-17-0336. Epub 2017 Jul 20.

3.

An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor.

Titze MI, Schaaf O, Hofmann MH, Sanderson MP, Zahn SK, Quant J, Lehr T.

Cancer Chemother Pharmacol. 2017 Mar;79(3):545-558. doi: 10.1007/s00280-017-3252-6. Epub 2017 Feb 27.

PMID:
28243682
4.

Local differences in calretinin immunoreactivity in the optic tectum of the ocellated dragonet.

Ulama T, Hofmann MH.

J Chem Neuroanat. 2016 Nov;77:55-59. doi: 10.1016/j.jchemneu.2016.05.003. Epub 2016 May 10.

PMID:
27177830
5.

A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques.

Titze MI, Schaaf O, Hofmann MH, Sanderson MP, Zahn SK, Quant J, Lehr T.

Cancer Chemother Pharmacol. 2016 Jun;77(6):1303-14. doi: 10.1007/s00280-016-3049-z. Epub 2016 May 9.

PMID:
27160688
6.

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.

Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Müller S, Nar H, Rogers C, Rumpel K, Schaaf O, Steurer S, Tallant C, Vakoc CR, Zeeb M, Zoephel A, Pearson M, Boehmelt G, McConnell D.

J Med Chem. 2016 May 26;59(10):4462-75. doi: 10.1021/acs.jmedchem.5b01865. Epub 2016 Mar 10.

7.

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.

Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N.

Mol Cancer Ther. 2015 Dec;14(12):2762-72. doi: 10.1158/1535-7163.MCT-15-0539. Epub 2015 Oct 5.

8.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.

Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N.

J Pharmacol Exp Ther. 2015 Mar;352(3):579-89. doi: 10.1124/jpet.114.221150. Epub 2015 Jan 9.

PMID:
25576074
9.

Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with rapamycin.

Friedbichler K, Hofmann MH, Kroez M, Ostermann E, Lamche HR, Koessl C, Borges E, Pollak MN, Adolf G, Adam PJ.

Mol Cancer Ther. 2014 Feb;13(2):399-409. doi: 10.1158/1535-7163.MCT-13-0598. Epub 2013 Dec 2.

10.

A direct primary afferent projection of the trigeminal nerve to the valvula cerebelli in the spiny eel Macrognathus zebrinus.

Schmidt M, Hofmann MH.

Neurosci Lett. 2013 Oct 25;554:39-41. doi: 10.1016/j.neulet.2013.08.052. Epub 2013 Sep 4.

PMID:
24012812
11.

Forebrain organization in elasmobranchs.

Hofmann MH, Northcutt RG.

Brain Behav Evol. 2012;80(2):142-51. doi: 10.1159/000339874. Epub 2012 Sep 13. Review.

PMID:
22986829
12.

Nonlinear dynamics of skin potentials in the electrosensory paddlefish.

Hofmann MH, Wilkens LA.

Chaos. 2011 Dec;21(4):047504. doi: 10.1063/1.3665698.

PMID:
22225378
13.

Two modes of information processing in the electrosensory system of the paddlefish (Polyodon spathula).

Pothmann L, Wilkens LA, Hofmann MH.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 Jan;198(1):1-10. doi: 10.1007/s00359-011-0681-2. Epub 2011 Sep 30.

PMID:
21960281
14.

Descending projections to the hindbrain and spinal cord in the paddlefish Polyodon spathula.

Metzen MG, Chambwa M, Wilkens LA, Hofmann MH.

Brain Res. 2010 Mar 4;1317:33-45. doi: 10.1016/j.brainres.2009.12.078. Epub 2010 Jan 4.

PMID:
20051233
15.

A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells.

Hofmann MH, Heinrich J, Radziwill G, Moelling K.

Mol Cancer Res. 2009 Oct;7(10):1635-44. doi: 10.1158/1541-7786.MCR-09-0043. Epub 2009 Oct 13. Erratum in: Mol Cancer Res. 2010 Jun;8(6):935. Radziwil, Gerald [corrected to Radziwill, Gerald].

