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Items: 1 to 50 of 94

1.

Diketopiperazine Formation in Fungi requires Dedicated Cyclization and Thiolation Domains.

Schroeder FC, Baccile J, Le H, Pfannenstiel B, Bok JW, Gomez C, Brandenburger E, Hoffmeister D, Keller N.

Angew Chem Int Ed Engl. 2019 Jul 24. doi: 10.1002/anie.201909052. [Epub ahead of print]

PMID:
31342608
2.

Enzymatic route toward 6-methylated baeocystin and psilocybin.

Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D.

Chembiochem. 2019 May 31. doi: 10.1002/cbic.201900358. [Epub ahead of print]

PMID:
31150155
3.

Melleolides impact fungal translation via elongation factor 2.

Dörfer M, Heine D, König S, Gore S, Werz O, Hertweck C, Gressler M, Hoffmeister D.

Org Biomol Chem. 2019 May 15;17(19):4906-4916. doi: 10.1039/c9ob00562e.

PMID:
31042251
4.

Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.

König S, Romp E, Krauth V, Rühl M, Dörfer M, Liening S, Hofmann B, Häfner AK, Steinhilber D, Karas M, Garscha U, Hoffmeister D, Werz O.

Cell Chem Biol. 2019 Jan 17;26(1):60-70.e4. doi: 10.1016/j.chembiol.2018.10.010. Epub 2018 Nov 8.

PMID:
30415966
5.

Iterative l-Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication.

Blei F, Fricke J, Wick J, Slot JC, Hoffmeister D.

Chembiochem. 2018 Oct 18;19(20):2160-2166. doi: 10.1002/cbic.201800336. Epub 2018 Oct 2.

PMID:
30098085
6.

A genomics perspective on natural product biosynthesis in plant pathogenic bacteria.

Baldeweg F, Hoffmeister D, Nett M.

Nat Prod Rep. 2019 Feb 20;36(2):307-325. doi: 10.1039/c8np00025e. Review.

PMID:
30063232
7.

Production Options for Psilocybin: Making of the Magic.

Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D.

Chemistry. 2019 Jan 18;25(4):897-903. doi: 10.1002/chem.201802758. Epub 2018 Nov 15.

PMID:
30011099
8.

Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi.

Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V.

Metab Eng. 2018 Jul;48:44-51. doi: 10.1016/j.ymben.2018.05.014. Epub 2018 May 26.

9.

Biocatalytic Production of Psilocybin and Derivatives in Tryptophan Synthase-Enhanced Reactions.

Blei F, Baldeweg F, Fricke J, Hoffmeister D.

Chemistry. 2018 May 11. doi: 10.1002/chem.201801047. [Epub ahead of print]

PMID:
29750381
10.

Analysis of basidiomycete pigments in situ by Raman spectroscopy.

Tauber JP, Matthäus C, Lenz C, Hoffmeister D, Popp J.

J Biophotonics. 2018 Jun;11(6):e201700369. doi: 10.1002/jbio.201700369. Epub 2018 Mar 12.

PMID:
29411940
11.

Dissimilar pigment regulation in Serpula lacrymans and Paxillus involutus during inter-kingdom interactions.

Tauber JP, Gallegos-Monterrosa R, Kovács ÁT, Shelest E, Hoffmeister D.

Microbiology. 2018 Jan;164(1):65-77. doi: 10.1099/mic.0.000582. Epub 2017 Dec 5.

PMID:
29205129
12.

Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product.

Lenz C, Wick J, Hoffmeister D.

J Nat Prod. 2017 Oct 27;80(10):2835-2838. doi: 10.1021/acs.jnatprod.7b00407. Epub 2017 Sep 20.

PMID:
28929753
13.

Structure of Ralsolamycin, the Interkingdom Morphogen from the Crop Plant Pathogen Ralstonia solanacearum.

Baldeweg F, Kage H, Schieferdecker S, Allen C, Hoffmeister D, Nett M.

Org Lett. 2017 Sep 15;19(18):4868-4871. doi: 10.1021/acs.orglett.7b02329. Epub 2017 Aug 28.

