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Items: 1 to 50 of 499

1.

Causal Role of Bile Acids in Irritable Bowel Syndrome-Constipation.

Hofmann AF.

Clin Gastroenterol Hepatol. 2019 Jan;17(1):213-214. doi: 10.1016/j.cgh.2018.05.008. No abstract available.

PMID:
30558894
2.

Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD.

Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R.

Aliment Pharmacol Ther. 2019 Jan;49(2):183-193. doi: 10.1111/apt.15035. Epub 2018 Dec 2.

PMID:
30506692
3.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R.

Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19.

4.

Absorption of Unconjugated Bile Acids from the Perfused Jejunum of the Anesthetized Rat: Structure-Activity Relationships and Rate-Limiting Steps.

Dupas JL, Ho NFH, Hofmann AF.

Lipids. 2018 May;53(5):465-468. doi: 10.1002/lipd.12052. Epub 2018 Aug 2. No abstract available.

5.

Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease.

Hegyi P, Maléth J, Walters JR, Hofmann AF, Keely SJ.

Physiol Rev. 2018 Oct 1;98(4):1983-2023. doi: 10.1152/physrev.00054.2017. Review.

6.

Bile Acids and the Microbiome in the Cow: Lack of Deoxycholic Acid Hydroxylation.

Hofmann AF, Herdt T, Ames NK, Chen Z, Hagey LR.

Lipids. 2018 Mar;53(3):269-270. doi: 10.1002/lipd.12036. Epub 2018 Apr 18. No abstract available.

PMID:
29668048
7.

Plasma Bile Acid Concentrations in Humans: Suggestions for Presentation in Tabular Form.

Hofmann AF, Marschall HU.

Hepatology. 2018 Aug;68(2):787. doi: 10.1002/hep.29909. No abstract available.

PMID:
29604219
8.

Chemical Synthesis of Rare Natural Bile Acids: 11α-Hydroxy Derivatives of Lithocholic and Chenodeoxycholic Acids.

Namegawa K, Iida K, Omura K, Ogawa S, Hofmann AF, Iida T.

Lipids. 2018 Apr;53(4):403-411. doi: 10.1002/lipd.12013. Epub 2018 Mar 9.

PMID:
29520792
9.

Bile Acid Replacement in Bile Acid Synthesis Defects.

Hofmann AF.

J Pediatr Gastroenterol Nutr. 2017 Dec;65(6):e134. doi: 10.1097/MPG.0000000000001709. No abstract available.

PMID:
28800025
10.

Two Inborn Errors of Bile Acid Biosynthesis: The Need for Recognition and Treatment by Primary Bile Acid Replacement.

Hofmann AF.

J Pediatr Gastroenterol Nutr. 2017 Jun;64(6):849-850. doi: 10.1097/MPG.0000000000001579. No abstract available.

PMID:
28333767
11.

Seventy Years of Polyethylene Glycols in Gastroenterology: The Journey of PEG 4000 and 3350 From Nonabsorbable Marker to Colonoscopy Preparation to Osmotic Laxative.

Fordtran JS, Hofmann AF.

Gastroenterology. 2017 Mar;152(4):675-680. doi: 10.1053/j.gastro.2017.01.027. Epub 2017 Jan 29. No abstract available.

PMID:
28147222
12.

Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage.

Edwards JE, LaCerte C, Peyret T, Gosselin NH, Marier JF, Hofmann AF, Shapiro D.

Clin Transl Sci. 2016 Dec;9(6):328-336. doi: 10.1111/cts.12421. Epub 2016 Oct 15.

13.

Chemical Synthesis of Uncommon Natural Bile Acids: The 9α-Hydroxy Derivatives of Chenodeoxycholic and Lithocholic Acids.

Iida T, Namegawa K, Nakane N, Iida K, Hofmann AF, Omura K.

Chem Pharm Bull (Tokyo). 2016 Sep 1;64(9):1397-402. doi: 10.1248/cpb.c16-00247. Epub 2016 Jun 18.

14.

Let the Bile Flow! 1.0.

Hofmann AF.

Hepatology. 2016 Oct;64(4):1387-8. doi: 10.1002/hep.28633. Epub 2016 Jun 11. No abstract available.