16.

Edge-detection filter improves spatial resolution in the electrosensory system of the paddlefish.

Hofmann MH, Chagnaud BP, Wilkens LA.

J Neurophysiol. 2009 Aug;102(2):797-804. doi: 10.1152/jn.91215.2008. Epub 2009 May 20.

17.

Two parallel ascending pathways from the dorsal octavolateral nucleus to the midbrain in the paddlefish Polyodon spathula.

Pothmann L, Wilkens LA, Schweitzer C, Hofmann MH.

Brain Res. 2009 Apr 10;1265:93-102. doi: 10.1016/j.brainres.2009.02.007. Epub 2009 Feb 20.

PMID:
19230828
18.

Organization of major telencephalic pathways in an elasmobranch, the thornback ray Platyrhinoidis triseriata.

Hofmann MH, Northcutt RG.

Brain Behav Evol. 2008;72(4):307-25. doi: 10.1159/000192466. Epub 2009 Jan 16.

PMID:
19147992
19.

Receptive field organization of electrosensory neurons in the paddlefish (Polyodon spathula).

Chagnaud BP, Wilkens LA, Hofmann MH.

J Physiol Paris. 2008 Jul-Nov;102(4-6):246-55. doi: 10.1016/j.jphysparis.2008.10.006. Epub 2008 Oct 17.

PMID:
18984044
20.

Measuring flow velocity and flow direction by spatial and temporal analysis of flow fluctuations.

Chagnaud BP, Brücker C, Hofmann MH, Bleckmann H.

J Neurosci. 2008 Apr 23;28(17):4479-87. doi: 10.1523/JNEUROSCI.4959-07.2008.

21.

Lateral line nerve fibers do not code bulk water flow direction in turbulent flow.

Chagnaud BP, Bleckmann H, Hofmann MH.

Zoology (Jena). 2008;111(3):204-17. doi: 10.1016/j.zool.2007.07.009. Epub 2008 Mar 7.

PMID:
18329260
22.

Response properties of electrosensory units in the midbrain tectum of the paddlefish (Polyodon spathula Walbaum).

Hofmann MH, Jung SN, Siebenaller U, Preissner M, Chagnaud BP, Wilkens LA.

J Exp Biol. 2008 Mar;211(Pt 5):773-9. doi: 10.1242/jeb.009795.

23.

Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver.

Hofmann MH, Blievernicht JK, Klein K, Saussele T, Schaeffeler E, Schwab M, Zanger UM.

J Pharmacol Exp Ther. 2008 Apr;325(1):284-92. doi: 10.1124/jpet.107.133306. Epub 2008 Jan 2.

PMID:
18171905
24.

Response properties of electrosensory neurons in the lateral mesencephalic nucleus of the paddlefish.

Chagnaud BP, Wilkens LA, Hofmann MH.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008 Mar;194(3):209-20. Epub 2007 Dec 4.

PMID:
18057942
25.

Resonant properties in the paddlefish electrosensory system caused by delayed feedback.

Hofmann MH, Jung SN, Wilkens LA.

Biol Cybern. 2007 Dec;97(5-6):413-21. Epub 2007 Oct 10.

PMID:
17926062
26.

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.

Zanger UM, Klein K, Saussele T, Blievernicht J, Hofmann MH, Schwab M.

Pharmacogenomics. 2007 Jul;8(7):743-59.

PMID:
17638512
27.

Kármán vortex street detection by the lateral line.

Chagnaud BP, Bleckmann H, Hofmann MH.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Jul;193(7):753-63. Epub 2007 May 15.

PMID:
17503054
28.

Responses to dipole stimuli of anterior lateral line nerve fibres in goldfish, Carassius auratus, under still and running water conditions.

Chagnaud BP, Hofmann MH, Mogdans J.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Feb;193(2):249-63. Epub 2006 Oct 31.

PMID:
17075719
29.

Response properties of diencephalic neurons to visual, acoustic and hydrodynamic stimulation in the goldfish, Carassius auratus.

