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Items: 1 to 50 of 2400

1.

Good outcome using anatomically pre-formed buttress plates for anteromedial facet fractures of the coronoid-a retrospective study of twenty-four patients.

Klug A, Buschbeck S, Gramlich Y, Buckup J, Hoffmann R, Schmidt-Horlohé K.

Int Orthop. 2019 Jun 7. doi: 10.1007/s00264-019-04354-6. [Epub ahead of print]

PMID:
31175393
2.

Chemosaturation with percutaneous hepatic perfusion of melphalan for liver-dominant metastatic uveal melanoma: a single center experience.

Artzner C, Mossakowski O, Hefferman G, Grosse U, Hoffmann R, Forschner A, Eigentler T, Syha R, Grözinger G.

Cancer Imaging. 2019 May 30;19(1):31. doi: 10.1186/s40644-019-0218-4.

3.

Squeezing all Elements in the Periodic Table: Electron Configuration and Electronegativity of the Atoms under Compression.

Rahm M, Cammi R, Ashcroft NW, Hoffmann R.

J Am Chem Soc. 2019 May 30. doi: 10.1021/jacs.9b02634. [Epub ahead of print]

PMID:
31144505
4.

The effect of complete caloric intake restriction on human body odour quality.

Fialová J, Hoffmann R, Roberts SC, Havlíček J.

Physiol Behav. 2019 May 23:112554. doi: 10.1016/j.physbeh.2019.05.015. [Epub ahead of print]

PMID:
31130296
5.

Local treatment of oligometastatic disease: current role.

Winkelmann MT, Clasen S, Pereira PL, Hoffmann R.

Br J Radiol. 2019 Jun 6:20180835. doi: 10.1259/bjr.20180835. [Epub ahead of print]

PMID:
31124700
6.

Complications after surgical treatment of proximal humerus fractures in the elderly-an analysis of complication patterns and risk factors for reverse shoulder arthroplasty and angular-stable plating.

Klug A, Wincheringer D, Harth J, Schmidt-Horlohé K, Hoffmann R, Gramlich Y.

J Shoulder Elbow Surg. 2019 May 2. pii: S1058-2746(19)30126-0. doi: 10.1016/j.jse.2019.02.017. [Epub ahead of print]

PMID:
31056394
7.

HELP@APP: development and evaluation of a self-help app for traumatized Syrian refugees in Germany - a study protocol of a randomized controlled trial.

Golchert J, Roehr S, Berg F, Grochtdreis T, Hoffmann R, Jung F, Nagl M, Plexnies A, Renner A, König HH, Kersting A, Riedel-Heller SG.

BMC Psychiatry. 2019 Apr 30;19(1):131. doi: 10.1186/s12888-019-2110-y.

8.

Next-generation reference intervals for pediatric hematology.

Zierk J, Hirschmann J, Toddenroth D, Arzideh F, Haeckel R, Bertram A, Cario H, Frühwald MC, Groß HJ, Groening A, Grützner S, Gscheidmeier T, Hoff T, Hoffmann R, Klauke R, Krebs A, Lichtinghagen R, Mühlenbrock-Lenter S, Neumann M, Nöllke P, Niemeyer CM, Razum O, Ruf HG, Steigerwald U, Streichert T, Torge A, Rascher W, Prokosch HU, Rauh M, Metzler M.

Clin Chem Lab Med. 2019 Apr 22. pii: /j/cclm.ahead-of-print/cclm-2018-1236/cclm-2018-1236.xml. doi: 10.1515/cclm-2018-1236. [Epub ahead of print]

PMID:
31005947
9.

EndoPredict versus uPA/PAI-1 in breast cancer: Comparison of markers and association with clinicopathological parameters.

Jakubowicz E, Martin B, Hoffmann R, Kröncke T, Jung T, Steierl R, Steinfeld D, Schenkirsch G, Kriegsmann J, Märkl B.

Breast J. 2019 May;25(3):450-454. doi: 10.1111/tbj.13258. Epub 2019 Apr 18.

PMID:
31001905
10.