PMID:
27178666
15.

Two Major Bile Acids in the Hornbills, (24R,25S)-3α,7α,24-Trihydroxy-5β-cholestan-27-oyl Taurine and Its 12α-Hydroxy Derivative.

Satoh R, Ogata H, Saito T, Zhou B, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Hagey LR, Hofmann AF, Iida T.

Lipids. 2016 Jun;51(6):757-68. doi: 10.1007/s11745-016-4150-0. Epub 2016 Apr 23.

PMID:
27108034
16.

Hepatobiliary Secretion Kinetics of Conjugated Bile Acids Measured in Pigs by 11C-Cholylsarcosine PET.

Sørensen M, Munk OL, Ørntoft NW, Frisch K, Andersen KJ, Mortensen FV, Alstrup AK, Ott P, Hofmann AF, Keiding S.

J Nucl Med. 2016 Jun;57(6):961-6. doi: 10.2967/jnumed.115.171579. Epub 2016 Mar 10.

17.

Novel, major 2α- and 2β-hydroxy bile alcohols and bile acids in the bile of Arapaima gigas, a large South American river fish.

Sato née Okihara R, Saito T, Ogata H, Nakane N, Namegawa K, Sekiguchi S, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Raines J, Hagey LR, Hofmann AF, Iida T.

Steroids. 2016 Mar;107:112-20. doi: 10.1016/j.steroids.2016.01.001. Epub 2016 Jan 6.

PMID:
26768415
18.

Gastrolithiasis in prehensile-tailed porcupines (Coendou prehensilis): nine cases and pathogenesis of stone formation.

Spriggs M, Thompson KA, Barton D, Talley J, Volle K, Stasiak I, Beyea L, Guthrie A, Roda A, Camborata C, Hofmann AF, Hagey LR.

J Zoo Wildl Med. 2014 Dec;45(4):883-91.

PMID:
25632677
19.

Focused metabolomics using liquid chromatography/electrospray ionization tandem mass spectrometry for analysis of urinary conjugated cholesterol metabolites from patients with Niemann-Pick disease type C and 3β-hydroxysteroid dehydrogenase deficiency.

Maekawa M, Shimada M, Ohno K, Togawa M, Nittono H, Iida T, Hofmann AF, Goto J, Yamaguchi H, Mano N.

Ann Clin Biochem. 2015 Sep;52(Pt 5):576-87. doi: 10.1177/0004563214568871. Epub 2015 Jan 9.

PMID:
25575700
20.

Improved chemical synthesis, X-ray crystallographic analysis, and NMR characterization of (22R)-/(22S)-hydroxy epimers of bile acids.

Omura K, Ohsaki A, Zhou B, Kushida M, Mitsuma T, Kobayashi A, Hagey LR, Hofmann AF, Iida T.

Lipids. 2014 Nov;49(11):1169-80. doi: 10.1007/s11745-014-3955-y. Epub 2014 Oct 16.

PMID:
25319478
21.

Origin of myofibroblasts in the fibrotic liver in mice.

Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3297-305. doi: 10.1073/pnas.1400062111. Epub 2014 Jul 29.

22.

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades.

Hofmann AF, Hagey LR.

J Lipid Res. 2014 Aug;55(8):1553-95. doi: 10.1194/jlr.R049437. Epub 2014 May 17. Review.

23.

A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS.

Kakiyama G, Muto A, Takei H, Nittono H, Murai T, Kurosawa T, Hofmann AF, Pandak WM, Bajaj JS.

J Lipid Res. 2014 May;55(5):978-90. doi: 10.1194/jlr.D047506. Epub 2014 Mar 13.

24.

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.

Wang L, Hartmann P, Haimerl M, Bathena SP, Sjöwall C, Almer S, Alnouti Y, Hofmann AF, Schnabl B.

J Hepatol. 2014 Jun;60(6):1259-67. doi: 10.1016/j.jhep.2014.02.012. Epub 2014 Feb 19.

25.

The bile acid TGR5 membrane receptor: from basic research to clinical application.

Duboc H, Taché Y, Hofmann AF.

Dig Liver Dis. 2014 Apr;46(4):302-12. doi: 10.1016/j.dld.2013.10.021. Epub 2014 Jan 9. Review.

