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NanoPARE: parallel analysis of RNA 5' ends from low-input RNA.

Schon MA, Kellner MJ, Plotnikova A, Hofmann F, Nodine MD.

Genome Res. 2018 Oct 24. doi: 10.1101/gr.239202.118. [Epub ahead of print]


A Joint Statement from the European Association of Urology Renal Cell Cancer Guidelines Panel and the International Kidney Cancer Coalition: The Rejection of Ipilimumab and Nivolumab for Renal Cancer by the Committee for Medicinal Products for Human Use Does not Change Evidence-based Guideline Recommendations.

Bex A, Albiges L, Staehler M, Bensalah K, Giles RH, Dabestani S, Hofmann F, Hora M, Kuczyk MA, Lam TB, Marconi L, Merseburger AS, Fernández-Pello S, Tahbaz R, Abu-Ghanem Y, Volpe A, Ljungberg B, Escudier B, Powles T.

Eur Urol. 2018 Dec;74(6):849-851. doi: 10.1016/j.eururo.2018.08.029. Epub 2018 Sep 7. No abstract available.


3D reconstruction of the spatial distribution of dislocation loops using an automated stereo-imaging approach.

Yu H, Yi X, Hofmann F.

Ultramicroscopy. 2018 Dec;195:58-68. doi: 10.1016/j.ultramic.2018.08.018. Epub 2018 Aug 27.


Updated European Association of Urology Guidelines for Cytoreductive Nephrectomy in Patients with Synchronous Metastatic Clear-cell Renal Cell Carcinoma.

Bex A, Albiges L, Ljungberg B, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB, Marconi L, Merseburger AS, Fernández-Pello S, Tahbaz R, Abu-Ghanem Y, Staehler M, Volpe A, Powles T.

Eur Urol. 2018 Dec;74(6):805-809. doi: 10.1016/j.eururo.2018.08.008. Epub 2018 Aug 31.


Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.

Jeay S, Ferretti S, Holzer P, Fuchs J, Chapeau EA, Wartmann M, Sterker D, Romanet V, Murakami M, Kerr G, Durand EY, Gaulis S, Cortes-Cros M, Ruetz S, Stachyra TM, Kallen J, Furet P, Würthner J, Guerreiro N, Halilovic E, Jullion A, Kauffmann A, Kuriakose E, Wiesmann M, Jensen MR, Hofmann F, Sellers WR.

Cancer Res. 2018 Nov 1;78(21):6257-6267. doi: 10.1158/0008-5472.CAN-18-0338. Epub 2018 Aug 22.


Probing multi-scale mechanics of peripheral nerve collagen and myelin by X-ray diffraction.

Bianchi F, Hofmann F, Smith AJ, Ye H, Thompson MS.

J Mech Behav Biomed Mater. 2018 Nov;87:205-212. doi: 10.1016/j.jmbbm.2018.07.030. Epub 2018 Jul 25.


HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

Sztukowski K, Nip K, Ostwald PN, Sathler MF, Sun JL, Shou J, Jorgensen ET, Brown TE, Elder JH, Miller C, Hofmann F, VandeWoude S, Kim S.

PLoS Biol. 2018 Jul 27;16(7):e2005315. doi: 10.1371/journal.pbio.2005315. eCollection 2018 Jul.


Linear response time-dependent density functional theory without unoccupied states: The Kohn-Sham-Sternheimer scheme revisited.

Hofmann F, Schelter I, Kümmel S.

J Chem Phys. 2018 Jul 14;149(2):024105. doi: 10.1063/1.5030652.


A concise discussion of the regulatory role of cGMP kinase I in cardiac physiology and pathology.

Hofmann F.

Basic Res Cardiol. 2018 Jun 22;113(4):31. doi: 10.1007/s00395-018-0690-1. Review.


CT attenuation of liver metastases before targeted therapy is a prognostic factor of overall survival in colorectal cancer patients. Results from the randomised, open-label FIRE-3/AIO KRK0306 trial.

Froelich MF, Heinemann V, Sommer WH, Holch JW, Schoeppe F, Hesse N, Baumann AB, Kunz WG, Reiser MF, Ricke J, D'Anastasi M, Stintzing S, Modest DP, Kazmierczak PM, Hofmann FO.

Eur Radiol. 2018 Jun 7. doi: 10.1007/s00330-018-5454-7. [Epub ahead of print]


Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases.

Winter KS, Hofmann FO, Thierfelder KM, Holch JW, Hesse N, Baumann AB, Modest DP, Stintzing S, Heinemann V, Ricke J, Sommer WH, D'Anastasi M.

Eur Radiol. 2018 May 7. doi: 10.1007/s00330-018-5424-0. [Epub ahead of print]


Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative.