Criteria for CITES species protection.

Challender DWS, Hoffmann M, Hoffmann R, Scott J, Robinson JE, Cremona P, Hilton-Taylor C, Jenkins RKB, Malsch K, Conde D, De Meulenaer T.

Science. 2019 Apr 19;364(6437):247-248. doi: 10.1126/science.aax1266. Epub 2019 Apr 18. No abstract available.

PMID:
31000654
11.

The Incidence and Management of Moderate to Severe Head Injury.

Maegele M, Lefering R, Sakowitz O, Kopp MA, Schwab JM, Steudel WI, Unterberg A, Hoffmann R, Uhl E, Marzi I.

Dtsch Arztebl Int. 2019 Mar 8;116(10):167-173. doi: 10.3238/arztebl.2019.0167.

12.

Diversity of advanced glycation end products in the bovine milk proteome.

Milkovska-Stamenova S, Hoffmann R.

Amino Acids. 2019 Jun;51(6):891-901. doi: 10.1007/s00726-019-02707-4. Epub 2019 Feb 13.

PMID:
30963298
13.

Accuracy of ultrasonography in the assessment of liver fat compared with MRI.

Kromrey ML, Ittermann T, Berning M, Kolb C, Hoffmann RT, Lerch MM, Völzke H, Kühn JP.

Clin Radiol. 2019 Jul;74(7):539-546. doi: 10.1016/j.crad.2019.02.014. Epub 2019 Apr 5.

PMID:
30955836
14.

Red-emitting K3HF2WO2F4:Mn4+ for application in warm-white phosphor-converted LEDs - optical properties and magnetic resonance characterization.

Jansen T, Funke LM, Gorobez J, Böhnisch D, Hoffmann RD, Heletta L, Pöttgen R, Hansen MR, Jüstel T, Eckert H.

Dalton Trans. 2019 Apr 16;48(16):5361-5371. doi: 10.1039/c9dt00091g.

PMID:
30945711
15.

Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma.

Khair DO, Bax HJ, Mele S, Crescioli S, Pellizzari G, Khiabany A, Nakamura M, Harris RJ, French E, Hoffmann RM, Williams IP, Cheung A, Thair B, Beales CT, Touizer E, Signell AW, Tasnova NL, Spicer JF, Josephs DH, Geh JL, MacKenzie Ross A, Healy C, Papa S, Lacy KE, Karagiannis SN.

Front Immunol. 2019 Mar 19;10:453. doi: 10.3389/fimmu.2019.00453. eCollection 2019. Review.

16.

Intra-procedural bronchial artery embolization planning: the usefulness of cone-beam CT.

Grosse U, Grözinger G, Syha R, Ketelsen D, Partovi S, Nikolaou K, Hoffmann R.

Acta Radiol. 2019 Mar 21:284185119837931. doi: 10.1177/0284185119837931. [Epub ahead of print]

PMID:
30897931
17.

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.

Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA.

J Biol Chem. 2019 May 3;294(18):7488-7502. doi: 10.1074/jbc.RA118.007288. Epub 2019 Mar 19.

PMID:
30890560
18.

Cross Conjugation in Polyenes and Related Hydrocarbons: What Can Be Learned from Valence Bond Theory about Single-Molecule Conductance?

Gu J, Wu W, Stuyver T, Danovich D, Hoffmann R, Tsuji Y, Shaik S.

J Am Chem Soc. 2019 Apr 10;141(14):6030-6047. doi: 10.1021/jacs.9b01420. Epub 2019 Apr 2.

PMID:
30887801
19.

Deformable registration of 3D ultrasound volumes using automatic landmark generation.

Figl M, Hoffmann R, Kaar M, Hummel J.

PLoS One. 2019 Mar 15;14(3):e0213004. doi: 10.1371/journal.pone.0213004. eCollection 2019.

20.

Comparison of sequential and high-pitch-spiral coronary CT-angiography: image quality and radiation exposure.

Seppelt D, Kolb C, Kühn JP, Speiser U, Radosa CG, Hoberück S, Hoffmann RT, Platzek I.

