Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 67


Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models.

Hoffmann PR, Hoffmann FW, Premeaux TA, Fujita T, Soprana E, Panigada M, Chew GM, Richard G, Hindocha P, Menor M, Khadka VS, Deng Y, Moise L, Ndhlovu LC, Siccardi A, Weinberg AD, De Groot AS, Bertino P.

Front Oncol. 2019 Aug 2;9:720. doi: 10.3389/fonc.2019.00720. eCollection 2019.


Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion.

Bertino P, Premeaux TA, Fujita T, Haun BK, Marciel MP, Hoffmann FW, Garcia A, Yiang H, Pastorino S, Carbone M, Niki T, Berestecky J, Hoffmann PR, Ndhlovu LC.

Oncoimmunology. 2019 Apr 17;8(8):1601482. doi: 10.1080/2162402X.2019.1601482. eCollection 2019.


Use of a Mouse Model and Human Umbilical Vein Endothelial Cells to Investigate the Effect of Arsenic Exposure on Vascular Endothelial Function and the Associated Role of Calpains.

Cai Z, Zhang Y, Zhang Y, Miao X, Li S, Yang H, Ling Q, Hoffmann PR, Huang Z.

Environ Health Perspect. 2019 Jul;127(7):77003. doi: 10.1289/EHP4538. Epub 2019 Jul 5.


Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer.

Marciel MP, Hoffmann PR.

Biol Trace Elem Res. 2019 Nov;192(1):60-68. doi: 10.1007/s12011-019-01774-8. Epub 2019 Jun 11.


Selenium, Selenoproteins, and Immunity.

Avery JC, Hoffmann PR.

Nutrients. 2018 Sep 1;10(9). pii: E1203. doi: 10.3390/nu10091203. Review.


Correction: Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis.

Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR.

Oncotarget. 2018 Jul 20;9(56):30937. doi: 10.18632/oncotarget.25857. eCollection 2018 Jul 20.


Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis.

Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR.

Oncotarget. 2018 Feb 3;9(17):13407-13422. doi: 10.18632/oncotarget.24388. eCollection 2018 Mar 2. Erratum in: Oncotarget. 2018 Jul 20;9(56):30937. Deng, Youpeng [corrected to Deng, Youping].


Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate.

Fredericks GJ, Hoffmann FW, Hondal RJ, Rozovsky S, Urschitz J, Hoffmann PR.

Antioxidants (Basel). 2017 Dec 29;7(1). pii: E4. doi: 10.3390/antiox7010004.


Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.

Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR.

Cancer Med. 2018 Jan;7(1):175-183. doi: 10.1002/cam4.1260. Epub 2017 Dec 6.


Selenoproteins and Metastasis.

Marciel MP, Hoffmann PR.

Adv Cancer Res. 2017;136:85-108. doi: 10.1016/bs.acr.2017.07.008. Epub 2017 Sep 1. Review.


Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin β3 Signaling.

Cai Z, Dong L, Song C, Zhang Y, Zhu C, Zhang Y, Ling Q, Hoffmann PR, Li J, Huang Z, Li W.

Sci Rep. 2017 Aug 25;7(1):9445. doi: 10.1038/s41598-017-09568-5.


Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis.

Pitts MW, Hoffmann PR.

Cell Calcium. 2018 Mar;70:76-86. doi: 10.1016/j.ceca.2017.05.001. Epub 2017 May 4. Review.


Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer.

Youngren-Ortiz SR, Hill DB, Hoffmann PR, Morris KR, Barrett EG, Forest MG, Chougule MB.

J Aerosol Med Pulm Drug Deliv. 2017 Oct;30(5):299-321. doi: 10.1089/jamp.2015.1286. Epub 2017 Mar 9.


Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation.

Zhu C, Zhang S, Song C, Zhang Y, Ling Q, Hoffmann PR, Li J, Chen T, Zheng W, Huang Z.

J Nanobiotechnology. 2017 Mar 7;15(1):20. doi: 10.1186/s12951-017-0252-y.


Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.

Zhang ZH, Wu QY, Zheng R, Chen C, Chen Y, Liu Q, Hoffmann PR, Ni JZ, Song GL.

J Neurosci. 2017 Mar 1;37(9):2449-2462. doi: 10.1523/JNEUROSCI.3229-16.2017. Epub 2017 Jan 30.


Selenoprotein Gene Nomenclature.

Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y.

J Biol Chem. 2016 Nov 11;291(46):24036-24040. Epub 2016 Sep 19.


Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcγR-mediated phagocytosis.

Norton RL, Fredericks GJ, Huang Z, Fay JD, Hoffmann FW, Hoffmann PR.

J Leukoc Biol. 2017 Feb;101(2):439-448. doi: 10.1189/jlb.2A0316-156RR. Epub 2016 Sep 6.


ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.

Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D.

Nat Commun. 2016 Sep 1;7:12702. doi: 10.1038/ncomms12702.


Selenomethionine reduces the deposition of beta-amyloid plaques by modulating β-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease.

Zhang ZH, Chen C, Wu QY, Zheng R, Liu Q, Ni JZ, Hoffmann PR, Song GL.

Metallomics. 2016 Aug 1;8(8):782-9. doi: 10.1039/c6mt00117c.


Selenium-Containing Phycocyanin from Se-Enriched Spirulina platensis Reduces Inflammation in Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Activation.

Zhu C, Ling Q, Cai Z, Wang Y, Zhang Y, Hoffmann PR, Zheng W, Zhou T, Huang Z.

J Agric Food Chem. 2016 Jun 22;64(24):5060-70. doi: 10.1021/acs.jafc.6b01308. Epub 2016 Jun 7.


Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Rose AH, Hoffmann FW, Hara JH, Urschitz J, Moisyadi S, Hoffmann PR, Bertino P.

Hum Vaccin Immunother. 2015;11(9):2305-11. doi: 10.1080/21645515.2015.1047567. Epub 2015 Jun 19.


Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.

Rose AH, Huang Z, Mafnas C, Hara JH, Hoffmann FW, Hashimoto AS, Bertino P, Hoffmann PR.

Inflamm Bowel Dis. 2015 Sep;21(9):2005-15. doi: 10.1097/MIB.0000000000000471.


Selenoprotein K and protein palmitoylation.

Fredericks GJ, Hoffmann PR.

Antioxid Redox Signal. 2015 Oct 1;23(10):854-62. doi: 10.1089/ars.2015.6375. Epub 2015 Jun 17. Review.


Preclinical development of HIvax: Human survivin highly immunogenic vaccines.

Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P.

Hum Vaccin Immunother. 2015;11(7):1585-95. doi: 10.1080/21645515.2015.1050572.


Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine.

Berry MJ, Astern J, Bellinger F, Brampton C, Cann R, Gerschenson M, Haymer D, James NG, Jameson DM, LeSaux O, Hoffmann PR, Nichols R, Pitts M, Seale L, Seifried S, Stokes AJ, Todorovic C.

Hawaii J Med Public Health. 2015 Apr;74(4):150-3. No abstract available.


Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.

Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier F, Hoffmann PR.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16478-83. doi: 10.1073/pnas.1417176111. Epub 2014 Nov 3.


Selenoproteins and cardiovascular stress.

Rose AH, Hoffmann PR.

Thromb Haemost. 2015 Mar;113(3):494-504. doi: 10.1160/TH14-07-0603. Epub 2014 Oct 30. Review.


Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses.

Bertino P, Urschitz J, Hoffmann FW, You BR, Rose AH, Park WH, Moisyadi S, Hoffmann PR.

Vaccine. 2014 Mar 26;32(15):1670-7. doi: 10.1016/j.vaccine.2014.01.063. Epub 2014 Feb 7.


Increasing dietary selenium elevates reducing capacity and ERK activation associated with accelerated progression of select mesothelioma tumors.

Rose AH, Bertino P, Hoffmann FW, Gaudino G, Carbone M, Hoffmann PR.

Am J Pathol. 2014 Apr;184(4):1041-1049. doi: 10.1016/j.ajpath.2013.12.008. Epub 2014 Feb 1.


STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells.

Youngren SR, Tekade RK, Gustilo B, Hoffmann PR, Chougule MB.

Biomed Res Int. 2013;2013:858946. doi: 10.1155/2013/858946. Epub 2013 Sep 26.


Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.

Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR.

J Immunol. 2013 Oct 1;191(7):3778-88. doi: 10.4049/jimmunol.1300972. Epub 2013 Aug 28.


MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.

Lee BC, Péterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN.

Mol Cell. 2013 Aug 8;51(3):397-404. doi: 10.1016/j.molcel.2013.06.019. Epub 2013 Aug 1.


Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation.

Youngren SR, Mulik R, Jun B, Hoffmann PR, Morris KR, Chougule MB.

AAPS PharmSciTech. 2013 Sep;14(3):1012-24.


Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis.

Meiler S, Baumer Y, Huang Z, Hoffmann FW, Fredericks GJ, Rose AH, Norton RL, Hoffmann PR, Boisvert WA.

J Leukoc Biol. 2013 May;93(5):771-80. doi: 10.1189/jlb.1212647. Epub 2013 Feb 26.


Fowlpox-based survivin vaccination for malignant mesothelioma therapy.

Bertino P, Panigada M, Soprana E, Bianchi V, Bertilaccio S, Sanvito F, Rose AH, Yang H, Gaudino G, Hoffmann PR, Siccardi A, Carbone M.

Int J Cancer. 2013 Aug 1;133(3):612-23. doi: 10.1002/ijc.28048. Epub 2013 Feb 25.


Asthma in children and nutritional selenium get another look.

Hoffmann PR.

Clin Exp Allergy. 2012 Apr;42(4):488-9. doi: 10.1111/j.1365-2222.2011.03949.x. No abstract available.


Stimulation of unprimed macrophages with immune complexes triggers a low output of nitric oxide by calcium-dependent neuronal nitric-oxide synthase.

Huang Z, Hoffmann FW, Fay JD, Hashimoto AC, Chapagain ML, Kaufusi PH, Hoffmann PR.

J Biol Chem. 2012 Feb 10;287(7):4492-502. doi: 10.1074/jbc.M111.315598. Epub 2011 Dec 28.


Selenium and asthma.

Norton RL, Hoffmann PR.

Mol Aspects Med. 2012 Feb;33(1):98-106. doi: 10.1016/j.mam.2011.10.003. Epub 2011 Oct 15. Review.


The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities.

Huang Z, Rose AH, Hoffmann PR.

Antioxid Redox Signal. 2012 Apr 1;16(7):705-43. doi: 10.1089/ars.2011.4145. Epub 2012 Jan 9. Review.


Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages.

Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR.

J Biol Chem. 2011 Oct 7;286(40):34830-8. doi: 10.1074/jbc.M111.265520. Epub 2011 Aug 17.


Specific antioxidant selenoproteins are induced in the heart during hypertrophy.

Hoffmann FW, Hashimoto AS, Lee BC, Rose AH, Shohet RV, Hoffmann PR.

Arch Biochem Biophys. 2011 Aug 1;512(1):38-44. doi: 10.1016/ Epub 2011 May 20.


Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.

Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR.

J Immunol. 2011 Feb 15;186(4):2127-37. doi: 10.4049/jimmunol.1002878. Epub 2011 Jan 10.


Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.

Hoffmann FW, Hashimoto AC, Shafer LA, Dow S, Berry MJ, Hoffmann PR.

J Nutr. 2010 Jun;140(6):1155-61. doi: 10.3945/jn.109.120725. Epub 2010 Apr 7.


The human selenoproteome: recent insights into functions and regulation.

Reeves MA, Hoffmann PR.

Cell Mol Life Sci. 2009 Aug;66(15):2457-78. doi: 10.1007/s00018-009-0032-4. Epub 2009 Apr 28. Review.


Finite element analysis of the proximal femur and hip fracture risk in older men.

Orwoll ES, Marshall LM, Nielson CM, Cummings SR, Lapidus J, Cauley JA, Ensrud K, Lane N, Hoffmann PR, Kopperdahl DL, Keaveny TM; Osteoporotic Fractures in Men Study Group.

J Bone Miner Res. 2009 Mar;24(3):475-83. doi: 10.1359/jbmr.081201.


Selenium and asthma: a complex relationship.

Hoffmann PR.

Allergy. 2008 Jul;63(7):854-6. doi: 10.1111/j.1398-9995.2008.01676.x.


The influence of selenium on immune responses.

Hoffmann PR, Berry MJ.

Mol Nutr Food Res. 2008 Nov;52(11):1273-80. doi: 10.1002/mnfr.200700330. Review.


Mechanisms by which selenium influences immune responses.

Hoffmann PR.

Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct;55(5):289-97. Review.


Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling.

Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK.

J Biol Chem. 2008 Feb 29;283(9):5760-8. Epub 2007 Dec 3.


A new approach for analyzing cellular infiltration during allergic airway inflammation.

Hoffmann PR, Gurary A, Hoffmann FW, Jourdan-Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ.

J Immunol Methods. 2007 Dec 1;328(1-2):21-33. Epub 2007 Aug 27.

Supplemental Content

Loading ...
Support Center