Neumann J, Hofmann FC, Heilmeier U, Ashmeik W, Tang K, Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Lane NE, McCulloch CE, Link TM.

Osteoarthritis Cartilage. 2018 Jun;26(6):751-761. doi: 10.1016/j.joca.2018.03.010. Epub 2018 Mar 29.


Prognostic value of radiologically enlarged lymph nodes in patients with metastatic colorectal cancer: Subgroup findings of the randomized, open-label FIRE-3/AIO KRK0306 trial.

Hofmann FO, Holch JW, Heinemann V, Ricard I, Reiser MF, Baumann AB, Hesse N, D'Anastasi M, Modest DP, Stintzing S, Sommer WH.

Eur J Radiol. 2018 Mar;100:124-129. doi: 10.1016/j.ejrad.2018.01.006. Epub 2018 Jan 6.


Intramolecular Aza-Diels-Alder Reactions of ortho-Quinone Methide Imines: Rapid, Catalytic, and Enantioselective Assembly of Benzannulated Quinolizidines.

Kretzschmar M, Hofmann F, Moock D, Schneider C.

Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4774-4778. doi: 10.1002/anie.201800787. Epub 2018 Mar 25.


Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.

Matei AE, Beyer C, Györfi AH, Soare A, Chen CW, Dees C, Bergmann C, Ramming A, Friebe A, Hofmann F, Distler O, Schett G, Distler JHW.

Ann Rheum Dis. 2018 Mar;77(3):459. doi: 10.1136/annrheumdis-2017-212489. Epub 2018 Jan 8.


Updated European Association of Urology Guidelines Recommendations for the Treatment of First-line Metastatic Clear Cell Renal Cancer.

Powles T, Albiges L, Staehler M, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB, Marconi L, Merseburger AS, Fernández-Pello S, Tahbaz R, Volpe A, Ljungberg B, Bex A.

Eur Urol. 2017 Dec 7. pii: S0302-2838(17)31001-1. doi: 10.1016/j.eururo.2017.11.016. [Epub ahead of print]


[Correction: Glove Disinfection: Knowledge, Experiences and Attitudes of Hygiene Team Members and Company Physicians].

Schulz-Stübner S, Hofmann F, Michaelis M.

Gesundheitswesen. 2018 Mar;80(S 02):S105. doi: 10.1055/s-0037-1600943. Epub 2017 Dec 5. German. No abstract available.


[Changes in Sense of Coherence, Mental Distress and Satisfaction with Life and Studies in the Course of Psychosocial Counselling].

Koutsoukou-Argyraki A, Bertolino A, Kreß V, Hofmann FH, Sperth M, Holm-Hadulla RM.

Psychother Psychosom Med Psychol. 2018 Feb;68(2):66-74. doi: 10.1055/s-0043-118651. Epub 2017 Nov 23. German.


PKC and calcium channel trafficking.

Hofmann F.

Channels (Austin). 2018 Jan 1;12(1):15-16. doi: 10.1080/19336950.2017.1397924. Epub 2017 Nov 21. No abstract available.


Altered Synaptic Membrane Retrieval after Strong Stimulation of Cerebellar Granule Neurons in Cyclic GMP-Dependent Protein Kinase II (cGKII) Knockout Mice.

Collado-Alsina A, Hofmann F, Sánchez-Prieto J, Torres M.

Int J Mol Sci. 2017 Oct 30;18(11). pii: E2281. doi: 10.3390/ijms18112281.


[Glove Disinfection: Knowledge, Experiences and Attitudes of Hygiene Team Members and Company Physicians].

Schulz-Stübner S, Hofmann F, Michaelis M.

Gesundheitswesen. 2018 Mar;80(S 02):S97-S104. doi: 10.1055/s-0043-119083. Epub 2017 Oct 25. German.


Rational design of botulinum neurotoxin A1 mutants with improved oxidative stability.

López de la Paz M, Scheps D, Jurk M, Hofmann F, Frevert J.

Toxicon. 2018 Jun 1;147:54-57. doi: 10.1016/j.toxicon.2017.10.011. Epub 2017 Oct 16.


Formulation development of SYN-004 (ribaxamase) oral solid dosage form, a β-lactamase to prevent intravenous antibiotic-associated dysbiosis of the colon.

Bristol A, Hubert S, Hofmann F, Baer H.

Int J Pharm. 2017 Dec 20;534(1-2):25-34. doi: 10.1016/j.ijpharm.2017.10.001. Epub 2017 Oct 3.


Mind the Gaps in Tumor Immunity: Impact of Connexin-Mediated Intercellular Connections.

Gleisner MA, Navarrete M, Hofmann F, Salazar-Onfray F, Tittarelli A.

Front Immunol. 2017 Sep 1;8:1067. doi: 10.3389/fimmu.2017.01067. eCollection 2017. Review.