Int J Cardiovasc Imaging. 2019 Mar 8. doi: 10.1007/s10554-019-01568-y. [Epub ahead of print]

PMID:
30850908
21.

Constraints on Minute-Scale Transient Astrophysical Neutrino Sources.

Aartsen MG, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Al Samarai I, Altmann D, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Backes P, Bagherpour H, Bai X, Barbano A, Barron JP, Barwick SW, Baum V, Bay R, Beatty JJ, Becker Tjus J, Becker KH, BenZvi S, Berley D, Bernardini E, Besson DZ, Binder G, Bindig D, Blaufuss E, Blot S, Bohm C, Börner M, Bos F, Böser S, Botner O, Bourbeau E, Bourbeau J, Bradascio F, Braun J, Brenzke M, Bretz HP, Bron S, Brostean-Kaiser J, Burgman A, Busse RS, Carver T, Cheung E, Chirkin D, Christov A, Clark K, Classen L, Collin GH, Conrad JM, Coppin P, Correa P, Cowen DF, Cross R, Dave P, Day M, de André JPAM, De Clercq C, DeLaunay JJ, Dembinski H, Deoskar K, De Ridder S, Desiati P, de Vries KD, de Wasseige G, de With M, DeYoung T, Díaz-Vélez JC, di Lorenzo V, Dujmovic H, Dumm JP, Dunkman M, Dvorak E, Eberhardt B, Ehrhardt T, Eichmann B, Eller P, Evans PA, Evenson PA, Fahey S, Fazely AR, Felde J, Filimonov K, Finley C, Franckowiak A, Friedman E, Fritz A, Gaisser TK, Gallagher J, Ganster E, Gerhardt L, Ghorbani K, Giang W, Glauch T, Glüsenkamp T, Goldschmidt A, Gonzalez JG, Grant D, Griffith Z, Haack C, Hallgren A, Halve L, Halzen F, Hanson K, Hebecker D, Heereman D, Helbing K, Hellauer R, Hickford S, Hignight J, Hill GC, Hoffman KD, Hoffmann R, Hoinka T, Hokanson-Fasig B, Hoshina K, Huang F, Huber M, Hultqvist K, Hünnefeld M, Hussain R, In S, Iovine N, Ishihara A, Jacobi E, Japaridze GS, Jeong M, Jero K, Jones BJP, Kalaczynski P, Kang W, Kappes A, Kappesser D, Karg T, Karle A, Katz U, Kauer M, Keivani A, Kelley JL, Kheirandish A, Kim J, Kintscher T, Kiryluk J, Kittler T, Klein SR, Koirala R, Kolanoski H, Köpke L, Kopper C, Kopper S, Koschinsky JP, Koskinen DJ, Kowalski M, Krings K, Kroll M, Krückl G, Kunwar S, Kurahashi N, Kyriacou A, Labare M, Lanfranchi JL, Larson MJ, Lauber F, Leonard K, Leuermann M, Liu QR, Lohfink E, Lozano Mariscal CJ, Lu L, Lünemann J, Luszczak W, Madsen J, Maggi G, Mahn KBM, Makino Y, Mancina S, Mariş IC, Maruyama R, Mase K, Maunu R, Meagher K, Medici M, Meier M, Menne T, Merino G, Meures T, Miarecki S, Micallef J, Momenté G, Montaruli T, Moore RW, Moulai M, Nagai R, Nahnhauer R, Nakarmi P, Naumann U, Neer G, Niederhausen H, Nowicki SC, Nygren DR, Obertacke Pollmann A, Olivas A, O'Murchadha A, Osborne JP, O'Sullivan E, Palczewski T, Pandya H, Pankova DV, Peiffer P, Pepper JA, Pérez de Los Heros C, Pieloth D, Pinat E, Pizzuto A, Plum M, Price PB, Przybylski GT, Raab C, Rameez M, Rauch L, Rawlins K, Rea IC, Reimann R, Relethford B, Renzi G, Resconi E, Rhode W, Richman M, Robertson S, Rongen M, Rott C, Ruhe T, Ryckbosch D, Rysewyk D, Safa I, Sanchez Herrera SE, Sandrock A, Sandroos J, Santander M, Sarkar S, Sarkar S, Satalecka K, Schaufel M, Schlunder P, Schmidt T, Schneider A, Schneider J, Schöneberg S, Schumacher L, Sclafani S, Seckel D, Seunarine S, Soedingrekso J, Soldin D, Song M, Spiczak GM, Spiering C, Stachurska J, Stamatikos M, Stanev T, Stasik A, Stein R, Stettner J, Steuer A, Stezelberger T, Stokstad RG, Stößl A, Strotjohann NL, Stuttard T, Sullivan GW, Sutherland M, Taboada I, Tenholt F, Ter-Antonyan S, Terliuk A, Tilav S, Toale PA, Tobin MN, Tönnis C, Toscano S, Tosi D, Tselengidou M, Tung CF, Turcati A, Turley CF, Ty B, Unger E, Unland Elorrieta MA, Usner M, Vandenbroucke J, Van Driessche W, van Eijk D, van Eijndhoven N, Vanheule S, van Santen J, Vraeghe M, Walck C, Wallace A, Wallraff M, Wandler FD, Wandkowsky N, Watson TB, Waza A, Weaver C, Weiss MJ, Wendt C, Werthebach J, Westerhoff S, Whelan BJ, Whitehorn N, Wiebe K, Wiebusch CH, Wille L, Williams DR, Wills L, Wolf M, Wood J, Wood TR, Woolsey E, Woschnagg K, Wrede G, Xu DL, Xu XW, Xu Y, Yanez JP, Yodh G, Yoshida S, Yuan T.