26.

N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish.

Satoh Née Okihara R, Saito T, Ogata H, Ohsaki A, Iida T, Asahina K, Mitamura K, Ikegawa S, Hofmann AF, Hagey LR.

Steroids. 2014 Feb;80:15-23. doi: 10.1016/j.steroids.2013.11.014. Epub 2013 Nov 27.

PMID:
24291417
27.

Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies.

Wang R, Liu L, Sheps JA, Forrest D, Hofmann AF, Hagey LR, Ling V.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G286-94. doi: 10.1152/ajpgi.00082.2013. Epub 2013 Jun 13.

28.

LC/ESI-MS/MS analysis of urinary 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its amides: new biomarkers for the detection of Niemann-Pick type C disease.

Maekawa M, Misawa Y, Sotoura A, Yamaguchi H, Togawa M, Ohno K, Nittono H, Kakiyama G, Iida T, Hofmann AF, Goto J, Shimada M, Mano N.

Steroids. 2013 Oct;78(10):967-72. doi: 10.1016/j.steroids.2013.05.017. Epub 2013 Jun 7.

PMID:
23751200
29.

An efficient synthesis of 7α,12α-dihydroxy-4-cholesten-3-one and its biological precursor 7α-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis.

Ogawa S, Zhou B, Kimoto Y, Omura K, Kobayashi A, Higashi T, Mitamura K, Ikegawa S, Hagey LR, Hofmann AF, Iida T.

Steroids. 2013 Sep;78(9):927-37. doi: 10.1016/j.steroids.2013.05.011. Epub 2013 May 23.

30.

Ursodeoxycholic acid attenuates colonic epithelial secretory function.

Kelly OB, Mroz MS, Ward JB, Colliva C, Scharl M, Pellicciari R, Gilmer JF, Fallon PG, Hofmann AF, Roda A, Murray FE, Keely SJ.

J Physiol. 2013 May 1;591(9):2307-18. doi: 10.1113/jphysiol.2013.252544. Epub 2013 Mar 18.

31.

Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency.

Setchell KD, Heubi JE, Shah S, Lavine JE, Suskind D, Al-Edreesi M, Potter C, Russell DW, O'Connell NC, Wolfe B, Jha P, Zhang W, Bove KE, Knisely AS, Hofmann AF, Rosenthal P, Bull LN.

Gastroenterology. 2013 May;144(5):945-955.e6; quiz e14-5. doi: 10.1053/j.gastro.2013.02.004. Epub 2013 Feb 13.

32.

A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster.

Hagey LR, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann AF, Iida T.

Steroids. 2012 Nov;77(13):1510-21. doi: 10.1016/j.steroids.2012.08.017. Epub 2012 Sep 15.

PMID:
22986074
33.

Synthesis of multiply deuterated 3- and 21-monosulfates of allo-tetrahydrocorticosteroids as internal standards for mass spectrometry.

Mitamura K, Mabuchi T, Nagae K, Nakajima M, Matsumoto R, Fujioka S, Sato K, Satoh née Okihara R, Iida T, Ogawa S, Hofmann AF, Ikegawa S.

Steroids. 2012 Nov;77(13):1423-37. doi: 10.1016/j.steroids.2012.08.007. Epub 2012 Aug 31.

PMID:
22960650
34.

Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids.

Muto A, Takei H, Unno A, Murai T, Kurosawa T, Ogawa S, Iida T, Ikegawa S, Mori J, Ohtake A, Hoshina T, Mizuochi T, Kimura A, Hofmann AF, Hagey LR, Nittono H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 1;900:24-31. doi: 10.1016/j.jchromb.2012.05.023. Epub 2012 May 24.

PMID:
22695323
35.

[N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs.

Frisch K, Jakobsen S, Sørensen M, Munk OL, Alstrup AK, Ott P, Hofmann AF, Keiding S.

J Nucl Med. 2012 May;53(5):772-8. doi: 10.2967/jnumed.111.098731. Epub 2012 Mar 27.

36.

Synthesis of the 3-sulfates of S-acyl glutathione conjugated bile acids and their biotransformation by a rat liver cytosolic fraction.