Design of modified botulinum neurotoxin A1 variants with a shorter persistence of paralysis and duration of action.

Scheps D, López de la Paz M, Jurk M, Hofmann F, Frevert J.

Toxicon. 2017 Dec 1;139:101-108. doi: 10.1016/j.toxicon.2017.09.006. Epub 2017 Sep 13.


Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene.

Ryan RA, Williams S, Martin AV, Dilanian RA, Darmanin C, Putkunz CT, Wood D, Streltsov VA, Jones MWM, Gaffney N, Hofmann F, Williams GJ, Boutet S, Messerschmidt M, Seibert MM, Curwood EK, Balaur E, Peele AG, Nugent KA, Quiney HM, Abbey B.

J Vis Exp. 2017 Aug 22;(126). doi: 10.3791/56296.


Micro-beam Laue alignment of multi-reflection Bragg coherent diffraction imaging measurements.

Hofmann F, Phillips NW, Harder RJ, Liu W, Clark JN, Robinson IK, Abbey B.

J Synchrotron Radiat. 2017 Sep 1;24(Pt 5):1048-1055. doi: 10.1107/S1600577517009183. Epub 2017 Aug 8.


Conservatively treated knee injury is associated with knee cartilage matrix degeneration measured with MRI-based T2 relaxation times: data from the osteoarthritis initiative.

Hofmann FC, Neumann J, Heilmeier U, Joseph GB, Nevitt MC, McCulloch CE, Link TM.

Skeletal Radiol. 2018 Jan;47(1):93-106. doi: 10.1007/s00256-017-2759-6. Epub 2017 Aug 29.


Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel.

Poomvanicha M, Matthes J, Domes K, Patrucco E, Angermeier E, Laugwitz KL, Schneider T, Hofmann F.

J Mol Cell Cardiol. 2017 Oct;111:10-16. doi: 10.1016/j.yjmcc.2017.07.119. Epub 2017 Aug 1.


Procedure to select test organisms for environmental risk assessment of genetically modified crops in aquatic systems.

Hilbeck A, Bundschuh R, Bundschuh M, Hofmann F, Oehen B, Otto M, Schulz R, Trtikova M.

Integr Environ Assess Manag. 2017 Nov;13(6):974-979. doi: 10.1002/ieam.1965. Epub 2017 Sep 20.


Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel.

Köves B, Cai T, Veeratterapillay R, Pickard R, Seisen T, Lam TB, Yuan CY, Bruyere F, Wagenlehner F, Bartoletti R, Geerlings SE, Pilatz A, Pradere B, Hofmann F, Bonkat G, Wullt B.

Eur Urol. 2017 Dec;72(6):865-868. doi: 10.1016/j.eururo.2017.07.014. Epub 2017 Jul 25. Review.


Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR.

Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.


Observation of crack growth in a polycrystalline ferroelectric by synchrotron X-ray diffraction.

Huber JE, Hofmann F, Barhli S, Marrow TJ, Hildersley C.

Scr Mater. 2017 Nov;140:23-26. doi: 10.1016/j.scriptamat.2017.06.053. Epub 2017 Jul 7.


Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.

Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM.

Mol Psychiatry. 2018 Mar;23(3):533-543. doi: 10.1038/mp.2017.133. Epub 2017 Jul 11.


Do Occupational Risks for Low Back Pain Differ From Risks for Specific Lumbar Disc Diseases?: Results of the German Lumbar Spine Study (EPILIFT).

Bergmann A, Bolm-Audorff U, Ditchen D, Ellegast R, Grifka J, Haerting J, Hofmann F, Jäger M, Linhardt O, Luttmann A, Meisel HJ, Michaelis M, Petereit-Haack G, Schumann B, Seidler A.

Spine (Phila Pa 1976). 2017 Oct 15;42(20):E1204-E1211. doi: 10.1097/BRS.0000000000002296.


A Medical Student-Delivered Smoking Prevention Program, Education Against Tobacco, for Secondary Schools in Germany: Randomized Controlled Trial.

Brinker TJ, Owczarek AD, Seeger W, Groneberg DA, Brieske CM, Jansen P, Klode J, Stoffels I, Schadendorf D, Izar B, Fries FN, Hofmann FJ.

J Med Internet Res. 2017 Jun 6;19(6):e199. doi: 10.2196/jmir.7906.


Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative.

Chanchek N, Gersing AS, Schwaiger BJ, Nevitt MC, Neumann J, Joseph GB, Lane NE, Zarnowski J, Hofmann FC, Heilmeier U, McCulloch CE, Link TM.

J Magn Reson Imaging. 2018 Feb;47(2):380-390. doi: 10.1002/jmri.25766. Epub 2017 May 26.


Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.