PMID:
28846435
14.

A Highly Conserved Basidiomycete Peptide Synthetase Produces a Trimeric Hydroxamate Siderophore.

Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D.

Appl Environ Microbiol. 2017 Oct 17;83(21). pii: e01478-17. doi: 10.1128/AEM.01478-17. Print 2017 Nov 1.

15.

Enzymatic Synthesis of Psilocybin.

Fricke J, Blei F, Hoffmeister D.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12352-12355. doi: 10.1002/anie.201705489. Epub 2017 Aug 25.

PMID:
28763571
16.

Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase.

Brandt P, García-Altares M, Nett M, Hertweck C, Hoffmeister D.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5937-5941. doi: 10.1002/anie.201700767. Epub 2017 Apr 25.

PMID:
28440038
17.

A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis.

Braga D, Hoffmeister D, Nett M.

Beilstein J Org Chem. 2016 Dec 16;12:2766-2770. doi: 10.3762/bjoc.12.274. eCollection 2016.

18.

Fungal variegatic acid and extracellular polysaccharides promote the site-specific generation of reactive oxygen species.

Zhu Y, Mahaney J, Jellison J, Cao J, Gressler J, Hoffmeister D, Goodell B.

J Ind Microbiol Biotechnol. 2017 Mar;44(3):329-338. doi: 10.1007/s10295-016-1889-5. Epub 2016 Dec 29.

PMID:
28032229
19.

Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles.

Schlegel M, Münsterkötter M, Güldener U, Bruggmann R, Duò A, Hainaut M, Henrissat B, Sieber CM, Hoffmeister D, Grünig CR.

BMC Genomics. 2016 Dec 9;17(1):1015.

20.

Biochemical and genetic basis of orsellinic acid biosynthesis and prenylation in a stereaceous basidiomycete.

Braesel J, Fricke J, Schwenk D, Hoffmeister D.

Fungal Genet Biol. 2017 Jan;98:12-19. doi: 10.1016/j.fgb.2016.11.007. Epub 2016 Nov 27.

PMID:
27903443
21.

Bacteria induce pigment formation in the basidiomycete Serpula lacrymans.

Tauber JP, Schroeckh V, Shelest E, Brakhage AA, Hoffmeister D.

Environ Microbiol. 2016 Dec;18(12):5218-5227. doi: 10.1111/1462-2920.13558. Epub 2016 Oct 24.

PMID:
27699944
22.

Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases.

Brandenburger E, Braga D, Kombrink A, Lackner G, Gressler J, Künzler M, Hoffmeister D.

Fungal Genet Biol. 2018 Mar;112:55-63. doi: 10.1016/j.fgb.2016.07.008. Epub 2016 Jul 22.

PMID:
27457378
23.

An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides.

Kalb D, Heinekamp T, Schieferdecker S, Nett M, Brakhage AA, Hoffmeister D.

Chembiochem. 2016 Oct 4;17(19):1813-1817. doi: 10.1002/cbic.201600293. Epub 2016 Aug 18.

PMID:
27442960
24.

Unexpected Metabolic Versatility in a Combined Fungal Fomannoxin/Vibralactone Biosynthesis.

Schwenk D, Brandt P, Blanchette RA, Nett M, Hoffmeister D.

J Nat Prod. 2016 May 27;79(5):1407-14. doi: 10.1021/acs.jnatprod.6b00147. Epub 2016 Apr 22.

PMID:
27104866
25.

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus.

Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC.

Nat Chem Biol. 2016 Jun;12(6):419-24. doi: 10.1038/nchembio.2061. Epub 2016 Apr 11.

26.

A Fivefold Parallelized Biosynthetic Process Secures Chlorination of Armillaria mellea (Honey Mushroom) Toxins.

Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D.

Appl Environ Microbiol. 2015 Dec 11;82(4):1196-1204. doi: 10.1128/AEM.03168-15. Print 2016 Feb 15.

27.

Active-Site Engineering Expands the Substrate Profile of the Basidiomycete L-Tryptophan Decarboxylase CsTDC.

