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Inhibition of motility by NEO100 through the calpain-1/RhoA pathway.

Marín-Ramos NI, Pérez-Hernández M, Tam A, Swenson SD, Cho HY, Thein TZ, Hofman FM, Chen TC.

J Neurosurg. 2019 Aug 16:1-12. doi: 10.3171/2019.5.JNS19798. [Epub ahead of print]


Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models.

Wang W, Swenson S, Cho HY, Hofman FM, Schönthal AH, Chen TC.

J Neurosurg. 2019 Mar 15:1-9. doi: 10.3171/2018.11.JNS181161. [Epub ahead of print]


Distribution of cancer stem cells in two human brain gliomas.

Peng L, Fu J, Wang W, Hofman FM, Chen TC, Chen L.

Oncol Lett. 2019 Feb;17(2):2123-2130. doi: 10.3892/ol.2018.9824. Epub 2018 Dec 12.


NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo.

Swenson S, Silva-Hirschberg C, Wang W, Singh A, Hofman FM, Chen KL, Schönthal AH, Chen TC.

Oncotarget. 2018 Dec 11;9(97):37026-37041. doi: 10.18632/oncotarget.26443. eCollection 2018 Dec 11.


The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway.

Cho HY, Thein TZ, Wang W, Swenson SD, Fayngor RA, Ou M, Marín-Ramos NI, Schönthal AH, Hofman FM, Chen TC.

Mol Cancer Ther. 2019 Mar;18(3):517-530. doi: 10.1158/1535-7163.MCT-18-0465. Epub 2019 Jan 15.


NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma.

Marín-Ramos NI, Jhaveri N, Thein TZ, Fayngor RA, Chen TC, Hofman FM.

Cancer Lett. 2019 Feb 1;442:170-180. doi: 10.1016/j.canlet.2018.10.034. Epub 2018 Oct 28.


Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts.

Bota DA, Chung J, Dandekar M, Carrillo JA, Kong XT, Fu BD, Hsu FP, Schönthal AH, Hofman FM, Chen TC, Zidovetzki R, Pretto C, Strik A, Schijns VE, Stathopoulos A.

CNS Oncol. 2018 Jul 1;7(3):CNS22. doi: 10.2217/cns-2018-0009. Epub 2018 Aug 29.


Therapeutic Immunization against Glioblastoma.

Schijns VEJC, Pretto C, Strik AM, Gloudemans-Rijkers R, Deviller L, Pierre D, Chung J, Dandekar M, Carrillo JA, Kong XT, Fu BD, Hsu FPK, Hofman FM, Chen TC, Zidovetzki R, Bota DA, Stathopoulos A.

Int J Mol Sci. 2018 Aug 27;19(9). pii: E2540. doi: 10.3390/ijms19092540. Review.


NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion.

Marín-Ramos NI, Hofman FM, Chen TC.

Oncoscience. 2018 Jun 27;5(5-6):148-149. doi: 10.18632/oncoscience.429. eCollection 2018 May. No abstract available.


NEO212 Inhibits Migration and Invasion of Glioma Stem Cells.

Marín-Ramos NI, Thein TZ, Cho HY, Swenson SD, Wang W, Schönthal AH, Chen TC, Hofman FM.

Mol Cancer Ther. 2018 Mar;17(3):625-637. doi: 10.1158/1535-7163.MCT-17-0591. Epub 2018 Feb 13.


Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram.

Chen TC, Chan N, Labib S, Yu J, Cho HY, Hofman FM, Schönthal AH.

Int J Mol Sci. 2018 Jan 17;19(1). pii: E277. doi: 10.3390/ijms19010277.


A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells.

Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Schönthal AH.

Cancer Lett. 2017 Aug 1;400:161-174. doi: 10.1016/j.canlet.2017.04.015. Epub 2017 Apr 24.


Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model.

Wang W, Cho HY, Rosenstein-Sisson R, Marín Ramos NI, Price R, Hurth K, Schönthal AH, Hofman FM, Chen TC.

J Neurosurg. 2018 Mar;128(3):695-700. doi: 10.3171/2016.11.JNS161212. Epub 2017 Apr 14.


Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and α6β1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties.

Rosa AI, Grade S, Santos SD, Bernardino L, Chen TC, Relvas J, Hofman FM, Agasse F.

Front Cell Neurosci. 2016 Dec 15;10:284. doi: 10.3389/fncel.2016.00284. eCollection 2016.


Monoamine oxidase A (MAO A) inhibitors decrease glioma progression.