Phys Rev Lett. 2019 Feb 8;122(5):051102. doi: 10.1103/PhysRevLett.122.051102.

PMID:
30822017
22.

Assessments of activities of daily living after arthroscopic SLAP repair with knot-tying versus knotless suture anchors.

Reinig Y, Welsch F, Hoffmann R, Müller D, Gramlich S, Fischer S, Schüttler KF, Zimmermann E, Stein T.

Arch Orthop Trauma Surg. 2019 Jul;139(7):981-990. doi: 10.1007/s00402-019-03151-5. Epub 2019 Feb 28.

PMID:
30820694
23.

Pancreatic Steatosis Is Associated With Impaired Exocrine Pancreatic Function.

Kromrey ML, Friedrich N, Hoffmann RT, Bülow R, Völzke H, Weiss FU, Lerch MM, Motosugi U, Kühn JP.

Invest Radiol. 2019 Jul;54(7):403-408. doi: 10.1097/RLI.0000000000000554.

PMID:
30817380
24.

[Percutaneous biliary and gallbladder interventions].

Radosa C, Schaab F, Hofmockel T, Kühn JP, Hoffmann RT.

Radiologe. 2019 Apr;59(4):342-347. doi: 10.1007/s00117-019-0506-9. Review. German.

PMID:
30806733
25.

[Cost estimation for hospital mass casualty exercises].

Schweigkofler U, Kleber C, Auhuber TC, Jung HG, Cwojdzinski D, Hoffmann R.

Unfallchirurg. 2019 May;122(5):381-386. doi: 10.1007/s00113-019-0619-7. German.

PMID:
30789998
26.

Sensitive and immunogen-specific serological detection of Rodentibacter pneumotropicus infections in mice.

Fingas F, Volke D, Hassert R, Fornefett J, Funk S, Baums CG, Hoffmann R.

BMC Microbiol. 2019 Feb 18;19(1):43. doi: 10.1186/s12866-019-1417-7.

27.

Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).

Henderson DJP, Houslay MD, Bangma CH, Hoffmann R.

Clin Sci (Lond). 2019 Jan 25;133(2):269-286. doi: 10.1042/CS20180519. Print 2019 Jan 31. Review.

PMID:
30683712
28.

Two-stage hip revision arthroplasty for periprosthetic joint infection without the use of spacer or cemented implants.

