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Items: 1 to 50 of 83

1.

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T, Ranatunga DK, Medina MW, Schaefer C, Krauss RM, Iribarren C, Risch N, Hoffmann TJ.

NPJ Genom Med. 2020 Jan 16;5:1. doi: 10.1038/s41525-019-0109-4. eCollection 2020.

2.

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-Amero KK, Anderson MG, Akafo S, Alhassan MB, Asimadu I, Ayyagari R, Bakayoko S, Nyamsi PB, Bowden DW, Bromley WC, Budenz DL, Carmichael TR, Challa P, Chen YI, Chuka-Okosa CM, Cooke Bailey JN, Costa VP, Cruz DA, DuBiner H, Ervin JF, Feldman RM, Flamme-Wiese M, Gaasterland DE, Garnai SJ, Girkin CA, Guirou N, Guo X, Haines JL, Hammond CJ, Herndon L, Hoffmann TJ, Hulette CM, Hydara A, Igo RP Jr, Jorgenson E, Kabwe J, Kilangalanga NJ, Kizor-Akaraiwe N, Kuchtey RW, Lamari H, Li Z, Liebmann JM, Liu Y, Loos RJF, Melo MB, Moroi SE, Msosa JM, Mullins RF, Nadkarni G, Napo A, Ng MCY, Nunes HF, Obeng-Nyarkoh E, Okeke A, Okeke S, Olaniyi O, Olawoye O, Oliveira MB, Pasquale LR, Perez-Grossmann RA, Pericak-Vance MA, Qin X, Ramsay M, Resnikoff S, Richards JE, Schimiti RB, Sim KS, Sponsel WE, Svidnicki PV, Thiadens AAHJ, Uche NJ, van Duijn CM, de Vasconcellos JPC, Wiggs JL, Zangwill LM, Risch N, Milea D, Ashaye A, Klaver CCW, Weinreb RN, Ashley Koch AE, Fingert JH, Khor CC.

JAMA. 2019 Nov 5;322(17):1682-1691. doi: 10.1001/jama.2019.16161.

PMID:
31688885
3.

Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.

Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS.

Nat Commun. 2019 Aug 28;10(1):3948. doi: 10.1038/s41467-019-11810-9.

4.

Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts.

Abuabara K, You Y, Margolis DJ, Hoffmann TJ, Risch N, Jorgenson E.

J Allergy Clin Immunol. 2020 Jan;145(1):192-198.e11. doi: 10.1016/j.jaci.2019.06.044. Epub 2019 Jul 29.

PMID:
31369801
5.

Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.

Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS.

Nat Commun. 2019 Jul 15;10(1):3107. doi: 10.1038/s41467-019-10808-7. Erratum in: Nat Commun. 2019 Aug 28;10(1):3948.

6.

Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.

Ley B, Torgerson DG, Oldham JM, Adegunsoye A, Liu S, Li J, Elicker BM, Henry TS, Golden JA, Jones KD, Dressen A, Yaspan BL, Arron JR, Noth I, Hoffmann TJ, Wolters PJ.

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1154-1163. doi: 10.1164/rccm.201902-0360OC.

PMID:
31268371
7.

A genome-wide association study of prostate cancer in Latinos.

Du Z, Hopp H, Ingles SA, Huff C, Sheng X, Weaver B, Stern M, Hoffmann TJ, John EM, Van Den Eeden SK, Strom S, Leach RJ, Thompson IM Jr, Witte JS, Conti DV, Haiman CA.

Int J Cancer. 2020 Apr 1;146(7):1819-1826. doi: 10.1002/ijc.32525. Epub 2019 Jul 3.

8.

Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction.

Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3349-3350. doi: 10.1073/pnas.1900162116. Epub 2019 Feb 12. No abstract available.

9.

Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.

Oni-Orisan A, Hoffmann TJ, Ranatunga D, Medina MW, Jorgenson E, Schaefer C, Krauss RM, Iribarren C, Risch N.

Circ Genom Precis Med. 2018 Sep;11(9):e002043. doi: 10.1161/CIRCGEN.117.002043.

10.

Genetic variation in the SIM1 locus is associated with erectile dysfunction.

Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11018-11023. doi: 10.1073/pnas.1809872115. Epub 2018 Oct 8.

11.

A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

Hoffmann TJ, Choquet H, Yin J, Banda Y, Kvale MN, Glymour M, Schaefer C, Risch N, Jorgenson E.

Genetics. 2018 Oct;210(2):499-515. doi: 10.1534/genetics.118.301479. Epub 2018 Aug 14.

12.

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E.

Nat Commun. 2018 Jun 11;9(1):2278. doi: 10.1038/s41467-018-04555-4.

13.

A large electronic-health-record-based genome-wide study of serum lipids.

Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N.

Nat Genet. 2018 Mar;50(3):401-413. doi: 10.1038/s41588-018-0064-5. Epub 2018 Mar 5.

14.

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.

Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E.

Nat Commun. 2017 Dec 13;8(1):2108. doi: 10.1038/s41467-017-01913-6.

15.

Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics.

Wu YH, Graff RE, Passarelli MN, Hoffman JD, Ziv E, Hoffmann TJ, Witte JS.