Mitamura K, Hori N, Mino S, Iida T, Hofmann AF, Ikegawa S.

Chem Phys Lipids. 2012 Apr;165(3):261-9. doi: 10.1016/j.chemphyslip.2012.02.001. Epub 2012 Feb 10.

PMID:
22343050
37.

Clinicians out of fashion for the Nobel Prize in Medicine and Physiology.

Hofmann AF.

J R Soc Med. 2011 Dec;104(12):493. doi: 10.1258/jrsm.2011.110302. No abstract available.

38.

Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS.

Mitamura K, Hori N, Iida T, Suzuki M, Shimizu T, Nittono H, Takaori K, Takikawa H, Hofmann AF, Ikegawa S.

Steroids. 2011 Dec 20;76(14):1609-14. doi: 10.1016/j.steroids.2011.10.001. Epub 2011 Oct 10.

PMID:
22019844
39.

Herbert Falk: a vital force in the renaissance of bile acid research and bile acid therapy.

Hofmann AF.

Dig Dis. 2011;29(1):23-36. doi: 10.1159/000327750. Epub 2011 Jun 17.

PMID:
21691101
40.

Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid.

Hagey LR, Iida T, Ogawa S, Adachi Y, Une M, Mushiake K, Maekawa M, Shimada M, Mano N, Hofmann AF.

Steroids. 2011 Sep-Oct;76(10-11):1126-35. doi: 10.1016/j.steroids.2011.04.017. Epub 2011 May 11.

PMID:
21600907
41.

Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates.

Ogawa S, Mitamura K, Ikegawa S, Krasowski MD, Hagey LR, Hofmann AF, Iida T.

Chem Phys Lipids. 2011 Jul;164(5):368-77. doi: 10.1016/j.chemphyslip.2011.04.008. Epub 2011 Apr 28.

PMID:
21554864
42.

Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release.

Hofmann AF.

Hepatology. 2011 May;53(5):1784. doi: 10.1002/hep.24100. Epub 2011 Jan 10. No abstract available.

PMID:
21520190
43.

Characterization of non-enzymatic acylation of amino or thiol groups of bionucleophiles by the acyl-adenylate or acyl-CoA thioester of cholic acid.

Mitamura K, Aoyama E, Sakai T, Iida T, Hofmann AF, Ikegawa S.

Anal Bioanal Chem. 2011 Jun;400(7):2253-9. doi: 10.1007/s00216-011-4961-z. Epub 2011 Apr 14.

PMID:
21491109
44.
45.

COMPLEX EVOLUTION OF BILE SALTS IN BIRDS.

Hagey LR, Vidal N, Hofmann AF, Krasowski MD.

Auk. 2010 Oct;127(4):820-831.

46.

Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.

Denk GU, Maitz S, Wimmer R, Rust C, Invernizzi P, Ferdinandusse S, Kulik W, Fuchsbichler A, Fickert P, Trauner M, Hofmann AF, Beuers U.

Hepatology. 2010 Nov;52(5):1758-68. doi: 10.1002/hep.23911.

PMID:
21038414
47.

Identification of bile acid S-acyl glutathione conjugates in rat bile by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry.

Mitamura K, Hori N, Iida T, Hofmann AF, Ikegawa S.

Steroids. 2011 Jan;76(1-2):68-77. doi: 10.1016/j.steroids.2010.09.002. Epub 2010 Sep 15.

PMID:
20837038
48.

Hepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters.

Megaraj V, Iida T, Jungsuwadee P, Hofmann AF, Vore M.

Drug Metab Dispos. 2010 Oct;38(10):1723-30. doi: 10.1124/dmd.110.033480. Epub 2010 Jul 19.

49.

Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid.

Hagey LR, Lida T, Tamegai H, Ogawa S, Une M, Asahina K, Mushiake K, Goto T, Mano N, Goto J, Krasowski MD, Hofmann AF.

Zoolog Sci. 2010 Jul;27(7):565-73. doi: 10.2108/zsj.27.565.

50.

Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites.

Hagey LR, Vidal N, Hofmann AF, Krasowski MD.

BMC Evol Biol. 2010 May 6;10:133. doi: 10.1186/1471-2148-10-133.

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