Gramlich Y, Hagebusch P, Faul P, Klug A, Walter G, Hoffmann R.

Int Orthop. 2019 Jan 18. doi: 10.1007/s00264-019-04297-y. [Epub ahead of print]

PMID:
30659319
29.

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion.

Heitz SD, Hamelin DJ, Hoffmann RM, Greenberg N, Salloum G, Erami Z, Khalil BD, Shymanets A, Steidle EA, Gong GQ, Nürnberg B, Burke JE, Flanagan JU, Bresnick AR, Backer JM.

J Biol Chem. 2019 Mar 22;294(12):4621-4633. doi: 10.1074/jbc.RA118.006032. Epub 2019 Jan 18.

PMID:
30659094
30.

Holmium-166 Radioembolization in Hepatocellular Carcinoma: Feasibility and Safety of a New Treatment Option in Clinical Practice.

Radosa CG, Radosa JC, Grosche-Schlee S, Zöphel K, Plodeck V, Kühn JP, Kotzerke J, Hoffmann RT.

Cardiovasc Intervent Radiol. 2019 Mar;42(3):405-412. doi: 10.1007/s00270-018-2133-7. Epub 2019 Jan 2.

PMID:
30603976
31.

Spatial variability of biogeochemistry in shallow coastal benthic communities of Potter Cove (Antarctica) and the impact of a melting glacier.

Hoffmann R, Pasotti F, Vázquez S, Lefaible N, Torstensson A, MacCormack W, Wenzhöfer F, Braeckman U.

PLoS One. 2018 Dec 19;13(12):e0207917. doi: 10.1371/journal.pone.0207917. eCollection 2018.

32.

Oncology Nurse Practitioner Web Education Resource(ONc-PoWER): An Evaluation of a Web-Enhanced Education Resource for Nurse Practitioners Who Are New to Cancer Care.

Hoffmann RL, Klein S, Connolly M, Rosenzweig MQ.

J Adv Pract Oncol. 2018 Jan-Feb;9(1):27-37. Epub 2018 Jan 1. Review.

33.

The reciprocal relationship between material factors and health in the life course: evidence from SHARE and ELSA.

Hoffmann R, Kröger H, Pakpahan E.

Eur J Ageing. 2018 Feb 19;15(4):379-391. doi: 10.1007/s10433-018-0458-3. eCollection 2018 Dec.

34.

Electronegativity Seen as the Ground-State Average Valence Electron Binding Energy.

Rahm M, Zeng T, Hoffmann R.

J Am Chem Soc. 2019 Jan 9;141(1):342-351. doi: 10.1021/jacs.8b10246. Epub 2018 Dec 17.

PMID:
30499303
35.

Use of Dapsone in the Treatment of Chronic Idiopathic and Autoimmune Urticaria.

Liang SE, Hoffmann R, Peterson E, Soter NA.

JAMA Dermatol. 2019 Jan 1;155(1):90-95. doi: 10.1001/jamadermatol.2018.3715.

PMID:
30476976
36.

Products of Early and Advanced Glycation in the Soy Milk Proteome.

Milkovska-Stamenova S, Krieg L, Hoffmann R.

Mol Nutr Food Res. 2019 Jan;63(2):e1800725. doi: 10.1002/mnfr.201800725. Epub 2018 Nov 28.

PMID:
30430721
37.

Aqueous Solution Processing of Combustible Precursor Compounds into Amorphous Indium Gallium Zinc Oxide (IGZO) Semiconductors for Thin Film Transistor Applications.

Sanctis S, Hoffmann RC, Koslowski N, Foro S, Bruns M, Schneider JJ.

Chem Asian J. 2018 Dec 18;13(24):3912-3919. doi: 10.1002/asia.201801371. Epub 2018 Nov 13.

PMID:
30426698
38.

Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.

Castro-Falcón G, Seiler GS, Demir Ö, Rathinaswamy MK, Hamelin D, Hoffmann RM, Makowski SL, Letzel AC, Field SJ, Burke JE, Amaro RE, Hughes CC.