Cancer Epidemiol Biomarkers Prev. 2018 Jan;27(1):75-85. doi: 10.1158/1055-9965.EPI-17-0516. Epub 2017 Nov 17.

16.

Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children.

Wade M, Prime H, Hoffmann TJ, Schmidt LA, O'Connor TG, Jenkins JM.

Dev Psychopathol. 2018 Feb;30(1):203-211. doi: 10.1017/S0954579417000578. Epub 2017 May 17.

PMID:
28511728
17.

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.

Jorgenson E, Thai KK, Hoffmann TJ, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Mertens J, Weisner C, Choquet H.

Mol Psychiatry. 2017 Sep;22(9):1359-1367. doi: 10.1038/mp.2017.101. Epub 2017 May 9.

18.

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock SJ, Mosley JD, Klein RJ, Middha M, Lilja H, Melander O, Kvale MN, Kwok PY, Schaefer C, Risch N, Van Den Eeden SK, Witte JS.

Nat Commun. 2017 Jan 31;8:14248. doi: 10.1038/ncomms14248.

19.

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

Hoffmann TJ, Ehret GB, Nandakumar P, Ranatunga D, Schaefer C, Kwok PY, Iribarren C, Chakravarti A, Risch N.

Nat Genet. 2017 Jan;49(1):54-64. doi: 10.1038/ng.3715. Epub 2016 Nov 14.

20.

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.

Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR.

PLoS Genet. 2016 Oct 20;12(10):e1006371. doi: 10.1371/journal.pgen.1006371. eCollection 2016 Oct.

21.

Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation.

Roberts JD, Dewland TA, Glidden DV, Hoffmann TJ, Arking DE, Chen LY, Psaty BM, Olgin JE, Alonso A, Heckbert SR, Marcus GM.

Am Heart J. 2016 May;175:9-17. doi: 10.1016/j.ahj.2016.02.002. Epub 2016 Feb 13.

22.

Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach.

Wade M, Hoffmann TJ, Knafo-Noam A, O'Connor TG, Jenkins JM.

Horm Behav. 2016 Jun;82:78-86. doi: 10.1016/j.yhbeh.2016.05.002. Epub 2016 May 4.

PMID:
27155104
23.

Genome-Wide Estimates of Heritability for Social Demographic Outcomes.

Domingue BW, Wedow R, Conley D, McQueen M, Hoffmann TJ, Boardman JD.

Biodemography Soc Biol. 2016;62(1):1-18. doi: 10.1080/19485565.2015.1068106.

24.

Mutational Landscape of Aggressive Prostate Tumors in African American Men.

Lindquist KJ, Paris PL, Hoffmann TJ, Cardin NJ, Kazma R, Mefford JA, Simko JP, Ngo V, Chen Y, Levin AM, Chitale D, Helfand BT, Catalona WJ, Rybicki BA, Witte JS.

Cancer Res. 2016 Apr 1;76(7):1860-8. doi: 10.1158/0008-5472.CAN-15-1787. Epub 2016 Feb 26.

25.

Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration.

Jorgenson E, Melles RB, Hoffmann TJ, Jia X, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Shen L.

Eur J Hum Genet. 2016 Jul;24(7):1049-55. doi: 10.1038/ejhg.2015.247. Epub 2016 Jan 6.

26.

Strategies for Imputing and Analyzing Rare Variants in Association Studies.

Hoffmann TJ, Witte JS.

Trends Genet. 2015 Oct;31(10):556-563. doi: 10.1016/j.tig.2015.07.006. Review.

27.

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.

Shen L, Hoffmann TJ, Melles RB, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Jorgenson E.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4290-9. doi: 10.1167/iovs.15-16533.

28.

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, Lu Y, Ludwig D, Mathauda GK, McGuire WB, Mei G, Miles S, Mittman M, Patil M, Quesenberry CP Jr, Ranatunga D, Rowell S, Sadler M, Sakoda LC, Shapero M, Shen L, Shenoy T, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Wan E, Webster T, Whitmer RA, Wong S, Zau C, Zhan Y, Schaefer C, Kwok PY, Risch N.

Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. Epub 2015 Jun 19.

29.

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH.

Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. Epub 2015 Jun 19.

30.

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Sciortino S, Shen L, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Schaefer C, Risch N.

Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19.

31.

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, Berndt SI, Chanock SJ, McDonnell SK, French AJ, Schaid DJ, Thibodeau SN, Li Q, Freedman ML, Penney KL, Mucci LA, Haiman CA, Henderson BE, Seminara D, Kvale MN, Kwok PY, Schaefer C, Risch N, Witte JS.

Cancer Discov. 2015 Aug;5(8):878-91. doi: 10.1158/2159-8290.CD-15-0315. Epub 2015 Jun 1.

32.

Detecting gene-environment interactions in human birth defects: Study designs and statistical methods.

Tai CG, Graff RE, Liu J, Passarelli MN, Mefford JA, Shaw GM, Hoffmann TJ, Witte JS.

Birth Defects Res A Clin Mol Teratol. 2015 Aug;103(8):692-702. doi: 10.1002/bdra.23382. Epub 2015 May 23.