Kalb D, Gressler J, Hoffmeister D.

Chembiochem. 2016 Jan;17(2):132-6. doi: 10.1002/cbic.201500438. Epub 2015 Dec 3.

PMID:
26632772
28.

Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors.

Shah F, Nicolás C, Bentzer J, Ellström M, Smits M, Rineau F, Canbäck B, Floudas D, Carleer R, Lackner G, Braesel J, Hoffmeister D, Henrissat B, Ahrén D, Johansson T, Hibbett DS, Martin F, Persson P, Tunlid A.

New Phytol. 2016 Mar;209(4):1705-19. doi: 10.1111/nph.13722. Epub 2015 Nov 3.

29.

Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus.

Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D.

Chem Biol. 2015 Oct 22;22(10):1325-34. doi: 10.1016/j.chembiol.2015.08.016.

30.

Involutin is an Fe3+ reductant secreted by the ectomycorrhizal fungus Paxillus involutus during Fenton-based decomposition of organic matter.

Shah F, Schwenk D, Nicolás C, Persson P, Hoffmeister D, Tunlid A.

Appl Environ Microbiol. 2015 Dec;81(24):8427-33. doi: 10.1128/AEM.02312-15. Epub 2015 Oct 2.

31.

Activity of α-Aminoadipate Reductase Depends on the N-Terminally Extending Domain.

Kalb D, Lackner G, Rappe M, Hoffmeister D.

Chembiochem. 2015 Jul 6;16(10):1426-30. doi: 10.1002/cbic.201500190. Epub 2015 Jun 11.

PMID:
25965424
32.

Fungal natural products-the mushroom perspective.

Stadler M, Hoffmeister D.

Front Microbiol. 2015 Feb 18;6:127. doi: 10.3389/fmicb.2015.00127. eCollection 2015. No abstract available.

33.

Insights on the evolution of mycoparasitism from the genome of Clonostachys rosea.

Karlsson M, Durling MB, Choi J, Kosawang C, Lackner G, Tzelepis GD, Nygren K, Dubey MK, Kamou N, Levasseur A, Zapparata A, Wang J, Amby DB, Jensen B, Sarrocco S, Panteris E, Lagopodi AL, Pöggeler S, Vannacci G, Collinge DB, Hoffmeister D, Henrissat B, Lee YH, Jensen DF.

Genome Biol Evol. 2015 Jan 8;7(2):465-80. doi: 10.1093/gbe/evu292.

34.

Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus.

Kalb D, Heinekamp T, Lackner G, Scharf DH, Dahse HM, Brakhage AA, Hoffmeister D.

Appl Environ Microbiol. 2015 Mar;81(5):1594-600. doi: 10.1128/AEM.03268-14. Epub 2014 Dec 19.

35.

Analysis of the Phlebiopsis gigantea genome, transcriptome and secretome provides insight into its pioneer colonization strategies of wood.

Hori C, Ishida T, Igarashi K, Samejima M, Suzuki H, Master E, Ferreira P, Ruiz-Dueñas FJ, Held B, Canessa P, Larrondo LF, Schmoll M, Druzhinina IS, Kubicek CP, Gaskell JA, Kersten P, St John F, Glasner J, Sabat G, Splinter BonDurant S, Syed K, Yadav J, Mgbeahuruike AC, Kovalchuk A, Asiegbu FO, Lackner G, Hoffmeister D, Rencoret J, Gutiérrez A, Sun H, Lindquist E, Barry K, Riley R, Grigoriev IV, Henrissat B, Kües U, Berka RM, Martínez AT, Covert SF, Blanchette RA, Cullen D.

PLoS Genet. 2014 Dec 4;10(12):e1004759. doi: 10.1371/journal.pgen.1004759. eCollection 2014 Dec.

36.

Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete.

Schwenk D, Nett M, Dahse HM, Horn U, Blanchette RA, Hoffmeister D.

J Nat Prod. 2014 Dec 26;77(12):2658-63. doi: 10.1021/np500552a. Epub 2014 Nov 24.

PMID:
25420175
37.

Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion.

Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C.

