Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 13

1.

In vitro methods to support transporter evaluation in drug discovery and development.

Brouwer KL, Keppler D, Hoffmaster KA, Bow DA, Cheng Y, Lai Y, Palm JE, Stieger B, Evers R; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):95-112. doi: 10.1038/clpt.2013.81. Epub 2013 Apr 10. Review. Erratum in: Clin Pharmacol Ther. 2013 Sep;94(3):412.

2.

Highlights from the International Transporter Consortium second workshop.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM.

Clin Pharmacol Ther. 2012 Nov;92(5):553-6. doi: 10.1038/clpt.2012.126.

PMID:
23085880
3.

Membrane transporters in drug development.

International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L.

Nat Rev Drug Discov. 2010 Mar;9(3):215-36. doi: 10.1038/nrd3028. Review.

4.

Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.

Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Brouwer KL.

Drug Metab Dispos. 2008 Nov;36(11):2156-8. doi: 10.1124/dmd.108.022053. Epub 2008 Aug 21.

5.

Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.

Zamek-Gliszczynski MJ, Hoffmaster KA, Humphreys JE, Tian X, Nezasa K, Brouwer KL.

J Pharmacol Exp Ther. 2006 Oct;319(1):459-67. Epub 2006 Jul 20.

PMID:
16857726
6.

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.

Turncliff RZ, Hoffmaster KA, Kalvass JC, Pollack GM, Brouwer KL.

J Pharmacol Exp Ther. 2006 Aug;318(2):881-9. Epub 2006 May 11.

PMID:
16690724
7.

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.

Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL.

Eur J Pharm Sci. 2006 Apr;27(5):447-86. Epub 2006 Feb 10. Review.

PMID:
16472997
8.

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, Zhao R, Polli JW, Humphreys JE, Webster LO, Bridges AS, Kalvass JC, Brouwer KL.

Drug Metab Dispos. 2005 Aug;33(8):1158-65. Epub 2005 Apr 28.

PMID:
15860656
9.

Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin.

Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL.

Drug Metab Dispos. 2005 Feb;33(2):287-93. Epub 2004 Nov 4.

PMID:
15528320
10.

Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.

Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL.

J Pharmacol Exp Ther. 2004 Dec;311(3):1203-10. Epub 2004 Aug 9.

PMID:
15302892
11.
12.

Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin.

Paine MF, Wagner DA, Hoffmaster KA, Watkins PB.

Clin Pharmacol Ther. 2002 Nov;72(5):524-35.

13.

Bioavailability, multiple-dose pharmacokinetics, and biotransformation of the aldose reductase inhibitor zopolrestat in dogs.

Schneider RP, Davenport CJ, Hoffmaster KA, Inskeep PB.

Drug Metab Dispos. 1998 Nov;26(11):1160-6.

PMID:
9806960

Supplemental Content

Loading ...
Support Center