33.

Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind.

Wade M, Hoffmann TJ, Jenkins JM.

Soc Cogn Affect Neurosci. 2015 Dec;10(12):1749-57. doi: 10.1093/scan/nsv064. Epub 2015 May 14.

34.

Replication and heritability of prostate cancer risk variants: impact of population-specific factors.

Virlogeux V, Graff RE, Hoffmann TJ, Witte JS.

Cancer Epidemiol Biomarkers Prev. 2015 Jun;24(6):938-43. doi: 10.1158/1055-9965.EPI-14-1372. Epub 2015 Mar 25.

35.

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM.

Clin Pharmacol Ther. 2015 May;97(5):518-25. doi: 10.1002/cpt.89. Epub 2015 Apr 6.

36.

Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.

Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP Jr, Schaefer C, Van Den Eeden SK, Risch N, Witte JS.

PLoS Genet. 2015 Jan 28;11(1):e1004930. doi: 10.1371/journal.pgen.1004930. eCollection 2015 Jan. Erratum in: PLoS Genet. 2015 Apr;11(4):e1005114. PLoS Genet. 2015 Jun;11(6):e1005362.

37.

Genome-wide discovery of drug-dependent human liver regulatory elements.

Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N.

PLoS Genet. 2014 Oct 2;10(10):e1004648. doi: 10.1371/journal.pgen.1004648. eCollection 2014 Oct.

38.

Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.

Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, Thomas F, Risch N.

Hum Mol Genet. 2014 Dec 15;23(24):6634-43. doi: 10.1093/hmg/ddu364. Epub 2014 Jul 15.

39.

Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers' executive functioning.

Wade M, Hoffmann TJ, Jenkins JM.

Brain Cogn. 2014 Oct;90:116-23. doi: 10.1016/j.bandc.2014.06.002. Epub 2014 Jul 11.

PMID:
25016245
40.

Copy number variation in bronchopulmonary dysplasia.

Hoffmann TJ, Shaw GM, Stevenson DK, Wang H, Quaintance CC, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Witte JS, O'Brodovich HM.

Am J Med Genet A. 2014 Oct;164A(10):2672-5. doi: 10.1002/ajmg.a.36659. Epub 2014 Jun 26. No abstract available.

41.

Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions.

Risch N, Hoffmann TJ, Anderson M, Croen LA, Grether JK, Windham GC.

Am J Psychiatry. 2014 Nov 1;171(11):1206-13. doi: 10.1176/appi.ajp.2014.13101359.

PMID:
24969362
42.

Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study.

Hoffmann TJ, Windham GC, Anderson M, Croen LA, Grether JK, Risch N.

JAMA Psychiatry. 2014 Aug;71(8):943-51. doi: 10.1001/jamapsychiatry.2014.420.

PMID:
24942798
43.

Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months.

Wade M, Hoffmann TJ, Wigg K, Jenkins JM.

Genes Brain Behav. 2014 Sep;13(7):603-10. doi: 10.1111/gbb.12148. Epub 2014 Jul 23.

44.

Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk.

Jenkins MM, Reefhuis J, Gallagher ML, Mulle JG, Hoffmann TJ, Koontz DA, Sturchio C, Rasmussen SA, Witte JS, Richter P, Honein MA; National Birth Defects Prevention Study.

Am J Med Genet A. 2014 Jun;164A(6):1454-63. doi: 10.1002/ajmg.a.36478. Epub 2014 Mar 25.

45.

Functional characterization of SIM1-associated enhancers.

Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N.

Hum Mol Genet. 2014 Apr 1;23(7):1700-8. doi: 10.1093/hmg/ddt559. Epub 2013 Nov 7.

46.

African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative.

Perez MV, Hoffmann TJ, Tang H, Thornton T, Stefanick ML, Larson JC, Kooperberg C, Reiner AP, Caan B, Iribarren C, Risch N.

Am Heart J. 2013 Sep;166(3):566-72. doi: 10.1016/j.ahj.2013.05.024. Epub 2013 Aug 7.

PMID:
24016508
47.

A genome-wide association study (GWAS) for bronchopulmonary dysplasia.

Wang H, St Julien KR, Stevenson DK, Hoffmann TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jelliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM.

Pediatrics. 2013 Aug;132(2):290-7. doi: 10.1542/peds.2013-0533. Epub 2013 Jul 29.

48.

Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.

Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H.

Am J Hum Genet. 2013 Jun 6;92(6):904-16. doi: 10.1016/j.ajhg.2013.04.025. Epub 2013 May 30.

49.

Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative.

Kaklamani VG, Hoffmann TJ, Thornton TA, Hayes G, Chlebowski R, Van Horn L, Mantzoros C.

Breast Cancer Res Treat. 2013 Jun;139(2):461-8. doi: 10.1007/s10549-013-2546-6. Epub 2013 Apr 30.

50.

The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies.

Lindquist KJ, Jorgenson E, Hoffmann TJ, Witte JS.

Genet Epidemiol. 2013 May;37(4):383-92. doi: 10.1002/gepi.21724. Epub 2013 Mar 25.

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