J Med Chem. 2018 Dec 13;61(23):10463-10472. doi: 10.1021/acs.jmedchem.8b00975. Epub 2018 Nov 28.

PMID:
30380865
39.

Measuring relative vibrotactile spatial acuity: effects of tactor type, anchor points and tactile anisotropy.

Hoffmann R, Valgeirsdóttir VV, Jóhannesson ÓI, Unnthorsson R, Kristjánsson Á.

Exp Brain Res. 2018 Dec;236(12):3405-3416. doi: 10.1007/s00221-018-5387-z. Epub 2018 Oct 6.

40.

[Treatment of Acute and Chronic Ruptures of the Extensor Mechanism of the Knee Joints].

Dettmer SM, Schweigkofler U, Hoffmann R.

Z Orthop Unfall. 2018 Oct;156(5):593-607. doi: 10.1055/s-0043-123410. Epub 2018 Oct 5. German.

PMID:
30290393
41.

Complications after radial head arthroplasty: a comparison between short-stemmed bipolar and monopolar long-stemmed osteointegrative rigidly fixed prostheses.

Gramlich Y, Krausch EL, Klug A, Buckup J, Schmidt-Horlohé K, Hoffmann R.

Int Orthop. 2018 Sep 29. doi: 10.1007/s00264-018-4173-7. [Epub ahead of print]

PMID:
30267243
42.

The CNO's role in a healthy work environment.

Burns HM, Gonzalez JFZ, Hoffmann RL, Fulginiti S.

Nurs Manage. 2018 Oct;49(10):22-28. doi: 10.1097/01.NUMA.0000546200.94337.06. No abstract available.

PMID:
30260825
43.

Roles of plasma membrane proton ATPases AHA2 and AHA7 in normal growth of roots and root hairs in Arabidopsis thaliana.

Hoffmann RD, Olsen LI, Ezike CV, Pedersen JT, Manstretta R, López-Marqués RL, Palmgren M.

Physiol Plant. 2019 Jul;166(3):848-861. doi: 10.1111/ppl.12842. Epub 2018 Nov 20.

PMID:
30238999
44.

Correlation of Bedside Pediatric Early Warning System Score to Interventions During Peritransport Period.

Page-Goertz CK, Dasgupta M, Hoffmann RG, Parshuram C, Forbes ML, Meyer MT.

Pediatr Crit Care Med. 2018 Nov;19(11):e618-e626. doi: 10.1097/PCC.0000000000001722.

PMID:
30234741
45.

Feasibility, efficacy, and safety of percutaneous MR-guided ablation of small (≤12 mm) hepatic malignancies.

Weiss J, Hoffmann R, Rempp H, Keβler DE, Pereira PL, Nikolaou K, Clasen S.

J Magn Reson Imaging. 2019 Feb;49(2):374-381. doi: 10.1002/jmri.26252. Epub 2018 Sep 17.

PMID:
30221797
46.

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE.

Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z.

47.

Spine Trauma Treatment: Recommendations of the German Society for Orthopaedics and Trauma (DGOU).

Hoffmann R, Kandziora F, Korge A, Schnake K, Kothe R.

Global Spine J. 2018 Sep;8(2 Suppl):4S. doi: 10.1177/2192568218774045. Epub 2018 Sep 7. No abstract available.

48.

Mirrors of Bonding in Metal Halide Perovskites.

Goesten MG, Hoffmann R.

J Am Chem Soc. 2018 Oct 10;140(40):12996-13010. doi: 10.1021/jacs.8b08038. Epub 2018 Oct 1.

PMID:
30207152
49.

Alkyl Isosteres.

Parambil PC, Hoffmann R.

J Am Chem Soc. 2018 Oct 10;140(40):12844-12852. doi: 10.1021/jacs.8b06141. Epub 2018 Sep 26.

PMID:
30203650
50.

Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development.

Ostorhazi E, Hoffmann R, Herth N, Wade JD, Kraus CN, Otvos L Jr.

Front Chem. 2018 Aug 21;6:359. doi: 10.3389/fchem.2018.00359. eCollection 2018.

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