Kushal S, Wang W, Vaikari VP, Kota R, Chen K, Yeh TS, Jhaveri N, Groshen SL, Olenyuk BZ, Chen TC, Hofman FM, Shih JC.

Oncotarget. 2016 Mar 22;7(12):13842-53. doi: 10.18632/oncotarget.7283.


A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells.

Jhaveri N, Agasse F, Armstrong D, Peng L, Commins D, Wang W, Rosenstein-Sisson R, Vaikari VP, Santiago SV, Santos T, Chen L, Schönthal AH, Chen TC, Hofman FM.

Cancer Lett. 2016 Feb 28;371(2):240-50. doi: 10.1016/j.canlet.2015.11.040. Epub 2015 Dec 9.


Nanoparticle biointerfacing by platelet membrane cloaking.

Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L.

Nature. 2015 Oct 1;526(7571):118-21. doi: 10.1038/nature15373. Epub 2015 Sep 16.


Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo.

Chen TC, Cho HY, Wang W, Wetzel SJ, Singh A, Nguyen J, Hofman FM, Schönthal AH.

J Biomed Sci. 2015 Aug 19;22:71. doi: 10.1186/s12929-015-0175-6.


First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity.

Schijns VE, Pretto C, Devillers L, Pierre D, Hofman FM, Chen TC, Mespouille P, Hantos P, Glorieux P, Bota DA, Stathopoulos A.

Vaccine. 2015 May 28;33(23):2690-6. doi: 10.1016/j.vaccine.2015.03.095. Epub 2015 Apr 10.


Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report.

Bota DA, Alexandru-Abrams D, Pretto C, Hofman FM, Chen TC, Fu B, Carrillo JA, Schijns VE, Stathopoulos A.

Perm J. 2015 Spring;19(2):41-6. doi: 10.7812/TPP/14-042. Epub 2015 Mar 1.


Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals.

Wang W, Sivakumar W, Torres S, Jhaveri N, Vaikari VP, Gong A, Howard A, Golden EB, Louie SG, Schönthal AH, Hofman FM, Chen TC.

Neurosurg Focus. 2015 Mar;38(3):E8. doi: 10.3171/2015.1.FOCUS14743.


Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors.

Golden EB, Cho HY, Hofman FM, Louie SG, Schönthal AH, Chen TC.

Neurosurg Focus. 2015 Mar;38(3):E12. doi: 10.3171/2014.12.FOCUS14748.


Tumor vasculature and glioma stem cells: Contributions to glioma progression.

Jhaveri N, Chen TC, Hofman FM.

Cancer Lett. 2016 Oct 1;380(2):545-51. doi: 10.1016/j.canlet.2014.12.028. Epub 2014 Dec 16. Review.


A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.

Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman FM, Schönthal AH.

Cancer Lett. 2015 Mar 28;358(2):144-151. doi: 10.1016/j.canlet.2014.12.021. Epub 2014 Dec 15.


Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy.

Golden EB, Cho HY, Jahanian A, Hofman FM, Louie SG, Schönthal AH, Chen TC.

Neurosurg Focus. 2014 Dec;37(6):E12. doi: 10.3171/2014.9.FOCUS14504.


Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model.

Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM.

Hum Gene Ther. 2015 Feb;26(2):82-93. doi: 10.1089/hum.2014.100. Epub 2015 Jan 19.


Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas.

Santos T, Fang X, Chen MT, Wang W, Ferreira R, Jhaveri N, Gundersen M, Zhou C, Pagnini P, Hofman FM, Chen TC.

Front Oncol. 2014 Jul 15;4:180. doi: 10.3389/fonc.2014.00180. eCollection 2014.


NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas.

Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman FM, Chen TC.

Mol Cancer Ther. 2014 Aug;13(8):2004-17. doi: 10.1158/1535-7163.MCT-13-0964. Epub 2014 Jul 3.


Argonaute-2 promotes miR-18a entry in human brain endothelial cells.

Ferreira R, Santos T, Amar A, Gong A, Chen TC, Tahara SM, Giannotta SL, Hofman FM.

J Am Heart Assoc. 2014 May 16;3(3):e000968. doi: 10.1161/JAHA.114.000968.


A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo.

Chen TC, Cho HY, Wang W, Barath M, Sharma N, Hofman FM, Schönthal AH.

Mol Cancer Ther. 2014 May;13(5):1181-93. doi: 10.1158/1535-7163.MCT-13-0882. Epub 2014 Mar 12.