Angew Chem Int Ed Engl. 2014 Dec 1;53(49):13409-13. doi: 10.1002/anie.201407624. Epub 2014 Oct 10.

PMID:
25302411
38.

Comments on the distribution and phylogeny of type I polyketide synthases and nonribosomal peptide synthetases in eukaryotes.

Sasso S, Shelest E, Hoffmeister D.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3946. doi: 10.1073/pnas.1412766111. Epub 2014 Sep 2. No abstract available.

39.

Functional and phylogenetic divergence of fungal adenylate-forming reductases.

Kalb D, Lackner G, Hoffmeister D.

Appl Environ Microbiol. 2014 Oct;80(19):6175-83. doi: 10.1128/AEM.01767-14. Epub 2014 Aug 1.

40.

Ralfuranone Is Produced by an Alternative Aryl-Substituted γ-Lactone Biosynthetic Route in Ralstonia solanacearum.

Pauly J, Nett M, Hoffmeister D.

J Nat Prod. 2014 Aug 22;77(8):1967-71. doi: 10.1021/np500263r.

PMID:
25033087
41.

Melleolides induce rapid cell death in human primary monocytes and cancer cells.

Bohnert M, Scherer O, Wiechmann K, König S, Dahse HM, Hoffmeister D, Werz O.

Bioorg Med Chem. 2014 Aug 1;22(15):3856-61. doi: 10.1016/j.bmc.2014.06.032. Epub 2014 Jun 25.

PMID:
25028062
42.

Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships.

Bohnert M, Nützmann HW, Schroeckh V, Horn F, Dahse HM, Brakhage AA, Hoffmeister D.

Phytochemistry. 2014 Sep;105:101-8. doi: 10.1016/j.phytochem.2014.05.009. Epub 2014 Jun 3.

PMID:
24906293
43.

Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae.

Kreutzer MF, Kage H, Herrmann J, Pauly J, Hermenau R, Müller R, Hoffmeister D, Nett M.

Org Biomol Chem. 2014 Jan 7;12(1):113-8. doi: 10.1039/c3ob41839a. Epub 2013 Nov 8.

PMID:
24202877
44.

Ralfuranone thioether production by the plant pathogen Ralstonia solanacearum.

Pauly J, Spiteller D, Linz J, Jacobs J, Allen C, Nett M, Hoffmeister D.

Chembiochem. 2013 Nov 4;14(16):2169-78. doi: 10.1002/cbic.201300364. Epub 2013 Sep 17.

PMID:
24106142
45.

Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity.

Lackner G, Bohnert M, Wick J, Hoffmeister D.

Chem Biol. 2013 Sep 19;20(9):1101-6. doi: 10.1016/j.chembiol.2013.07.009. Epub 2013 Aug 29.

46.

Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus.

Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D.

Appl Environ Microbiol. 2013 Nov;79(21):6670-6. doi: 10.1128/AEM.02642-13. Epub 2013 Aug 23.

47.

An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin.

Kage H, Kreutzer MF, Wackler B, Hoffmeister D, Nett M.

Chem Biol. 2013 Jun 20;20(6):764-71. doi: 10.1016/j.chembiol.2013.04.010.

48.

A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans.

Elliott CE, Callahan DL, Schwenk D, Nett M, Hoffmeister D, Howlett BJ.

Fungal Genet Biol. 2013 Apr;53:50-8. doi: 10.1016/j.fgb.2013.01.008. Epub 2013 Feb 7.

PMID:
23396262
49.

Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus.

Forseth RR, Amaike S, Schwenk D, Affeldt KJ, Hoffmeister D, Schroeder FC, Keller NP.

Angew Chem Int Ed Engl. 2013 Jan 28;52(5):1590-4. doi: 10.1002/anie.201207456. Epub 2012 Dec 20. No abstract available.

50.

Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases.

Lackner G, Misiek M, Braesel J, Hoffmeister D.

Fungal Genet Biol. 2012 Dec;49(12):996-1003. doi: 10.1016/j.fgb.2012.09.009. Epub 2012 Oct 16.

PMID:
23078836

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