Kirsch JA, Hofmann MH, Mogdans J, Bleckmann H.

Zoology (Jena). 2002;105(1):61-70.

PMID:
16351857
30.

Response properties of electrosensory afferent fibers and secondary brain stem neurons in the paddlefish.

Hofmann MH, Chagnaud B, Wilkens LA.

J Exp Biol. 2005 Nov;208(Pt 22):4213-22.

31.

Temporal analysis of moving DC electric fields in aquatic media.

Hofmann MH, Wilkens LA.

Phys Biol. 2005 Mar;2(1):23-8.

PMID:
16204853
32.

The electric sense of the paddlefish: a passive system for the detection and capture of zooplankton prey.

Wilkens LA, Hofmann MH, Wojtenek W.

J Physiol Paris. 2002 Sep-Dec;96(5-6):363-77.

PMID:
14692485
33.

Responses of diencephalic neurons to sensory stimulation in the goldfish, Carassius auratus.

Kirsch JA, Hofmann MH, Mogdans J, Bleckmann H.

Brain Res Bull. 2002 Feb-Mar 1;57(3-4):419-21.

PMID:
11923001
34.

Effects of dopaminergic drugs and telencephalic ablation on eye movements in the goldfish, Carassius auratus.

Dietrich M, Hofmann MH, Bleckmann H.

Brain Res Bull. 2002 Feb-Mar 1;57(3-4):393-5.

PMID:
11922996
35.

Central organization of the electrosensory system in the paddlefish (Polyodon spathula).

Hofmann MH, Wojtenek W, Wilkens LA.

J Comp Neurol. 2002 Apr 22;446(1):25-36.

PMID:
11920717
36.

A direct projection from the cerebellum to the telencephalon in the goldfish, Carassius auratus.

Vonderschen K, Bleckmann H, Hofmann MH.

Neurosci Lett. 2002 Mar 1;320(1-2):37-40.

PMID:
11849758
37.

VIEWER: a program for visualising, recording, and analysing animal behaviour.

Schwarz S, Hofmann MH, Gutzen C, Schlax S, von der Emde G.

Comput Methods Programs Biomed. 2002 Jan;67(1):55-66.

PMID:
11750947
38.

The ability of Rhodnius prolixus (Hemiptera; Reduviidae) to approach a thermal source solely by its infrared radiation.

Schmitz H, Trenner S, Hofmann MH, Bleckmann H.

J Insect Physiol. 2000 May 1;46(5):745-751.

PMID:
10742523
39.

Effect of temperature and calcium on transneuronal diffusion of DiI in fixed brain preparations.

Hofmann MH, Bleckmann H.

J Neurosci Methods. 1999 Apr 1;88(1):27-31.

PMID:
10379576
40.

Subdivisions of the olfactory system in the sterlet Acipenser ruthenus.

Hofmann MH, Bleckmann H.

Neurosci Lett. 1997 Sep 19;233(2-3):154-6.

PMID:
9350856
41.
42.
43.

Visual-evoked responses in the salmon telencephalon change during smolt transformation.

Hofmann MH, Meyer DL.

Neurosci Lett. 1993 Jun 11;155(2):234-6.

PMID:
8377954
44.
45.

Peripheral origin of olfactory nerve fibers by-passing the olfactory bulb in Xenopus laevis.

Hofmann MH, Meyer DL.

Brain Res. 1992 Aug 28;589(1):161-3.

PMID:
1422816
46.

Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".

Erdö SL, Meyer DL, Malz CR, Hofmann MH, Ebbesson SO.

J Hirnforsch. 1992;33(4-5):467-9.

PMID:
1336023
47.
48.

Subdivisions of the terminal nerve in Xenopus laevis.

Hofmann MH, Meyer DL.

J Exp Zool. 1991 Sep;259(3):324-9.

PMID:
1919462
50.

Event-related potentials in the retina and optic tectum of fish.

Bullock TH, Hofmann MH, Nahm FK, New JG, Prechtl JC.

J Neurophysiol. 1990 Sep;64(3):903-14.

PMID:
2230933

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