Hofman FM, Taylor CR.

Curr Protoc Immunol. 2013 Nov 18;103:Unit 21.4.. doi: 10.1002/0471142735.im2104s103.


MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function.

Ferreira R, Santos T, Amar A, Tahara SM, Chen TC, Giannotta SL, Hofman FM.

Stroke. 2014 Jan;45(1):293-7. doi: 10.1161/STROKEAHA.113.003578. Epub 2013 Nov 7.


Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.

Thomas S, Sharma N, Gonzalez R, Pao PW, Hofman FM, Chen TC, Louie SG, Pirrung MC, Schönthal AH.

PLoS One. 2013 Jun 6;8(6):e65695. doi: 10.1371/journal.pone.0065695. Print 2013.


Perillyl alcohol for the treatment of temozolomide-resistant gliomas.

Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis NA, Louie SG, Schönthal AH, Hofman FM, Chen TC.

Mol Cancer Ther. 2012 Nov;11(11):2462-72. doi: 10.1158/1535-7163.MCT-12-0321. Epub 2012 Aug 28.


Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent.

Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, Schönthal AH, Louie SG.

Cancer Lett. 2012 Dec 30;326(2):143-54. doi: 10.1016/j.canlet.2012.07.029. Epub 2012 Aug 1.


Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation.

Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Kruse C, Jadus M, Chen TC, Schijns VE.

Oncoimmunology. 2012 May 1;1(3):298-305.


Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.

Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman FM, Louie SG, Schönthal AH.

Cancer Lett. 2012 Dec 1;325(1):63-71. doi: 10.1016/j.canlet.2012.05.030. Epub 2012 Jun 1.


Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators.

Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE.

J Clin Cell Immunol. 2012;Suppl 5:004.


Noscapine inhibits tumor growth in TMZ-resistant gliomas.

Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, Louie SG, Hofman FM, Chen TC.

Cancer Lett. 2011 Dec 22;312(2):245-52. doi: 10.1016/j.canlet.2011.08.015. Epub 2011 Aug 28.


Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response.

Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA.

Curr Pharm Des. 2011;17(23):2428-38. Review.


A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis.

Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, Jhaveri N, Zhu G, Ye R, Liu Z, Bruhn KW, Craft N, Groshen S, Hofman FM, Lee AS.

Cancer Res. 2011 Apr 15;71(8):2848-57. doi: 10.1158/0008-5472.CAN-10-3151. Epub 2011 Apr 5.


Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells.

Stapleton CJ, Armstrong DL, Zidovetzki R, Liu CY, Giannotta SL, Hofman FM.

Neurosurgery. 2011 May;68(5):1342-53; discussion 1353. doi: 10.1227/NEU.0b013e31820c0a68.


Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models.

Chen TC, Wang W, Golden EB, Thomas S, Sivakumar W, Hofman FM, Louie SG, Schönthal AH.

Cancer Lett. 2011 Mar 28;302(2):100-8. doi: 10.1016/j.canlet.2010.11.008. Epub 2011 Jan 22.


Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells.

Hofman FM, Stathopoulos A, Kruse CA, Chen TC, Schijns VE.

Anticancer Agents Med Chem. 2010 Jul;10(6):462-70. Review.


Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo. Laboratory investigation.

Wang W, Ghandi A, Liebes L, Louie SG, Hofman FM, Schönthal AH, Chen TC.

J Neurosurg. 2011 Mar;114(3):689-94. doi: 10.3171/2010.2.JNS09719. Epub 2010 Apr 23.


Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature.

Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schönthal AH, Chen TC, Hofman FM.

Mol Cancer Ther. 2010 Mar;9(3):631-41. doi: 10.1158/1535-7163.MCT-09-0652. Epub 2010 Mar 2.


Glioma-associated endothelial cells are chemoresistant to temozolomide.

Virrey JJ, Golden EB, Sivakumar W, Wang W, Pen L, Schönthal AH, Hofman FM, Chen TC.

J Neurooncol. 2009 Oct;95(1):13-22. doi: 10.1007/s11060-009-9891-7. Epub 2009 Apr 18.


Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress.

Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH.

Cancer Lett. 2009 Sep 8;282(1):87-97. doi: 10.1016/j.canlet.2009.03.007. Epub 2009 Apr 3.


Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.

Zandian M, Belisle R, Mott KR, Nusinowitz S, Hofman FM, Ghiasi H.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3275-82. doi: 10.1167/iovs.08-3211. Epub 2009 Feb 21.

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