Bialucha CU, Collins SD, Li X, Saxena P, Zhang X, Dürr C, Lafont B, Prieur P, Shim Y, Mosher R, Lee D, Ostrom L, Hu T, Bilic S, Rajlic IL, Capka V, Jiang W, Wagner JP, Elliott G, Veloso A, Piel JC, Flaherty MM, Mansfield KG, Meseck EK, Rubic-Schneider T, London AS, Tschantz WR, Kurz M, Nguyen D, Bourret A, Meyer MJ, Faris JE, Janatpour MJ, Chan VW, Yoder NC, Catcott KC, McShea MA, Sun X, Gao H, Williams J, Hofmann F, Engelman JA, Ettenberg SA, Sellers WR, Lees E.

Cancer Discov. 2017 Sep;7(9):1030-1045. doi: 10.1158/2159-8290.CD-16-1414. Epub 2017 May 19.


Five-Year Outcomes After Treatment for Acute Instability of the Tibiofibular Syndesmosis Using a Suture-Button Fixation System.

Förschner PF, Beitzel K, Imhoff AB, Buchmann S, Feuerriegel G, Hofmann F, Karampinos DC, Jungmann P, Pogorzelski J.

Orthop J Sports Med. 2017 Apr 27;5(4):2325967117702854. doi: 10.1177/2325967117702854. eCollection 2017 Apr.


Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis.

Schinner E, Wetzl V, Schramm A, Kees F, Sandner P, Stasch JP, Hofmann F, Schlossmann J.

FEBS Open Bio. 2017 Mar 1;7(4):550-561. doi: 10.1002/2211-5463.12202. eCollection 2017 Apr.


Spectral focusing of broadband silver electroluminescence in nanoscopic FRET-LEDs.

Puchert RP, Steiner F, Plechinger G, Hofmann FJ, Caspers I, Kirschner J, Nagler P, Chernikov A, Schüller C, Korn T, Vogelsang J, Bange S, Lupton JM.

Nat Nanotechnol. 2017 Jul;12(7):637-641. doi: 10.1038/nnano.2017.48. Epub 2017 Apr 10.


3D lattice distortions and defect structures in ion-implanted nano-crystals.

Hofmann F, Tarleton E, Harder RJ, Phillips NW, Ma PW, Clark JN, Robinson IK, Abbey B, Liu W, Beck CE.

Sci Rep. 2017 Apr 6;7:45993. doi: 10.1038/srep45993.


Reply to the EFSA (2016) on the relevance of recent publications (Hofmann et al. 2014, 2016) on environmental risk assessment and management of Bt-maize events (MON810, Bt11 and 1507).

Kruse-Plass M, Hofmann F, Kuhn U, Otto M, Schlechtriemen U, Schröder B, Vögel R, Wosniok W.

Environ Sci Eur. 2017;29(1):12. doi: 10.1186/s12302-017-0106-0. Epub 2017 Mar 7.


The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR.

Nature. 2017 Mar 30;543(7647):733-737. doi: 10.1038/nature21702. Epub 2017 Mar 22.


Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.

Chapeau EA, Gembarska A, Durand EY, Mandon E, Estadieu C, Romanet V, Wiesmann M, Tiedt R, Lehar J, de Weck A, Rad R, Barys L, Jeay S, Ferretti S, Kauffmann A, Sutter E, Grevot A, Moulin P, Murakami M, Sellers WR, Hofmann F, Jensen MR.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156. doi: 10.1073/pnas.1620262114. Epub 2017 Mar 6.


Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.

Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9659. doi: 10.1126/scisignal.aaf9659.


Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9647. doi: 10.1126/scisignal.aaf9647.


Bragg coherent diffraction imaging and metrics for radiation damage in protein micro-crystallography.

Coughlan HD, Darmanin C, Kirkwood HJ, Phillips NW, Hoxley D, Clark JN, Vine DJ, Hofmann F, Harder RJ, Maxey E, Abbey B.

J Synchrotron Radiat. 2017 Jan 1;24(Pt 1):83-94. doi: 10.1107/S1600577516017525. Epub 2017 Jan 1.


cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.

Wang R, Islam BN, Bridges A, Sharman SK, Hu M, Hou Y, Somanath PR, Venable L, Singh N, Kim S, Sridhar S, Hofmann F, Browning DD.

Am J Pathol. 2017 Feb;187(2):377-389. doi: 10.1016/j.ajpath.2016.10.016. Epub 2016 Dec 18.


Updated European Association of Urology Guidelines Regarding Adjuvant Therapy for Renal Cell Carcinoma.

Bex A, Albiges L, Ljungberg B, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB, Marconi L, Merseburger AS, Staehler M, Volpe A, Powles T.

Eur Urol. 2017 May;71(5):719-722. doi: 10.1016/j.eururo.2016.11.034. Epub 2016 Dec 13.


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